Cd160 (CD160 molecule) - Rat Genome Database

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Gene: Cd160 (CD160 molecule) Rattus norvegicus
Analyze
Symbol: Cd160
Name: CD160 molecule
RGD ID: 1563598
Description: Predicted to enable several functions, including MHC class I protein complex binding activity; immune receptor activity; and kinase binding activity. Predicted to be involved in several processes, including negative regulation of adaptive immune memory response; positive regulation of natural killer cell mediated immunity; and regulation of T cell activation. Predicted to act upstream of or within defense response to Gram-negative bacterium. Predicted to be active in plasma membrane. Orthologous to human CD160 (CD160 molecule); INTERACTS WITH bisphenol A; formaldehyde; Monobutylphthalate.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CD160 antigen; LOC502585; RGD1563598; similar to CD160 antigen
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,029,654 - 187,042,447 (-)NCBIGRCr8
mRatBN7.22184,340,820 - 184,383,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,340,599 - 184,375,834 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02198,933,681 - 198,965,380 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,935,133 - 198,942,732 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,417,674 - 218,452,179 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,611,172 - 191,619,320 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2176,868,030 - 176,900,337 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cd160Ratcataract 46 juvenile-onset  ISOCD160 (Homo sapiens)8554872ClinVar Annotator: match by term: Cataract 46 juvenile-onsetClinVarPMID:29464339 and PMID:31690835
Cd160Ratgastrointestinal stromal tumor  ISOCD160 (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
Cd160Ratparathyroid carcinoma  ISOCD160 (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
Cd160Ratschizophrenia  ISOCD160 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
Cd160Ratthrombocytopenia-absent radius syndrome  ISOCD160 (Homo sapiens)8554872ClinVar Annotator: match by term: Radial aplasia-thrombocytopenia syndromeClinVar 

1 to 20 of 31 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cd160Rat1-chloro-2,4-dinitrobenzene affects expressionISOCd160 (Mus musculus)6480464Dinitrochlorobenzene affects the expression of CD160 mRNACTDPMID:22302311
Cd160Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCd160 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of CD160 mRNACTDPMID:16102516
Cd160Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCd160 (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CD160 promoter]CTDPMID:19654925
Cd160Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOCd160 (Mus musculus)64804642 more ...CTDPMID:38648751
Cd160Ratacrylamide increases expressionISOCD160 (Homo sapiens)6480464Acrylamide results in increased expression of CD160 mRNACTDPMID:32763439
Cd160Rataflatoxin B1 increases methylationISOCD160 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of CD160 geneCTDPMID:27153756
Cd160Rataldehydo-D-glucose decreases expressionISOCd160 (Mus musculus)6480464Glucose results in decreased expression of CD160 mRNACTDPMID:31525975
Cd160Ratalpha-hexylcinnamaldehyde affects expressionISOCd160 (Mus musculus)6480464hexyl cinnamic aldehyde affects the expression of CD160 mRNACTDPMID:22302311
Cd160Rataristolochic acid A increases expressionISOCD160 (Homo sapiens)6480464aristolochic acid I results in increased expression of CD160 mRNACTDPMID:33212167
Cd160Ratbenzo[a]pyrene multiple interactionsISOCd160 (Mus musculus)6480464Benzo(a)pyrene promotes the reaction [AHR protein binds to CD160 promoter]CTDPMID:19654925
Cd160Ratbenzo[a]pyrene decreases methylationISOCD160 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of CD160 5' UTRCTDPMID:27901495
Cd160Ratbenzo[a]pyrene increases expressionISOCD160 (Homo sapiens)6480464Benzo(a)pyrene results in increased expression of CD160 mRNACTDPMID:22316170
Cd160Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of CD160 mRNACTDPMID:25181051
Cd160RatCGP 52608 multiple interactionsISOCD160 (Homo sapiens)6480464CGP 52608 promotes the reaction [RORA protein binds to CD160 gene]CTDPMID:28238834
Cd160RatD-glucose decreases expressionISOCd160 (Mus musculus)6480464Glucose results in decreased expression of CD160 mRNACTDPMID:31525975
Cd160RatDibutyl phosphate affects expressionISOCD160 (Homo sapiens)6480464di-n-butylphosphoric acid affects the expression of CD160 mRNACTDPMID:37042841
Cd160Ratformaldehyde increases expressionEXP 6480464Formaldehyde results in increased expression of CD160 mRNACTDPMID:24304932
Cd160Ratgenistein decreases expressionISOCd160 (Mus musculus)6480464Genistein results in decreased expression of CD160 mRNACTDPMID:32186404
Cd160Ratglucose decreases expressionISOCd160 (Mus musculus)6480464Glucose results in decreased expression of CD160 mRNACTDPMID:31525975
Cd160Rathydroquinone O-beta-D-glucopyranoside decreases expressionISOCD160 (Homo sapiens)6480464Arbutin results in decreased expression of CD160 mRNACTDPMID:17103032

