Amn (amnion associated transmembrane protein) - Rat Genome Database

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Gene: Amn (amnion associated transmembrane protein) Rattus norvegicus
Analyze
Symbol: Amn
Name: amnion associated transmembrane protein
RGD ID: 1308634
Description: Predicted to enable cargo receptor activity and signaling receptor binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane protein transport; cobalamin metabolic process; and cobalamin transport. Predicted to act upstream of or within renal protein absorption. Located in brush border membrane and endocytic vesicle. Part of protein-containing complex. Human ortholog(s) of this gene implicated in megaloblastic anemia. Orthologous to human AMN (amnion associated transmembrane protein); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amnionless; amnionless homolog; amnionless homolog (mouse); LOC314459; protein amnionless
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,132,567 - 136,140,008 (+)NCBIGRCr8
mRatBN7.26130,311,372 - 130,318,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,311,372 - 130,318,815 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6130,482,175 - 130,489,610 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06130,778,168 - 130,785,603 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,141,430 - 130,148,872 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06135,724,455 - 135,731,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6135,724,455 - 135,731,896 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,682,579 - 144,690,020 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,031,478 - 136,038,919 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16136,035,629 - 136,044,796 (+)NCBI
Celera6127,868,669 - 127,876,110 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
AmnRatImerslund-Grasbeck Syndrome 2  ISORGD:131852211071839DNA:mutation:splice site:RGD 
AmnRatmegaloblastic anemia susceptibilityISORGD:13185221599101 RGD 
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Original Reference(s)
AmnRatCharcot-Marie-Tooth disease axonal type 2O  ISORGD:13185228554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease axonal type 2OClinVarPMID:28492532|PMID:30510536
AmnRatgenetic disease  ISORGD:13185228554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868|PMID:28492532
AmnRatImerslund-Grasbeck Syndrome  ISORGD:13185228554872ClinVar Annotator: match by term: Imerslund-Grasbeck syndromeClinVarPMID:12590260|PMID:13852753|PMID:15024727|PMID:16199547|PMID:17114957|PMID:17285242|PMID:17576681|PMID:18181028|PMID:21750092|PMID:22078000|PMID:22631584|PMID:22929189|PMID:24044590|PMID:24156255|PMID:25741868|PMID:26040326|PMID:28492532|PMID:30523278|PMID:30691194|PMID:32045704|PMID:33491342|PMID:6741523|PMID:9536098
AmnRatImerslund-Grasbeck Syndrome 1  ISORGD:13185228554872ClinVar Annotator: match by term: Enterocyte cobalamin malabsorption | ClinVar Annotator: match by term: Enterocyte more ...ClinVarPMID:12590260|PMID:13852753|PMID:15024727|PMID:16199547|PMID:17114957|PMID:17285242|PMID:17576681|PMID:21750092|PMID:22078000|PMID:22929189|PMID:24044590|PMID:24156255|PMID:25741868|PMID:26040326|PMID:28492532|PMID:30523278|PMID:32045704|PMID:6741523|PMID:9536098
AmnRatImerslund-Grasbeck Syndrome 2  ISORGD:13185228554872ClinVar Annotator: match by term: MEGALOBLASTIC ANEMIA, NORWEGIAN TYPE | ClinVar Annotator: match by term: more ...ClinVarPMID:12590260|PMID:13852753|PMID:15024727|PMID:16199547|PMID:17114957|PMID:17285242|PMID:17576681|PMID:22078000|PMID:22929189|PMID:24044590|PMID:24156255|PMID:25741868|PMID:26040326|PMID:28492532|PMID:30523278|PMID:32045704|PMID:6741523|PMID:9536098
AmnRatimmunodeficiency 132A  ISORGD:13185228554872ClinVar Annotator: match by term: Herpes simplex encephalitis, susceptibility to, 3ClinVarPMID:28492532
AmnRatmegaloblastic anemia  ISORGD:13185228554872ClinVar Annotator: match by term: Megaloblastic anemia | ClinVar Annotator: match by term: Megaloblastic anemia more ...ClinVarPMID:12590260|PMID:13852753|PMID:15024727|PMID:16199547|PMID:17114957|PMID:17285242|PMID:17576681|PMID:21750092|PMID:22078000|PMID:22929189|PMID:24044590|PMID:24156255|PMID:25741868|PMID:26040326|PMID:28492532|PMID:30523278|PMID:32045704|PMID:6741523|PMID:9536098
AmnRatmitochondrial complex IV deficiency nuclear type 17  ISORGD:13185228554872ClinVar Annotator: match by term: MITOCHONDRIAL COMPLEX IV DEFICIENCY, NUCLEAR TYPE 17ClinVarPMID:25175347|PMID:25741868|PMID:29577824
AmnRatvitamin B12 deficiency  ISORGD:13185228554872ClinVar Annotator: match by term: Vitamin B12 deficiencyClinVarPMID:25741868
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Original Reference(s)
AmnRatacute kidney failure  ISORGD:131852211554173CTD Direct Evidence: therapeuticCTDPMID:20514524
AmnRatEdema  ISORGD:131852211554173CTD Direct Evidence: therapeuticCTDPMID:17698245
AmnRatExtravasation of Diagnostic and Therapeutic Materials  ISORGD:131852211554173CTD Direct Evidence: therapeuticCTDPMID:17698245
AmnRatNeurogenic Inflammation  ISORGD:131852211554173CTD Direct Evidence: therapeuticCTDPMID:16938409|PMID:17698245
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Original Reference(s)
AmnRatImerslund-Grasbeck Syndrome 2  ISORGD:13185227240710 OMIM 

