Symbol:
Dock6
Name:
dedicator of cytokinesis 6
RGD ID:
1306517
Description:
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human DOCK6 (dedicator of cytokinesis 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aristolochic acid A.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
dedicator of cytokinesis protein 6; LOC367039
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 8 28,618,523 - 28,670,741 (-) NCBI GRCr8 mRatBN7.2 8 20,342,430 - 20,394,660 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 8 20,342,089 - 20,394,552 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 8 24,377,909 - 24,430,028 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 8 22,673,454 - 22,725,573 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 8 20,572,031 - 20,624,157 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 8 22,822,412 - 22,874,670 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 22,822,412 - 22,874,645 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 8 22,876,566 - 22,928,950 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 8 20,896,180 - 20,966,159 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 8 20,894,958 - 20,962,815 (-) NCBI Celera 8 21,732,745 - 21,785,834 (-) NCBI Celera Cytogenetic Map 8 q13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - ClinVar
Dock6 Rat Adams-Oliver syndrome ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Adams-Oliver syndrome | ClinVar Annotator: match by term: Scalp defects more ... ClinVar PMID:21820096|PMID:24033266|PMID:25558065|PMID:25741868|PMID:25824905|PMID:26457590|PMID:28492532|PMID:29924900 Dock6 Rat Adams-Oliver Syndrome 1 ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Adams-Oliver syndrome 1 ClinVar PMID:21820096|PMID:25741868|PMID:25824905|PMID:26457590|PMID:28492532|PMID:29924900 Dock6 Rat Adams-Oliver Syndrome 2 ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Adams-Oliver syndrome 2 | ClinVar Annotator: match by term: DOCK6-related more ... ClinVar PMID:16199547|PMID:17159513|PMID:17576681|PMID:21820096|PMID:23522784|PMID:25091416|PMID:25558065|PMID:25724810|PMID:25741868|PMID:25824905|PMID:26457590|PMID:28135719|PMID:28160419|PMID:28492532|PMID:28884918|PMID:29924900|PMID:29961505|PMID:30111349|PMID:30293987|PMID:31131953|PMID:8849019|PMID:9536098 Dock6 Rat alpha-mannosidosis ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Deficiency of alpha-mannosidase ClinVar PMID:28492532 Dock6 Rat Charcot-Marie-Tooth disease dominant intermediate B ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate B ClinVar PMID:28492532 Dock6 Rat episodic ataxia type 2 ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Episodic ataxia type 2 ClinVar PMID:28492532 Dock6 Rat Familial Hypercholanemia 1 ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Hypercholanemia, familial 1 ClinVar Dock6 Rat familial hypercholesterolemia ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Hypercholesterolemia, familial, 1 ClinVar PMID:14756670|PMID:17094996|PMID:19538517|PMID:20045108|PMID:22698793|PMID:25741868 Dock6 Rat genetic disease ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:16199547|PMID:21820096|PMID:23522784|PMID:25091416|PMID:25558065|PMID:25724810|PMID:25741868|PMID:25824905|PMID:25954003|PMID:27618451|PMID:28160419|PMID:28490743|PMID:28492532|PMID:28884918|PMID:29961505|PMID:30111349|PMID:30293987|PMID:31131953 Dock6 Rat glutaric acidemia I ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Glutaric aciduria, type 1 ClinVar PMID:28492532 Dock6 Rat glycogen storage disease III ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Cori disease ClinVar PMID:11727201|PMID:12673792|PMID:12955720|PMID:16385454|PMID:16783378|PMID:20301500|PMID:20301601|PMID:20301718|PMID:20301788|PMID:21735565|PMID:21820096|PMID:25741868|PMID:28492532 Dock6 Rat hydrocephalus ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Hydrocephalus, nonsyndromic, autosomal recessive 1 ClinVar Dock6 Rat intellectual disability ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Intellectual disability ClinVar PMID:25741868|PMID:28492532 Dock6 Rat microcephaly ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Microcephaly ClinVar PMID:25741868|PMID:28492532 Dock6 Rat neurodegeneration with brain iron accumulation 2A ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Infantile neuroaxonal dystrophy 1 ClinVar PMID:11727201|PMID:12673792|PMID:12955720|PMID:16385454|PMID:16783378|PMID:20301500|PMID:20301601|PMID:20301718|PMID:20301788|PMID:21735565|PMID:21820096|PMID:25741868|PMID:28492532 Dock6 Rat Paget's disease of bone ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Paget disease of bone ClinVar PMID:25741868|PMID:28492532 Dock6 Rat rhabdoid tumor predisposition syndrome 2 ISO RGD:1315180 8554872 ClinVar Annotator: match by term: Rhabdoid tumor predisposition syndrome 2 ClinVar PMID:28492532
Imported Disease Annotations - CTD
Imported Disease Annotations - OMIM
Only show annotations with direct experimental evidence (0 objects hidden)
Dock6 Rat 1,2-dimethylhydrazine affects expression ISO RGD:1556889 6480464 1,2-Dimethylhydrazine affects the expression of DOCK6 mRNA CTD PMID:22206623 Dock6 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of DOCK6 mRNA CTD PMID:34747641 Dock6 Rat 2-hydroxypropanoic acid decreases expression ISO RGD:1315180 6480464 Lactic Acid results in decreased expression of DOCK6 mRNA CTD PMID:30851411 Dock6 Rat 4,4'-sulfonyldiphenol increases methylation ISO RGD:1556889 6480464 bisphenol S results in increased methylation of DOCK6 exon CTD PMID:33297965 Dock6 Rat 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1315180 6480464 [bisphenol S co-treated with Fulvestrant] results in increased methylation of DOCK6 gene CTD PMID:31601247 Dock6 Rat acetamide increases expression EXP 6480464 acetamide results in increased expression of DOCK6 mRNA CTD PMID:31881176 Dock6 Rat acrylamide decreases expression ISO RGD:1315180 6480464 Acrylamide results in decreased expression of DOCK6 mRNA CTD PMID:32763439 Dock6 Rat aflatoxin B1 decreases methylation ISO RGD:1315180 6480464 Aflatoxin B1 results in decreased methylation of DOCK6 intron CTD PMID:30157460 Dock6 Rat Aflatoxin B2 alpha increases methylation ISO RGD:1315180 6480464 aflatoxin B2 results in increased methylation of DOCK6 exon CTD PMID:30157460 Dock6 Rat all-trans-retinoic acid decreases expression ISO RGD:1315180 6480464 Tretinoin results in decreased expression of DOCK6 mRNA CTD PMID:33167477 Dock6 Rat antirheumatic drug increases expression ISO RGD:1315180 6480464 Antirheumatic Agents results in increased expression of DOCK6 mRNA CTD PMID:24449571 Dock6 Rat aristolochic acid A increases expression EXP 6480464 aristolochic acid I results in increased expression of DOCK6 protein CTD PMID:38428544 Dock6 Rat aristolochic acid A multiple interactions EXP 6480464 [aristolochic acid I co-treated with Probenecid] results in increased expression of DOCK6 protein CTD PMID:38428544 Dock6 Rat aristolochic acids increases expression EXP 6480464 Aristolochic Acids results in increased expression of DOCK6 mRNA CTD PMID:19717638 Dock6 Rat arsenite(3-) decreases methylation ISO RGD:1315180 6480464 arsenite results in decreased methylation of DOCK6 promoter CTD PMID:23974009 Dock6 Rat arsenite(3-) multiple interactions ISO RGD:1315180 6480464 arsenite inhibits the reaction [G3BP1 protein binds to DOCK6 mRNA] CTD PMID:32406909 Dock6 Rat atrazine increases expression ISO RGD:1315180 6480464 Atrazine results in increased expression of DOCK6 mRNA CTD PMID:22378314 Dock6 Rat atrazine affects methylation EXP 6480464 Atrazine affects the methylation of DOCK6 gene CTD PMID:35440735 Dock6 Rat benzo[a]pyrene increases methylation ISO RGD:1556889 6480464 Benzo(a)pyrene results in increased methylation of DOCK6 exon; Benzo(a)pyrene results in increased methylation of DOCK6 more ... CTD PMID:27901495 Dock6 Rat benzo[a]pyrene affects methylation ISO RGD:1315180 6480464 Benzo(a)pyrene affects the methylation of DOCK6 exon CTD PMID:30157460 Dock6 Rat beta-lapachone increases expression ISO RGD:1315180 6480464 beta-lapachone results in increased expression of DOCK6 mRNA CTD PMID:38218311 Dock6 Rat bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1556889 6480464 PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of DOCK6 mRNA] CTD PMID:19850644 Dock6 Rat bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DOCK6 more ... CTD PMID:23359474 Dock6 Rat bis(2-ethylhexyl) phthalate increases expression ISO RGD:1556889 6480464 Diethylhexyl Phthalate results in increased expression of DOCK6 mRNA CTD PMID:19850644 Dock6 Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DOCK6 more ... CTD PMID:23359474 Dock6 Rat bisphenol A decreases methylation ISO RGD:1315180 6480464 bisphenol A results in decreased methylation of DOCK6 gene CTD PMID:31601247 Dock6 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of DOCK6 mRNA CTD PMID:25181051|PMID:34947998 Dock6 Rat bisphenol F decreases expression ISO RGD:1556889 6480464 bisphenol F results in decreased expression of DOCK6 mRNA CTD PMID:38685157 Dock6 Rat cadmium atom multiple interactions ISO RGD:1315180 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DOCK6 more ... CTD PMID:35301059 Dock6 Rat cadmium dichloride multiple interactions ISO RGD:1315180 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of DOCK6 more ... CTD PMID:35301059 Dock6 Rat carbon nanotube decreases expression ISO RGD:1556889 6480464 Nanotubes, Carbon analog results in decreased expression of DOCK6 mRNA; Nanotubes, Carbon results in decreased more ... CTD PMID:25554681|PMID:25620056 Dock6 Rat chlorpyrifos increases expression ISO RGD:1556889 6480464 Chlorpyrifos results in increased expression of DOCK6 mRNA CTD PMID:37019170 Dock6 Rat choline multiple interactions ISO RGD:1556889 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... CTD PMID:20938992 Dock6 Rat cobalt dichloride decreases expression ISO RGD:1315180 6480464 cobaltous chloride results in decreased expression of DOCK6 mRNA CTD PMID:19320972 Dock6 Rat corosolic acid increases expression ISO RGD:1315180 6480464 corosolic acid results in increased expression of DOCK6 mRNA CTD PMID:37939859 Dock6 Rat crocidolite asbestos increases expression ISO RGD:1556889 6480464 Asbestos, Crocidolite results in increased expression of DOCK6 mRNA CTD PMID:29279043 Dock6 Rat Cuprizon increases expression EXP 6480464 Cuprizone results in increased expression of DOCK6 mRNA CTD PMID:26577399 Dock6 Rat cyclosporin A increases expression ISO RGD:1315180 6480464 Cyclosporine results in increased expression of DOCK6 mRNA CTD PMID:25562108 Dock6 Rat dibutyl phthalate multiple interactions EXP 6480464 [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of DOCK6 more ... CTD PMID:23359474 Dock6 Rat dicrotophos increases expression ISO RGD:1315180 6480464 dicrotophos results in increased expression of DOCK6 mRNA CTD PMID:28302478 Dock6 Rat dorsomorphin multiple interactions ISO RGD:1315180 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Dock6 Rat doxorubicin decreases expression ISO RGD:1315180 6480464 Doxorubicin results in decreased expression of DOCK6 mRNA CTD PMID:29803840 Dock6 Rat entinostat increases expression ISO RGD:1315180 6480464 entinostat results in increased expression of DOCK6 mRNA CTD PMID:27188386 Dock6 Rat epoxiconazole decreases expression ISO RGD:1556889 6480464 epoxiconazole results in decreased expression of DOCK6 mRNA CTD PMID:35436446 Dock6 Rat ethanol increases expression ISO RGD:1556889 6480464 Ethanol results in increased expression of DOCK6 mRNA CTD PMID:30319688 Dock6 Rat fipronil increases expression EXP 6480464 fipronil results in increased expression of DOCK6 mRNA CTD PMID:34044035 Dock6 Rat folic acid multiple interactions ISO RGD:1556889 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... CTD PMID:20938992 Dock6 Rat FR900359 affects phosphorylation ISO RGD:1315180 6480464 FR900359 affects the phosphorylation of DOCK6 protein CTD PMID:37730182 Dock6 Rat fulvestrant multiple interactions ISO RGD:1315180 6480464 [bisphenol S co-treated with Fulvestrant] results in increased methylation of DOCK6 gene CTD PMID:31601247 Dock6 Rat ivermectin decreases expression ISO RGD:1315180 6480464 Ivermectin results in decreased expression of DOCK6 protein CTD PMID:32959892 Dock6 Rat ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of DOCK6 mRNA CTD PMID:36653537 Dock6 