Dcun1d5 (defective in cullin neddylation 1 domain containing 5) - Rat Genome Database

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Gene: Dcun1d5 (defective in cullin neddylation 1 domain containing 5) Rattus norvegicus
Analyze
Symbol: Dcun1d5
Name: defective in cullin neddylation 1 domain containing 5
RGD ID: 1307008
Description: Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in several processes, including positive regulation of protein neddylation; protein neddylation; and regulation of cell growth. Located in nucleus. Orthologous to human DCUN1D5 (defective in cullin neddylation 1 domain containing 5); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DCN1, defective in cullin neddylation 1, domain containing 5; DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae); DCN1-like protein 5; DCUN1 domain-containing protein 5; defective in cullin neddylation protein 1-like protein 5; LOC315405; MGC105763; RGD1307008; similar to RIKEN cDNA 4833420K19; squamous cell carcinoma-related oncogene 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8812,697,160 - 12,718,242 (+)NCBIGRCr8
mRatBN7.284,412,266 - 4,433,380 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,412,221 - 4,433,367 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,371,760 - 8,392,848 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,669,543 - 6,690,631 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,671,942 - 4,693,024 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,437,071 - 5,458,152 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,437,071 - 5,458,152 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,444,112 - 5,465,193 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,072,746 - 4,094,149 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,072,745 - 4,094,149 (+)NCBI
Celera85,976,086 - 5,997,168 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleus  (IDA,IEA,ISO,ISS)
spindle  (IEA,ISO,ISS)
ubiquitin ligase complex  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation. Thomas Y, etal., PLoS One. 2018 Jun 29;13(6):e0199197. doi: 10.1371/journal.pone.0199197. eCollection 2018.
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
Dcun1d5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8812,697,160 - 12,718,242 (+)NCBIGRCr8
mRatBN7.284,412,266 - 4,433,380 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,412,221 - 4,433,367 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,371,760 - 8,392,848 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,669,543 - 6,690,631 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,671,942 - 4,693,024 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,437,071 - 5,458,152 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,437,071 - 5,458,152 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,444,112 - 5,465,193 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,072,746 - 4,094,149 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,072,745 - 4,094,149 (+)NCBI
Celera85,976,086 - 5,997,168 (+)NCBICelera
Cytogenetic Map8q11NCBI
DCUN1D5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811103,050,686 - 103,092,160 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11103,050,686 - 103,092,194 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,921,415 - 102,962,889 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,438,031 - 102,468,079 (-)NCBINCBI36Build 36hg18NCBI36
Celera11100,082,951 - 100,124,478 (-)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef1198,850,127 - 98,891,660 (-)NCBIHuRef
CHM1_111102,804,380 - 102,845,910 (-)NCBICHM1_1
T2T-CHM13v2.011103,054,420 - 103,095,887 (-)NCBIT2T-CHM13v2.0
Dcun1d5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,176,590 - 7,220,880 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,184,520 - 7,208,205 (+)EnsemblGRCm39 Ensembl
GRCm3897,176,590 - 7,220,880 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,184,520 - 7,208,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,184,566 - 7,207,031 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,184,566 - 7,207,031 (+)NCBIMGSCv36mm8
Celera94,587,683 - 4,610,118 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Dcun1d5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554126,185,858 - 6,217,935 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554126,185,858 - 6,217,935 (-)NCBIChiLan1.0ChiLan1.0
DCUN1D5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,860,929 - 103,891,065 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,949,280 - 104,979,376 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,996,643 - 98,038,108 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,481,472 - 101,522,920 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,493,113 - 101,522,920 (-)Ensemblpanpan1.1panPan2
DCUN1D5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1528,740,154 - 28,767,526 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl528,740,087 - 28,766,858 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,686,248 - 28,713,846 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0528,791,096 - 28,818,703 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl528,791,138 - 28,819,007 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1528,826,023 - 28,853,622 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0528,705,876 - 28,733,470 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0528,880,323 - 28,907,920 (+)NCBIUU_Cfam_GSD_1.0
Dcun1d5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,561,146 - 86,600,179 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365514,936,293 - 4,966,088 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365514,936,337 - 4,966,053 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCUN1D5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,674,268 - 33,707,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,674,524 - 33,707,648 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,621,897 - 37,651,183 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCUN1D5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,436,498 - 94,467,003 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,436,784 - 94,466,989 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,402,889 - 31,443,401 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dcun1d5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249182,090,733 - 2,123,926 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249182,090,727 - 2,123,926 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dcun1d5
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:14
Interacting mature miRNAs:14
Transcripts:ENSRNOT00000061916
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat

Markers in Region
RH138722  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map1477.5UniSTS
Cytogenetic Map8q11UniSTS
BE119287  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.284,427,489 - 4,427,658 (+)MAPPERmRatBN7.2
Rnor_6.085,452,273 - 5,452,441NCBIRnor6.0
Rnor_5.085,459,314 - 5,459,482UniSTSRnor5.0
RGSC_v3.484,087,827 - 4,087,996UniSTSRGSC3.4
Celera85,991,289 - 5,991,457UniSTS
Cytogenetic Map8q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000061916   ⟹   ENSRNOP00000058633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,412,221 - 4,433,364 (+)Ensembl
Rnor_6.0 Ensembl85,437,071 - 5,458,152 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102552   ⟹   ENSRNOP00000080804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,412,268 - 4,433,367 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106587   ⟹   ENSRNOP00000093791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl84,413,510 - 4,431,967 (+)Ensembl
RefSeq Acc Id: NM_001009696   ⟹   NP_001009696
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8812,697,160 - 12,718,242 (+)NCBI
mRatBN7.284,412,285 - 4,433,369 (+)NCBI
Rnor_6.085,437,071 - 5,458,152 (+)NCBI
Rnor_5.085,444,112 - 5,465,193 (+)NCBI
RGSC_v3.484,072,746 - 4,094,149 (+)RGD
Celera85,976,086 - 5,997,168 (+)RGD
Sequence:
RefSeq Acc Id: XM_063265324   ⟹   XP_063121394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8812,699,112 - 12,718,242 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001009696   ⟸   NM_001009696
- UniProtKB: Q5PPL2 (UniProtKB/Swiss-Prot),   A6JN26 (UniProtKB/TrEMBL),   A0A8L2QSK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000058633   ⟸   ENSRNOT00000061916
RefSeq Acc Id: ENSRNOP00000093791   ⟸   ENSRNOT00000106587
RefSeq Acc Id: ENSRNOP00000080804   ⟸   ENSRNOT00000102552
RefSeq Acc Id: XP_063121394   ⟸   XM_063265324
- Peptide Label: isoform X1
Protein Domains
DCUN1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PPL2-F1-model_v2 AlphaFold Q5PPL2 1-237 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695730
Promoter ID:EPDNEW_R6254
Type:initiation region
Name:Dcun1d5_1
Description:defective in cullin neddylation 1 domain containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.085,437,063 - 5,437,123EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307008 AgrOrtholog
BioCyc Gene G2FUF-31794 BioCyc
Ensembl Genes ENSRNOG00000008390 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061916 ENTREZGENE
  ENSRNOT00000061916.4 UniProtKB/TrEMBL
  ENSRNOT00000102552.1 UniProtKB/TrEMBL
  ENSRNOT00000106587.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.238.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7318159 IMAGE-MGC_LOAD
InterPro DCN-prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DCN1-like_PONY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PONY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:315405 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105763 IMAGE-MGC_LOAD
NCBI Gene 315405 ENTREZGENE
PANTHER DCN1-LIKE PROTEIN 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cullin_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dcun1d5 PhenoGen
PROSITE DCUN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008390 RatGTEx
UniProt A0A8I5ZQW1_RAT UniProtKB/TrEMBL
  A0A8I6AJH3_RAT UniProtKB/TrEMBL
  A0A8L2QSK9 ENTREZGENE, UniProtKB/TrEMBL
  A6JN25_RAT UniProtKB/TrEMBL
  A6JN26 ENTREZGENE, UniProtKB/TrEMBL
  A6JN27_RAT UniProtKB/TrEMBL
  DCNL5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 Dcun1d5  defective in cullin neddylation 1 domain containing 5  Dcun1d5  DCN1, defective in cullin neddylation 1, domain containing 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-07-09 Dcun1d5  DCN1, defective in cullin neddylation 1, domain containing 5  Dcun1d5  DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dcun1d5  DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)  RGD1307008  similar to RIKEN cDNA 4833420K19  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1307008  similar to RIKEN cDNA 4833420K19  RGD1307008_predicted  similar to RIKEN cDNA 4833420K19 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307008_predicted  similar to RIKEN cDNA 4833420K19 (predicted)  LOC315405_predicted  similar to RIKEN cDNA 4833420K19 (predicted)  Symbol and Name status set to approved 1331353 APPROVED