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Original Reference(s)
AmnRat(1->4)-beta-D-glucan multiple interactionsISORGD:13185236480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of AMN mRNACTDPMID:36331819
AmnRat1,2-dichloroethane increases expressionISORGD:13185236480464ethylene dichloride results in increased expression of AMN mRNACTDPMID:28960355
AmnRat1,2-dimethylhydrazine decreases expressionISORGD:131852364804641,2-Dimethylhydrazine results in decreased expression of AMN mRNACTDPMID:22206623
AmnRat17beta-estradiol multiple interactionsISORGD:13185226480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of AMN mRNACTDPMID:30165855
AmnRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13185236480464Tetrachlorodibenzodioxin affects the expression of AMN mRNACTDPMID:18343893|PMID:21570461|PMID:26377647
AmnRat2,3,7,8-Tetrachlorodibenzofuran affects expressionISORGD:131852364804642,3,7,8-tetrachlorodibenzofuran affects the expression of AMN mRNACTDPMID:18343893
AmnRat4,4'-sulfonyldiphenol affects expressionISORGD:13185236480464bisphenol S affects the expression of AMN mRNACTDPMID:30951980
AmnRat4-hydroxyphenyl retinamide increases expressionISORGD:13185236480464Fenretinide results in increased expression of AMN mRNACTDPMID:28973697
AmnRat6-propyl-2-thiouracil affects expressionEXP 6480464Propylthiouracil affects the expression of AMN mRNACTDPMID:24780913
AmnRataflatoxin B1 increases expressionISORGD:13185236480464Aflatoxin B1 results in increased expression of AMN mRNACTDPMID:19770486
AmnRatall-trans-retinoic acid affects expressionISORGD:13185226480464Tretinoin affects the expression of AMN mRNACTDPMID:31600526
AmnRataristolochic acid A increases expressionISORGD:13185226480464aristolochic acid I results in increased expression of AMN mRNACTDPMID:33212167
AmnRatbenzo[a]pyrene increases expressionISORGD:13185236480464Benzo(a)pyrene results in increased expression of AMN mRNACTDPMID:19770486
AmnRatbenzo[a]pyrene decreases expressionISORGD:13185226480464Benzo(a)pyrene results in decreased expression of AMN mRNACTDPMID:32234424
AmnRatbenzo[a]pyrene increases methylationISORGD:13185226480464Benzo(a)pyrene results in increased methylation of AMN exon; Benzo(a)pyrene results in increased methylation of AMN more ...CTDPMID:27901495
AmnRatbenzo[a]pyrene decreases expressionISORGD:13185236480464Benzo(a)pyrene results in decreased expression of AMN mRNACTDPMID:27195522
AmnRatbenzo[a]pyrene multiple interactionsISORGD:13185236480464Benzo(a)pyrene promotes the reaction [AHR protein binds to AMN promoter]CTDPMID:19654925
AmnRatbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of AMN mRNACTDPMID:25181051
AmnRatbisphenol A increases expressionISORGD:13185236480464bisphenol A results in increased expression of AMN mRNACTDPMID:34585602
AmnRatbisphenol A decreases methylationISORGD:13185236480464bisphenol A results in decreased methylation of AMN promoterCTDPMID:27312807