Rat L-methionine multiple interactions ISO RGD:1556889 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... CTD PMID:20938992 Dock6 Rat lead(0) increases expression ISO RGD:1315180 6480464 Lead results in increased expression of DOCK6 mRNA CTD PMID:19921347 Dock6 Rat mercury dibromide decreases expression ISO RGD:1315180 6480464 mercuric bromide results in decreased expression of DOCK6 mRNA CTD PMID:26272509 Dock6 Rat mercury dibromide multiple interactions ISO RGD:1315180 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Dock6 Rat methamphetamine increases expression ISO RGD:1556889 6480464 Methamphetamine results in increased expression of DOCK6 mRNA CTD PMID:26307267 Dock6 Rat methotrexate increases expression ISO RGD:1315180 6480464 Methotrexate results in increased expression of DOCK6 mRNA CTD PMID:24449571 Dock6 Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of DOCK6 gene CTD PMID:35440735 Dock6 Rat N-methyl-4-phenylpyridinium increases expression ISO RGD:1315180 6480464 1-Methyl-4-phenylpyridinium results in increased expression of DOCK6 mRNA CTD PMID:24810058 Dock6 Rat ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of DOCK6 mRNA CTD PMID:19717638 Dock6 Rat p-chloromercuribenzoic acid decreases expression ISO RGD:1315180 6480464 p-Chloromercuribenzoic Acid results in decreased expression of DOCK6 mRNA CTD PMID:26272509 Dock6 Rat p-chloromercuribenzoic acid multiple interactions ISO RGD:1315180 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Dock6 Rat paracetamol affects expression ISO RGD:1556889 6480464 Acetaminophen affects the expression of DOCK6 mRNA CTD PMID:17562736 Dock6 Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of DOCK6 mRNA CTD PMID:33387578 Dock6 Rat phenylmercury acetate decreases expression ISO RGD:1315180 6480464 Phenylmercuric Acetate results in decreased expression of DOCK6 mRNA CTD PMID:26272509 Dock6 Rat phenylmercury acetate multiple interactions ISO RGD:1315180 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Dock6 Rat pirinixic acid increases expression ISO RGD:1556889 6480464 pirinixic acid results in increased expression of DOCK6 mRNA CTD PMID:23811191 Dock6 Rat probenecid multiple interactions EXP 6480464 [aristolochic acid I co-treated with Probenecid] results in increased expression of DOCK6 protein CTD PMID:38428544 Dock6 Rat rac-lactic acid decreases expression ISO RGD:1315180 6480464 Lactic Acid results in decreased expression of DOCK6 mRNA CTD PMID:30851411 Dock6 Rat SB 431542 multiple interactions ISO RGD:1315180 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... CTD PMID:27188386 Dock6 Rat sodium arsenite increases expression ISO RGD:1315180 6480464 sodium arsenite results in increased expression of DOCK6 mRNA CTD PMID:38568856 Dock6 Rat sunitinib increases expression ISO RGD:1315180 6480464 Sunitinib results in increased expression of DOCK6 mRNA CTD PMID:31533062 Dock6 Rat temozolomide increases expression ISO RGD:1315180 6480464 Temozolomide results in increased expression of DOCK6 mRNA CTD PMID:31758290 Dock6 Rat tetrachloroethene decreases expression ISO RGD:1556889 6480464 Tetrachloroethylene results in decreased expression of DOCK6 mRNA CTD PMID:28973375 Dock6 Rat tetraphene increases expression ISO RGD:1556889 6480464 benz(a)anthracene results in increased expression of DOCK6 mRNA CTD PMID:26377693 Dock6 Rat thimerosal decreases expression ISO RGD:1315180 6480464 Thimerosal results in decreased expression of DOCK6 mRNA CTD PMID:27188386 Dock6 Rat tremolite asbestos decreases expression ISO RGD:1556889 6480464 tremolite results in decreased expression of DOCK6 mRNA CTD PMID:29279043 Dock6 Rat triphenyl phosphate affects expression ISO RGD:1315180 6480464 triphenyl phosphate affects the expression of DOCK6 mRNA CTD PMID:37042841 Dock6 Rat valproic acid affects expression ISO RGD:1315180 6480464 Valproic Acid affects the expression of DOCK6 mRNA CTD PMID:25979313 Dock6 Rat valproic acid increases expression ISO RGD:1556889 6480464 Valproic Acid results in increased expression of DOCK6 mRNA CTD PMID:24896083
References
References - curated
#
Reference Title
Reference Citation
1.
DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits.
Chi HC, etal., Oncogene. 2020 Sep;39(37):5933-5949. doi: 10.1038/s41388-020-01390-0. Epub 2020 Aug 4.
2.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.
miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis.
Li X, etal., J Exp Clin Cancer Res. 2018 Mar 27;37(1):71. doi: 10.1186/s13046-018-0729-z.
4.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
5.
GOA pipeline
RGD automated data pipeline
6.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
8.
DOCK6 mutations are responsible for a distinct autosomal-recessive variant of Adams-Oliver syndrome associated with brain and eye anomalies.
Sukalo M, etal., Hum Mutat. 2015 Jun;36(6):593-8. doi: 10.1002/humu.22795. Epub 2015 Apr 21.
9.
Overexpression of DOCK6 in oral squamous cell cancer promotes cellular migration and invasion and is associated with poor prognosis.
Zhang ZY, etal., Arch Oral Biol. 2022 Jan;133:105297. doi: 10.1016/j.archoralbio.2021.105297. Epub 2021 Oct 28.
Genomics
Comparative Map Data
Dock6 Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 8 28,618,523 - 28,670,741 (-) NCBI GRCr8 mRatBN7.2 8 20,342,430 - 20,394,660 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 8 20,342,089 - 20,394,552 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 8 24,377,909 - 24,430,028 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 8 22,673,454 - 22,725,573 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 8 20,572,031 - 20,624,157 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 8 22,822,412 - 22,874,670 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 8 22,822,412 - 22,874,645 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 8 22,876,566 - 22,928,950 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 8 20,896,180 - 20,966,159 (-) NCBI RGSC3.4 RGSC_v3.4 rn4 RGSC3.4 RGSC_v3.1 8 20,894,958 - 20,962,815 (-) NCBI Celera 8 21,732,745 - 21,785,834 (-) NCBI Celera Cytogenetic Map 8 q13 NCBI
DOCK6 Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 19 11,199,295 - 11,262,524 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 19 11,199,295 - 11,262,524 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 19 11,309,971 - 11,373,200 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 19 11,170,971 - 11,234,157 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 19 11,170,972 - 11,234,128 NCBI Celera 19 11,204,784 - 11,268,011 (-) NCBI Celera Cytogenetic Map 19 p13.2 NCBI HuRef 19 10,886,047 - 10,940,482 (-) NCBI HuRef CHM1_1 19 11,311,180 - 11,374,238 (-) NCBI CHM1_1 T2T-CHM13v2.0 19 11,326,296 - 11,389,499 (-) NCBI T2T-CHM13v2.0
Dock6 Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 9 21,711,476 - 21,764,006 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 9 21,711,156 - 21,763,931 (-) Ensembl GRCm39 Ensembl GRCm38 9 21,800,180 - 21,852,718 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 9 21,799,860 - 21,852,635 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 9 21,604,624 - 21,657,079 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 9 21,594,033 - 21,603,018 (-) NCBI MGSCv36 mm8 Celera 9 19,069,771 - 19,122,226 (-) NCBI Celera Cytogenetic Map 9 A3 NCBI cM Map 9 7.89 NCBI
Dock6 Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955495 2,174,966 - 2,216,423 (-) Ensembl ChiLan1.0 ChiLan1.0 NW_004955495 2,174,802 - 2,216,424 (-) NCBI ChiLan1.0 ChiLan1.0
DOCK6 Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 20 16,114,565 - 16,178,192 (-) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 19 15,113,252 - 15,176,888 (-) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 19 10,747,850 - 10,811,483 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 19 11,458,860 - 11,521,029 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 19 11,459,062 - 11,513,220 (-) Ensembl panpan1.1 panPan2
DOCK6 Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 20 50,029,354 - 50,066,829 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 20 50,029,369 - 50,066,829 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 20 49,898,472 - 49,940,350 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 20 50,545,683 - 50,587,769 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 20 50,545,643 - 50,587,757 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 20 49,756,044 - 49,797,955 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 20 50,182,747 - 50,224,812 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 20 50,425,668 - 50,467,527 (+) NCBI UU_Cfam_GSD_1.0
Dock6 Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024405118 208,967,152 - 209,013,562 (+) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936659 1,341,331 - 1,379,728 (-) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936659 1,341,144 - 1,394,484 (-) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
DOCK6
DOCK6
Dock6
.