1 to 20 of 31 rows

Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cd160Ratdefense response to Gram-negative bacterium acts_upstream_of_or_withinISOCd160 (Mus musculus)1624291 PMID:22801499RGDPMID:22801499
Cd160Ratmucosal immune response involved_inISOCd160 (Mus musculus)1624291 PMID:22801499RGDPMID:22801499
Cd160Ratnegative regulation of adaptive immune memory response involved_inISOCD160 (Homo sapiens)1624291 PMID:18193050RGDPMID:18193050
Cd160Ratnegative regulation of angiogenesis involved_inISOCD160 (Homo sapiens)1624291 PMID:16809620RGDPMID:16809620
Cd160Ratnegative regulation of CD4-positive, alpha-beta T cell costimulation involved_inISOCD160 (Homo sapiens)1624291 PMID:18193050RGDPMID:18193050
Cd160Ratnegative regulation of T cell receptor signaling pathway involved_inISOCD160 (Homo sapiens)1624291 PMID:18193050RGDPMID:18193050
Cd160Ratphosphatidylinositol 3-kinase/protein kinase B signal transduction involved_inISOCD160 (Homo sapiens)1624291 PMID:17307798RGDPMID:17307798
Cd160Ratpositive regulation of endothelial cell apoptotic process involved_inISOCD160 (Homo sapiens)1624291 PMID:16809620RGDPMID:16809620
Cd160Ratpositive regulation of natural killer cell cytokine production involved_inISOCD160 (Homo sapiens)1624291 PMID:17307798RGDPMID:17307798
Cd160Ratpositive regulation of natural killer cell degranulation involved_inISOCD160 (Homo sapiens) and UniProtKB:O95971-31624291 PMID:19109136RGDPMID:19109136
Cd160Ratpositive regulation of natural killer cell mediated cytotoxicity involved_inISOCD160 (Homo sapiens)1624291 PMID:12486241 and PMID:17307798RGDPMID:12486241 and PMID:17307798
Cd160Ratpositive regulation of natural killer cell mediated immune response to tumor cell involved_inISOCd160 (Mus musculus)1624291 PMID:25711213RGDPMID:25711213
Cd160Ratpositive regulation of type II interferon production involved_inISOCd160 (Mus musculus)1624291 PMID:25711213RGDPMID:25711213
Cd160RatT cell costimulation involved_inISOCD160 (Homo sapiens)1624291 PMID:11978774 and PMID:9973372RGDPMID:11978774 and PMID:9973372
1 to 14 of 14 rows

Cellular Component

  


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:9973372   PMID:11978774   PMID:12486241   PMID:15494480   PMID:16177084   PMID:16809620   PMID:17307798   PMID:18193050   PMID:19109136   PMID:22801499   PMID:25711213  



