Ezhip (EZH inhibitory protein) - Rat Genome Database

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Gene: Ezhip (EZH inhibitory protein) Rattus norvegicus
Analyze
Symbol: Ezhip
Name: EZH inhibitory protein
RGD ID: 7681336
Description: Predicted to enable histone methyltransferase inhibitor activity. Predicted to be involved in epigenetic regulation of gene expression. Predicted to act upstream of or within chromatin organization and oocyte development. Predicted to be located in cytosol and nucleoplasm. Orthologous to human EZHIP (EZH inhibitory protein); INTERACTS WITH valproic acid; 4,4'-sulfonyldiphenol (ortholog); arsenite(3-) (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: hypothetical protein LOC680214; LOC102547118; LOC680214; retinitis pigmentosa 1-like 1 protein-like; uncharacterized protein CXorf67 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X19,040,397 - 19,043,463 (-)NCBIGRCr8
mRatBN7.2X16,368,582 - 16,371,648 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX16,368,962 - 16,372,256 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX21,180,651 - 21,183,717 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X18,899,561 - 18,902,627 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X15,164,482 - 15,167,548 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X17,250,334 - 17,253,582 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX17,250,687 - 17,252,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X18,029,935 - 18,032,503 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X28,724,907 - 28,727,450 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX16,437,159 - 16,440,751 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
Additional References at PubMed
PMID:29909548   PMID:30923826   PMID:31451685  


Genomics

Comparative Map Data
Ezhip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X19,040,397 - 19,043,463 (-)NCBIGRCr8
mRatBN7.2X16,368,582 - 16,371,648 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX16,368,962 - 16,372,256 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX21,180,651 - 21,183,717 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X18,899,561 - 18,902,627 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X15,164,482 - 15,167,548 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X17,250,334 - 17,253,582 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX17,250,687 - 17,252,877 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X18,029,935 - 18,032,503 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X28,724,907 - 28,727,450 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX16,437,159 - 16,440,751 (-)NCBICelera
Cytogenetic MapXq12NCBI
EZHIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X51,406,948 - 51,408,843 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX51,406,948 - 51,408,843 (+)EnsemblGRCh38hg38GRCh38
GRCh37X51,149,800 - 51,151,695 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X51,166,507 - 51,168,430 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX55,193,599 - 55,195,516 (+)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX48,590,883 - 48,593,002 (+)NCBIHuRef
CHM1_1X51,229,495 - 51,231,612 (+)NCBICHM1_1
T2T-CHM13v2.0X50,678,233 - 50,680,128 (+)NCBIT2T-CHM13v2.0
Ezhip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X5,993,272 - 5,995,474 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX5,993,273 - 5,995,473 (-)EnsemblGRCm39 Ensembl
GRCm38X6,081,218 - 6,083,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX6,081,219 - 6,083,419 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X5,658,336 - 5,660,538 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X5,256,713 - 5,258,895 (-)NCBIMGSCv36mm8
CeleraX5,320,819 - 5,323,021 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX2.7NCBI
Ezhip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555432,532,636 - 2,537,978 (+)NCBIChiLan1.0ChiLan1.0
EZHIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X52,797,737 - 52,799,723 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X52,801,342 - 52,803,328 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X43,583,952 - 43,585,933 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X51,294,137 - 51,296,046 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX51,294,233 - 51,295,741 (+)Ensemblpanpan1.1panPan2
EZHIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_TashaX14,513,722 - 14,516,673 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X44,064,870 - 44,067,823 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X43,924,930 - 43,927,881 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X44,160,455 - 44,163,404 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X44,387,692 - 44,390,643 (+)NCBIUU_Cfam_GSD_1.0
Ezhip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X37,552,180 - 37,554,401 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936909106,077 - 107,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EZHIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X44,858,057 - 44,863,263 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
EZHIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X48,154,542 - 48,156,871 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660861,804,020 - 1,808,625 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ezhip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248933,426,674 - 3,429,310 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ezhip
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:33
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000060213
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system nervous system renal system reproductive system
High
Medium 2
Low 35 25
Below cutoff 5 37 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000060213   ⟹   ENSRNOP00000056961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX16,368,962 - 16,372,256 (-)Ensembl
Rnor_6.0 EnsemblX17,250,687 - 17,252,877 (-)Ensembl
RefSeq Acc Id: NM_001401246   ⟹   NP_001388175
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X19,040,397 - 19,043,463 (-)NCBI
mRatBN7.2X16,368,582 - 16,371,648 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388175 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056961.4
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000056961   ⟸   ENSRNOT00000060213
RefSeq Acc Id: NP_001388175   ⟸   NM_001401246

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LWI7-F1-model_v2 AlphaFold F1LWI7 1-585 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7681336 AgrOrtholog
BioCyc Gene G2FUF-2858 BioCyc
Ensembl Genes ENSRNOG00000039305 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060213.4 UniProtKB/TrEMBL
NCBI Gene LOC102547118 ENTREZGENE
PANTHER EZH INHIBITORY PROTEIN UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
PhenoGen Ezhip PhenoGen
RatGTEx ENSRNOG00000039305 RatGTEx
UniProt F1LWI7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-22 Ezhip  EZH inhibitory protein  LOC102547118  retinitis pigmentosa 1-like 1 protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 LOC102547118  retinitis pigmentosa 1-like 1 protein-like  LOC680214  hypothetical protein LOC680214  Data merged from RGD:1594217 737654 PROVISIONAL
2013-12-18 LOC102547118  retinitis pigmentosa 1-like 1 protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC680214  hypothetical protein LOC680214  LOC683204  hypothetical protein LOC683204  Data merged from RGD:1589277 1643240 APPROVED
2006-11-20 LOC680214  hypothetical protein LOC680214      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683204  hypothetical protein LOC683204      Symbol and Name status set to provisional 70820 PROVISIONAL