Entpd3 (ectonucleoside triphosphate diphosphohydrolase 3)

Gene: Entpd3 (ectonucleoside triphosphate diphosphohydrolase 3) Rattus norvegicus

Analyze

Symbol:

Entpd3

Name:

ectonucleoside triphosphate diphosphohydrolase 3

RGD ID:

631326

Description:

Predicted to enable GDP phosphatase activity; UDP phosphatase activity; and ribonucleoside triphosphate phosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Predicted to act upstream of or within nucleoside triphosphate catabolic process. Predicted to be active in plasma membrane. Orthologous to human ENTPD3 (ectonucleoside triphosphate diphosphohydrolase 3); PARTICIPATES IN purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

NTPDase3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	129,124,540 - 129,155,528 (+)	NCBI		GRCr8
mRatBN7.2	8	120,246,412 - 120,277,943 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	120,247,121 - 120,277,943 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	125,824,177 - 125,855,128 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	124,023,199 - 124,054,146 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	121,865,417 - 121,896,317 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	129,201,000 - 129,232,436 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	129,201,669 - 129,232,677 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	128,399,554 - 128,430,329 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	125,542,934 - 125,573,945 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	125,586,832 - 125,593,682 (+)	NCBI
Celera	8	119,389,184 - 119,419,978 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-dichloroaniline (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (EXP,ISO)

amitrole (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

azathioprine (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[e]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

cocaine (ISO)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

cyhalothrin (EXP)

diuron (ISO)

genistein (ISO)

glyphosate (ISO)

methapyrilene (ISO)

methimazole (EXP)

methotrexate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nickel atom (ISO)

nicotine (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

phenobarbital (EXP)

resveratrol (ISO)

sodium arsenite (ISO)

sodium aurothiomalate (ISO)

sulfadimethoxine (EXP)

titanium dioxide (EXP)

triclosan (ISO)

triptonide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nucleoside diphosphate catabolic process (IBA,ISO)

nucleoside triphosphate catabolic process (ISO)

Cellular Component

plasma membrane (IBA,ISO)

Molecular Function

5'-nucleotidase activity (ISO)

ATP binding (IEA)

GDP phosphatase activity (IBA)

nucleoside diphosphate phosphatase activity (ISO)

protein binding (ISO)

ribonucleoside triphosphate phosphatase activity (IBA,ISO)

UDP phosphatase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

purine metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3.	Lavoie EG, etal., Biochem Pharmacol 2004 May 15;67(10):1917-26.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:16338080	PMID:17910474	PMID:19383175	PMID:19527530	PMID:20620196	PMID:27049676

Genomics

Comparative Map Data

Entpd3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	129,124,540 - 129,155,528 (+)	NCBI		GRCr8
mRatBN7.2	8	120,246,412 - 120,277,943 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	120,247,121 - 120,277,943 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	125,824,177 - 125,855,128 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	124,023,199 - 124,054,146 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	121,865,417 - 121,896,317 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	129,201,000 - 129,232,436 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	129,201,669 - 129,232,677 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	128,399,554 - 128,430,329 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	125,542,934 - 125,573,945 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	125,586,832 - 125,593,682 (+)	NCBI
Celera	8	119,389,184 - 119,419,978 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

ENTPD3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	40,387,184 - 40,428,744 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	40,387,184 - 40,428,744 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	40,428,675 - 40,470,235 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	40,403,694 - 40,445,114 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	40,403,696 - 40,445,113	NCBI
Celera	3	40,371,496 - 40,412,942 (+)	NCBI		Celera
Cytogenetic Map	3	p22.1	NCBI
HuRef	3	40,473,275 - 40,514,184 (+)	NCBI		HuRef
CHM1_1	3	40,379,250 - 40,420,697 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	40,402,253 - 40,443,812 (+)	NCBI		T2T-CHM13v2.0

Entpd3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	120,368,884 - 120,397,393 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	120,368,884 - 120,397,393 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	120,539,818 - 120,568,327 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	120,539,818 - 120,568,327 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	120,448,936 - 120,477,444 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	120,388,541 - 120,417,015 (+)	NCBI		MGSCv36	mm8
Celera	9	121,009,378 - 121,037,928 (+)	NCBI		Celera
Cytogenetic Map	9	F4	NCBI
cM Map	9	71.71	NCBI