Cd160
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,029,654 - 187,042,447 (-)NCBIGRCr8
mRatBN7.22184,340,820 - 184,383,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,340,599 - 184,375,834 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02198,933,681 - 198,965,380 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,935,133 - 198,942,732 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,417,674 - 218,452,179 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,611,172 - 191,619,320 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2176,868,030 - 176,900,337 (-)NCBICelera
Cytogenetic Map2q34NCBI
CD160
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,719,499 - 145,739,288 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1145,719,471 - 145,739,288 (+)EnsemblGRCh38hg38GRCh38
GRCh371145,695,798 - 145,715,586 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361144,407,155 - 144,426,922 (-)NCBINCBI36Build 36hg18NCBI36
Build 341143,184,841 - 143,204,609NCBI
Celera1119,898,820 - 119,918,586 (-)NCBICelera
Cytogenetic Map1q21.1NCBI
HuRef1119,659,599 - 119,679,439 (-)NCBIHuRef
CHM1_11147,087,572 - 147,107,414 (+)NCBICHM1_1
T2T-CHM13v2.01144,836,284 - 144,856,072 (+)NCBIT2T-CHM13v2.0
Cd160
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,706,079 - 96,736,667 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,706,079 - 96,736,667 (-)EnsemblGRCm39 Ensembl
GRCm38396,798,763 - 96,829,351 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,798,763 - 96,829,351 (-)EnsemblGRCm38mm10GRCm38
MGSCv37396,602,686 - 96,633,274 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,885,560 - 96,899,898 (-)NCBIMGSCv36mm8
Celera398,207,829 - 98,238,332 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.99NCBI
Cd160
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955568365,700 - 372,149 (-)NCBIChiLan1.0ChiLan1.0
CD160
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,548,137 - 58,564,077 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,555,851 - 58,563,341 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,016,474 - 58,032,017 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,544,989 - 59,560,532 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,540,328 - 59,560,163 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,417,840 - 58,433,382 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,478,903 - 58,494,452 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,205,233 - 59,220,782 (+)NCBIUU_Cfam_GSD_1.0
Cd160
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,602,449 - 20,609,114 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936867478,625 - 485,905 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD160
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1499,579,891 - 99,585,808 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,357,175 - 109,364,053 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CD160
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12013,009,168 - 13,029,766 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2013,012,460 - 13,020,466 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603815,688,530 - 15,708,959 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Cd160
326 total Variants

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:130
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000000109, ENSRNOT00000073913
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 69 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat

1 to 10 of 69 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 9 21 41 57 56 25 25 25 6 144 66 21 36 42 31



Ensembl Acc Id: ENSRNOT00000000109   ⟹   ENSRNOP00000000109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2184,340,599 - 184,375,834 (-)Ensembl
Rnor_6.0 Ensembl2198,935,133 - 198,942,732 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000073913   ⟹   ENSRNOP00000064477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2198,938,940 - 198,942,732 (-)Ensembl
RefSeq Acc Id: XM_039103937   ⟹   XP_038959865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82187,029,654 - 187,042,447 (-)NCBI
mRatBN7.22184,340,820 - 184,383,421 (-)NCBI
Protein RefSeqs XP_038959865 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85604 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000109.6
Ensembl Acc Id: ENSRNOP00000000109   ⟸   ENSRNOT00000000109
Ensembl Acc Id: ENSRNOP00000064477   ⟸   ENSRNOT00000073913
RefSeq Acc Id: XP_038959865   ⟸   XM_039103937
- UniProtKB: A6K396 (UniProtKB/TrEMBL)
Ig-like

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBA3-F1-model_v2 AlphaFold D3ZBA3 1-184 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 19 of 19 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51958 BioCyc
Ensembl Genes ENSRNOG00000000097 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000109.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro CD160 UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
NCBI Gene 502585 ENTREZGENE
PANTHER CD160 ANTIGEN UniProtKB/TrEMBL
  PTHR15425 UniProtKB/TrEMBL
PhenoGen Cd160 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000097 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A6K396 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBA3_RAT UniProtKB/TrEMBL
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-05 Cd160  CD160 molecule  Cd160  CD160 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Cd160  CD160 antigen  RGD1563598_predicted  similar to CD160 antigen (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563598_predicted  similar to CD160 antigen (predicted)  LOC502585  similar to CD160 antigen  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502585  similar to CD160 antigen      Symbol and Name status set to provisional 70820 PROVISIONAL