Fam163b (family with sequence similarity 163, member B) - Rat Genome Database

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Gene: Fam163b (family with sequence similarity 163, member B) Rattus norvegicus
Analyze
Symbol: Fam163b
Name: family with sequence similarity 163, member B
RGD ID: 1597714
Description: Predicted to be located in membrane. Orthologous to human FAM163B (family with sequence similarity 163 member B); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC685169; LOC685169; uncharacterized protein LOC685169
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,834,145 - 30,865,802 (-)NCBIGRCr8
mRatBN7.2310,437,383 - 10,466,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,437,383 - 10,466,458 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,503,225 - 13,532,345 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,088,623 - 22,117,739 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,343,913 - 20,373,031 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,656,400 - 5,693,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,656,163 - 5,693,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,018,783 - 11,054,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,007,361 - 6,036,371 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera35,235,362 - 5,264,429 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam163bRatdevelopmental and epileptic encephalopathy 14  ISOFAM163B (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 14ClinVarPMID:28492532
Fam163bRatEhlers-Danlos syndrome classic type 1  ISOFAM163B (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndrome and classic typeClinVarPMID:28492532
Fam163bRatKleefstra syndrome 1  ISOFAM163B (Homo sapiens)8554872ClinVar Annotator: match by term: Kleefstra syndrome 1ClinVarPMID:22318994 more ...
Fam163bRatLeigh disease  ISOFAM163B (Homo sapiens)8554872ClinVar Annotator: match by term: Leigh syndromeClinVarPMID:28492532
Fam163bRatprimary coenzyme Q10 deficiency 7  ISOFAM163B (Homo sapiens)8554872ClinVar Annotator: match by term: Neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndromeClinVarPMID:28492532
Fam163bRatRafiq syndrome  ISOFAM163B (Homo sapiens)8554872ClinVar Annotator: match by term: Rafiq syndromeClinVarPMID:28492532
Fam163bRattuberous sclerosis 1  ISOFAM163B (Homo sapiens)8554872ClinVar Annotator: match by term: Tuberous sclerosis 1ClinVarPMID:28492532

1 to 20 of 35 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam163bRat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of FAM163B mRNACTDPMID:32741896
Fam163bRat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of FAM163B mRNACTDPMID:32741896
Fam163bRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOFam163b (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of FAM163B mRNACTDPMID:24680724
Fam163bRat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Fam163bRatacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of FAM163B mRNACTDPMID:28959563
Fam163bRatacrylamide decreases expressionISOFAM163B (Homo sapiens)6480464Acrylamide results in decreased expression of FAM163B mRNACTDPMID:32763439
Fam163bRataldehydo-D-glucose multiple interactionsISOFam163b (Mus musculus)6480464[lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of FAM163B mRNACTDPMID:37567420
Fam163bRatarsane decreases expressionISOFAM163B (Homo sapiens)6480464Arsenic results in decreased expression of FAM163B mRNACTDPMID:36861143
Fam163bRatarsenic atom decreases expressionISOFAM163B (Homo sapiens)6480464Arsenic results in decreased expression of FAM163B mRNACTDPMID:36861143
Fam163bRatbenzo[a]pyrene decreases expressionISOFam163b (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of FAM163B mRNACTDPMID:22228805
Fam163bRatbenzo[a]pyrene affects methylationISOFAM163B (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of FAM163B polyA tailCTDPMID:30157460
Fam163bRatbenzo[a]pyrene increases methylationISOFAM163B (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of FAM163B promoterCTDPMID:27901495
Fam163bRatbis(2-ethylhexyl) phthalate decreases expressionEXP 6480464Diethylhexyl Phthalate results in decreased expression of FAM163B mRNACTDPMID:29945229
Fam163bRatbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of FAM163B mRNACTDPMID:25181051
Fam163bRatbisphenol A decreases expressionISOFam163b (Mus musculus)6480464bisphenol A results in decreased expression of FAM163B mRNACTDPMID:32156529
Fam163bRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of FAM163B mRNACTDPMID:34947998
Fam163bRatcopper atom increases expressionEXP 6480464Copper deficiency results in increased expression of FAM163B mRNACTDPMID:26033743
Fam163bRatcopper atom multiple interactionsEXP 6480464[Copper co-treated with Dietary Sucrose] results in increased expression of FAM163B mRNACTDPMID:26033743
Fam163bRatcopper(0) increases expressionEXP 6480464Copper deficiency results in increased expression of FAM163B mRNACTDPMID:26033743
Fam163bRatcopper(0) multiple interactionsEXP 6480464[Copper co-treated with Dietary Sucrose] results in increased expression of FAM163B mRNACTDPMID:26033743

1 to 20 of 35 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam163bRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Fam163bRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Fam163bRatprotein binding enablesISOFAM163B (Homo sapiens)1624291UniProtKB:Q12959 more ...RGDPMID:24550280 more ...


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Fam163b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,834,145 - 30,865,802 (-)NCBIGRCr8
mRatBN7.2310,437,383 - 10,466,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,437,383 - 10,466,458 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,503,225 - 13,532,345 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,088,623 - 22,117,739 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,343,913 - 20,373,031 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,656,400 - 5,693,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,656,163 - 5,693,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,018,783 - 11,054,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,007,361 - 6,036,371 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera35,235,362 - 5,264,429 (-)NCBICelera
Cytogenetic Map3p12NCBI
FAM163B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,577,081 - 133,609,389 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,577,081 - 133,609,389 (-)EnsemblGRCh38hg38GRCh38
GRCh379136,442,203 - 136,474,511 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,433,965 - 135,435,166 (-)NCBINCBI36Build 36hg18NCBI36
Celera9106,991,068 - 106,992,269 (-)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9105,943,556 - 105,945,387 (-)NCBIHuRef
CHM1_19136,593,007 - 136,594,838 (-)NCBICHM1_1
T2T-CHM13v2.09145,791,075 - 145,825,393 (-)NCBIT2T-CHM13v2.0
Fam163b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,000,391 - 27,032,489 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl227,000,392 - 27,032,503 (-)EnsemblGRCm39 Ensembl
GRCm38227,110,379 - 27,142,477 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,110,380 - 27,142,491 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,967,523 - 26,997,994 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,934,012 - 26,964,483 (-)NCBIMGSCv36mm8
Celera226,815,061 - 26,845,378 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.25NCBI
Fam163b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,880,253 - 2,903,575 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,880,253 - 2,903,575 (-)NCBIChiLan1.0ChiLan1.0
FAM163B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,741,791 - 5,776,163 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,744,125 - 5,778,499 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,700,420 - 104,734,748 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,311,168 - 133,343,841 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,311,168 - 133,343,841 (-)Ensemblpanpan1.1panPan2
FAM163B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,960,093 - 49,988,263 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,961,706 - 49,962,807 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,241,103 - 49,269,296 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,835,023 - 50,862,647 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,834,763 - 50,862,632 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,595,837 - 49,623,982 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,937,772 - 49,965,933 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0950,016,111 - 50,044,314 (-)NCBIUU_Cfam_GSD_1.0
Fam163b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947200,011,983 - 200,037,568 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,360,236 - 3,361,686 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,337,490 - 3,363,077 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM163B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,156,751 - 273,186,756 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,156,749 - 273,186,756 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,130,575 - 307,160,599 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAM163B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,525,338 - 4,560,676 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,557,505 - 4,558,705 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058428,478 - 464,163 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam163b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,978,293 - 2,001,410 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,978,667 - 2,002,131 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Fam163b
136 total Variants

Predicted Target Of
Summary Value
Count of predictions:315
Count of miRNA genes:183
Interacting mature miRNAs:209
Transcripts:ENSRNOT00000008660
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 16 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat

1 to 10 of 16 rows
bnlg1246b  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0311,030,918 - 11,031,390NCBIRnor5.0
RGSC_v3.436,015,696 - 6,016,167UniSTSRGSC3.4
Celera35,243,893 - 5,244,364UniSTS
Cytogenetic Map3p12UniSTS
Cytogenetic Map2q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 5 49 110 55 53 31 17 31 3 158 83 93 34 58 22



Ensembl Acc Id: ENSRNOT00000008660   ⟹   ENSRNOP00000008660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl35,656,163 - 5,693,147 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111342   ⟹   ENSRNOP00000079918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,437,383 - 10,466,458 (-)Ensembl
RefSeq Acc Id: NM_001109458   ⟹   NP_001102928
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,835,461 - 30,864,530 (-)NCBI
mRatBN7.2310,437,383 - 10,466,458 (-)NCBI
Rnor_6.035,657,716 - 5,693,273 (-)NCBI
Rnor_5.0311,018,783 - 11,054,772 (-)NCBI
RGSC_v3.436,007,361 - 6,036,371 (-)RGD
Celera35,235,362 - 5,264,429 (-)RGD
Sequence:
RefSeq Acc Id: XM_063284556   ⟹   XP_063140626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,834,145 - 30,865,802 (-)NCBI
Protein RefSeqs NP_001102928 (Get FASTA)   NCBI Sequence Viewer  
  XP_063140626 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93442 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079918.1
RefSeq Acc Id: NP_001102928   ⟸   NM_001109458
- UniProtKB: D3Z988 (UniProtKB/TrEMBL),   A6JTK5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008660   ⟸   ENSRNOT00000008660
Ensembl Acc Id: ENSRNOP00000079918   ⟸   ENSRNOT00000111342
RefSeq Acc Id: XP_063140626   ⟸   XM_063284556
- Peptide Label: isoform X1
- UniProtKB: A6JTK5 (UniProtKB/TrEMBL),   D3Z988 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-D3Z988-F1-model_v2 AlphaFold D3Z988 1-167 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 16 of 16 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-50306 BioCyc
Ensembl Genes ENSRNOG00000006591 Ensembl
  ENSRNOG00000065438 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000111342.1 UniProtKB/TrEMBL
InterPro FAM163 UniProtKB/TrEMBL
  FAM163B UniProtKB/TrEMBL
KEGG Report rno:685169 UniProtKB/TrEMBL
NCBI Gene 685169 ENTREZGENE
PANTHER PROTEIN FAM163B UniProtKB/TrEMBL
  PTHR31396 UniProtKB/TrEMBL
Pfam FAM163 UniProtKB/TrEMBL
PhenoGen Fam163b PhenoGen
RatGTEx ENSRNOG00000006591 RatGTEx
  ENSRNOG00000065438 RatGTEx
UniProt A6JTK5 ENTREZGENE, UniProtKB/TrEMBL
  D3Z988 ENTREZGENE, UniProtKB/TrEMBL
1 to 16 of 16 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-21 Fam163b  family with sequence similarity 163, member B  LOC685169  hypothetical protein LOC685169  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC685169  hypothetical protein LOC685169  LOC687497  hypothetical protein LOC687497  Data merged from RGD:1585309 1643240 APPROVED
2006-11-20 LOC685169  hypothetical protein LOC685169      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687497  hypothetical protein LOC687497      Symbol and Name status set to provisional 70820 PROVISIONAL