Tmem63c (transmembrane protein 63c) - Rat Genome Database

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Gene: Tmem63c (transmembrane protein 63c) Rattus norvegicus
Analyze
Symbol: Tmem63c
Name: transmembrane protein 63c
RGD ID: 1310207
Description: Predicted to enable calcium-activated cation channel activity and osmolarity-sensing monoatomic cation channel activity. Involved in glomerular filtration. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 87. Orthologous to human TMEM63C (transmembrane protein 63C); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium permeable stress-gated cation channel 1; LOC314332; RGD1310207; similar to RIKEN cDNA 9330187M14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,398,308 - 112,469,732 (+)NCBIGRCr8
mRatBN7.26106,667,389 - 106,738,778 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,672,934 - 106,736,990 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6106,840,002 - 106,904,597 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06107,138,859 - 107,203,436 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06106,508,502 - 106,573,112 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06111,044,099 - 111,120,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6111,049,559 - 111,120,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06120,334,031 - 120,406,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46111,159,623 - 111,223,801 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16111,189,606 - 111,226,710 (+)NCBI
Celera6104,494,900 - 104,558,453 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage. Schulz A, etal., Elife. 2019 Mar 22;8. pii: 42068. doi: 10.7554/eLife.42068.
Additional References at PubMed
PMID:24503647   PMID:27045885  


Genomics

Comparative Map Data
Tmem63c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86112,398,308 - 112,469,732 (+)NCBIGRCr8
mRatBN7.26106,667,389 - 106,738,778 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6106,672,934 - 106,736,990 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6106,840,002 - 106,904,597 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06107,138,859 - 107,203,436 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06106,508,502 - 106,573,112 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06111,044,099 - 111,120,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6111,049,559 - 111,120,799 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06120,334,031 - 120,406,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46111,159,623 - 111,223,801 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16111,189,606 - 111,226,710 (+)NCBI
Celera6104,494,900 - 104,558,453 (+)NCBICelera
Cytogenetic Map6q31NCBI
TMEM63C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381477,181,798 - 77,259,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1477,116,568 - 77,259,495 (+)EnsemblGRCh38hg38GRCh38
GRCh371477,648,141 - 77,725,838 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361476,717,923 - 76,795,591 (+)NCBINCBI36Build 36hg18NCBI36
Celera1457,686,703 - 57,764,477 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1457,815,884 - 57,892,329 (+)NCBIHuRef
CHM1_11477,587,465 - 77,665,362 (+)NCBICHM1_1
T2T-CHM13v2.01471,391,595 - 71,468,802 (+)NCBIT2T-CHM13v2.0
Tmem63c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391287,068,114 - 87,138,598 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1287,068,114 - 87,136,817 (+)EnsemblGRCm39 Ensembl
GRCm381287,021,340 - 87,091,824 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1287,021,340 - 87,090,043 (+)EnsemblGRCm38mm10GRCm38
MGSCv371288,367,514 - 88,430,991 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361287,915,667 - 87,979,144 (+)NCBIMGSCv36mm8
Celera1288,490,107 - 88,554,534 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1241.21NCBI
Tmem63c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554381,090,847 - 1,156,166 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554381,091,324 - 1,155,878 (+)NCBIChiLan1.0ChiLan1.0
TMEM63C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21578,265,213 - 78,343,158 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11477,481,715 - 77,563,149 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01457,734,857 - 57,812,529 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11476,936,751 - 77,014,318 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1476,974,416 - 77,011,555 (+)Ensemblpanpan1.1panPan2
