Aspg (asparaginase) - Rat Genome Database

Name: Aspg
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Aspg (asparaginase) Rattus norvegicus

Analyze

Symbol:

Aspg

Name:

asparaginase

RGD ID:

708388

Description:

Enables acyltransferase activity, transferring groups other than amino-acyl groups; asparaginase activity; and carboxylic ester hydrolase activity. Involved in asparagine metabolic process and phospholipid metabolic process. Orthologous to human ASPG (asparaginase); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,4,7,8-Pentachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

60 kDa lysophospholipase; asparaginase homolog; asparaginase homolog (S. cerevisiae); LOC246266; lysophospholipase; lysophospholipase-transacylase; MGC112599

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ASPG (asparaginase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Aspg (asparaginase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Aspg (asparaginase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ASPG (asparaginase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ASPG (asparaginase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aspg (asparaginase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ASPG (asparaginase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ASPG (asparaginase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Aspg (asparaginase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ASPG (asparaginase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Aspg (asparaginase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	aspg (asparaginase homolog (S. cerevisiae))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ASP3-4	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C27A7.5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6428	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG8526	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ASP3-2	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ASP3-3	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ASP3-1	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	aspg	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	136,997,832 - 137,017,417 (+)	NCBI		GRCr8
mRatBN7.2	6	131,176,727 - 131,196,268 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	131,176,874 - 131,196,268 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	131,349,885 - 131,369,265 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	131,646,851 - 131,666,231 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	131,006,402 - 131,025,782 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	136,682,279 - 136,701,673 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	136,682,126 - 136,701,628 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	145,692,075 - 145,711,786 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	136,909,407 - 136,928,801 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	136,915,593 - 136,934,988 (+)	NCBI
Celera	6	128,729,464 - 128,748,858 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Anaphylaxis (ISO)

anemia (ISO)

Charcot-Marie-Tooth disease axonal type 2O (ISO)

choledocholithiasis (ISO)

cholelithiasis (ISO)

Fever (ISO)

Hematuria (ISO)

hepatocellular carcinoma (ISO)

leukopenia (ISO)

thrombocytopenia (ISO)

Vomiting (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,4,7,8-Pentachlorodibenzofuran (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-D (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5-triiodo-L-thyronine (EXP)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aldehydo-D-glucose (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

carbon nanotube (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

D-glucose (ISO)

endosulfan (EXP)

fipronil (EXP)

flutamide (EXP)

fructose (ISO)

furan (EXP)

glucose (ISO)

indole-3-methanol (EXP)

leflunomide (EXP)

lidocaine (EXP)

methapyrilene (ISO)

methimazole (EXP)

N-nitrosodiethylamine (EXP,ISO)

nefazodone (EXP)

nimesulide (EXP)

obeticholic acid (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

propiconazole (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

Tesaglitazar (EXP)

testosterone (EXP)

tetrachloromethane (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

troglitazone (EXP)

valproic acid (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

asparagine metabolic process (IDA)

aspartate family amino acid metabolic process (IEA)

lipid catabolic process (IEA)

phospholipid metabolic process (IDA)

Molecular Function

1-alkyl-2-acetylglycerophosphocholine esterase activity (IMP)

acyltransferase activity, transferring groups other than amino-acyl groups (IDA)

asparaginase activity (IBA,IDA,IEA,IMP)

lysophospholipase activity (IDA,IMP)

phosphatidyl phospholipase B activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Characterization of the transacylase activity of rat liver 60-kDa lysophospholipase-transacylase. Acyl transfer from the sn-2 to the sn-1 position.	Sugimoto H and Yamashita S, Biochim Biophys Acta. 1999 May 18;1438(2):264-72. doi: 10.1016/s1388-1981(99)00059-1.
6.	Purification, characterization, and inhibition by phosphatidic acid of lysophospholipase transacylase from rat liver.	Sugimoto H and Yamashita S, J Biol Chem. 1994 Feb 25;269(8):6252-8.
7.	Cloning and expression of cDNA encoding rat liver 60-kDa lysophospholipase containing an asparaginase-like region and ankyrin repeat.	Sugimoto H, etal., J Biol Chem 1998 May 15;273(20):12536-42.

