Mir224 (microRNA 224) - Rat Genome Database

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Gene: Mir224 (microRNA 224) Rattus norvegicus
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Symbol: Mir224
Name: microRNA 224
RGD ID: 2325530
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in miRNA-mediated post-transcriptional gene silencing and negative regulation of cell migration. Predicted to act upstream of or within several processes, including Wnt signaling pathway; cellular response to leukemia inhibitory factor; and cellular response to lipopolysaccharide. Biomarker of hepatocellular carcinoma and steatotic liver disease. Orthologous to human MIR224 (microRNA 224); INTERACTS WITH 2,5-hexanedione; amiodarone; dexamethasone.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-224
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X155,107,130 - 155,107,211 (-)NCBIGRCr8
mRatBN7.2X150,065,088 - 150,065,169 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX150,065,088 - 150,065,169 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX152,256,499 - 152,256,580 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X155,790,708 - 155,790,789 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X153,332,281 - 153,332,362 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X152,223,754 - 152,223,835 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX152,223,754 - 152,223,835 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01147,949,930 - 147,950,011 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1131,042,463 - 131,042,544 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms. Amankwatia EB, etal., Br J Cancer. 2015 Apr 28;112(9):1480-90. doi: 10.1038/bjc.2015.125.
2. Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224. Lan SH, etal., Hepatology. 2014 Feb;59(2):505-17. doi: 10.1002/hep.26659. Epub 2013 Dec 13.
3. Elevated miR-33a and miR-224 in steatotic chronic hepatitis C liver biopsies. Lendvai G, etal., World J Gastroenterol. 2014 Nov 7;20(41):15343-50. doi: 10.3748/wjg.v20.i41.15343.
4. Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function. Okajima W, etal., Oncotarget. 2016 Aug 16;7(33):53820-53836. doi: 10.18632/oncotarget.10781.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). Sun D, etal., J Biol Chem. 2013 Mar 29;288(13):9508-18. doi: 10.1074/jbc.M112.367763. Epub 2013 Jan 15.
7. MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms. Wang Y, etal., FASEB J. 2012 Jul;26(7):3032-41. doi: 10.1096/fj.11-201855. Epub 2012 Mar 29.
8. MicroRNA-224 targets SMAD family member 4 to promote cell proliferation and negatively influence patient survival. Wang Y, etal., PLoS One. 2013 Jul 29;8(7):e68744. doi: 10.1371/journal.pone.0068744. Print 2013.
9. MicroRNA-224 upregulation and AKT activation synergistically predict poor prognosis in patients with hepatocellular carcinoma. Yu L, etal., Cancer Epidemiol. 2014 Aug;38(4):408-13. doi: 10.1016/j.canep.2014.05.001. Epub 2014 Jun 10.
Additional References at PubMed
PMID:16274478   PMID:16381832   PMID:16682203   PMID:18762567   PMID:20403161   PMID:20439489   PMID:20548288   PMID:21247879   PMID:25822872   PMID:29520011   PMID:30817060   PMID:32748313  
PMID:35217336   PMID:38977348  


Genomics

Comparative Map Data
Mir224
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X155,107,130 - 155,107,211 (-)NCBIGRCr8
mRatBN7.2X150,065,088 - 150,065,169 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX150,065,088 - 150,065,169 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX152,256,499 - 152,256,580 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X155,790,708 - 155,790,789 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X153,332,281 - 153,332,362 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X152,223,754 - 152,223,835 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX152,223,754 - 152,223,835 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01147,949,930 - 147,950,011 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1131,042,463 - 131,042,544 (-)NCBICelera
Cytogenetic MapXq37NCBI
MIR224
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X151,958,578 - 151,958,658 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX151,958,578 - 151,958,658 (-)EnsemblGRCh38hg38GRCh38
GRCh37X151,127,050 - 151,127,130 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X150,877,705 - 150,877,785 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX151,372,641 - 151,372,721 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX139,981,345 - 139,981,425 (-)NCBIHuRef
CHM1_1X151,001,985 - 151,002,065 (-)NCBICHM1_1
T2T-CHM13v2.0X150,224,792 - 150,224,872 (-)NCBIT2T-CHM13v2.0
Mir224
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X71,304,637 - 71,304,718 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX71,304,637 - 71,304,718 (-)EnsemblGRCm39 Ensembl
GRCm38X72,261,031 - 72,261,112 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX72,261,031 - 72,261,112 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X69,506,370 - 69,506,451 (-)NCBIGRCm37MGSCv37mm9NCBIm37
CeleraX63,229,471 - 63,229,552 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.21NCBI
MIR224
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X119,925,345 - 119,925,413 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX119,925,345 - 119,925,413 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX105,307,889 - 105,307,957 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X122,146,174 - 122,146,242 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X118,866,161 - 118,866,229 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X121,356,881 - 121,356,949 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X121,231,524 - 121,231,592 (-)NCBIUU_Cfam_GSD_1.0
MIR224
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX123,283,427 - 123,283,507 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X123,283,427 - 123,283,507 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X140,860,060 - 140,860,140 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:8216
Count of gene targets:5273
Count of transcripts:5622
Interacting mature miRNAs:rno-miR-224-3p, rno-miR-224-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 29 8 3 11 2 3 2 53 35 7 16 31 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_032111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000088901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX150,065,088 - 150,065,169 (-)Ensembl
Rnor_6.0 EnsemblX152,223,754 - 152,223,835 (-)Ensembl
RefSeq Acc Id: NR_032111
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X155,107,130 - 155,107,211 (-)NCBI
mRatBN7.2X150,065,088 - 150,065,169 (-)NCBI
Rnor_6.0X152,223,754 - 152,223,835 (-)NCBI
Rnor_5.01147,949,930 - 147,950,011 (-)NCBI
Celera1131,042,463 - 131,042,544 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325530 AgrOrtholog
BioCyc Gene G2FUF-706 BioCyc
Ensembl Genes ENSRNOG00000060270 Ensembl
miRBase MI0003483 ENTREZGENE
NCBI Gene 100314075 ENTREZGENE
PhenoGen Mir224 PhenoGen
RatGTEx ENSRNOG00000060270 RatGTEx
RNAcentral URS0000236D35 RNACentral
  URS00004A785A RNACentral
  URS000069953F RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir224  microRNA 224  Mir224  microRNA mir-224  Name updated 61478 APPROVED
2010-06-02 Mir224  microRNA mir-224      Symbol and Name status set to provisional 70820 PROVISIONAL