Entpd3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955420	29,445,909 - 29,468,709 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955420	29,445,252 - 29,471,024 (-)	NCBI	ChiLan1.0	ChiLan1.0

ENTPD3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	40,346,180 - 40,389,231 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	40,350,942 - 40,393,992 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	40,290,586 - 40,333,632 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	40,561,694 - 40,604,181 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	40,561,694 - 40,604,181 (+)	Ensembl	panpan1.1		panPan2

ENTPD3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	9,858,328 - 9,891,244 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	9,858,764 - 9,890,483 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	9,892,661 - 9,925,852 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	10,145,225 - 10,178,416 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	10,145,274 - 10,188,613 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	9,955,711 - 9,988,629 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	10,093,446 - 10,126,611 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	10,081,070 - 10,114,262 (+)	NCBI		UU_Cfam_GSD_1.0

Entpd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	196,209,767 - 196,243,685 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	29,348,318 - 29,382,270 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936473	29,348,370 - 29,382,258 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ENTPD3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	24,624,417 - 24,659,639 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	24,623,579 - 24,659,642 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	26,979,110 - 27,013,233 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ENTPD3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	1,881,640 - 1,923,708 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	1,882,978 - 1,923,837 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	165,279,983 - 165,321,188 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Entpd3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	78,304,771 - 78,324,393 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	78,298,340 - 78,326,982 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Entpd3
261 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	164
Count of miRNA genes:	108
Interacting mature miRNAs:	115
Transcripts:	ENSRNOT00000025663
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat

Markers in Region

RH134636

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	120,277,666 - 120,277,880 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	129,232,160 - 129,232,373	NCBI	Rnor6.0
Rnor_5.0	8	128,430,053 - 128,430,266	UniSTS	Rnor5.0
RGSC_v3.4	8	125,573,669 - 125,573,882	UniSTS	RGSC3.4
Celera	8	119,419,702 - 119,419,915	UniSTS
RH 3.4 Map	8	1284.89	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH144532

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	120,267,231 - 120,267,520 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	129,221,699 - 129,221,987	NCBI	Rnor6.0
Rnor_5.0	8	128,420,275 - 128,420,563	UniSTS	Rnor5.0
RGSC_v3.4	8	125,563,146 - 125,563,434	UniSTS	RGSC3.4
Celera	8	119,409,225 - 119,409,513	UniSTS
RH 3.4 Map	8	1317.8	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									9		1
Low	3	20	20	18		18			45	35	32	11
Below cutoff		12	25	14	13	14	2	2	20		8		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_178106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006244097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595701	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ437217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000025663 ⟹ ENSRNOP00000025663

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	120,247,121 - 120,277,943 (+)	Ensembl
Rnor_6.0 Ensembl	8	129,201,669 - 129,232,436 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000082377 ⟹ ENSRNOP00000073543

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	120,251,447 - 120,277,943 (+)	Ensembl
Rnor_6.0 Ensembl	8	129,205,931 - 129,232,677 (+)	Ensembl

RefSeq Acc Id:

NM_178106 ⟹ NP_835207

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	129,124,709 - 129,155,528 (+)	NCBI
mRatBN7.2	8	120,247,121 - 120,277,943 (+)	NCBI
Rnor_6.0	8	129,201,669 - 129,232,436 (+)	NCBI
Rnor_5.0	8	128,399,554 - 128,430,329 (+)	NCBI
RGSC_v3.4	8	125,542,934 - 125,573,945 (+)	RGD
Celera	8	119,389,184 - 119,419,978 (+)	RGD