TMEM63C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1850,000,306 - 50,076,457 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl850,020,823 - 50,074,060 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha849,687,784 - 49,764,299 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0850,233,518 - 50,310,109 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl850,240,047 - 50,310,107 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1849,896,215 - 49,972,789 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0849,919,478 - 49,995,813 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0850,317,684 - 50,394,015 (+)NCBIUU_Cfam_GSD_1.0
Tmem63c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864025,980,157 - 26,051,461 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364886,034,618 - 6,086,207 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364886,050,368 - 6,086,881 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM63C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7100,263,549 - 100,334,292 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17100,262,732 - 100,334,300 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27106,289,466 - 106,341,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM63C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12454,428,903 - 54,504,276 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2454,360,369 - 54,505,179 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605342,630,096 - 42,705,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem63c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473424,648,563 - 24,714,507 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473424,649,895 - 24,745,693 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:209
Count of miRNA genes:144
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000015571
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat

Markers in Region
AW530551  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26106,736,780 - 106,736,962 (+)MAPPERmRatBN7.2
Rnor_6.06111,118,664 - 111,118,845NCBIRnor6.0
Rnor_5.06120,404,646 - 120,404,827UniSTSRnor5.0
RGSC_v3.46111,223,592 - 111,223,773UniSTSRGSC3.4
Celera6104,558,244 - 104,558,425UniSTS
RH 3.4 Map6743.6UniSTS
Cytogenetic Map6q31UniSTS
BE120308  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26106,725,061 - 106,725,219 (+)MAPPERmRatBN7.2
Rnor_6.06111,106,936 - 111,107,093NCBIRnor6.0
Rnor_5.06120,393,580 - 120,393,737UniSTSRnor5.0
RGSC_v3.46111,212,276 - 111,212,433UniSTSRGSC3.4
Celera6104,546,635 - 104,546,792UniSTS
RH 3.4 Map6748.9UniSTS
Cytogenetic Map6q31UniSTS
AU049055  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26105,879,396 - 105,879,588 (+)MAPPERmRatBN7.2
Rnor_6.06111,102,018 - 111,102,207NCBIRnor6.0
Rnor_6.06110,089,758 - 110,089,949NCBIRnor6.0
Rnor_5.06120,391,778 - 120,391,967UniSTSRnor5.0
RGSC_v3.46110,350,272 - 110,350,461UniSTSRGSC3.4
Celera6103,705,742 - 103,705,931UniSTS
Cytogenetic Map6q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 83 82 51 25 51 6 210 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005505527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010052096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000015571   ⟹   ENSRNOP00000015571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6106,672,934 - 106,736,990 (+)Ensembl
Rnor_6.0 Ensembl6111,049,559 - 111,118,873 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089644   ⟹   ENSRNOP00000068547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6106,672,934 - 106,736,368 (+)Ensembl
Rnor_6.0 Ensembl6111,076,351 - 111,120,799 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106610   ⟹   ENSRNOP00000079813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6106,672,934 - 106,734,224 (+)Ensembl
RefSeq Acc Id: NM_001108045   ⟹   NP_001101515
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,403,893 - 112,467,946 (+)NCBI
mRatBN7.26106,672,934 - 106,736,990 (+)NCBI
Rnor_6.06111,049,559 - 111,118,873 (+)NCBI
Rnor_5.06120,334,031 - 120,406,641 (+)NCBI
RGSC_v3.46111,159,623 - 111,223,801 (+)RGD
Celera6104,494,900 - 104,558,453 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240382   ⟹   XP_006240444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,403,884 - 112,469,732 (+)NCBI
mRatBN7.26106,672,920 - 106,738,778 (+)NCBI
Rnor_6.06111,049,517 - 111,120,659 (+)NCBI
Rnor_5.06120,334,031 - 120,406,641 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240383   ⟹   XP_006240445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,403,887 - 112,469,732 (+)NCBI
