Entpd3 (ectonucleoside triphosphate diphosphohydrolase 3) - Rat Genome Database

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Gene: Entpd3 (ectonucleoside triphosphate diphosphohydrolase 3) Mus musculus
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Symbol: Entpd3
Name: ectonucleoside triphosphate diphosphohydrolase 3
RGD ID: 1552865
MGI Page MGI
Description: Enables nucleoside-diphosphatase activity and nucleoside-triphosphatase activity. Acts upstream of or within nucleoside diphosphate catabolic process and nucleoside triphosphate catabolic process. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and skeleton. Orthologous to human ENTPD3 (ectonucleoside triphosphate diphosphohydrolase 3); PARTICIPATES IN purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 4,4'-diaminodiphenylmethane; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD39 antigen-like 3; Cd39l; Cd39l3; HB6; NTPDa; NTPDase-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399120,368,884 - 120,397,393 (+)NCBIGRCm39mm39
GRCm39 Ensembl9120,368,884 - 120,397,393 (+)Ensembl
GRCm389120,539,818 - 120,568,327 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,539,818 - 120,568,327 (+)EnsemblGRCm38mm10GRCm38
MGSCv379120,448,936 - 120,477,444 (+)NCBIGRCm37mm9NCBIm37
MGSCv369120,388,541 - 120,417,015 (+)NCBImm8
Celera9121,009,378 - 121,037,928 (+)NCBICelera
Cytogenetic Map9F4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IBA)
plasma membrane  (IBA,IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:9676430   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:17727821   PMID:18404504  
PMID:18554416   PMID:21233276   PMID:21267068   PMID:21807070   PMID:21873635   PMID:24085034   PMID:24464643   PMID:25717362   PMID:26924460   PMID:27173853   PMID:27706204   PMID:28472257  
PMID:33631144  


Genomics

Comparative Map Data
Entpd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399120,368,884 - 120,397,393 (+)NCBIGRCm39mm39
GRCm39 Ensembl9120,368,884 - 120,397,393 (+)Ensembl
GRCm389120,539,818 - 120,568,327 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9120,539,818 - 120,568,327 (+)EnsemblGRCm38mm10GRCm38
MGSCv379120,448,936 - 120,477,444 (+)NCBIGRCm37mm9NCBIm37
MGSCv369120,388,541 - 120,417,015 (+)NCBImm8
Celera9121,009,378 - 121,037,928 (+)NCBICelera
Cytogenetic Map9F4NCBI
ENTPD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl340,387,184 - 40,428,744 (+)EnsemblGRCh38hg38GRCh38
GRCh38340,387,182 - 40,428,744 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37340,428,675 - 40,470,235 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36340,403,694 - 40,445,114 (+)NCBINCBI36hg18NCBI36
Build 34340,403,696 - 40,445,113NCBI
Celera340,371,496 - 40,412,942 (+)NCBI
Cytogenetic Map3p22.1NCBI
HuRef340,473,275 - 40,514,184 (+)NCBIHuRef
CHM1_1340,379,250 - 40,420,697 (+)NCBICHM1_1
Entpd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28120,246,412 - 120,277,943 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl8120,247,121 - 120,277,943 (+)Ensembl
Rnor_6.08129,201,000 - 129,232,436 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8129,201,669 - 129,232,677 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08128,399,554 - 128,430,329 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48125,542,934 - 125,573,945 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18125,586,832 - 125,593,682 (+)NCBI
Celera8119,389,184 - 119,419,978 (+)NCBICelera
Cytogenetic Map8q32NCBI
Entpd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542029,445,909 - 29,468,709 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542029,445,252 - 29,471,024 (-)NCBIChiLan1.0ChiLan1.0
ENTPD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1340,561,694 - 40,604,181 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl340,561,694 - 40,604,181 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0340,290,586 - 40,333,632 (+)NCBIMhudiblu_PPA_v0panPan3
ENTPD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1239,858,328 - 9,891,244 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl239,858,764 - 9,890,483 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,892,661 - 9,925,852 (+)NCBI
ROS_Cfam_1.02310,145,225 - 10,178,416 (+)NCBI
UMICH_Zoey_3.1239,955,711 - 9,988,629 (+)NCBI
UNSW_CanFamBas_1.02310,093,446 - 10,126,611 (+)NCBI
UU_Cfam_GSD_1.02310,081,070 - 10,114,262 (+)NCBI
Entpd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118196,209,767 - 196,243,685 (+)NCBI
SpeTri2.0NW_00493647329,348,370 - 29,382,258 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENTPD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1324,624,417 - 24,659,639 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11324,623,579 - 24,659,642 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21326,979,110 - 27,013,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ENTPD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1221,881,640 - 1,923,708 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl221,882,978 - 1,923,837 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041165,279,983 - 165,321,188 (-)NCBIVero_WHO_p1.0
Entpd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473078,298,340 - 78,326,982 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:709
Count of miRNA genes:481
Interacting mature miRNAs:556
Transcripts:ENSMUST00000047687, ENSMUST00000143579
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000047687   ⟹   ENSMUSP00000036830
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9120,368,884 - 120,397,393 (+)Ensembl
GRCm38.p6 Ensembl9120,539,818 - 120,568,327 (+)Ensembl
RefSeq Acc Id: ENSMUST00000143579
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9120,387,100 - 120,390,020 (+)Ensembl
GRCm38.p6 Ensembl9120,558,034 - 120,560,954 (+)Ensembl
RefSeq Acc Id: NM_178676   ⟹   NP_848791
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399120,368,884 - 120,397,393 (+)NCBI
GRCm389120,539,818 - 120,568,327 (+)ENTREZGENE
MGSCv379120,448,936 - 120,477,444 (+)RGD
Celera9121,009,378 - 121,037,928 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036154831   ⟹   XP_036010724
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399120,373,065 - 120,396,886 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_848791   ⟸   NM_178676
- Sequence:
RefSeq Acc Id: ENSMUSP00000036830   ⟸   ENSMUST00000047687
RefSeq Acc Id: XP_036010724   ⟸   XM_036154831
- Peptide Label: isoform X1

Promoters
RGD ID:8671232
Promoter ID:EPDNEW_M13647
Type:initiation region
Name:Entpd3_1
Description:Mus musculus ectonucleoside triphosphate diphosphohydrolase 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389120,539,859 - 120,539,919EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1321386 AgrOrtholog
Ensembl Genes ENSMUSG00000041608 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000036830 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000047687 ENTREZGENE, UniProtKB/TrEMBL
InterPro GDA1_CD39_NTPase UniProtKB/TrEMBL
KEGG Report mmu:215446 UniProtKB/TrEMBL
MGD MGI:1321386 ENTREZGENE
NCBI Gene 215446 ENTREZGENE
PANTHER GDA1_CD39_NTPase UniProtKB/TrEMBL
Pfam GDA1_CD39 UniProtKB/TrEMBL
PhenoGen Entpd3 PhenoGen
PROSITE GDA1_CD39_NTPASE UniProtKB/TrEMBL
UniProt Q3TC04_MOUSE UniProtKB/TrEMBL
  Q3TDX3_MOUSE UniProtKB/TrEMBL
  Q8BFW6_MOUSE UniProtKB/TrEMBL
  Q8CCV2_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9PYV0 UniProtKB/TrEMBL