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Gene: Eras (ES cell expressed Ras) Rattus norvegicus

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Symbol:

Eras

Name:

ES cell expressed Ras

RGD ID:

1585907

Description:

Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in endomembrane system. Predicted to be active in plasma membrane. Orthologous to human ERAS (ES cell expressed Ras); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; 5-fluorouracil (ortholog).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GTPase ERas; hypothetical protein LOC679682; LOC108348138; LOC679682; similar to ES cell-expressed Ras

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ERAS (ES cell expressed Ras)	RGD	RGD
Mus musculus (house mouse):	Eras (ES cell-expressed Ras)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Eras (ES cell expressed Ras)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ERAS (ES cell expressed Ras)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ERAS (ES cell expressed Ras)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Eras (ES cell expressed Ras)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ERAS (ES cell expressed Ras)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ERAS (ES cell expressed Ras)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Eras (ES cell expressed Ras)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ERAS (ES cell expressed Ras)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Eras (ES cell-expressed Ras)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	17,245,915 - 17,250,301 (+)	NCBI		GRCr8
mRatBN7.2	X	14,573,987 - 14,578,455 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	14,573,987 - 14,578,374 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	19,387,537 - 19,391,924 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	20,691,188 - 20,695,575 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	16,956,357 - 16,960,744 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	15,318,215 - 15,322,601 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	15,321,713 - 15,322,396 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	X	15,419,028 - 15,423,414 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	16,098,270 - 16,102,842 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	26,608,537 - 26,612,923 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	14,658,743 - 14,663,129 (+)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eras	Rat	autistic disorder		ISO	RGD:1345319	8554872	ClinVar Annotator: match by term: Autism	ClinVar	PMID:21681106\|PMID:30208311
Eras	Rat	congenital disorder of glycosylation type IIm		ISO	RGD:1345319	8554872	ClinVar Annotator: match by term: DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 22 \| ClinVar Annotator: match by more ...	ClinVar	PMID:28492532
Eras	Rat	immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome		ISO	RGD:1345319	8554872	ClinVar Annotator: match by term: Insulin-dependent diabetes mellitus secretory diarrhea syndrome	ClinVar	PMID:11137992\|PMID:11137993\|PMID:28492532
Eras	Rat	neurodegeneration with brain iron accumulation 5		ISO	RGD:1345319	8554872	ClinVar Annotator: match by term: Beta-propeller protein-associated neurodegeneration	ClinVar	PMID:28492532
Eras	Rat	syndromic X-linked intellectual disability Lubs type		ISO	RGD:1345319	8554872	ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs type	ClinVar	PMID:25741868
Eras	Rat	Thrombocytopenia 1		ISO	RGD:1345319	8554872	ClinVar Annotator: match by term: Thrombocytopenia, X-linked	ClinVar	PMID:28492532
Eras	Rat	Wiskott-Aldrich syndrome		ISO	RGD:1345319	8554872	ClinVar Annotator: match by term: WISKOTT-ALDRICH SYNDROME 1	ClinVar	PMID:28492532
Eras	Rat	X-linked epilepsy with variable learning disabilities and behavior disorders		ISO	RGD:1345319	8554872	ClinVar Annotator: match by term: Epilepsy, X-linked 1, with variable learning disabilities and behavior disorders more ...	ClinVar	PMID:28492532
Eras	Rat	X-linked severe congenital neutropenia		ISO	RGD:1345319	8554872	ClinVar Annotator: match by term: X-linked severe congenital neutropenia	ClinVar	PMID:28492532