mRatBN7.26106,672,920 - 106,738,778 (+)NCBI
Rnor_6.06111,049,517 - 111,120,659 (+)NCBI
Rnor_5.06120,334,031 - 120,406,641 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240384   ⟹   XP_006240446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,398,330 - 112,469,732 (+)NCBI
mRatBN7.26106,667,389 - 106,738,778 (+)NCBI
Rnor_6.06111,044,099 - 111,120,659 (+)NCBI
Rnor_5.06120,334,031 - 120,406,641 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240385   ⟹   XP_006240447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,403,884 - 112,469,732 (+)NCBI
mRatBN7.26106,673,237 - 106,738,778 (+)NCBI
Rnor_6.06111,049,846 - 111,120,659 (+)NCBI
Rnor_5.06120,334,031 - 120,406,641 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240386   ⟹   XP_006240448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,399,099 - 112,469,732 (+)NCBI
mRatBN7.26106,668,139 - 106,738,778 (+)NCBI
Rnor_6.06111,044,802 - 111,120,659 (+)NCBI
Rnor_5.06120,334,031 - 120,406,641 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240387   ⟹   XP_006240449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,404,560 - 112,469,732 (+)NCBI
mRatBN7.26106,673,581 - 106,738,778 (+)NCBI
Rnor_6.06111,049,980 - 111,120,659 (+)NCBI
Rnor_5.06120,334,031 - 120,406,641 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240389   ⟹   XP_006240451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,403,884 - 112,469,732 (+)NCBI
mRatBN7.26106,672,920 - 106,738,778 (+)NCBI
Rnor_6.06111,049,517 - 111,120,659 (+)NCBI
Rnor_5.06120,334,031 - 120,406,641 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006240390   ⟹   XP_006240452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,431,247 - 112,469,732 (+)NCBI
mRatBN7.26106,700,296 - 106,738,778 (+)NCBI
Rnor_6.06111,077,722 - 111,120,659 (+)NCBI
Rnor_5.06120,334,031 - 120,406,641 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594158   ⟹   XP_017449647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,403,887 - 112,469,732 (+)NCBI
mRatBN7.26106,672,920 - 106,738,778 (+)NCBI
Rnor_6.06111,049,517 - 111,120,659 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594159   ⟹   XP_017449648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,403,884 - 112,469,732 (+)NCBI
mRatBN7.26106,672,920 - 106,738,778 (+)NCBI
Rnor_6.06111,049,517 - 111,120,659 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594161   ⟹   XP_017449650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,403,884 - 112,469,732 (+)NCBI
mRatBN7.26106,672,920 - 106,738,778 (+)NCBI
Rnor_6.06111,049,517 - 111,120,659 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112326   ⟹   XP_038968254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,399,144 - 112,469,732 (+)NCBI
mRatBN7.26106,668,273 - 106,738,778 (+)NCBI
RefSeq Acc Id: XM_039112327   ⟹   XP_038968255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,399,136 - 112,469,732 (+)NCBI
mRatBN7.26106,668,214 - 106,738,778 (+)NCBI
RefSeq Acc Id: XM_039112328   ⟹   XP_038968256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,446,204 - 112,469,732 (+)NCBI
mRatBN7.26106,715,256 - 106,738,778 (+)NCBI
RefSeq Acc Id: XM_039112330   ⟹   XP_038968258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,403,886 - 112,456,383 (+)NCBI
mRatBN7.26106,672,920 - 106,725,426 (+)NCBI
RefSeq Acc Id: XM_063261948   ⟹   XP_063118018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,399,130 - 112,469,732 (+)NCBI
RefSeq Acc Id: XM_063261950   ⟹   XP_063118020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,399,099 - 112,469,732 (+)NCBI
RefSeq Acc Id: XM_063261951   ⟹   XP_063118021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,398,308 - 112,469,732 (+)NCBI
RefSeq Acc Id: XR_005505527
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,403,886 - 112,467,267 (+)NCBI
mRatBN7.26106,672,919 - 106,736,311 (+)NCBI
RefSeq Acc Id: XR_010052096
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86112,399,123 - 112,467,267 (+)NCBI
RefSeq Acc Id: NP_001101515   ⟸   NM_001108045
- UniProtKB: D3ZNF5 (UniProtKB/TrEMBL),   A0A8L2QZP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240446   ⟸   XM_006240384
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/TrEMBL),   A0A8L2QZP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240448   ⟸   XM_006240386
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/TrEMBL),   A0A8L2QZP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240445   ⟸   XM_006240383
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/TrEMBL),   A0A8L2QZP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240444   ⟸   XM_006240382