miRNA Target Status (No longer updated)
Predicted Target Of
Count of predictions: 180 Count of miRNA genes: 126 Interacting mature miRNAs: 152 Transcripts: ENSRNOT00000064551 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
QTLs in Region (GRCr8)
1558646 Swd5 Spike wave discharge measurement QTL 5 3.45 0.00036 brain electrophysiology trait (VT:0010557) brain spike-and-wave discharge frequency (CMO:0001742) 8 14906751 59906751 Rat 1357398 Slep3 Serum leptin concentration QTL 3 3.43 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 8 9712463 41866876 Rat 2317030 Wbc5 White blood cell count QTL 5 3.21 0.005 leukocyte quantity (VT:0000217) white blood cell count (CMO:0000027) 8 8736635 53736635 Rat 731182 Uae24 Urinary albumin excretion QTL 24 6.4 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 8 19331152 93965294 Rat 12880044 Am9 Aortic mass QTL 9 0.007 aorta mass (VT:0002845) aorta weight to aorta length to body weight ratio (CMO:0002722) 8 2097640 47097640 Rat 2317032 Ginf2 Gastrointestinal inflammation QTL 2 3.21 0.005 liver integrity trait (VT:0010547) liver granuloma severity score (CMO:0002157) 8 4705810 49705810 Rat 2301416 Bp315 Blood pressure QTL 315 0.008 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 8 7670578 52670578 Rat 631650 Stl6 Serum triglyceride level QTL 6 4 0.0019 blood triglyceride amount (VT:0002644) plasma triglyceride level (CMO:0000548) 8 10378157 112202585 Rat 1581557 Eae16 Experimental allergic encephalomyelitis QTL 16 3.8 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 8 8462195 110921472 Rat 631271 Lecl1 Lens clarity QTL 1 0.001 lens clarity trait (VT:0001304) age of onset/diagnosis of cataract (CMO:0001584) 8 18984168 84531599 Rat 2317036 Livw3 Liver weight QTL 3 2.43 0.01 liver mass (VT:0003402) liver weight to body weight ratio (CMO:0000633) 8 4705810 49705810 Rat 1598824 Memor4 Memory QTL 4 2.5 exploratory behavior trait (VT:0010471) total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443) 8 9712220 53356647 Rat 12880023 Bw184 Body weight QTL 184 0.001 body mass (VT:0001259) body weight (CMO:0000012) 8 2097640 47097640 Rat 9590084 Insglur5 Insulin/glucose ratio QTL 5 18.54 0.001 blood insulin amount (VT:0001560) calculated plasma insulin level (CMO:0002170) 8 1 24597739 Rat 1354595 Despr4 Despair related QTL 4 2.16 0.0036 locomotor behavior trait (VT:0001392) amount of time spent in voluntary immobility (CMO:0001043) 8 7688955 52688955 Rat 1354627 Despr14 Despair related QTL 14 0.0056 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 8 7688955 52688955 Rat 12880028 Cm103 Cardiac mass QTL 103 0.02 