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Biological Process
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Original Reference(s)
AmnRatbiological_process  ND 159840701/2007: no relevant rat dataRGD 
AmnRatcobalamin metabolic process involved_inISORGD:13185221624291 PMID:14576052RGDPMID:14576052
AmnRatcobalamin metabolic process involved_inIEAUniProtKB:Q9BXJ7|ensembl:ENSP000002991551600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatcobalamin transport involved_inISORGD:13185221624291 PMID:14576052RGDPMID:14576052
AmnRatcobalamin transport involved_inIEAUniProtKB:Q9BXJ7|ensembl:ENSP000002991551600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatGolgi to plasma membrane protein transport involved_inISORGD:13185221624291 PMID:14576052RGDPMID:14576052
AmnRatGolgi to plasma membrane protein transport involved_inIEAUniProtKB:Q9BXJ7|ensembl:ENSP000002991551600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatprotein localization acts_upstream_of_or_withinIEAUniProtKB:Q99JB7|ensembl:ENSMUSP000000217071600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatprotein localization acts_upstream_of_or_withinISORGD:13185231624291MGI:2135304|MGI:2135454 PMID:15342463RGDPMID:15342463
AmnRatprotein localization involved_inIBAMGI:1934943|PANTHER:PTN001029969|UniProtKB:Q9BXJ71600115GO_REF:0000033GO_CentralGO_REF:0000033
AmnRatprotein transport involved_inIEAUniProtKB-KW:KW-06531600115GO_REF:0000043UniProtGO_REF:0000043
AmnRatreceptor-mediated endocytosis involved_inISORGD:13185221624291 PMID:14576052, PMID:20088845RGDPMID:14576052|PMID:20088845
AmnRatreceptor-mediated endocytosis involved_inIEAUniProtKB:Q9BXJ7|ensembl:ENSP000002991551600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatreceptor-mediated endocytosis involved_inIBAFB:FBgn0025686|PANTHER:PTN001029969|UniProtKB:Q9BXJ71600115GO_REF:0000033GO_CentralGO_REF:0000033
AmnRatrenal protein absorption acts_upstream_of_or_withinIEAUniProtKB:Q99JB7|ensembl:ENSMUSP000000217071600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatrenal protein absorption acts_upstream_of_or_withinISORGD:13185231624291MGI:2135304|MGI:2135454 PMID:15342463RGDPMID:15342463
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Cellular Component
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Original Reference(s)
AmnRatapical part of cell located_inISORGD:13185231624291 PMID:15342463RGDPMID:15342463
AmnRatapical part of cell located_inIEAUniProtKB:Q99JB7|ensembl:ENSMUSP000000217071600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatapical plasma membrane located_inISORGD:13185221624291 PMID:14576052RGDPMID:14576052
AmnRatapical plasma membrane is_active_inIBAPANTHER:PTN001029969|UniProtKB:Q6UKI2|UniProtKB:Q9BXJ71600115GO_REF:0000033GO_CentralGO_REF:0000033
AmnRatapical plasma membrane located_inIEAUniProtKB:Q9BXJ7|ensembl:ENSP000002991551600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatapical plasma membrane part_ofISORGD:121194031624291 PMID:15845892RGDPMID:15845892
AmnRatbrush border membrane  IDA 2317831 RGD 
AmnRatendocytic vesicle  IDA 11250404 RGD 
AmnRatendocytic vesicle located_inIEAUniProtKB:Q9BXJ7|ensembl:ENSP000002991551600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatendocytic vesicle is_active_inIBAPANTHER:PTN001029969|RGD:1308634|UniProtKB:Q9BXJ71600115GO_REF:0000033GO_CentralGO_REF:0000033
AmnRatendocytic vesicle located_inISORGD:13185221624291 PMID:14576052RGDPMID:14576052
AmnRatextracellular space located_inISORGD:13185221624291 PMID:14576052RGDPMID:14576052
AmnRatextracellular space located_inIEAUniProtKB:Q9BXJ7|ensembl:ENSP000002991551600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatmembrane located_inIEAUniProtKB:Q9BXJ7|ensembl:ENSP000002991551600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
AmnRatmembrane located_inISORGD:13185221624291 PMID:14576052RGDPMID:14576052
AmnRatmicrovillus membrane is_active_inISORGD:13185221624291 PMID:14576052RGDPMID:14576052
AmnRatmicrovillus membrane is_active_inIEAUniProtKB:Q9BXJ7|ensembl:ENSP000002991551600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
AmnRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function

  
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Original Reference(s)
AmnRatcargo receptor activity enablesISORGD:13185221624291 PMID:14576052RGDPMID:14576052
AmnRatcargo receptor activity enablesIEAUniProtKB:Q9BXJ7|ensembl:ENSP000002991551600115GO_REF:0000107EnsemblGO_REF:0000107
AmnRatprotein binding enablesISORGD:13185221624291UniProtKB:O60494 PMID:30523278RGDPMID:30523278
AmnRatsignaling receptor binding enablesISORGD:13185221624291UniProtKB:O60494 PMID:14576052RGDPMID:14576052
AmnRatsignaling receptor binding enablesIEAUniProtKB:Q9BXJ7|ensembl:ENSP000002991551600115GO_REF:0000107EnsemblGO_REF:0000107


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Reference Title
Reference Citation
1. Interactions of cubilin with megalin and the product of the amnionless gene (AMN): effect on its stability. Ahuja R, etal., Biochem J. 2008 Mar 1;410(2):301-8.
2. Imerslund-Grasbeck syndrome associated with recurrent aphthous stomatitis and defective neutrophil function. Broides A, etal., J Pediatr Hematol Oncol. 2006 Nov;28(11):715-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia. Tanner SM, etal., Nat Genet. 2003 Mar;33(3):426-9. Epub 2003 Feb 18.
10. Dab2, megalin, cubilin and amnionless receptor complex might mediate intestinal endocytosis in the suckling rat. Vazquez-Carretero MD, etal., J Cell Biochem. 2014 Mar;115(3):510-22. doi: 10.1002/jcb.24685.
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PMID:14576052   PMID:15342463   PMID:15845892   PMID:15976000   PMID:19056867   PMID:20088845   PMID:23376485  



Amn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,132,567 - 136,140,008 (+)NCBIGRCr8
mRatBN7.26130,311,372 - 130,318,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,311,372 - 130,318,815 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6130,482,175 - 130,489,610 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06130,778,168 - 130,785,603 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,141,430 - 130,148,872 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06135,724,455 - 135,731,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6135,724,455 - 135,731,896 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,682,579 - 144,690,020 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,031,478 - 136,038,919 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16136,035,629 - 136,044,796 (+)NCBI
Celera6127,868,669 - 127,876,110 (+)NCBICelera
Cytogenetic Map6q32NCBI
AMN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814102,922,663 - 102,930,842 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14102,922,663 - 102,933,596 (+)EnsemblGRCh38hg38GRCh38
GRCh3714103,389,000 - 103,397,179 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614102,458,747 - 102,467,282 (+)NCBINCBI36Build 36hg18NCBI36
Build 3414102,458,756 - 102,467,282NCBI
Celera1483,443,115 - 83,451,301 (+)NCBICelera
Cytogenetic Map14q32.32NCBI
HuRef1483,564,008 - 83,572,214 (+)NCBIHuRef
CHM1_114103,326,435 - 103,334,619 (+)NCBICHM1_1
T2T-CHM13v2.01497,158,908 - 97,167,087 (+)NCBIT2T-CHM13v2.0
Amn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,237,530 - 111,242,860 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12111,237,529 - 111,242,860 (+)EnsemblGRCm39 Ensembl
GRCm3812111,271,096 - 111,276,426 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,271,095 - 111,276,426 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712112,509,322 - 112,514,637 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612111,718,919 - 111,724,234 (+)NCBIMGSCv36mm8
Celera12112,465,414 - 112,470,727 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.94NCBI
Amn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555382,017,476 - 2,021,890 (+)NCBIChiLan1.0ChiLan1.0
AMN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215104,076,211 - 104,083,152 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114103,292,709 - 103,299,650 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01483,541,891 - 83,550,346 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114103,356,523 - 103,364,163 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14103,356,773 - 103,365,352 (+)Ensemblpanpan1.1panPan2
AMN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1870,800,435 - 70,807,835 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha870,312,298 - 70,320,278 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0871,077,067 - 71,085,111 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl871,077,060 - 71,088,041 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1870,740,802 - 70,748,789 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0870,805,229 - 70,813,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0871,205,503 - 71,213,499 (+)NCBIUU_Cfam_GSD_1.0
Amn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086403,225,612 - 3,234,832 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936835961,826 - 970,234 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936835961,840 - 970,287 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.27128,896,585 - 128,904,655 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12480,884,149 - 80,895,977 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2480,883,911 - 80,893,066 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605368,081,278 - 68,085,885 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247341,720,216 - 1,725,045 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247341,720,119 - 1,725,042 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Amn
52 total Variants

Predicted Target Of
Summary Value
Count of predictions:263
Count of miRNA genes:184
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000012469
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat

1 to 10 of 21 rows
RH140666  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86136,138,599 - 136,138,982 (+)Marker Load Pipeline
mRatBN7.26130,317,406 - 130,317,789 (+)MAPPERmRatBN7.2
Rnor_6.06135,730,488 - 135,730,870NCBIRnor6.0
Rnor_5.06144,683,605 - 144,683,987UniSTSRnor5.0
RGSC_v3.46136,037,511 - 136,037,893UniSTSRGSC3.4
Celera6127,874,702 - 127,875,084UniSTS
RH 3.4 Map6781.8UniSTS
Cytogenetic Map6q32UniSTS
BI276097  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,318,434 - 130,318,570 (+)MAPPERmRatBN7.2
Rnor_6.06135,731,516 - 135,731,651NCBIRnor6.0
Rnor_5.06144,682,824 - 144,682,959UniSTSRnor5.0
RGSC_v3.46136,038,539 - 136,038,674UniSTSRGSC3.4
Celera6127,875,730 - 127,875,865UniSTS
RH 3.4 Map6782.2UniSTS
Cytogenetic Map6q32UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 3 21 96 66 65 42 22 42 6 153 58 81 41 53 23



Ensembl Acc Id: ENSRNOT00000012469   ⟹   ENSRNOP00000012469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6130,311,372 - 130,318,815 (+)Ensembl
Rnor_6.0 Ensembl6135,724,455 - 135,731,896 (+)Ensembl
RefSeq Acc Id: NM_001108061   ⟹   NP_001101531
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,132,567 - 136,140,008 (+)NCBI
mRatBN7.26130,311,372 - 130,318,815 (+)NCBI
Rnor_6.06135,724,455 - 135,731,896 (+)NCBI
Rnor_5.06144,682,579 - 144,690,020 (-)NCBI
RGSC_v3.46136,031,478 - 136,038,919 (+)RGD
Celera6127,868,669 - 127,876,110 (+)RGD
Sequence:
RefSeq Acc Id: XM_006240588   ⟹   XP_006240650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,132,622 - 136,139,826 (+)NCBI
mRatBN7.26130,311,427 - 130,318,633 (+)NCBI
Rnor_6.06135,724,472 - 135,731,714 (+)NCBI
Rnor_5.06144,682,579 - 144,690,020 (-)NCBI
Sequence:
Protein RefSeqs NP_001101531 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240650 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97480 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012469
  ENSRNOP00000012469.4
RefSeq Acc Id: NP_001101531   ⟸   NM_001108061
- Peptide Label: precursor
- UniProtKB: D3ZFK9 (UniProtKB/TrEMBL),   A6KBQ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240650   ⟸   XM_006240588
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000012469   ⟸   ENSRNOT00000012469

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZFK9-F1-model_v2 AlphaFold D3ZFK9 1-459 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694835
Promoter ID:EPDNEW_R5360
Type:multiple initiation site
Name:Amn_1
Description:amnion associated transmembrane protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06135,724,501 - 135,724,561EPDNEW


1 to 14 of 14 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-35854 BioCyc
Ensembl Genes ENSRNOG00000009050 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012469 ENTREZGENE
  ENSRNOT00000012469.6 UniProtKB/TrEMBL
InterPro AMN UniProtKB/TrEMBL
KEGG Report rno:314459 UniProtKB/TrEMBL
NCBI Gene 314459 ENTREZGENE
PANTHER PROTEIN AMNIONLESS UniProtKB/TrEMBL
  PTHR14995 UniProtKB/TrEMBL
Pfam Amnionless UniProtKB/TrEMBL
PhenoGen Amn PhenoGen
RatGTEx ENSRNOG00000009050 RatGTEx
UniProt A6KBQ1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZFK9 ENTREZGENE, UniProtKB/TrEMBL
1 to 14 of 14 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Amn  amnion associated transmembrane protein  Amn  amnionless homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Amn  amnionless homolog (mouse)  Amn  amnionless   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Amn  amnionless   Amn_predicted  amnionless (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Amn_predicted  amnionless (predicted)      Symbol and Name status set to approved 70820 APPROVED