Sequence:

show sequence

AGCGAGCGCAGCGCGCAGGTAAGGTCTGGACCGGCGCGCAGGAGTGGGATGGAGCAGCTGCCGG
AGGCTTGAAGCACGGAGAGAAGGACCCGGCACAGCTTCCCACAGAGGACCGCAGGCTGGAGCCG
AAACCCGGGGAGCTGGGCACTGTCATCTGACAGGCACAGGACACCGCGTCACGAAACGCCCCAA
GACCTGCAGCTCGGACTGAAGATGTTTACGGTGATGACCCGCCAGCCCTGTGAACAGGCAGGCT
TCAGGGCCCTCTCGAGGACTCCAGCCATCGTCACCTTGGTGGTCCTGCTTGTGAGCATCGTGGT
ACTTGTGACACTTACACTCATCCAGATCCACCACCCACAGGTTCTCTCTCCAGGGCTGAAGTAT
GGAATCGTGTTGGATGCCGGCTCTTCCAGAACCACTGTCTATGTGTATCAGTGGCCAGCAGAGA
AGGAGAATAACACAGGAGTGGTCAGCCAAACCTTCAGATGTAGTGTGAAAGGCTCGGGAATCTC
CAGCTATGAGAATAACCCCCAAGATGCCCCCAAAGCCTTTGAGGACTGCATGCTAAAGGTCAAG
GAACAGGTCCCAAAGCATCTCCACGAATCCACCCGAGTTTACCTGGGGGCCACAGCTGGGATGC
GCTTGCTGAGGTTGCAAAATGAGACAGCAGCTCATGAAGTCCTTGAGAGCATCCAAAGCTACTT
CAAGTCCCAGCCTTTTGATTTTAGGGGTGCTCAAATCATTTCTGGGCAAGAGGAAGGGGTGTAT
GGATGGATTACAGCCAACTATATAATGGGAAATTTCCTGGAGAAGAACCTGTGGCACATGTGGG
TGCACCCGCACGGAGTAGACACCACAGGAGCCCTGGATTTGGGCGGCGCCTCCACCCAGATATC
CTTTGTGTCGGAAGAGAAGATGGAGCCGAACGCCAGCGACACAGTGCAGGTGTCCTTGTACGGC
TACACGTACACTCTCTACACGCACAGTTTCCAGTGCTACGGCCGGAACGAAGCAGAGAAGAAGT
TCCTGGCGATGCTTCTGCAGAGCCCTTCTACAGATGCCAACATCAGCAACCCCTGCTACCCTCA
CGGTTACAGCACCACCTTCACAATGGGCCACGTGTTTGGCAGCCTGTGCACGGAGAAGCAGAGG
CCGAAGAGCTACAACCCCAGTGATACCATCACCTTCACAGGAACTGGTGACCCACAGCTGTGCA
GGGAGAAGGTGGCTTCTGTGTTTGACTTCAGTGCTTGCCAAGAGCAAGATGCCTGCTCCTTTGA
TGGCATTTACCAGCCCAAGGTTCAAGGGCCATTTGTGGCATTTGCAGGATTCTATTACACAGCC
AGTGCCCTAAACCTCTCTGGAAGCTTCTCCCTTACCTCCTTCAATGACAGCAGCTGGGACTTCT
GCAGACACACTTGGAGCGAGCTCCCGTCCCTGCTCCCCAGATTTGATGAGACGTATGCCCGGTC
CTACTGCTTCTCAGCTCACTACATCTACCACTTGCTCATAAATGGATACAAATTCACTGAGGCA
ACTTGGCCTCAGATACGGTTTGAAAAAGAAGTGGGGAATAGCAGCATCGCCTGGTCCCTAGGCT
ACATGCTCAGCTTGACCAACCAGATCCCAGCTGGAAGTCCGCTGATCCAACTACCCATACAGCC
GCCGGTGTTTATGGGAGTCCTGGCCTTCTTCACGGCTATCGCCTTGCTGTGCCTGGCATTTCTT
TTCTATCTATGTTCAGCATTTAGGACAAAGGAGCGCTCTGAGAATGCCTTTGACCAAGCAGTGG
ATTCTGATTGAATCTTCCAAGCAGCACCTGGGGCCTGAGGCTGCCATAACCCACCAGAGTGACA
CCAGGCAGGGAGTGAAGTGGCTGCCACCAGGACCTGTCCCGTGGTTAAATGCCAAGATCACGTG
CCTCTCAGCCACTGGTTCCTGCTGGAGCACCTCCTGGGAGTCCCTCAGCCACCCAGTGGGTGTT
GCCTCTGCACCCTTCGTACCCGCTTGCTGATCCATTGGAAATCAAGGAGACACTGGCAGTTGGT
GTCAAGGGCTTCACCCTGTCTCCTCCAGAGGATGTTGAGAGTATAATTTAATTCGGAAGGATTG
ACCCAGGCTGGGTTTCCATTTTCTCTCCCTCCGTATTCCTCCTAGCAAGCTGCCCAGGAAGGCT
CTGACTCAGACACTTCACCCTGTAGGTTTGACCTGTAGTTCCTTTGCAAGGCCTTCCAGTCTTT
TAGTTGAGTGGGGCCCTATCTCAAGCCACTGATACTTTCTCTTAGCAATCTGGTAAGCACTAAG
CTCCCTGACTGGTAGCTTGTAGCACTTAGCAGGGAAGATGATACCTTTTGAGACAGAGTTTCAT
GTAGCCCATTCACTATGTAGCCAAGACCACTCACTAAGTAGCTCTTTTCCTGAGGGCTGCGATT
ATGGGTTGTGAGGTCCTGGGGGTGGAACCCCAGGGCTTCATGTATGCTAGGCAATTATTCGACC
AGCCTGAGTCACATGCCCAGCCTAAGAAGACTCACAGCCCCAAGGACAGACGGCCTCTGTCATG
TAGGCAGAACCTGAAGCACAAAGCCACACAGGAGTCCCTAAGCTATTAGCTATTCTTATTTTGG
AATGCCCACTTGGAGCTCTGGTCATGACTTTGCTACTTGGAGTATGTCATCCTTGTGTAACTGC
CTCCCCGCTGTTCCCTCTTGTAAATCGCACCCAGTGGACTGCACCAAGGTGGGAGGTTGGGGGT
GGATCCCATTGACCTGACAAAGCTCCTGCCCAAGGTGCCTTTGGGCTATAACCATGTCGGCGTG
TGCTTTCTTCCCACTGCTCCCACAGGTATCCAGGATCCTGTCCAAAAAACATCCCTACGTTTCT
TCCTGCATAACTGCTTCCCAGCTTGACTTTGGGGAAAGAAAAGGCAGTCTTGGGAATGTTTGCT
TCCAAAGTGGGATGGGAAAGGTCTTCAAACCCAGTAGCTACAAGCGACAAATCAATGCTGTGCC
TCAAGGCTGGTCGTTGGCTCCATATGGAATAAACTATTATTTTTATTTTGCAATATGAAAAAAA
AAAAAAAAAAAAAGG