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/TrEMBL),   A0A8L2QZP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240451   ⟸   XM_006240389
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/TrEMBL),   A0A8L2QZP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240447   ⟸   XM_006240385
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/TrEMBL),   A0A8L2QZP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240449   ⟸   XM_006240387
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/TrEMBL),   A0A8L2QZP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240452   ⟸   XM_006240390
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017449647   ⟸   XM_017594158
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/TrEMBL),   A0A8L2QZP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449648   ⟸   XM_017594159
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/TrEMBL),   A0A8L2QZP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449650   ⟸   XM_017594161
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/TrEMBL),   A0A8L2QZP2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068547   ⟸   ENSRNOT00000089644
Ensembl Acc Id: ENSRNOP00000015571   ⟸   ENSRNOT00000015571
RefSeq Acc Id: XP_038968255   ⟸   XM_039112327
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/Swiss-Prot),   A0A8L2QZP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968254   ⟸   XM_039112326
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/Swiss-Prot),   A0A8L2QZP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038968258   ⟸   XM_039112330
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038968256   ⟸   XM_039112328
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000079813   ⟸   ENSRNOT00000106610
RefSeq Acc Id: XP_063118021   ⟸   XM_063261951
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/Swiss-Prot),   A0A8L2QZP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118020   ⟸   XM_063261950
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/Swiss-Prot),   A0A8L2QZP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118018   ⟸   XM_063261948
- Peptide Label: isoform X1
- UniProtKB: D3ZNF5 (UniProtKB/Swiss-Prot),   A0A8L2QZP2 (UniProtKB/TrEMBL)
Protein Domains
CSC1/OSCA1-like 7TM region   CSC1/OSCA1-like cytosolic   CSC1/OSCA1-like N-terminal transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZNF5-F1-model_v2 AlphaFold D3ZNF5 1-802 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310207 AgrOrtholog
BioCyc Gene G2FUF-36729 BioCyc
Ensembl Genes ENSRNOG00000011334 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055024523 UniProtKB/Swiss-Prot
  ENSRNOG00060018186 UniProtKB/Swiss-Prot
  ENSRNOG00065026016 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015571.7 UniProtKB/Swiss-Prot
  ENSRNOT00000089644.2 UniProtKB/TrEMBL
  ENSRNOT00000106610.1 UniProtKB/TrEMBL
  ENSRNOT00055042187 UniProtKB/Swiss-Prot
  ENSRNOT00060031253 UniProtKB/Swiss-Prot
  ENSRNOT00065044861 UniProtKB/Swiss-Prot
InterPro Csc1-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Csc1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHM7_cyt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RSN1_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:314332 UniProtKB/Swiss-Prot
NCBI Gene 314332 ENTREZGENE
PANTHER CALCIUM PERMEABLE STRESS-GATED CATION CHANNEL 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13018 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PHM7_cyt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RSN1_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RSN1_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem63c PhenoGen
RatGTEx ENSRNOG00000011334 RatGTEx
  ENSRNOG00055024523 RatGTEx
  ENSRNOG00060018186 RatGTEx
  ENSRNOG00065026016 RatGTEx
UniProt A0A8I5ZNW8_RAT UniProtKB/TrEMBL
  A0A8L2QZP2 ENTREZGENE, UniProtKB/TrEMBL
  CSC1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tmem63c  transmembrane protein 63c   Tmem63c_predicted  transmembrane protein 63c (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Tmem63c_predicted  transmembrane protein 63c (predicted)  RGD1310207_predicted  similar to RIKEN cDNA 9330187M14 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1310207_predicted  similar to RIKEN cDNA 9330187M14 (predicted)  LOC314332_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314332_predicted  similar to RIKEN cDNA 9330187M14 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL