Sulf1 (sulfatase 1) - Rat Genome Database

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Gene: Sulf1 (sulfatase 1) Rattus norvegicus
Analyze
Symbol: Sulf1
Name: sulfatase 1
RGD ID: 708554
Description: Predicted to enable N-acetylglucosamine-6-sulfatase activity; arylsulfatase activity; and glycosaminoglycan binding activity. Predicted to be involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; regulation of signal transduction; and skeletal system development. Located in cell surface. Orthologous to human SULF1 (sulfatase 1); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arylsulfatase; extracellular sulfatase Sulf-1; LOC171396; N-acetylglucosamine-6-sulfatase; RSulfFP1; sulfatase FP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Vetf3
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8511,145,950 - 11,308,622 (-)NCBIGRCr8
mRatBN7.256,362,894 - 6,526,174 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl56,362,911 - 6,525,584 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx58,506,204 - 8,668,267 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0510,145,085 - 10,307,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.059,840,811 - 10,002,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.055,999,520 - 6,186,901 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl55,999,475 - 6,186,329 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0510,835,826 - 11,022,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.455,582,896 - 5,748,106 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.155,582,895 - 5,748,106 (-)NCBI
Celera55,940,442 - 6,101,438 (-)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sulf1Ratsyndromic microphthalmia 5  ISOSULF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Anophthalmia-microphthalmia syndromeClinVarPMID:26893459 and PMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sulf1Ratautism spectrum disorder  ISOSULF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Sulf1RatOvarian Neoplasms  ISOSULF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17310998
Sulf1Ratpre-malignant neoplasm  ISOSULF1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30127996

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Object Symbol
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Evidence
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Original Reference(s)
Sulf1Rat1,2-dimethylhydrazine multiple interactionsISOSulf1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SULF1 mRNACTDPMID:22206623
Sulf1Rat1,3,5-trinitro-1,3,5-triazinane decreases expressionEXP 6480464cyclonite results in decreased expression of SULF1 mRNACTDPMID:25559034
Sulf1Rat17beta-estradiol multiple interactionsISOSULF1 (Homo sapiens)6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of SULF1 mRNA and [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SULF1 mRNACTDPMID:19619570 and PMID:20823114
Sulf1Rat17beta-estradiol decreases expressionISOSULF1 (Homo sapiens)6480464Estradiol results in decreased expression of SULF1 mRNACTDPMID:31614463
Sulf1Rat17beta-estradiol increases expressionISOSULF1 (Homo sapiens)6480464Estradiol results in increased expression of SULF1 mRNACTDPMID:19619570 and PMID:21185374
Sulf1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOSULF1 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SULF1 mRNACTDPMID:19619570
Sulf1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of SULF1 mRNACTDPMID:33387578 and PMID:34747641
Sulf1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOSulf1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of SULF1 mRNACTDPMID:33956508
Sulf1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOSulf1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of SULF1 mRNACTDPMID:21570461
Sulf1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOSULF1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of SULF1 mRNACTDPMID:19619570
Sulf1Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Sulf1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOSulf1 (Mus musculus)64804642 more ...CTDPMID:38648751
Sulf1Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:23196670
Sulf1Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOSULF1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SULF1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of SULF1 mRNACTDPMID:28628672
Sulf1Rat3-Nitrobenzanthrone decreases expressionISOSULF1 (Homo sapiens)64804643-nitrobenzanthrone results in decreased expression of SULF1 mRNACTDPMID:34036453
Sulf1Rat4,4'-sulfonyldiphenol multiple interactionsISOSULF1 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of SULF1 mRNACTDPMID:28628672
Sulf1Rat4,4'-sulfonyldiphenol increases methylationISOSULF1 (Homo sapiens)6480464bisphenol S results in increased methylation of SULF1 geneCTDPMID:31601247
Sulf1Rat4,4'-sulfonyldiphenol multiple interactionsISOSulf1 (Mus musculus)6480464[bisphenol S co-treated with Tretinoin] results in decreased expression of SULF1 mRNACTDPMID:30951980
Sulf1Rat4,4'-sulfonyldiphenol increases expressionISOSulf1 (Mus musculus)6480464bisphenol S results in increased expression of SULF1 mRNACTDPMID:30951980
Sulf1Rat4-hydroxyphenyl retinamide decreases expressionISOSulf1 (Mus musculus)6480464Fenretinide results in decreased expression of SULF1 mRNACTDPMID:28973697