hide sequence

RefSeq Acc Id:

XM_006244097 ⟹ XP_006244159

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	129,124,540 - 129,155,524 (+)	NCBI
mRatBN7.2	8	120,246,412 - 120,277,943 (+)	NCBI
Rnor_6.0	8	129,201,000 - 129,232,434 (+)	NCBI
Rnor_5.0	8	128,399,554 - 128,430,329 (+)	NCBI

Sequence:

show sequence

ACTACCACACAGGGGGTGCCTCTTGGGACTGGAGGCAAGGTCACATCGCCTCCTCTTCTGCCTT
GGGTTCAGGGGACTGCGCAGGGAGTTAGAAGATAAAAGTGTGAGAAGCTATCTGGCTGGGTCCT
GGTGGGACACTGAGATAACTAACCCTGTCAGCTTGACAGCATCTACAATCACCTAGGAGACACA
CTTCTGAGAACGTCTGAGACTAGGGGTCTAGGCTCGGTTAATTGAGGCGGAAAGACTCATCTTA
AACGAGGGTGGTACCAGTGTGTCAGGCTGGGGTCTCAGGTACTGACTGCTGACGGTGTGGCCGC
TGTCCAAACTCCTGCCAACGTGCCTTCCCGGCCATCAAGGACAGTACCTACAACCGGCAGGCTG
GGGTGAAGTGGAAGGGAGGAGCCTGGGAAGGTGAAAGAGGTCCTGGCCTCCGCGCCGAGGCGGC
CCCAGCAGGCTGCGCCACCCACGCCACCTCGCTCCGCCTCTTAGGCTCCCGCGCCTCCCGCACC
CCAGAGGCGCCTCCGCTTTTCAGCGATCCGCAGCGAGCGCAGCGCGCAGCTCGGACTGAAGATG
TTTACGGTGATGACCCGCCAGCCCTGTGAACAGGCAGGCTTCAGGGCCCTCTCGAGGACTCCAG
CCATCGTCACCTTGGTGGTCCTGCTTGTGAGCATCGTGGTACTTGTGACACTTACACTCATCCA
GATCCACCACCCACAGGTTCTCTCTCCAGGGCTGAAGTATGGAATCGTGTTGGATGCCGGCTCT
TCCAGAACCACTGTCTATGTGTATCAGTGGCCAGCAGAGAAGGAGAATAACACAGGAGTGGTCA
GCCAAACCTTCAGATGTAGTGTGAAAGGCTCGGGAATCTCCAGCTATGAGAATAACCCCCAAGA
TGCCCCCAAAGCCTTTGAGGACTGCATGCTAAAGGTCAAGGAACAGGTCCCAAAGCATCTCCAC
GAATCCACCCGAGTTTACCTGGGGGCCACAGCTGGGATGCGCTTGCTGAGGTTGCAAAATGAGA
CAGCAGCTCATGAAGTCCTTGAGAGCATCCAAAGCTACTTCAAGTCCCAGCCTTTTGATTTTAG
GGGTGCTCAAATCATTTCTGGGCAAGAGGAAGGGGTGTATGGATGGATTACAGCCAACTATATA
ATGGGAAATTTCCTGGAGAAGAACCTGTGGCACATGTGGGTGCACCCGCACGGAGTAGACACCA
CAGGAGCCCTGGATTTGGGCGGCGCCTCCACCCAGATATCCTTTGTGTCGGAAGAGAAGATGGA
GCCGAACGCCAGCGACACAGTGCAGGTGTCCTTGTACGGCTACACGTACACTCTCTACACGCAC
AGTTTCCAGTGCTACGGCCGGAACGAAGCAGAGAAGAAGTTCCTGGCGATGCTTCTGCAGAGCC
CTTCTACAGATGCCAACATCAGCAACCCCTGCTACCCTCACGGTTACAGCACCACCTTCACAAT
GGGCCACGTGTTTGGCAGCCTGTGCACGGAGAAGCAGAGGCCGAAGAGCTACAACCCCAGTGAT
