Ighg1 (immunoglobulin heavy constant gamma 1) - Rat Genome Database

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Gene: Ighg1 (immunoglobulin heavy constant gamma 1) Rattus norvegicus
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Symbol: Ighg1
Name: immunoglobulin heavy constant gamma 1
RGD ID: 1359539
Description: Predicted to enable Fc-gamma receptor I complex binding activity and antigen binding activity. Predicted to be involved in B cell differentiation; adaptive immune response; and complement-dependent cytotoxicity. Predicted to act upstream of or within several processes, including antibody-dependent cellular cytotoxicity; phagocytosis; and positive regulation of immune response. Predicted to be located in external side of plasma membrane and extracellular space. Predicted to be part of IgG immunoglobulin complex and immunoglobulin complex, circulating. Predicted to be active in cytoplasm. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); PARTICIPATES IN interleukin-4 signaling pathway; INTERACTS WITH Mesaconitine; nitrofen; (-)-demecolcine (ortholog).
Type: gene (Ensembl: protein-coding)
Previously known as: Ighg; Immunoglobulin heavy chain (gamma polypeptide); LOC299354; RGD1359539; similar to IG GAMMA-1 CHAIN C REGION; similar to Ig gamma-1, chain C region
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2 Ensembl6132,389,370 - 132,393,397 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.06139,140,572 - 139,784,388 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6139,140,679 - 139,142,218 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06147,106,967 - 147,241,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.06148,128,786 - 148,134,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46138,310,041 - 138,311,688 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6129,920,648 - 129,922,321 (-)NCBICelera
Cytogenetic Map6q32NCBI


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:3016742   PMID:3149946   PMID:4098598   PMID:6952213   PMID:7688139   PMID:8041705   PMID:8047141   PMID:8418208   PMID:8552190   PMID:8566034   PMID:8769481   PMID:9492004  
PMID:9551950   PMID:9707605   PMID:9743367   PMID:9834074   PMID:9834201   PMID:10395649   PMID:10704460   PMID:11057672   PMID:11714799   PMID:11901193   PMID:11911823   PMID:11911824  
PMID:12477932   PMID:12867038   PMID:12882831   PMID:14988498   PMID:15692051   PMID:16275384   PMID:16492738   PMID:16502470   PMID:17658279   PMID:18762567   PMID:20031218   PMID:22516433  
PMID:23376485   PMID:23533145   PMID:23580065   PMID:25645918  


Genomics

Comparative Map Data
Ighg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2 Ensembl6132,389,370 - 132,393,397 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.06139,140,572 - 139,784,388 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6139,140,679 - 139,142,218 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06147,106,967 - 147,241,786 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.06148,128,786 - 148,134,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46138,310,041 - 138,311,688 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6129,920,648 - 129,922,321 (-)NCBICelera
Cytogenetic Map6q32NCBI
IGHG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814105,741,473 - 105,743,070 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14105,736,343 - 105,743,071 (-)EnsemblGRCh38hg38GRCh38
GRCh3714106,207,810 - 106,209,407 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614105,278,749 - 105,280,452 (-)NCBINCBI36Build 36hg18NCBI36
Celera1486,146,753 - 86,148,456 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1486,340,115 - 86,341,712 (-)NCBIHuRef
CHM1_114106,106,771 - 106,107,520 (-)NCBICHM1_1
T2T-CHM13v2.014100,012,671 - 100,014,268 (-)NCBIT2T-CHM13v2.0
Ighg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912113,290,161 - 113,294,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12113,288,860 - 113,294,143 (-)EnsemblGRCm39 Ensembl
GRCm3812113,326,541 - 113,330,523 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12113,325,240 - 113,330,523 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712114,564,755 - 114,568,734 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12114,512,547 - 114,780,893 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1262.1NCBI

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:49
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000006975
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006975   ⟹   ENSRNOP00000006975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6132,389,370 - 132,393,397 (-)Ensembl
Rnor_6.0 Ensembl6139,140,679 - 139,142,218 (-)Ensembl
Protein Sequences
GenBank Protein AAA60736 (Get FASTA)   NCBI Sequence Viewer  
  AAH88271 (Get FASTA)   NCBI Sequence Viewer  
  AAH92584 (Get FASTA)   NCBI Sequence Viewer  
  AAH95846 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006975.5
  ENSRNOP00065041183
GenBank Protein P20759 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000006975   ⟸   ENSRNOT00000006975

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P20759-F1-model_v2 AlphaFold P20759 1-326 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359539 AgrOrtholog
Ensembl Genes ENSRNOG00000030332 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00065029014 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006975.6 UniProtKB/Swiss-Prot
  ENSRNOT00065050131 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7379698 IMAGE-MGC_LOAD
  IMAGE:7384581 IMAGE-MGC_LOAD
  IMAGE:7388075 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_C1-set UniProtKB/Swiss-Prot
MGC_CLONE MGC:108947 IMAGE-MGC_LOAD
  MGC:109111 IMAGE-MGC_LOAD
  MGC:112743 IMAGE-MGC_LOAD
NCBI Gene 299354 ENTREZGENE
PANTHER IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1-RELATED UniProtKB/Swiss-Prot
  TAPASIN UniProtKB/Swiss-Prot
Pfam C1-set UniProtKB/Swiss-Prot
PhenoGen Ighg1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030332 RatGTEx
  ENSRNOG00065029014 RatGTEx
SMART IGc1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt IGHG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-18 Ighg1  immunoglobulin heavy constant gamma 1  Ighg  Immunoglobulin heavy chain (gamma polypeptide)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-04-20 Ighg  Immunoglobulin heavy chain (gamma polypeptide)  Ighg  Immunoglobulin heavy chain (gamma polypeptide)  Type changed (type changed from [gene] to [protein-coding]) 629549 APPROVED
2008-03-07 Ighg  Immunoglobulin heavy chain (gamma polypeptide)  RGD1359539  similar to Ig gamma-1, chain C region  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 RGD1359539  similar to Ig gamma-1, chain C region  LOC299354  similar to IG GAMMA-1 CHAIN C REGION  Symbol and Name updated 1299863 APPROVED
2005-07-29 LOC299354  similar to IG GAMMA-1 CHAIN C REGION      Symbol and Name status set to provisional 70820 PROVISIONAL