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Biological Process
1 to 20 of 61 rows

  
Object Symbol
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Reference
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Original Reference(s)
Sulf1Ratbone development involved_inISSUniProtKB:Q8K0071600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1Ratbone development involved_inISOSulf1 (Mus musculus)1624291UniProtKB:Q8CFG0 and PMID:17593974RGDPMID:17593974
Sulf1Ratbone development involved_inIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
Sulf1Ratcartilage condensation involved_inISSUniProtKB:Q90XB61600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1Ratcartilage development involved_inISSUniProtKB:Q8K0071600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1Ratcartilage development involved_inIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
Sulf1Ratcartilage development involved_inISOSulf1 (Mus musculus)1624291 PMID:20479257RGDPMID:20479257
Sulf1Ratcell adhesion involved_inISSUniProtKB:Q90XB61600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1Ratchondrocyte development involved_inISOSulf1 (Mus musculus)1624291 PMID:20479257RGDPMID:20479257
Sulf1Ratchondrocyte development involved_inISSUniProtKB:Q8K0071600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1Ratchondrocyte development involved_inIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
Sulf1Ratembryonic skeletal system development involved_inISSUniProtKB:Q8K0071600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1Ratembryonic skeletal system development involved_inIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
Sulf1Ratembryonic skeletal system development involved_inISOSulf1 (Mus musculus)1624291UniProtKB:Q8CFG0 and PMID:18213582RGDPMID:18213582
Sulf1Ratesophagus smooth muscle contraction involved_inIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
Sulf1Ratesophagus smooth muscle contraction involved_inISOSulf1 (Mus musculus)1624291UniProtKB:Q8CFG0 and PMID:17720696RGDPMID:17720696
Sulf1Ratesophagus smooth muscle contraction involved_inISSUniProtKB:Q8K0071600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1Ratglial cell-derived neurotrophic factor receptor signaling pathway involved_inISSUniProtKB:Q8K0071600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1Ratglial cell-derived neurotrophic factor receptor signaling pathway involved_inISOSulf1 (Mus musculus)1624291 PMID:17720696RGDPMID:17720696
Sulf1Ratglial cell-derived neurotrophic factor receptor signaling pathway involved_inIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
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Cellular Component
1 to 20 of 26 rows

  
Object Symbol
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Evidence
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Reference
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Source
Original Reference(s)
Sulf1Ratcell surface  IDA 1302407 RGD 
Sulf1Ratcell surface located_inIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
Sulf1Ratcell surface is_active_inIBAPANTHER:PTN000038172 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sulf1Ratcell surface located_inISOSULF1 (Homo sapiens)1624291 PMID:12368295 more ...RGDPMID:12368295 more ...
Sulf1Ratcell surface located_inIEAInterPro:IPR0146151600115GO_REF:0000002InterProGO_REF:0000002
Sulf1Ratcell surface located_inIEAUniProtKB-SubCell:SL-03101600115GO_REF:0000044UniProtGO_REF:0000044
Sulf1Ratcell surface located_inISSUniProtKB:Q8IWU61600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1Ratendoplasmic reticulum located_inISOSULF1 (Homo sapiens)1624291 PMID:18687675RGDPMID:18687675
Sulf1Ratendoplasmic reticulum located_inIEAInterPro:IPR0146151600115GO_REF:0000002InterProGO_REF:0000002
Sulf1Ratendoplasmic reticulum is_active_inIBAPANTHER:PTN000038172 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sulf1Ratendoplasmic reticulum located_inIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
Sulf1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Sulf1Ratendoplasmic reticulum located_inIEAUniProtKB-SubCell:SL-00951600115GO_REF:0000044UniProtGO_REF:0000044
Sulf1Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Sulf1Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Sulf1Ratextracellular space located_inISSUniProtKB:Q8IWU61600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1Ratextracellular space located_inISOSULF1 (Homo sapiens)1624291 PMID:19666466RGDPMID:19666466
Sulf1Ratextracellular space located_inIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
Sulf1RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
Sulf1RatGolgi apparatus located_inIEAInterPro:IPR0146151600115GO_REF:0000002InterProGO_REF:0000002
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Molecular Function
1 to 15 of 15 rows

  
Object Symbol
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Reference
Notes
Source
Original Reference(s)
Sulf1Ratarylsulfatase activity enablesIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
Sulf1Ratarylsulfatase activity enablesISOSULF1 (Homo sapiens)1624291 PMID:12368295 and PMID:19520866RGDPMID:12368295 and PMID:19520866
Sulf1Ratarylsulfatase activity enablesISSUniProtKB:Q8IWU61600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1Ratarylsulfatase activity NOT|enablesIDA 1302407PMID:11895481UniProt 
Sulf1Ratcalcium ion binding enablesIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
Sulf1Ratcalcium ion binding enablesIEAInterPro:IPR0146151600115GO_REF:0000002InterProGO_REF:0000002
Sulf1Ratglycosaminoglycan binding enablesIBAPANTHER:PTN000038170 and Gns (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sulf1Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Sulf1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Sulf1RatN-acetylglucosamine-6-sulfatase activity enablesISSUniProtKB:Q8IWU61600115GO_REF:0000024UniProtGO_REF:0000024
Sulf1RatN-acetylglucosamine-6-sulfatase activity enablesIBAFB:FBgn0040271 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sulf1RatN-acetylglucosamine-6-sulfatase activity enablesISOSulf1 (Mus musculus)1624291 PMID:18687675RGDPMID:18687675
Sulf1RatN-acetylglucosamine-6-sulfatase activity enablesISOSULF1 (Homo sapiens)1624291 PMID:12686563 more ...RGDPMID:12686563 more ...
Sulf1RatN-acetylglucosamine-6-sulfatase activity enablesIEAUniRule:UR0006187601600115GO_REF:0000104UniProtGO_REF:0000104
Sulf1Ratsulfuric ester hydrolase activity enablesIEAInterPro:IPR0146151600115GO_REF:0000002InterProGO_REF:0000002
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Identification of a novel nonlysosomal sulphatase expressed in the floor plate, choroid plexus and cartilage. Ohto T, etal., Genes Cells 2002 Feb;7(2):173-85.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12368295   PMID:16289059   PMID:16778174   PMID:17593974   PMID:17720696   PMID:18213582   PMID:18687675   PMID:19520866   PMID:19666466   PMID:19822709   PMID:20410206   PMID:20479257  
PMID:21266348   PMID:21719793   PMID:22664934   PMID:25448158   PMID:25469740   PMID:26464246   PMID:33128921  



Sulf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8511,145,950 - 11,308,622 (-)NCBIGRCr8
mRatBN7.256,362,894 - 6,526,174 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl56,362,911 - 6,525,584 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx58,506,204 - 8,668,267 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0510,145,085 - 10,307,145 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.059,840,811 - 10,002,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.055,999,520 - 6,186,901 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl55,999,475 - 6,186,329 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0510,835,826 - 11,022,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.455,582,896 - 5,748,106 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.155,582,895 - 5,748,106 (-)NCBI
Celera55,940,442 - 6,101,438 (-)NCBICelera
Cytogenetic Map5q11NCBI
SULF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38869,466,781 - 69,660,912 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl869,466,624 - 69,660,915 (+)EnsemblGRCh38hg38GRCh38
GRCh37870,379,016 - 70,573,147 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36870,541,427 - 70,735,701 (+)NCBINCBI36Build 36hg18NCBI36
Build 34870,541,426 - 70,735,701NCBI
Celera866,376,556 - 66,570,879 (+)NCBICelera
Cytogenetic Map8q13.2-q13.3NCBI
HuRef865,873,300 - 66,067,259 (+)NCBIHuRef
CHM1_1870,434,286 - 70,628,552 (+)NCBICHM1_1
T2T-CHM13v2.0869,896,604 - 70,090,566 (+)NCBIT2T-CHM13v2.0
Sulf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39112,762,421 - 12,946,090 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl112,762,501 - 12,931,416 (+)EnsemblGRCm39 Ensembl
GRCm38112,692,197 - 12,861,192 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl112,692,277 - 12,861,192 (+)EnsemblGRCm38mm10GRCm38
MGSCv37112,708,626 - 12,850,453 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36112,703,759 - 12,845,586 (+)NCBIMGSCv36mm8
Celera112,674,009 - 12,818,160 (+)NCBICelera
Cytogenetic Map1A3NCBI
cM Map13.35NCBI
Sulf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554449,899,941 - 9,974,666 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554449,902,334 - 10,066,929 (-)NCBIChiLan1.0ChiLan1.0
SULF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2785,190,266 - 85,392,219 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1860,855,619 - 61,031,477 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0865,992,961 - 66,194,112 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1867,647,122 - 67,848,704 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl867,744,801 - 67,848,704 (+)Ensemblpanpan1.1panPan2
SULF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12918,709,406 - 18,885,248 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2918,709,445 - 18,884,378 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2919,128,552 - 19,208,583 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02918,801,739 - 18,977,405 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2918,801,808 - 18,977,403 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12918,940,318 - 19,020,356 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02919,006,936 - 19,086,917 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02919,287,388 - 19,367,499 (+)NCBIUU_Cfam_GSD_1.0
Sulf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530369,853,463 - 70,029,671 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364964,755,754 - 4,893,027 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364964,755,806 - 4,931,964 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SULF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl465,595,951 - 65,778,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1465,595,947 - 65,778,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2471,262,318 - 71,419,942 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SULF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1865,242,921 - 65,435,374 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl865,341,154 - 65,435,450 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603976,027,348 - 76,229,656 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sulf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474421,484,834 - 21,685,577 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474421,484,934 - 21,685,476 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Sulf1
1235 total Variants

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:32
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000012610
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 9 of 9 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat

1 to 9 of 9 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000012610   ⟹   ENSRNOP00000012611
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl56,373,040 - 6,525,584 (-)Ensembl
Rnor_6.0 Ensembl56,000,772 - 6,186,329 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000072411   ⟹   ENSRNOP00000064072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl56,362,911 - 6,525,565 (-)Ensembl
Rnor_6.0 Ensembl55,999,475 - 6,083,083 (-)Ensembl
RefSeq Acc Id: NM_134378   ⟹   NP_599205
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8511,145,950 - 11,308,622 (-)NCBI
mRatBN7.256,362,894 - 6,525,581 (-)NCBI
Rnor_6.056,000,772 - 6,186,329 (-)NCBI
Rnor_5.0510,835,826 - 11,022,966 (-)NCBI
RGSC_v3.455,582,896 - 5,748,106 (-)RGD
Celera55,940,442 - 6,101,438 (-)RGD
Sequence:
Protein RefSeqs NP_599205 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL71906 (Get FASTA)   NCBI Sequence Viewer  
  EDM11535 (Get FASTA)   NCBI Sequence Viewer  
  EDM11536 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064072
GenBank Protein Q8VI60 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_599205   ⟸   NM_134378
- Peptide Label: precursor
- UniProtKB: Q8VI60 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064072   ⟸   ENSRNOT00000072411
Ensembl Acc Id: ENSRNOP00000012611   ⟸   ENSRNOT00000012610
Extracellular sulfatase C-terminal   Sulfatase N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q8VI60-F1-model_v2 AlphaFold Q8VI60 1-870 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693532
Promoter ID:EPDNEW_R4056
Type:initiation region
Name:Sulf1_1
Description:sulfatase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.056,186,319 - 6,186,379EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-42240 BioCyc
Ensembl Genes ENSRNOG00000009037 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000072411 ENTREZGENE
Gene3D-CATH 3.40.720.10 UniProtKB/Swiss-Prot
InterPro Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot
  Extracellular_sulfatase UniProtKB/Swiss-Prot
  Extracellular_sulfatase_C UniProtKB/Swiss-Prot
  Sulfatase_CS UniProtKB/Swiss-Prot
  Sulfatase_N UniProtKB/Swiss-Prot
KEGG Report rno:171396 UniProtKB/Swiss-Prot
NCBI Gene 171396 ENTREZGENE
PANTHER EXTRACELLULAR SULFATASE SULF-1 UniProtKB/Swiss-Prot
  N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER UniProtKB/Swiss-Prot
Pfam DUF3740 UniProtKB/Swiss-Prot
  Sulfatase UniProtKB/Swiss-Prot
PhenoGen Sulf1 PhenoGen
PIRSF Sulf1 UniProtKB/Swiss-Prot
PROSITE SULFATASE_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009037 RatGTEx
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot
UniProt A0A8J8YBA4_RAT UniProtKB/TrEMBL
  A6JFE0_RAT UniProtKB/TrEMBL
  F1LNA6_RAT UniProtKB/TrEMBL
  Q8VI60 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-04-22 Sulf1  sulfatase 1  LOC171396  sulfatase FP  Symbol and Name updated to reflect Human and Mouse nomenclature 625702 APPROVED