Additional References at PubMed

PMID:12477932	PMID:15489334

Genomics

Comparative Map Data

Aspg
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	136,997,832 - 137,017,417 (+)	NCBI		GRCr8
mRatBN7.2	6	131,176,727 - 131,196,268 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	131,176,874 - 131,196,268 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	131,349,885 - 131,369,265 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	131,646,851 - 131,666,231 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	131,006,402 - 131,025,782 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	136,682,279 - 136,701,673 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	136,682,126 - 136,701,628 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	145,692,075 - 145,711,786 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	136,909,407 - 136,928,801 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	136,915,593 - 136,934,988 (+)	NCBI
Celera	6	128,729,464 - 128,748,858 (+)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

ASPG
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	104,085,700 - 104,115,582 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	104,085,686 - 104,115,582 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	104,552,037 - 104,581,919 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	103,621,801 - 103,648,678 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	14	84,606,252 - 84,633,128 (+)	NCBI		Celera
Cytogenetic Map	14	q32.33	NCBI
HuRef	14	84,732,013 - 84,758,881 (+)	NCBI		HuRef
CHM1_1	14	104,490,428 - 104,517,504 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	98,322,937 - 98,352,910 (+)	NCBI		T2T-CHM13v2.0

Aspg
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	112,073,117 - 112,094,007 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	112,073,113 - 112,093,993 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	112,106,683 - 112,127,573 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	112,106,679 - 112,127,559 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	113,344,894 - 113,365,784 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	112,554,487 - 112,575,381 (+)	NCBI		MGSCv36	mm8
Celera	12	113,303,837 - 113,329,491 (+)	NCBI		Celera
Cytogenetic Map	12	F1	NCBI
cM Map	12	61.14	NCBI

Aspg
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955538	2,765,104 - 2,785,526 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955538	2,765,215 - 2,785,390 (+)	NCBI	ChiLan1.0	ChiLan1.0

ASPG
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	105,244,431 - 105,272,292 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	104,460,933 - 104,488,793 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	84,711,400 - 84,739,769 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	104,517,278 - 104,544,589 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	104,517,278 - 104,544,589 (+)	Ensembl	panpan1.1		panPan2

ASPG
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	71,747,319 - 71,764,570 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	71,753,164 - 71,765,349 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	71,256,632 - 71,279,134 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	72,022,962 - 72,051,699 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	8	71,711,394 - 71,740,236 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	71,752,029 - 71,780,930 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	72,150,669 - 72,179,628 (+)	NCBI		UU_Cfam_GSD_1.0

Aspg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	2,312,411 - 2,334,699 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936621	1,140,658 - 1,163,589 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936621	1,140,651 - 1,163,608 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ASPG
(Sus scrofa - pig)

No map positions available.

ASPG
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	82,021,590 - 82,049,281 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	82,021,726 - 82,049,355 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	69,348,460 - 69,375,985 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aspg
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	931,946 - 950,553 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	932,877 - 950,509 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Aspg
54 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	80
Count of miRNA genes:	69
Interacting mature miRNAs:	73
Transcripts:	ENSRNOT00000017454
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
71111	Iddm8	Insulin dependent diabetes mellitus QTL 8	1.9	0.002	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	6	105156861	140994061	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	85311061	133478515	Rat
737976	Pia24	Pristane induced arthritis QTL 24			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	6	112636280	140994061	Rat
731173	Uae22	Urinary albumin excretion QTL 22	10.1		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
1641917	Colcr5	Colorectal carcinoma resistance QTL 5	3.18	0.0009	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	6	122549046	137801795	Rat
2313399	Anxrr28	Anxiety related response QTL 28			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	6	100671796	132340886	Rat
1358355	Srcrt4	Stress Responsive Cort QTL 4	6.39		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	100364669	140994061	Rat
1300076	Glom8	Glomerulus QTL 8	7	0.000000009	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	6	86894788	131894788	Rat
2290393	Uae37	Urinary albumin excretion QTL 37		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	65531555	140994061	Rat
2312560	Pur20	Proteinuria QTL 20	2.1	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	6	125628133	137801795	Rat
2303624	Vencon5	Ventilatory control QTL 5	4.45		respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	6	88047916	133047916	Rat
2293085	Iddm29	Insulin dependent diabetes mellitus QTL 29	7.66		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	6	122549046	140286318	Rat
61329	Eae9	Experimental allergic encephalomyelitis QTL 9	3.7		body mass (VT:0001259)	change in body weight (CMO:0002045)	6	122549046	140994061	Rat
61414	Pia3	Pristane induced arthritis QTL 3	4.5		joint integrity trait (VT:0010548)	post-insult time to onset of experimental arthritis (CMO:0001450)	6	94968928	137848904	Rat
8552796	Vie3	Viral induced encephalitis QTL 3	2.6		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	6	96833997	140994061	Rat
4145118	Mcs26	Mammary carcinoma susceptibility QTL 26		0.0001	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	106752656	132339866	Rat
12801411	Schws8	Schwannoma susceptibility QTL 8			nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	6	94968928	139968928	Rat