ACCATCACCTTCACAGGAACTGGTGACCCACAGCTGTGCAGGGAGAAGGTGGCTTCTGTGTTTG
ACTTCAGTGCTTGCCAAGAGCAAGATGCCTGCTCCTTTGATGGCATTTACCAGCCCAAGGTTCA
AGGGCCATTTGTGGCATTTGCAGGATTCTATTACACAGCCAGTGCCCTAAACCTCTCTGGAAGC
TTCTCCCTTACCTCCTTCAATGACAGCAGCTGGGACTTCTGCAGACACACTTGGAGCGAGCTCC
CGTCCCTGCTCCCCAGATTTGATGAGACGTATGCCCGGTCCTACTGCTTCTCAGCCCACTACAT
CTACCACTTGCTCATAAATGGATACAAATTCACTGAGGCAACTTGGCCTCAGATACGGTTTGAA
AAAGAAGTGGGGAATAGCAGCATCGCCTGGTCCCTAGGCTACATGCTCAGCTTGACCAACCAGA
TCCCAGCTGGAAGTCCGCTGATCCAACTACCCATACAGCCGCCGGTGTTTATGGGAGTCCTGGC
CTTCTTCACGGCTATCGCCTTGCTGTGCCTGGCATTTCTTTTCTATCTATGTTCAGCATTTAGG
ACAAAGGAGCGCTCTGAGAATGCCTTTGACCAAGCAGTGGATTCTGATTGAATCTTCCAAGCAG
CACCTGGGGCCTGAGGCTGCCATAACCCACCAGAGTGACACCAGGCAGGGAGTGAAGTGGCTGC
CACCAGGACCTGTCCCGTGGTTAAATGCCAAGATCACGTGCCTCTCAGCCACTGGTTCCTGCTG
GAGCACCTCCTGGGAGTCCCTCAGCCACCCAGTGGGTGTTGCCTCTGCACCCTTCGTACCCGCT
TGCTGATCCATTGGAAATCAAGGAGACACTGGCAGTTGGTGTCAAGGGCTTCACCCTGTCTCCT
CCAGAGGATGTTGAGAGTATAATTTAATTCGGAAGGATTGACCCAGGCTGGGTTTCCATTTTCT
CTCCCTCCGTATTCCTCCTAGCAAGCTGCCCAGGAAGGCTCTGACTCAGACACTTCACCCTGTA
GGTTTGACCTGTAGTTCCTTTGCAAGGCCTTCCAGTCTTTTAGTTGAGTGGGGCCCTATCTCAA
GCCACTGATACTTTCTCTTAGCAATCTGGTAAGCACTAAGCTCCCTGACTGGTAGCTTGTAGCA
CTTAGCAGGGAAGATGATACCTTTTGAGACAGAGTTTCATGTAGCCCATTCACTATGTAGCCAA
GACCACTCACTAAGTAGCTCTTTTCCTGAGGGCTGCGATTATGGGTTGTGAGGTCCTGGGGGTG
GAACCCCAGGGCTTCATGTATGCTAGGCAATTATTCGACCAGCCTGAGTCACATGCCCAGCCTA
AGAAGACTCACAGCCCCAAGGACAGACGGCCTCTGTCATGTAGGCAGAACCTGAAGCACAAAGC
CACACAGGAGTCCCTAAGCTATTAGCTATTCTTATTTTGGAATGCCCACTTGGAGCTCTGGTCA
TGACTTTGCTACTTGGAGTATGTCATCCTTGTGTAACTGCCTCCCCGCTGTTCCCTCTTGTAAA
TCGCACCCAGTGGACTGCACCAAGGTGGGAGGTTGGGGGTGGATCCCATTGACCTGACAAAGCT
CCTGCCCAAGGTGCCTTTGGGCTATAACCATGTCGGCGTGTGCTTTCTTCCCACTGCTCCCACA
GGTATCCAGGATCCTGTCCAAAAAACATCCCTACGTTTCTTCCTGCATAACTGCTTCCCAGCTT
GACTTTGGGGAAAGAAAAGGCAGTCTTGGGAATGTTTGCTTCCAAAGTGGGATGGGAAAGGTCT
TCAAACCCAGTAGCTACAAGCGACAAATCAATGCTGTGCCTCAAGGCTGGTCGTTGGCTCCATA
TGGAATAAACTATTATTTTTATTTTGCAATA

hide sequence

Protein Sequences


Protein RefSeqs	NP_835207	(Get FASTA)	NCBI Sequence Viewer
	XP_006244159	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	CAD24724	(Get FASTA)	NCBI Sequence Viewer
	EDL76862	(Get FASTA)	NCBI Sequence Viewer
	EDL76863	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025663
	ENSRNOP00000025663.3
	ENSRNOP00000073543.2

RefSeq Acc Id:

NP_835207 ⟸ NM_178106

- UniProtKB:

Q80Z26 (UniProtKB/TrEMBL), A6I415 (UniProtKB/TrEMBL), A0A0G2K5S7 (UniProtKB/TrEMBL), A6I414 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFTVMTRQPCEQAGFRALSRTPAIVTLVVLLVSIVVLVTLTLIQIHHPQVLSPGLKYGIVLDAG
SSRTTVYVYQWPAEKENNTGVVSQTFRCSVKGSGISSYENNPQDAPKAFEDCMLKVKEQVPKHL
HESTRVYLGATAGMRLLRLQNETAAHEVLESIQSYFKSQPFDFRGAQIISGQEEGVYGWITANY
IMGNFLEKNLWHMWVHPHGVDTTGALDLGGASTQISFVSEEKMEPNASDTVQVSLYGYTYTLYT
HSFQCYGRNEAEKKFLAMLLQSPSTDANISNPCYPHGYSTTFTMGHVFGSLCTEKQRPKSYNPS
DTITFTGTGDPQLCREKVASVFDFSACQEQDACSFDGIYQPKVQGPFVAFAGFYYTASALNLSG
SFSLTSFNDSSWDFCRHTWSELPSLLPRFDETYARSYCFSAHYIYHLLINGYKFTEATWPQIRF
EKEVGNSSIAWSLGYMLSLTNQIPAGSPLIQLPIQPPVFMGVLAFFTAIALLCLAFLFYLCSAF
RTKERSENAFDQAVDSD