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 8 2097640 47097640 Rat 2317051 Aia18 Adjuvant induced arthritis QTL 18 2.42 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 8 8736635 53736635 Rat 2317882 Alcrsp24 Alcohol response QTL 24 3.2 0.05 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 8 1 25902202 Rat 2317048 Ginf1 Gastrointestinal inflammation QTL 1 3.52 0.005 cecum mucosa thickness (VT:0010234) enterocolitis severity score (CMO:0002138) 8 4705810 49705810 Rat 2302367 Slep5 Serum leptin concentration QTL 5 3.43 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 8 9712463 41866876 Rat 12880025 Cm102 Cardiac mass QTL 102 0.044 heart mass (VT:0007028) heart wet weight to body weight ratio (CMO:0002408) 8 2097640 47097640 Rat 61373 Mcs4 Mammary carcinoma susceptibility QTL 4 1.1 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 8 16290444 61290444 Rat
Markers in Region
D8Rat52
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 8 20,391,196 - 20,391,407 (+) MAPPER mRatBN7.2 Rnor_6.0 8 22,871,284 - 22,871,494 NCBI Rnor6.0 Rnor_5.0 8 22,925,583 - 22,925,793 UniSTS Rnor5.0 RGSC_v3.4 8 20,962,778 - 20,963,147 RGD RGSC3.4 RGSC_v3.4 8 20,962,806 - 20,963,016 UniSTS RGSC3.4 RGSC_v3.1 8 20,962,806 - 20,963,016 RGD Celera 8 21,782,481 - 21,782,691 UniSTS RH 3.4 Map 8 207.89 RGD RH 3.4 Map 8 207.89 UniSTS SHRSP x BN Map 8 14.26 UniSTS SHRSP x BN Map 8 14.26 RGD FHH x ACI Map 8 10.7699 RGD Cytogenetic Map 8 q13 UniSTS
BI274505
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 8 20,378,226 - 20,378,386 (+) MAPPER mRatBN7.2 Rnor_6.0 8 22,858,304 - 22,858,463 NCBI Rnor6.0 Rnor_5.0 8 22,912,744 - 22,912,903 UniSTS Rnor5.0 RGSC_v3.4 8 20,949,826 - 20,949,985 UniSTS RGSC3.4 Celera 8 21,769,503 - 21,769,662 UniSTS RH 3.4 Map 1 962.71 UniSTS Cytogenetic Map 8 q13 UniSTS
BI282731
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 8 20,376,710 - 20,377,030 (+) MAPPER mRatBN7.2 Rnor_6.0 8 22,856,788 - 22,857,107 NCBI Rnor6.0 Rnor_5.0 8 22,911,228 - 22,911,547 UniSTS Rnor5.0 RGSC_v3.4 8 20,948,310 - 20,948,629 UniSTS RGSC3.4 Celera 8 21,767,987 - 21,768,306 UniSTS Cytogenetic Map 8 q13 UniSTS
AI009950
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 8 20,379,223 - 20,379,454 (+) MAPPER mRatBN7.2 Rnor_6.0 8 22,859,301 - 22,859,531 NCBI Rnor6.0 Rnor_5.0 8 22,913,601 - 22,913,831 UniSTS Rnor5.0 RGSC_v3.4 8 20,950,823 - 20,951,053 UniSTS RGSC3.4 Celera 8 21,770,500 - 21,770,730 UniSTS Cytogenetic Map 8 q13 UniSTS
Expression
RNA-SEQ Expression
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
Too many to show, limit is 500. Download them if you would like to view them all.