Markers in Region

BG371487

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	131,195,923 - 131,196,064 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	136,701,329 - 136,701,469	NCBI	Rnor6.0
Rnor_5.0	6	145,711,442 - 145,711,582	UniSTS	Rnor5.0
RGSC_v3.4	6	136,928,457 - 136,928,597	UniSTS	RGSC3.4
Celera	6	128,748,514 - 128,748,654	UniSTS
RH 3.4 Map	6	781.8	UniSTS
Cytogenetic Map	6	q32	UniSTS

AU049933

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	131,194,631 - 131,194,911 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	136,700,037 - 136,700,316	NCBI	Rnor6.0
Rnor_5.0	6	145,710,150 - 145,710,429	UniSTS	Rnor5.0
RGSC_v3.4	6	136,927,165 - 136,927,444	UniSTS	RGSC3.4
Celera	6	128,747,222 - 128,747,501	UniSTS
Cytogenetic Map	6	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1		25	23		23				16
Low	2	12	13	6	5	6	1	1	68	19	35	6	1
Below cutoff		21	17	10	14	10	6	7	6		6	5	6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_144750	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005505443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB009372	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC120242	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000017454 ⟹ ENSRNOP00000017454

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	131,176,874 - 131,196,268 (+)	Ensembl
Rnor_6.0 Ensembl	6	136,682,126 - 136,701,628 (+)	Ensembl

RefSeq Acc Id:

NM_144750 ⟹ NP_653351

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	136,998,023 - 137,017,417 (+)	NCBI
mRatBN7.2	6	131,176,874 - 131,196,268 (+)	NCBI
Rnor_6.0	6	136,682,279 - 136,701,673 (+)	NCBI
Rnor_5.0	6	145,692,075 - 145,711,786 (+)	NCBI
RGSC_v3.4	6	136,909,407 - 136,928,801 (+)	RGD
Celera	6	128,729,464 - 128,748,858 (+)	RGD

Sequence:

show sequence

CACCCTGCGGGCTCCTCCGCTTCCCGGTCTTGCTTTCCCTTTGGCTCTGTCCCCACTGAGGAGT
CCGCTGTCCCAGCCATGGCGCGTGCTACCGGACCCGAGCAGCGGCTGCTGGCCATCTACACTGG
CGGCACCATCGGCATGCGGAGTGAAGGCGGAGTGCTGGTACCTGGGAGAGGCCTGGCTGCTGTC
CTGAGGACACTTCACATGCTCCACGATGAAGAGTATGCCAGAGCCCACAGCCTGCCCGAGGATA
CGCTGGTGTTGCCCCCGGCCAGTTCTGACCAGAGGATCATCTACAAGGTGCTGGAGTGCCAGCC
ACTCTTCGACTCCAGTGACATGACCATCACTGAATGGGTTCAGATTGCCCAAACGATAGAGAGA
CACTACACACAGTACCAGGGCTTTGTGGTCATCCACGGCACGGACACCATGGCCTTTGCTGCGT
CAGTGCTCTCTTTCATGCTGGAAAACCTGCAGAAACCGGTCATCCTCACAGGTGCCCAGGTTCC
TATCCACGAACTGTGGAGTGATGGCCGTGAGAACCTGCTGGGGGCTCTGCTCATGGCTGGCCAG
TACGTCATCCCTGAGGTCTGCCTGTTCTTCCAGAATCAGCTCTTTCGGGGCAATCGGACAACCA
AGGTGGACGCTCGGAGATTTGCGGCCTTCTGCTCCCCTAACCTGCCCCCTCTAGCCACTGTGGG
CGCAGACGTAACAATCAACCGTGAGCTGGTACGGAAGGCCAGTTGGAAGAGCCACCTGGTGGTC
CACAGCAACATGGAGCCTGATGTGGGCCTACTGCGCCTCTACCCTGGGATTCCCGCCTCCCTGG
TCCGGACCTTCCTCCAGCCCCCACTGAAGGGCGTGGTCATGGAGACCTTTGGCTCCGGGAATGG
GCCCACCAAGCCGGACCTAATACAGGAGCTCCGGGCGGCGGCCGAAAGAGGCCTGATCATTGTC
AACTGTACCCATTGCCTTCAGGGGGCTGTGACTTCCGACTATGCACCTGGGATGGCCATGGCAG
GAGCCGGCATAATCTCAGGCTTCGACATGACATCAGAAGCTGCCCTGGCCAAACTGTCCTATGT
GCTGGGCCAGCCAGGGCTGAGCCTGAGTGACAGGAAGAAGCTGCTGGCCAAGGATCTTCGCGGG
GAGATGACACTGCCTACAACAGATGACTTGCTGGGAGATGACATGCTGGGCTGCAGGGCCACAT
GGCTTCTCAGTATGAATGGCAGCCAGGATGCCGATGCCATGAAGGATGTTCTGCTGCCCGGCCT
GGCCCTGGCTGCAGCTCATGCTGGTGACCTGGACACTCTGCAGGCCTTTGTGGAGCTGGGCAGA
GACCTCAACCTGAAGGACTACAGTGGCCAGACGCCACTGCATGTGGCTGCACGGAGAGGGCATG
CTTCAGTGGTCGCCATGCTACTGCAGAAGGGTGTGGATGTGGATGCCTGTAATGAGGACGGTCA
GAGCCCACTGCTGCTGGCCGTGAGGGGCAGGCATCAGAGTGTCATCAGGCTGCTGAGGGCCGCT
GGGGCTCACCTGTCTCCCCAGGAGCTGGAGGACGTGGGGACAGAGCTGTGCAGGCTGGCATCAA
GGGCGGACAGCGAAGGCCTGCGGGCGTGGTGGCAGGCTGGGGCTGACCTAGGACAGCCGGACTA
TGATGGACACTGTGCCCTGCAAGTTGCTGAAGCAGCAGGGAATGCAGATGTGGTGGCTCTGCTG
CAGAGTCTTGAGGACAGGGTCAGCGCCCAGCCCCAGCCCCATTAGTTCTTGGGCTGGTCTGATG
CCTCCTCAGTGAACTCTCATTGGTTTACGACTGGATCCTGGCACCAGAGCCAGTTCTGGAGACG
GCTAGAGGAAGTGGGCATAAGAGATGGGTCATTCGTCCAGAGCCCTTCTTGGGGACCCCGAGAG
TAAACACGGTCTTCGGGAGATAGGGCTGGTGGGGCTTCGTGTAGAAGCCCAGCTCAGACCTTCA
CCCTACCCAGTCTGGAGCTGATTGACTGGAAGGACCTAGGCCTGCTCCCAGCTGACATCCATCC
CCACTGCTCTGGAGTTTTGAGGCTTGGCGGACTATCCTCAACTCCTGGGACTGCCTGGATTCCA
TACACAAGGCTTCTGGGGTGGAGTACGGGGAGGCCTGCCCTGGATGCATCCCTGTAGTCCTCGG
AAGACCTTGTTTCCAGGAAGTGCTCCTTGGCCCCCAACCTGTTGCAGCAGGAGCTGTGTCTTAC
TGCCCGTGGGACCTCACGCACATACCAGCAGACTGGCTGCTATGTTAGCACCATTCTAGTTGGT
GAGACCTCGAAGCTTTCAGAAGCCAGCTCTGTTCTGGCCTTGTTATCTCCTGCAGCCAGGTGTC
CCAGGAGCTGACTCAGAGCTATGGACTCCTCCTCCCTAAGTTGCGGGGGCGGGGGGGGGGGTCG
TCTTCTGCTAAACTGCTTCCCAGCCTGTTGGCATGACAAATCTGGAGGTCTTTGTTGAGTAGAA
TGTCAATAAAGCCATCCGGACAGCTGCT

hide sequence

RefSeq Acc Id:

XR_005505443

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	136,997,832 - 137,013,194 (+)	NCBI
mRatBN7.2	6	131,176,727 - 131,192,056 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_653351	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98655	(Get FASTA)	NCBI Sequence Viewer
	BAA31197	(Get FASTA)	NCBI Sequence Viewer
	EDL97433	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017454
	ENSRNOP00000017454.2
GenBank Protein	O88202	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_653351 ⟸ NM_144750

- UniProtKB:

Q4G088 (UniProtKB/Swiss-Prot), O88202 (UniProtKB/Swiss-Prot), A0A0G2JSM2 (UniProtKB/TrEMBL), A6KBU8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARATGPEQRLLAIYTGGTIGMRSEGGVLVPGRGLAAVLRTLHMLHDEEYARAHSLPEDTLVLP
PASSDQRIIYKVLECQPLFDSSDMTITEWVQIAQTIERHYTQYQGFVVIHGTDTMAFAASVLSF
MLENLQKPVILTGAQVPIHELWSDGRENLLGALLMAGQYVIPEVCLFFQNQLFRGNRTTKVDAR
RFAAFCSPNLPPLATVGADVTINRELVRKASWKSHLVVHSNMEPDVGLLRLYPGIPASLVRTFL
QPPLKGVVMETFGSGNGPTKPDLIQELRAAAERGLIIVNCTHCLQGAVTSDYAPGMAMAGAGII
SGFDMTSEAALAKLSYVLGQPGLSLSDRKKLLAKDLRGEMTLPTTDDLLGDDMLGCRATWLLSM
NGSQDADAMKDVLLPGLALAAAHAGDLDTLQAFVELGRDLNLKDYSGQTPLHVAARRGHASVVA
MLLQKGVDVDACNEDGQSPLLLAVRGRHQSVIRLLRAAGAHLSPQELEDVGTELCRLASRADSE
GLRAWWQAGADLGQPDYDGHCALQVAEAAGNADVVALLQSLEDRVSAQPQPH

hide sequence

RefSeq Acc Id:

ENSRNOP00000017454 ⟸ ENSRNOT00000017454

Protein Domains

Asparaginase/glutaminase Asparaginase/glutaminase C-terminal L-asparaginase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O88202-F1-model_v2	AlphaFold	O88202	1-564	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694848

Promoter ID:

EPDNEW_R5372

Type:

multiple initiation site

Name:

Aspg_1

Description:

asparaginase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	136,682,333 - 136,682,393	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708388	AgrOrtholog
BioCyc Gene	G2FUF-35807	BioCyc
BioCyc Pathway	ASPARAGINE-DEG1-PWY-1 [L-asparagine degradation III (mammalian)]	BioCyc
BioCyc Pathway Image	ASPARAGINE-DEG1-PWY-1	BioCyc
Ensembl Genes	ENSRNOG00000012843	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017454	ENTREZGENE
	ENSRNOT00000017454.5	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.1170	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.40.50.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7373402	IMAGE-MGC_LOAD
InterPro	Ankyrin_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	AsnA_fam	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	Asp/glu_Ase-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Asparaginase/glutaminase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Asparaginase/glutaminase_AS2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Asparaginase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L-asparaginase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L-asparaginase_I	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L-asparaginase_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L-asparaginase_N_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:246266	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:112599	IMAGE-MGC_LOAD
NCBI Gene	246266	ENTREZGENE
PANTHER	60 KDA LYSOPHOSPHOLIPASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L-ASPARAGINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ank_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Asparaginase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Asparaginase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Aspg	PhenoGen
PIRSF	L-ASNase_gatD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	L_ASNase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	ANKYRIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ASNGLNASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ASN_GLN_ASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ASN_GLN_ASE_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012843	RatGTEx
SMART	ANK	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Asparaginase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	ANK	UniProtKB/Swiss-Prot
	Asp/Glutamnse	UniProtKB/Swiss-Prot
	SSF48403	UniProtKB/TrEMBL
	SSF53774	UniProtKB/TrEMBL
UniProt	A0A0G2JSM2	ENTREZGENE, UniProtKB/TrEMBL
	A6KBU8	ENTREZGENE, UniProtKB/TrEMBL
	LPP60_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q4G088	ENTREZGENE
UniProt Secondary	Q4G088	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-03-27	Aspg	asparaginase	Aspg	asparaginase homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-02-26	Aspg	asparaginase homolog (S. cerevisiae)	LOC246266	lysophospholipase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-09-30	LOC246266				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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