hide sequence

RefSeq Acc Id:	XP_006244159 ⟸ XM_006244097
- Peptide Label:	isoform X1
- UniProtKB:	Q80Z26 (UniProtKB/TrEMBL), A6I415 (UniProtKB/TrEMBL), A0A0G2K5S7 (UniProtKB/TrEMBL), A6I414 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFTVMTRQPCEQAGFRALSRTPAIVTLVVLLVSIVVLVTLTLIQIHHPQVLSPGLKYGIVLDAG SSRTTVYVYQWPAEKENNTGVVSQTFRCSVKGSGISSYENNPQDAPKAFEDCMLKVKEQVPKHL HESTRVYLGATAGMRLLRLQNETAAHEVLESIQSYFKSQPFDFRGAQIISGQEEGVYGWITANY IMGNFLEKNLWHMWVHPHGVDTTGALDLGGASTQISFVSEEKMEPNASDTVQVSLYGYTYTLYT HSFQCYGRNEAEKKFLAMLLQSPSTDANISNPCYPHGYSTTFTMGHVFGSLCTEKQRPKSYNPS DTITFTGTGDPQLCREKVASVFDFSACQEQDACSFDGIYQPKVQGPFVAFAGFYYTASALNLSG SFSLTSFNDSSWDFCRHTWSELPSLLPRFDETYARSYCFSAHYIYHLLINGYKFTEATWPQIRF EKEVGNSSIAWSLGYMLSLTNQIPAGSPLIQLPIQPPVFMGVLAFFTAIALLCLAFLFYLCSAF RTKERSENAFDQAVDSD hide sequence

RefSeq Acc Id:

ENSRNOP00000073543 ⟸ ENSRNOT00000082377

RefSeq Acc Id:

ENSRNOP00000025663 ⟸ ENSRNOT00000025663

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K5S7-F1-model_v2	AlphaFold	A0A0G2K5S7	1-547	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696386

Promoter ID:

EPDNEW_R6909

Type:

single initiation site

Name:

Entpd3_1

Description:

ectonucleoside triphosphate diphosphohydrolase 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	129,201,658 - 129,201,718	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:631326	AgrOrtholog
BioCyc Gene	G2FUF-28734	BioCyc
Ensembl Genes	ENSRNOG00000018982	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025663	ENTREZGENE
	ENSRNOT00000025663.6	UniProtKB/TrEMBL
	ENSRNOT00000082377.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.420.40	UniProtKB/TrEMBL
	Exopolyphosphatase. Domain 2	UniProtKB/TrEMBL
InterPro	GDA1_CD39_NTPase	UniProtKB/TrEMBL
KEGG Report	rno:316077	UniProtKB/TrEMBL
NCBI Gene	316077	ENTREZGENE
PANTHER	ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3	UniProtKB/TrEMBL
	GDA1_CD39_NTPase	UniProtKB/TrEMBL
Pfam	GDA1_CD39	UniProtKB/TrEMBL
PhenoGen	Entpd3	PhenoGen
PROSITE	GDA1_CD39_NTPASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018982	RatGTEx
UniProt	A0A0G2K5S7	ENTREZGENE, UniProtKB/TrEMBL
	A6I414	ENTREZGENE, UniProtKB/TrEMBL
	A6I415	ENTREZGENE, UniProtKB/TrEMBL
	Q80Z26	ENTREZGENE
UniProt Secondary	Q80Z26	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-11	Entpd3	ectonucleoside triphosphate diphosphohydrolase 3			Symbol and Name status set to approved	625702	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)