Igkvl15 (immunoglobulin kappa variable like 15) - Rat Genome Database

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Gene: Igkvl15 (immunoglobulin kappa variable like 15) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Igkvl15 (Ensembl: Igkvl14)
Name: immunoglobulin kappa variable like 15 (Ensembl:immunoglobulin kappa variable like 14)
RGD ID: 1565617
Description: Predicted to be involved in immune response. Predicted to be part of immunoglobulin complex. Orthologous to several human genes including IGKV3-11 (immunoglobulin kappa variable 3-11); IGKV3-15 (immunoglobulin kappa variable 3-15); and IGKV3-20 (immunoglobulin kappa variable 3-20); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ig kappa chain V region; Ig kappa chain V-III region MOPC 63; LOC502807; mCG142161-like; RGD1560632; RGD1565617; RGD1565617_predicted; similar to Ig variable region, light chain; similar to Ig variable region, light chain (predicted); uncharacterized protein LOC679997
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,099,541 - 3,100,174 (+)NCBIGRCr8
mRatBN7.2193,093,174 - 3,093,807 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,093,182 - 3,093,807 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl4100,487,842 - 100,488,541 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0193,325,794 - 3,326,519 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0193,309,608 - 3,310,232 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera193,070,157 - 3,070,795 (+)NCBICelera
Cytogenetic Map19p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
Additional References at PubMed
PMID:15057822  


Genomics

Variants

.
Variants in Igkvl15
52 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:212
Count of miRNA genes:122
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000043673, ENSRNOT00000048879
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
16 5 7 39 62 20 39 20 92 47 5 9 35 42

Sequence


Ensembl Acc Id: ENSRNOT00000043673   ⟹   ENSRNOP00000040170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl319,320,304 - 19,320,915 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000048879   ⟹   ENSRNOP00000049080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl193,093,182 - 3,093,807 (+)Ensembl
Rnor_6.0 Ensembl193,325,893 - 3,326,489 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110054   ⟹   ENSRNOP00000094190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4100,487,842 - 100,488,541 (+)Ensembl
RefSeq Acc Id: XM_002729450   ⟹   XP_002729496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,099,541 - 3,100,174 (+)NCBI
mRatBN7.2193,093,174 - 3,093,807 (+)NCBI
Rnor_6.0193,325,794 - 3,326,519 (+)NCBI
Rnor_5.0193,309,608 - 3,310,232 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_002729496 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049080.6
  ENSRNOP00000094190.1
RefSeq Acc Id: XP_002729496   ⟸   XM_002729450
- UniProtKB: A0A8I6AKA7 (UniProtKB/TrEMBL),   D3ZYE2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040170   ⟸   ENSRNOT00000043673
Ensembl Acc Id: ENSRNOP00000049080   ⟸   ENSRNOT00000048879
Ensembl Acc Id: ENSRNOP00000094190   ⟸   ENSRNOT00000110054
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7I8-F1-model_v2 AlphaFold F1M7I8 1-124 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565617 AgrOrtholog
BioCyc Gene G2FUF-6612 BioCyc
Ensembl Genes ENSRNOG00000038254 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000047836 Ensembl
  ENSRNOG00000069376 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048879.6 UniProtKB/TrEMBL
  ENSRNOT00000110054.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  IgV_Light_Chain UniProtKB/TrEMBL
NCBI Gene Igkvl15 ENTREZGENE
PANTHER IMMUNOGLOBULIN LAMBDA VARIABLE 2-18-RELATED UniProtKB/TrEMBL
  IMMUNOGLOBULIN LIGHT CHAIN UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Igkvl15 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038254 RatGTEx
  ENSRNOG00000047836 RatGTEx
  ENSRNOG00000069376 RatGTEx
SMART IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A8I6AKA7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYE2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Igkvl15  immunoglobulin kappa variable like 15  RGD1565617  similar to Ig variable region, light chain  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1565617  similar to Ig variable region, light chain   RGD1565617_predicted  similar to Ig variable region, light chain (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565617_predicted  similar to Ig variable region, light chain (predicted)  LOC502807  similar to Ig variable region, light chain  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502807  similar to Ig variable region, light chain      Symbol and Name status set to provisional 70820 PROVISIONAL