Acoxl (acyl-CoA oxidase-like) - Rat Genome Database

Name: Acoxl
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Acoxl (acyl-CoA oxidase-like) Rattus norvegicus

Analyze

Symbol:

Acoxl

Name:

acyl-CoA oxidase-like

RGD ID:

1306814

Description:

Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and lipid homeostasis. Predicted to be active in peroxisome. Orthologous to human ACOXL (acyl-CoA oxidase like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

acyl-Coenzyme A oxidase-like; LOC296138

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ACOXL (acyl-CoA oxidase like)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Acoxl (acyl-Coenzyme A oxidase-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Acoxl (acyl-CoA oxidase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ACOXL (acyl-CoA oxidase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ACOXL (acyl-CoA oxidase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ACOXL (acyl-CoA oxidase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ACOXL (acyl-CoA oxidase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Acoxl (acyl-CoA oxidase like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ACOXL (acyl-CoA oxidase like)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Acoxl (acyl-Coenzyme A oxidase-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	acoxl (acyl-CoA oxidase-like)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	POX1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	acoxl	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

Acoxl^{Tn(sb-T2/Bart3)2.342Mcwi}

Genetic Models:

F344-Acoxl^{Tn(sb-T2/Bart3)2.342Mcwi}

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	135,514,340 - 135,820,291 (+)	NCBI		GRCr8
mRatBN7.2	3	115,061,069 - 115,367,032 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	115,061,060 - 115,364,686 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	118,950,964 - 119,254,148 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	127,546,512 - 127,849,696 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	125,206,847 - 125,510,037 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	120,414,311 - 120,724,809 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	120,414,291 - 120,726,336 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	126,606,586 - 126,919,666 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	115,365,279 - 115,687,566 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	115,270,851 - 115,592,468 (+)	NCBI
Celera	3	113,895,591 - 114,198,178 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

B-Cell Chronic Lymphocytic Leukemia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

chrysene (ISO)

cyclosporin A (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP)

dioxygen (ISO)

dorsomorphin (ISO)

entinostat (ISO)

gentamycin (EXP)

methimazole (EXP)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

pentachlorophenol (ISO)

SB 431542 (ISO)

tetraphene (ISO)

titanium dioxide (ISO)

triadimefon (EXP)

tributylstannane (EXP)

trichloroethene (EXP)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid beta-oxidation using acyl-CoA oxidase (IBA)

lipid homeostasis (IBA)

Cellular Component

peroxisome (IBA)

Molecular Function

acyl-CoA oxidase activity (IBA)

FAD binding (IEA)

fatty acid binding (IBA)

flavin adenine dinucleotide binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Acoxl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	135,514,340 - 135,820,291 (+)	NCBI		GRCr8
mRatBN7.2	3	115,061,069 - 115,367,032 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	115,061,060 - 115,364,686 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	118,950,964 - 119,254,148 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	127,546,512 - 127,849,696 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	125,206,847 - 125,510,037 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	120,414,311 - 120,724,809 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	120,414,291 - 120,726,336 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	126,606,586 - 126,919,666 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	115,365,279 - 115,687,566 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	115,270,851 - 115,592,468 (+)	NCBI
Celera	3	113,895,591 - 114,198,178 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

ACOXL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	110,732,573 - 111,118,548 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	110,732,539 - 111,118,548 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	111,490,150 - 111,876,125 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	111,206,680 - 111,568,392 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	111,272,844 - 111,568,152	NCBI
Celera	2	105,140,860 - 105,526,394 (+)	NCBI		Celera
Cytogenetic Map	2	q13	NCBI
HuRef	2	104,369,277 - 104,754,954 (+)	NCBI		HuRef
CHM1_1	2	111,494,442 - 111,880,041 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	111,155,418 - 111,543,674 (+)	NCBI		T2T-CHM13v2.0

Acoxl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	127,680,717 - 127,968,172 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	127,680,796 - 127,965,793 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	127,838,797 - 128,126,252 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	127,838,876 - 128,123,873 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	127,680,364 - 127,949,629 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	127,546,069 - 127,815,314 (+)	NCBI		MGSCv36	mm8
Celera	2	129,081,476 - 129,354,207 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	62.1	NCBI

Acoxl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955470	2,788,249 - 3,077,277 (-)	NCBI	ChiLan1.0	ChiLan1.0

ACOXL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	16,964,858 - 17,353,025 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	16,963,917 - 17,355,790 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	90,912,247 - 91,300,770 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	111,947,662 - 112,337,894 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	111,985,358 - 112,335,160 (+)	Ensembl	panpan1.1		panPan2

ACOXL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	35,269,824 - 35,617,068 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	35,269,501 - 35,617,335 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	35,041,171 - 35,388,766 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	36,043,374 - 36,395,139 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	36,043,364 - 36,395,148 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	35,169,680 - 35,512,611 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	35,239,120 - 35,586,585 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	35,449,542 - 35,797,620 (+)	NCBI		UU_Cfam_GSD_1.0

ACOXL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	45,203,195 - 45,538,220 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	45,202,875 - 45,563,062 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	47,107,541 - 47,551,348 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ACOXL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	13,768,917 - 14,176,639 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666080	5,842,499 - 5,886,576 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Acoxl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624749	1,130,192 - 1,487,040 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Acoxl
1990 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	236
Count of miRNA genes:	156
Interacting mature miRNAs:	175
Transcripts:	ENSRNOT00000021740
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	96127817	115665732	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	102200529	115665732	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	112287552	135181505	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat

Markers in Region

D3Got300

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	115,238,195 - 115,238,324 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	120,598,424 - 120,598,552	NCBI	Rnor6.0
Rnor_5.0	3	126,732,904 - 126,733,032	UniSTS	Rnor5.0
RGSC_v3.4	3	115,544,052 - 115,544,180	UniSTS	RGSC3.4
Celera	3	114,072,271 - 114,072,399	UniSTS
Cytogenetic Map	3	q36	UniSTS

AU048179

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	115,123,916 - 115,124,092 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	120,480,625 - 120,480,802	NCBI	Rnor6.0
Rnor_5.0	3	126,852,639 - 126,852,816	UniSTS	Rnor5.0
RGSC_v3.4	3	115,428,985 - 115,429,162	UniSTS	RGSC3.4
Celera	3	113,958,189 - 113,958,364	UniSTS
Cytogenetic Map	3	q36	UniSTS

BE100986

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	115,071,898 - 115,072,046 (+)	MAPPER	mRatBN7.2
mRatBN7.2	6	49,859,431 - 49,859,582 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	52,558,183 - 52,558,333	NCBI	Rnor6.0
Rnor_6.0	3	120,425,154 - 120,425,301	NCBI	Rnor6.0
Rnor_5.0	6	62,181,585 - 62,181,735	UniSTS	Rnor5.0
Rnor_5.0	3	126,908,213 - 126,908,360	UniSTS	Rnor5.0
RGSC_v3.4	3	115,376,557 - 115,376,704	UniSTS	RGSC3.4
RGSC_v3.4	6	51,594,421 - 51,594,571	UniSTS	RGSC3.4
Celera	6	49,049,695 - 49,049,845	UniSTS
Celera	3	113,906,291 - 113,906,438	UniSTS
RH 3.4 Map	3	986.4	UniSTS
Cytogenetic Map	3	q36	UniSTS
Cytogenetic Map	6	q16	UniSTS

OMY6803INRA

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	3	126,784,005 - 126,785,446	UniSTS	Rnor5.0
Cytogenetic Map	3	q36	UniSTS

Genetic Models

This gene Acoxl is modified in the following models/strains:

F344-Acoxl^{Tn(sb-T2/Bart3)2.342Mcwi}

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium												10
Low			8		14		1	1	8		9	1	1
Below cutoff	3	17	25	17	5	17	7	9	11	35	21		7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001415677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111715	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000021740 ⟹ ENSRNOP00000021740

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	115,061,137 - 115,364,686 (+)	Ensembl
Rnor_6.0 Ensembl	3	120,414,395 - 120,724,809 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000083627 ⟹ ENSRNOP00000072762

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	115,061,060 - 115,364,684 (+)	Ensembl
Rnor_6.0 Ensembl	3	120,414,291 - 120,726,336 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108346 ⟹ ENSRNOP00000080838

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	115,061,060 - 115,364,686 (+)	Ensembl

RefSeq Acc Id:

NM_001106508 ⟹ NP_001099978

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	135,514,340 - 135,820,291 (+)	NCBI
mRatBN7.2	3	115,061,069 - 115,367,032 (+)	NCBI
Rnor_6.0	3	120,414,395 - 120,724,809 (+)	NCBI
Rnor_5.0	3	126,606,586 - 126,919,666 (-)	NCBI
RGSC_v3.4	3	115,365,279 - 115,687,566 (+)	RGD
Celera	3	113,895,591 - 114,198,178 (+)	RGD

Sequence:

show sequence

ATGGAGCAGACTCCGGAGGGCCTGGGTCTTGGGGACTCATCGCTGCACCGCTACCTGGACGGGG
AATTCTGGAGCCTCAAGAATGAGCTTCGCAGAGCCCTGGAGAGCTCTCCTCTCTTCCAGCCCAG
GTATGATTTAAGTTTGGATGAAATGAGAGATTTGACAAATCAGCGAGTGAAGTTTGTCTTGAGT
CTCCCTCTGTTAAAGCGTGTACTCCAGGATCAGATCTTTCCTTTTTGGGCTTGGGCCTTCTGGC
TTCTGTTTGTCCTGGAACCTTGGCTTTTCCGAGCAGGCTGTGACAGGCTGCCCTGGATCTTGGT
CTGTGTGCTGCTTTTGGCAGGAGTCTTTGTCCCAGTCTACCCCCATGGACTTGGATGCTGGCCA
CCTGGCCAGTACTCTGGTTAGGCCAGCCCTGGCCCCATGGGATCCTGTGGAAGAGTTGAACAGA
GATGACAGGATGGAGTGGACTGTTTATAGAAGTCCCTCTGTATAGATTGGCATTCGAAGTGTGC
TGTCATCTGCAGGGACCACAGGGATTTCTTCAGAGAGCCTGCCAGGGAGTGAGTTGTCTGCCAA
GGGACTCCAGAGCAGCTGGAATCATGGAAGAAAAAAGGAATAACTTCATCAGCCAAAGCTTTGT
CCTGGGAGAAGTGCTCTGCATGGTAGATGTGTCCATGTCTATAAAGTGTGGAGTCATTTTTCTG
TTATTTGGCGGTGCAGTCAACAATCTTGGAAGTCCTGAACATGTTATCAAGTGGTTTCGCCCAC
TCAAGGAGCAGAAGTATACAGGGATGTTTGCGATGACCGAGAAGGGCCATGGGAGCAACATCAG
AGGGATCCAGACTGAGGCTACCTTTGACTGTGACAGTCAGGAGTTTGTGATTGACATGCCATGT
GAAAACGCCCAGAAGATGTACATTGGCAACGCCATGCATGGGAACTATGCTGCTGTCTTCGCCC
AGCTCATCATCGAGGGAAAGTCTCAAGGGCCCCATTGTTTCATTGTTCCTATCAGGGATGAAAA
TGGAAACTTGTACCCTGGAGTGACAGCTATTGACATGATGTACAAAGAAGGTCTGAATGGTGTG
GATAATGGAATTTTGATATTTGACAAGGTTCGGATTCCAAGAGAGAACATGCTGGATAAGTTAG
GTTCTGTGACTCCAGATGGACAATACCACTCACCTATTCAAAGCAAGAGTGCAAGATTCAATGC
AATGCTGGCCATACTGACCCCTTCAAGACTGGCAGTGACTTTCCAAGCGATGGGTGCCATGAAG
CTTGGACTGATGATAGCCATCCGCTATAGCCACAGCCGAAGGCAGTTTGGACCCAAGGGCAAAG
