Mifl3 (macrophage migration inhibitory factor like 3) - Rat Genome Database

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Gene: Mifl3 (macrophage migration inhibitory factor like 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mifl3
Name: macrophage migration inhibitory factor like 3
RGD ID: 1559921
Description: Predicted to enable cytokine activity and phenylpyruvate tautomerase activity. Predicted to be involved in signal transduction. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor); INTERACTS WITH bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07064983.2; LOC366675; macrophage migration inhibitory factor-like; RGD1559921; similar to Macrophage migration inhibitory factor (MIF) (Delayed early response protein 6); similar to Macrophage migration inhibitory factor (MIF) (Phenylpyruvate tautomerase) (Glycosylation-inhibiting factor) (GIF) (Delayed early response protein 6) (DER6)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86105,002,879 - 105,003,802 (-)NCBIGRCr8
mRatBN7.2699,269,962 - 99,270,606 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl699,270,190 - 99,270,600 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.06103,615,821 - 103,616,771 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,616,004 - 103,616,342 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.06111,791,197 - 111,792,121 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46103,461,926 - 103,462,258 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera697,625,714 - 97,626,664 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mifl3Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of MIFL3 mRNACTDPMID:25181051


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mifl3Ratsignal transduction involved_inIEAGO:00051251600115GO_REF:0000108GOCGO_REF:0000108

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mifl3Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Mifl3Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Mifl3Ratextracellular space is_active_inIBAMGI:1298381 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mifl3Ratextracellular space located_inIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mifl3Ratcytokine activity enablesIBAMGI:96982 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mifl3Ratcytokine activity enablesIEAUniProtKB-KW:KW-02021600115GO_REF:0000043UniProtGO_REF:0000043
Mifl3Ratisomerase activity enablesIEAUniProtKB-KW:KW-04131600115GO_REF:0000043UniProtGO_REF:0000043
Mifl3Ratphenylpyruvate tautomerase activity enablesIBAMGI:96982 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Mifl3
4 total Variants

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:42
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000008621
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 33 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat

1 to 10 of 33 rows






Ensembl Acc Id: ENSRNOT00000008621   ⟹   ENSRNOP00000008621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl699,270,190 - 99,270,600 (-)Ensembl
RefSeq Acc Id: XM_039113032   ⟹   XP_038968960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86105,002,879 - 105,003,802 (-)NCBI
mRatBN7.2699,269,962 - 99,270,606 (-)NCBI
Protein RefSeqs XP_038968960 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008621.4
RefSeq Acc Id: XP_038968960   ⟸   XM_039113032
- UniProtKB: F1LTZ6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000008621   ⟸   ENSRNOT00000008621

Name Modeler Protein Id AA Range Protein Structure
AF-F1LTZ6-F1-model_v2 AlphaFold F1LTZ6 1-112 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 14 of 14 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-36929 BioCyc
Ensembl Genes ENSRNOG00000006599 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008621.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.429.10 UniProtKB/TrEMBL
InterPro Macrophage_inhib_fac UniProtKB/TrEMBL
  Tautomerase/MIF_sf UniProtKB/TrEMBL
NCBI Gene 366675 ENTREZGENE
PANTHER MACROPHAGE MIGRATION INHIBITORY FACTOR UniProtKB/TrEMBL
  PTHR11954 UniProtKB/TrEMBL
Pfam MIF UniProtKB/TrEMBL
PhenoGen Mifl3 PhenoGen
RatGTEx ENSRNOG00000006599 RatGTEx
Superfamily-SCOP SSF55331 UniProtKB/TrEMBL
UniProt F1LTZ6 ENTREZGENE, UniProtKB/TrEMBL
1 to 14 of 14 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Mifl3  macrophage migration inhibitory factor like 3  RGD1559921  similar to Macrophage migration inhibitory factor (MIF) (Delayed early response protein 6)  Symbol and Name Changed 1299863 APPROVED
2022-06-02 RGD1559921  similar to Macrophage migration inhibitory factor (MIF) (Delayed early response protein 6)  AABR07064983.2    Data merged from RGD:15003314 737654 PROVISIONAL
2019-11-08 AABR07064983.2        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 RGD1559921  similar to Macrophage migration inhibitory factor (MIF) (Delayed early response protein 6)   RGD1559921_predicted  similar to Macrophage migration inhibitory factor (MIF) (Delayed early response protein 6) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-10 RGD1559921_predicted  similar to Macrophage migration inhibitory factor (MIF) (Delayed early response protein 6) (predicted)    similar to Macrophage migration inhibitory factor (MIF) (Phenylpyruvate tautomerase) (Glycosylation-inhibiting factor) (GIF) (Delayed early response protein 6) (DER6) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1559921_predicted  similar to Macrophage migration inhibitory factor (MIF) (Phenylpyruvate tautomerase) (Glycosylation-inhibiting factor) (GIF) (Delayed early response protein 6) (DER6) (predicted)  LOC366675  similar to Macrophage migration inhibitory factor (MIF) (Phenylpyruvate tautomerase) (Glycosylation-inhibiting factor) (GIF) (Delayed early response protein 6) (DER6)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC366675  similar to Macrophage migration inhibitory factor (MIF) (Phenylpyruvate tautomerase) (Glycosylation-inhibiting factor) (GIF) (Delayed early response protein 6) (DER6)      Symbol and Name status set to provisional 70820 PROVISIONAL