Sequence
Ensembl Acc Id:
ENSRNOT00000064551 ⟹ ENSRNOP00000063161
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 8 20,342,089 - 20,394,552 (-) Ensembl Rnor_6.0 Ensembl 8 22,822,412 - 22,874,637 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000090424 ⟹ ENSRNOP00000075398
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 8 20,342,089 - 20,394,552 (-) Ensembl Rnor_6.0 Ensembl 8 22,822,729 - 22,874,645 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000106365 ⟹ ENSRNOP00000079526
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 8 20,342,089 - 20,389,096 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000118947 ⟹ ENSRNOP00000096113
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 8 20,342,089 - 20,389,096 (-) Ensembl
RefSeq Acc Id:
NM_001394344 ⟹ NP_001381273
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 28,618,523 - 28,670,648 (-) NCBI mRatBN7.2 8 20,342,430 - 20,394,557 (-) NCBI
RefSeq Acc Id:
NM_001413911 ⟹ NP_001400840
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 28,618,523 - 28,670,648 (-) NCBI mRatBN7.2 8 20,342,430 - 20,394,557 (-) NCBI
RefSeq Acc Id:
XM_039081850 ⟹ XP_038937778
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 28,618,523 - 28,670,726 (-) NCBI mRatBN7.2 8 20,342,430 - 20,394,635 (-) NCBI
RefSeq Acc Id:
XM_039081851 ⟹ XP_038937779
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 28,618,523 - 28,670,726 (-) NCBI mRatBN7.2 8 20,342,430 - 20,394,635 (-) NCBI
RefSeq Acc Id:
XM_039081852 ⟹ XP_038937780
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 28,618,523 - 28,670,726 (-) NCBI mRatBN7.2 8 20,342,430 - 20,394,635 (-) NCBI
RefSeq Acc Id:
XM_039081854 ⟹ XP_038937782
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 28,623,124 - 28,670,729 (-) NCBI mRatBN7.2 8 20,347,263 - 20,394,654 (-) NCBI
RefSeq Acc Id:
XM_039081855 ⟹ XP_038937783
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 28,632,872 - 28,670,741 (-) NCBI mRatBN7.2 8 20,356,779 - 20,394,660 (-) NCBI
RefSeq Acc Id:
XM_063265869 ⟹ XP_063121939
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 28,619,855 - 28,670,726 (-) NCBI
RefSeq Acc Id:
XM_063265870 ⟹ XP_063121940
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 8 28,618,523 - 28,664,514 (-) NCBI
Ensembl Acc Id:
ENSRNOP00000075398 ⟸ ENSRNOT00000090424
Ensembl Acc Id:
ENSRNOP00000063161 ⟸ ENSRNOT00000064551
RefSeq Acc Id:
XP_038937780 ⟸ XM_039081852
- Peptide Label:
isoform X3
- UniProtKB:
A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038937779 ⟸ XM_039081851
- Peptide Label:
isoform X2
- UniProtKB:
A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038937778 ⟸ XM_039081850
- Peptide Label:
isoform X1
- UniProtKB:
A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038937782 ⟸ XM_039081854
- Peptide Label:
isoform X6
- UniProtKB:
A6JNU8 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_038937783 ⟸ XM_039081855
- Peptide Label:
isoform X7
Ensembl Acc Id:
ENSRNOP00000079526 ⟸ ENSRNOT00000106365
Ensembl Acc Id:
ENSRNOP00000096113 ⟸ ENSRNOT00000118947
RefSeq Acc Id:
NP_001400840 ⟸ NM_001413911
- Peptide Label:
isoform 2
- UniProtKB:
A0A8I6ANH8 (UniProtKB/TrEMBL), A0A0G2KAH4 (UniProtKB/TrEMBL)
RefSeq Acc Id:
NP_001381273 ⟸ NM_001394344
- Peptide Label:
isoform 1
- UniProtKB:
D3ZY19 (UniProtKB/TrEMBL), A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063121940 ⟸ XM_063265870
- Peptide Label:
isoform X5
- UniProtKB:
A0A8I6ANH8 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063121939 ⟸ XM_063265869
- Peptide Label:
isoform X4
- UniProtKB:
A0A8I6ANH8 (UniProtKB/TrEMBL)
Promoters
RGD ID: 13695791 Promoter ID: EPDNEW_R6315 Type: multiple initiation site Name: Dock6_1 Description: dedicator of cytokinesis 6 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 8 22,874,640 - 22,874,700 EPDNEW
Additional Information
Nomenclature History
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2008-04-30
Dock6
dedicator of cytokinesis 6
Dock6_predicted
dedicator of cytokinesis 6 (predicted)
'predicted' is removed
2292626 APPROVED
2005-01-12
Dock6_predicted
dedicator of cytokinesis 6 (predicted)
Symbol and Name status set to approved
70820 APPROVED