AAGAGGTGAAGATCATTGAGCACCAAATGCAGGCACTGAGGCTGATGTCTCACCTGGCCACAGC
CCTGGCCCTGACCTTCACCAGCAGGCATGCAGGCCACATCTTGGATGAAGACATCCTCCAGGGA
AGGGAGCTCATCAACAGACGCTCGCTACAGGCACTGATGGCTGGGCTGAAAGCCTACAGCACTT
GGGAGACTGTCCGCTGCCTACAGGACTGTCGTGAATGCACTGGAGGCATGGGTTACATGATGGA
AAACCGACTCTCAGGCCTGAAATGTGACACAGATGTGTTTGTAACCTTTGAAGGTGACAATGTG
GTCATGCTTCAGGTTGTGGCCCGGGAACTGCTGGCCCAGTACAGCAAGCAGCATAAGAAAAACC
CATTCTTGGGTATGATCCAGAACTGGACTGAAACTGCCATGGACAAGCTGAGAACCAGTTTCCT
GGTGTTTAACACTGACACAGTAGGACATCTTGCCTTTCTGCTGAAAGCAGTGAATTTTCGAGAA
AGAGTTCTTCAGCGAAGTTTGGTGTCCAGAATTTACTATAAGGTGGTGACCGAGAAGGGGGACT
TCTTCAGGGCCTGGAACTCCTGTATGCACCATGTCATCTCGTTGTCTCTGGCACACGTTCACAG
AGTTGCACTAGAACAGTTCACGCTGGCAGTGAGGCAGTGTCCCAACAGGGAGGACCAGGCTTTG
CTAATGAAGTTTTGTCTGTTGTATGGAACGAAGCTGCTGTTCCAGGAGCGGGGCTGGTACTTAG
AACATAAGTACCTGACTCCTGCGGCCAGCATGCGGATCAGGGCTCAGTTGCTGAATTTGTGCGA
GTCCGTGAAGGATGACTCCCTGAAGGTGATCTCTGCCTTCAATATTCCACACACCACCATCCAC
GCACCAACAGCGGGAACCCCCAACACCGGGGCTGCGGAGGCCTTCTCCCCGGCGCCCACGCAGC
CACTGGTGCAGAATGGGACGCGGTCTCGACTGGCCAAGCTGTGAGCCAGGCGAGAAATTTAGTG
TCCCATCTTCCGAATATTTGGCTAGAACCGGAGCAGAGGGCAAAGTGGCAGATGCAGGGCAACC
ACCTTGGGGAATTTCATCAGGCAGAGGAGGAGGTCCGGCTAAGGCTGGCAAGGAGCACGACAAG
TTGTCCGGGAGAGGGAGCCCTAGATGGACGCCCCAGTAGCATAGTGACTTATCCAGGTCTAGTA
ACCTCCCTGGCCCTTGCCTTGACTTCTCCCAGCCATGGCCATGGATCCCCAGACAATCGTCTCG
CCCACCGCACGGTGCCACCAAAGATCTCTACCGTCAGCGGTGACTCAGATTCACAGAGACTTCG
AAAGACATTGGGGCTGGGTGAAAAAAAAATCAAAACATAAAAATCAAACACCCTTAGGCAAAAG
GGGTGGAGGAAAGCTCCACCCTCTCCAAGCTCGGGCAAAAGTTCAACAAGGGATGATTAGTGAA
TCAGACTTGCTCCAACTCTGTGAGGAAATGCGCTGTCGAGAGCGGAGAGCTTAAGCCCGGAGTC
GCCCTAGTCTTACCAGGTAGGCGATCTCCGGACCGCAGGATCATGCGCAACAAGTTTCTCCTCG
CTAAACTGTTACCTAGCCTTCAGAAAAGCGTACGTGTGAAAAGTTTAATATATTAAACGGTAGA
AAGGTGCTCCGGCGACTTGGAAAGGTAGGGATGGCGGGTCTGGGGAATAGTTGGAATAAAGTGT
TTTTGGAATTTGGAGAGATTAC