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eras	Rat	5-fluorouracil	decreases expression	ISO	RGD:1556987	6480464	Fluorouracil results in decreased expression of ERAS protein	CTD	PMID:21296659
Eras	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of ERAS mRNA	CTD	PMID:24780913\|PMID:25825206
Eras	Rat	acetic acid	increases expression	ISO	RGD:1556987	6480464	Acetic Acid results in increased expression of ERAS protein	CTD	PMID:21296659
Eras	Rat	benzo[a]pyrene	decreases methylation	ISO	RGD:1345319	6480464	Benzo(a)pyrene results in decreased methylation of ERAS exon; Benzo(a)pyrene results in decreased methylation of ERAS more ...	CTD	PMID:27901495
Eras	Rat	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of ERAS mRNA	CTD	PMID:25181051
Eras	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of ERAS mRNA	CTD	PMID:30816183\|PMID:32528016
Eras	Rat	bromochloroacetic acid	increases expression	ISO	RGD:1556987	6480464	bromochloroacetic acid results in increased expression of ERAS protein	CTD	PMID:21296659
Eras	Rat	CGP 52608	multiple interactions	ISO	RGD:1345319	6480464	CGP 52608 promotes the reaction [RORA protein binds to ERAS gene]	CTD	PMID:28238834
Eras	Rat	diethyl maleate	decreases expression	ISO	RGD:1556987	6480464	diethyl maleate results in decreased expression of ERAS mRNA	CTD	PMID:25270620
Eras	Rat	lead diacetate	decreases expression	ISO	RGD:1556987	6480464	lead acetate results in decreased expression of ERAS mRNA	CTD	PMID:25270620
Eras	Rat	lead diacetate	increases expression	ISO	RGD:1556987	6480464	lead acetate results in increased expression of ERAS mRNA	CTD	PMID:22609695
Eras	Rat	Licochalcone B	increases expression	ISO	RGD:1345319	6480464	licochalcone B results in increased expression of ERAS mRNA	CTD	PMID:33647349
Eras	Rat	okadaic acid	decreases expression	ISO	RGD:1345319	6480464	Okadaic Acid results in decreased expression of ERAS mRNA	CTD	PMID:38832940
Eras	Rat	pirinixic acid	decreases expression	ISO	RGD:1556987	6480464	pirinixic acid results in decreased expression of ERAS mRNA	CTD	PMID:25270620
Eras	Rat	triptonide	increases expression	ISO	RGD:1556987	6480464	triptonide results in increased expression of ERAS mRNA	CTD	PMID:33045310
Eras	Rat	valproic acid	increases methylation	ISO	RGD:1345319	6480464	Valproic Acid results in increased methylation of ERAS gene	CTD	PMID:29154799

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eras	Rat	Ras protein signal transduction	involved_in	IBA	FB:FBgn0003205\|FB:FBgn0015286\|MGI:108054\|MGI:96224\|MGI:96680\|PANTHER:PTN008604616\|RGD:2827\|UniProtKB:A0A1L8EVG4\|UniProtKB:P01111\|UniProtKB:P01112\|UniProtKB:P11233\|UniProtKB:Q92963	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Eras	Rat	signal transduction	involved_in	IEA	InterPro:IPR020849	1600115	GO_REF:0000002	InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eras	Rat	endomembrane system	located_in	IEA	UniProtKB-SubCell:SL-0147	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Eras	Rat	membrane	located_in	IEA	InterPro:IPR020849	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Eras	Rat	plasma membrane	is_active_in	IBA	CGD:CAL0000184093\|CGD:CAL0000199219\|FB:FBgn0003205\|FB:FBgn0015286\|MGI:108053\|MGI:108054\|MGI:97852\|PANTHER:PTN000631348\|PomBase:SPAC17H9.09c\|RGD:2827\|RGD:619851\|RGD:620590\|SGD:S000003384\|SGD:S000005042\|SGD:S000005627\|UniProtKB:E9QX28\|UniProtKB:O95057\|UniProtKB:P01112\|UniProtKB:P01116\|UniProtKB:P10114\|UniProtKB:P11233\|UniProtKB:P11234\|UniProtKB:P61225\|UniProtKB:P62070\|UniProtKB:Q96HU8\|UniProtKB:Q99578\|UniProtKB:Q9Y3L5\|dictyBase:DDB_G0291237\|dictyBase:DDB_G0292998\|dictyBase:DDB_G0293434	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Eras	Rat	GDP binding	enables	IBA	PANTHER:PTN000631348\|PomBase:SPAC17H9.09c\|PomBase:SPBC428.16c\|RGD:2981\|RGD:621840\|UniProtKB:P01112\|UniProtKB:P10114\|UniProtKB:P10301\|UniProtKB:P11233\|UniProtKB:P11234\|UniProtKB:P61224\|UniProtKB:P61225\|UniProtKB:Q15382\|UniProtKB:Q9Y3L5	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Eras	Rat	GTP binding	enables	IEA	InterPro:IPR001806\|InterPro:IPR005225\|InterPro:IPR020849	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Eras	Rat	GTP binding	enables	IEA	UniProtKB-KW:KW-0342	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Eras	Rat	GTP binding	enables	IBA	MGI:108053\|MGI:108054\|MGI:96224\|MGI:97912\|PANTHER:PTN000631348\|PomBase:SPAC17H9.09c\|PomBase:SPBC428.16c\|RGD:1359694\|RGD:621840\|SGD:S000005042\|UniProtKB:O95057\|UniProtKB:P01112\|UniProtKB:P10114\|UniProtKB:P11233\|UniProtKB:P11234\|UniProtKB:P61224\|UniProtKB:P61225\|UniProtKB:Q15382\|UniProtKB:Q8TAI7\|UniProtKB:Q92963\|UniProtKB:Q96HU8\|UniProtKB:Q9Y3L5\|WB:WBGene00002335\|dictyBase:DDB_G0281385\|dictyBase:DDB_G0291237\|dictyBase:DDB_G0293434	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Eras	Rat	GTPase activity	enables	IEA	InterPro:IPR001806	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Eras	Rat	GTPase activity	enables	IBA	CGD:CAL0000181665\|CGD:CAL0000184093\|CGD:CAL0000199219\|FB:FBgn0003205\|FB:FBgn0004636\|FB:FBgn0015286\|FB:FBgn0041191\|MGI:108054\|MGI:1927243\|MGI:96680\|MGI:97852\|PANTHER:PTN000631348\|PomBase:SPAC17H9.09c\|PomBase:SPBC428.16c\|RGD:621840\|SGD:S000003384\|SGD:S000005042\|SGD:S000005627\|UniProtKB:O14807\|UniProtKB:O95057\|UniProtKB:P01111\|UniProtKB:P01112\|UniProtKB:P01116\|UniProtKB:P10114\|UniProtKB:P10301\|UniProtKB:P11233\|UniProtKB:P11234\|UniProtKB:P61224\|UniProtKB:P62070\|UniProtKB:Q12526\|UniProtKB:Q15382\|UniProtKB:Q92963\|UniProtKB:Q96A58\|UniProtKB:Q96HU8	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Eras	Rat	protein binding	enables	ISO	RGD:1345319	1624291	UniProtKB:O43711\|UniProtKB:Q96JP2 PMID:32296183	RGD	PMID:32296183

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:26884329

Eras
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	17,245,915 - 17,250,301 (+)	NCBI		GRCr8
mRatBN7.2	X	14,573,987 - 14,578,455 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	14,573,987 - 14,578,374 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	19,387,537 - 19,391,924 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	20,691,188 - 20,695,575 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	16,956,357 - 16,960,744 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	15,318,215 - 15,322,601 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	15,321,713 - 15,322,396 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	X	15,419,028 - 15,423,414 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	16,098,270 - 16,102,842 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	26,608,537 - 26,612,923 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	14,658,743 - 14,663,129 (+)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

ERAS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	48,826,513 - 48,829,869 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	48,826,513 - 48,830,138 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	48,684,923 - 48,688,279 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	48,572,227 - 48,573,492 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	48,443,531 - 48,444,797	NCBI
Celera	X	52,974,981 - 52,976,246 (-)	NCBI		Celera
Cytogenetic Map	X	p11.23	NCBI
HuRef	X	46,344,561 - 46,347,994 (+)	NCBI		HuRef
CHM1_1	X	48,716,067 - 48,719,421 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	48,237,009 - 48,240,364 (+)	NCBI		T2T-CHM13v2.0

Eras
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	7,790,515 - 7,794,846 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	7,790,515 - 7,794,846 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	7,924,276 - 7,928,607 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	7,924,276 - 7,928,607 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	7,501,402 - 7,505,733 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	7,081,235 - 7,085,566 (-)	NCBI		MGSCv36	mm8
Celera	X	3,540,725 - 3,545,056 (+)	NCBI		Celera
Cytogenetic Map	X	A1.1	NCBI
cM Map	X	3.58	NCBI

Eras
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955543	381,756 - 383,093 (+)	NCBI	ChiLan1.0	ChiLan1.0

ERAS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	50,317,880 - 50,319,208 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	50,321,353 - 50,322,574 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	41,125,895 - 41,127,757 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	48,984,189 - 48,987,653 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	48,986,812 - 48,987,513 (+)	Ensembl	panpan1.1		panPan2

ERAS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	42,024,867 - 42,029,649 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	42,028,711 - 42,029,412 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	16,401,245 - 16,405,081 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	42,162,000 - 42,165,837 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	42,164,899 - 42,165,600 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	42,148,247 - 42,152,082 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	42,136,523 - 42,140,359 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	42,230,679 - 42,234,515 (+)	NCBI		UU_Cfam_GSD_1.0

Eras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	34,539,541 - 34,543,018 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936721	782,525 - 783,208 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936721	782,343 - 783,591 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ERAS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	42,941,664 - 42,946,524 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	42,942,033 - 42,946,715 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	47,883,777 - 47,888,037 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ERAS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	45,955,444 - 45,957,170 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	45,955,803 - 45,956,504 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666076	11,434,706 - 11,436,678 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eras
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624893	631,033 - 632,244 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Eras
10 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	204
Count of miRNA genes:	146
Interacting mature miRNAs:	160
Transcripts:	ENSRNOT00000042140, ENSRNOT00000071835
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1448129	31706553	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	1447972	20991088	Rat
631204	Gluco15	Glucose level QTL 15		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	1623715	22646544	Rat

RH134245

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	14,572,163 - 14,572,372 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	15,417,205 - 15,417,413	NCBI	Rnor6.0
Rnor_6.0	X	15,316,392 - 15,316,600	NCBI	Rnor6.0
Rnor_5.0	X	16,198,440 - 16,198,648	UniSTS	Rnor5.0
Rnor_5.0	X	16,096,633 - 16,096,841	UniSTS	Rnor5.0
RGSC_v3.4	X	26,606,714 - 26,606,922	UniSTS	RGSC3.4
Celera	X	14,656,920 - 14,657,128	UniSTS
RH 3.4 Map	X	164.6	UniSTS
Cytogenetic Map	X	q13	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
3	1	102	42	31	17	7	17	2	78	19	90	38	62	14


RefSeq Transcripts	NM_001109375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001434382	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017602155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000042140 ⟹ ENSRNOP00000047699

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	14,573,987 - 14,578,374 (+)	Ensembl
Rnor_6.0 Ensembl	X	15,419,028 - 15,423,414 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000071835 ⟹ ENSRNOP00000066895

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	15,321,713 - 15,322,396 (+)	Ensembl

RefSeq Acc Id:

NM_001109375 ⟹ NP_001102845

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	17,245,915 - 17,250,301 (+)	NCBI
mRatBN7.2	X	14,573,987 - 14,578,374 (+)	NCBI
Rnor_6.0	X	15,318,215 - 15,322,601 (+)	NCBI
Rnor_5.0	X	16,098,270 - 16,102,842 (+)	NCBI
RGSC_v3.4	X	26,608,537 - 26,612,923 (+)	RGD
Celera	X	14,658,743 - 14,663,129 (+)	RGD

Sequence:

show sequence

CAGGGGTCGGGCAGGTGGGAGGGGGCAAGCCCACATCTCCGCCCCTTGCTGCCGCTGGGGGTAGGGAGCATCCTAACCCCCAACTGTCCGGTCAGATCCGCCTGCTGCCCCTCAGCCGACTGCTACTC
CGGGAACACAGCACCTGCTGTTCACACCTCTTCCTTGAGCTGCTTGGGAATGGCCTTGCCAACAAAGTCTAGCATCTTGGACCTGAGCCCCGGCACACAGTGCAGCAGATCGCCAGAGGAGAGCCACG
AGGCTTGGGCACAATGCAAAGATGCTGGCAGGCAGCTACCGGAGTACAAGGCAGTGGTGGTGGGTGCGAGCGGTGTGGGTAAAAGTGCTCTCACGATCCAGATGACCCACCACTGCTTTGTGAAAGAC
CATGACCCCACTATCCAGGATTCCTACTGGAAGGAAGTGGCCCTGGACAACGGAGGCTACATTCTAAATGTGCTAGATACAGCTGGCCAGGATAGTCACCGGGCCCTGCGTGACCAGTGTTTGGCAGC
TGGTGATGGTGTGCTGGGTGTCTTTGCTCTTGATGACCCGTCGTCTCTGGACCAACTGCAGCAGATATGCTCCACCTGGAACCCTCACCACAAGCAACCTCTGGTACTCGTGGGCAACAAGTCTGACC
TGGTGAGCAGTGCTGGAGACGCCCACACCGCTGCAGCTGTCCTTGCTCACAAGTTGGGAGCCCCCTTAGTGAAGACTTCCGCCAAGACACGGCAAGGTGTAGAGGAAGCTTTTGCTCTGCTCGTCCAT
GAGATTCAGAGGGCCCAGGAGGCTGTTGCTGAGTCAAGCAAGAAGACCCGACACCACAAGGCCGTGTGTAGCTGTGGCTGCTCTGTAGCCTGAAGACCTTAGTCTAGCAAACTGACCCGTCTCATGTC
AAGGTGACAGTTCTCTCTTGTCACGATTCCCCTCCCCGACCAATACCTTTTTATTGCCATTTGGTGTGAGGAGTTAGGTGGTAACATGGGGTGTCCCTTGTTGGCTGTGTTCAGTGAAACTCTATGCA
AAATTAAATAAATGTTCTCAGGATTCAAAGCTTCCTCTATAG

hide sequence

RefSeq Acc Id:

XM_017602155 ⟹ XP_017457644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	17,245,921 - 17,250,294 (+)	NCBI
mRatBN7.2	X	14,573,993 - 14,578,455 (+)	NCBI
Rnor_6.0	X	15,318,221 - 15,322,595 (+)	NCBI

Sequence:

show sequence

TCGGGCAGGTGGGAGGGGGCAAGCCCACATCTCCGCCCCTTGCTGCCGCTGGGGGTAGGGAGCA
TCCTAACCCCCAACTGTCCGGTCAGATCCGCCTGCTGCCCCTCAGCCGACTGCTACTCCGGGAACACAGCCAGTCACACCTGATCCCCATCCGGCTGACTCAGCACCTGCTGTTCACACCTCTTCCTT
GAGCTGCTTGGGAATGGCCTTGCCAACAAAGTCTAGCATCTTGGACCTGAGCCCCGGCACACAGTGCAGCAGATCGCCAGAGGAGAGCCACGAGGCTTGGGCACAATGCAAAGATGCTGGCAGGCAGC
TACCGGAGTACAAGGCAGTGGTGGTGGGTGCGAGCGGTGTGGGTAAAAGTGCTCTCACGATCCAGATGACCCACCACTGCTTTGTGAAAGACCATGACCCCACTATCCAGGATTCCTACTGGAAGGAA
GTGGCCCTGGACAACGGAGGCTACATTCTAAATGTGCTAGATACAGCTGGCCAGGATAGTCACCGGGCCCTGCGTGACCAGTGTTTGGCAGCTGGTGATGGTGTGCTGGGTGTCTTTGCTCTTGATGA
CCCGTCGTCTCTGGACCAACTGCAGCAGATATGCTCCACCTGGAACCCTCACCACAAGCAACCTCTGGTACTCGTGGGCAACAAGTCTGACCTGGTGAGCAGTGCTGGAGACGCCCACACCGCTGCAG
CTGTCCTTGCTCACAAGTTGGGAGCCCCCTTAGTGAAGACTTCCGCCAAGACACGGCAAGGTGTAGAGGAAGCTTTTGCTCTGCTCGTCCATGAGATTCAGAGGGCCCAGGAGGCTGTTGCTGAGTCA
AGCAAGAAGACCCGACACCACAAGGCCGTGTGTAGCTGTGGCTGCTCTGTAGCCTGAAGACCTTAGTCTAGCAAACTGACCCGTCTCATGTCAAGGTGACAGTTCTCTCTTGTCACGATTCCCCTCCC
CGACCAATACCTTTTTATTGCCATTTGGTGTGAGGAGTTAGGTGGTAACATGGGGTGTCCCTTGTTGGCTGTGTTCAGTGAAACTCTATGCAAAATTAAATAAATGTTCTCAGGATTCAAAGCTTCCT

hide sequence


Protein RefSeqs	NP_001102845	(Get FASTA)	NCBI Sequence Viewer
	NP_001421311	(Get FASTA)	NCBI Sequence Viewer
	XP_017457644	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL83810	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000047699
	ENSRNOP00000047699.3

RefSeq Acc Id:

NP_001102845 ⟸ NM_001109375

- UniProtKB:

D3ZTE4 (UniProtKB/TrEMBL), A6KP62 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MALPTKSSILDLSPGTQCSRSPEESHEAWAQCKDAGRQLPEYKAVVVGASGVGKSALTIQMTHHCFVKDHDPTIQDSYWKEVALDNGGYILNVLDTAGQDSHRALRDQCLAAGDGVLGVFALDDPSSL
DQLQQICSTWNPHHKQPLVLVGNKSDLVSSAGDAHTAAAVLAHKLGAPLVKTSAKTRQGVEEAFALLVHEIQRAQEAVAESSKKTRHHKAVCSCGCSVA

hide sequence

RefSeq Acc Id:

XP_017457644 ⟸ XM_017602155

- Peptide Label:

isoform X1

- Sequence:

show sequence

MALPTKSSILDLSPGTQCSRSPEESHEAWAQCKDAGRQLPEYKAVVVGASGVGKSALTIQMTHHCFVKDHDPTIQDSYWKEVALDNGGYILNVLDTAGQDSHRALRDQCLAAGDGVLGVFALDDPSSL
DQLQQICSTWNPHHKQPLVLVGNKSDLVSSAGDAHTAAAVLAHKLGAPLVKTSAKTRQGVEEAFALLVHEIQRAQEAVAESSKKTRHHKAVCSCGCSVA

hide sequence

Ensembl Acc Id:

ENSRNOP00000047699 ⟸ ENSRNOT00000042140

Ensembl Acc Id:

ENSRNOP00000066895 ⟸ ENSRNOT00000071835

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZTE4-F1-model_v2	AlphaFold	D3ZTE4	1-227	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-2932	BioCyc
Ensembl Genes	ENSRNOG00000042470	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000048396	Ensembl
Ensembl Transcript	ENSRNOT00000042140	ENTREZGENE
	ENSRNOT00000042140.4	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Ras_GTPase	UniProtKB/TrEMBL
	Ras_small_GTPase	UniProtKB/TrEMBL
	Small_GTP-bd	UniProtKB/TrEMBL
KEGG Report	rno:679682	UniProtKB/TrEMBL
NCBI Gene	679682	ENTREZGENE
PANTHER	PTHR24070	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PhenoGen	Eras	PhenoGen
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000042470	RatGTEx
	ENSRNOG00000048396	RatGTEx
SMART	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A6KP62	ENTREZGENE, UniProtKB/TrEMBL
	D3ZTE4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Eras	ES cell expressed Ras	LOC108348138	GTPase ERas	Data merged from RGD:11427050	737654	PROVISIONAL
2016-08-02	LOC108348138	GTPase ERas			Symbol and Name status set to provisional	70820	PROVISIONAL
2011-05-27	Eras	ES cell expressed Ras	LOC679682	similar to ES cell-expressed Ras	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC679682	similar to ES cell-expressed Ras	LOC682898	similar to ES cell-expressed Ras	Data merged from RGD:1593951	1643240	APPROVED
2006-11-20	LOC682898	similar to ES cell-expressed Ras			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC679682	similar to ES cell-expressed Ras			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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Imported Disease Annotations - ClinVar