hide sequence

RefSeq Acc Id:

NM_001415677 ⟹ NP_001402606

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	135,514,340 - 135,820,291 (+)	NCBI
mRatBN7.2	3	115,061,069 - 115,367,032 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099978	(Get FASTA)	NCBI Sequence Viewer
	NP_001402606	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL80130	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000021740
	ENSRNOP00000021740.3
	ENSRNOP00000072762.1
	ENSRNOP00000080838
	ENSRNOP00000080838.1

RefSeq Acc Id:	NP_001099978 ⟸ NM_001106508
- Peptide Label:	isoform 2
- UniProtKB:	D4A257 (UniProtKB/TrEMBL), A6HQ29 (UniProtKB/TrEMBL), A0A0G2K3T0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTGWSGLFIEVPLYRLAFEVCCHLQGPQGFLQRACQGVSCLPRDSRAAGIMEEKRNNFISQSFV LGEVLCMVDVSMSIKCGVIFLLFGGAVNNLGSPEHVIKWFRPLKEQKYTGMFAMTEKGHGSNIR GIQTEATFDCDSQEFVIDMPCENAQKMYIGNAMHGNYAAVFAQLIIEGKSQGPHCFIVPIRDEN GNLYPGVTAIDMMYKEGLNGVDNGILIFDKVRIPRENMLDKLGSVTPDGQYHSPIQSKSARFNA MLAILTPSRLAVTFQAMGAMKLGLMIAIRYSHSRRQFGPKGKEEVKIIEHQMQALRLMSHLATA LALTFTSRHAGHILDEDILQGRELINRRSLQALMAGLKAYSTWETVRCLQDCRECTGGMGYMME NRLSGLKCDTDVFVTFEGDNVVMLQVVARELLAQYSKQHKKNPFLGMIQNWTETAMDKLRTSFL VFNTDTVGHLAFLLKAVNFRERVLQRSLVSRIYYKVVTEKGDFFRAWNSCMHHVISLSLAHVHR VALEQFTLAVRQCPNREDQALLMKFCLLYGTKLLFQERGWYLEHKYLTPAASMRIRAQLLNLCE SVKDDSLKVISAFNIPHTTIHAPTAGTPNTGAAEAFSPAPTQPLVQNGTRSRLAKL hide sequence

RefSeq Acc Id:

ENSRNOP00000021740 ⟸ ENSRNOT00000021740

RefSeq Acc Id:

ENSRNOP00000072762 ⟸ ENSRNOT00000083627

RefSeq Acc Id:

ENSRNOP00000080838 ⟸ ENSRNOT00000108346

RefSeq Acc Id:	NP_001402606 ⟸ NM_001415677
- Peptide Label:	isoform 1
- UniProtKB:	A0A8I5ZRR5 (UniProtKB/TrEMBL)

Protein Domains

Acyl-CoA dehydrogenase/oxidase C-terminal Acyl-CoA oxidase C-terminal Acyl-CoA oxidase/dehydrogenase middle

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A257-F1-model_v2	AlphaFold	D4A257	1-632	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306814	AgrOrtholog
BioCyc Gene	G2FUF-47956	BioCyc
Ensembl Genes	ENSRNOG00000016179	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000021740	ENTREZGENE
	ENSRNOT00000021740.4	UniProtKB/TrEMBL
	ENSRNOT00000083627.2	UniProtKB/TrEMBL
	ENSRNOT00000108346	ENTREZGENE
	ENSRNOT00000108346.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.110.10	UniProtKB/TrEMBL
	Butyryl-CoA Dehydrogenase, subunit A, domain 3	UniProtKB/TrEMBL
InterPro	Acyl-CoA_Oxase/DH_cen-dom	UniProtKB/TrEMBL
	Acyl-CoA_Oxase/DH_mid-dom_sf	UniProtKB/TrEMBL
	Acyl-CoA_oxidase	UniProtKB/TrEMBL
	Acyl-CoA_oxidase_C	UniProtKB/TrEMBL
	AcylCo_DH/oxidase_C	UniProtKB/TrEMBL
	AcylCo_DH_C-like	UniProtKB/TrEMBL
	AcylCoA_DH/oxidase	UniProtKB/TrEMBL
KEGG Report	rno:296138	UniProtKB/TrEMBL
NCBI Gene	296138	ENTREZGENE
PANTHER	ACYL-COENZYME A OXIDASE-LIKE PROTEIN	UniProtKB/TrEMBL
	PTHR10909	UniProtKB/TrEMBL
Pfam	ACOX	UniProtKB/TrEMBL
	Acyl-CoA_dh_1	UniProtKB/TrEMBL
	Acyl-CoA_dh_M	UniProtKB/TrEMBL
PhenoGen	Acoxl	PhenoGen
PIRSF	Acyl-CoA_oxidase	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000016179	RatGTEx
Superfamily-SCOP	AcylCoA_dehyd_NM	UniProtKB/TrEMBL
	AcylCoADH_C_like	UniProtKB/TrEMBL
UniProt	A0A0G2K3T0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZRR5	ENTREZGENE, UniProtKB/TrEMBL
	A6HQ29	ENTREZGENE, UniProtKB/TrEMBL
	D4A257	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-07-28	Acoxl	acyl-CoA oxidase-like	Acoxl	acyl-Coenzyme A oxidase-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Acoxl	acyl-Coenzyme A oxidase-like	Acoxl_predicted	acyl-Coenzyme A oxidase-like (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Acoxl_predicted	acyl-Coenzyme A oxidase-like (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD