Angel2 (angel homolog 2) - Rat Genome Database

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Gene: Angel2 (angel homolog 2) Rattus norvegicus
Analyze
Symbol: Angel2
Name: angel homolog 2
RGD ID: 1305056
Description: Predicted to enable 3'-5'-RNA exonuclease activity and mRNA 3'-UTR binding activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Predicted to be located in Cajal body and cytoplasm. Orthologous to human ANGEL2 (angel homolog 2); INTERACTS WITH 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: angel homolog 2 (Drosophila); LOC305035; RGD1305056; similar to D1Ertd396e protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,041,727 - 105,060,640 (+)NCBIGRCr8
mRatBN7.213102,509,111 - 102,529,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13102,510,589 - 102,529,493 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13105,030,677 - 105,049,589 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013106,414,651 - 106,433,563 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013103,629,646 - 103,648,559 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013109,505,021 - 109,520,976 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13109,505,697 - 109,520,419 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,107,705 - 114,122,390 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413107,013,927 - 107,030,231 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113107,193,936 - 107,219,345 (+)NCBI
Celera13101,982,099 - 101,997,573 (+)NCBICelera
Cytogenetic Map13q27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Cajal body  (ISO)
cytoplasm  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090   PMID:17178830   PMID:22547059  


Genomics

Comparative Map Data
Angel2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813105,041,727 - 105,060,640 (+)NCBIGRCr8
mRatBN7.213102,509,111 - 102,529,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13102,510,589 - 102,529,493 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13105,030,677 - 105,049,589 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013106,414,651 - 106,433,563 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013103,629,646 - 103,648,559 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013109,505,021 - 109,520,976 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13109,505,697 - 109,520,419 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013114,107,705 - 114,122,390 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413107,013,927 - 107,030,231 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113107,193,936 - 107,219,345 (+)NCBI
Celera13101,982,099 - 101,997,573 (+)NCBICelera
Cytogenetic Map13q27NCBI
ANGEL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381212,992,182 - 213,015,867 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1212,992,182 - 213,015,867 (-)EnsemblGRCh38hg38GRCh38
GRCh371213,165,524 - 213,189,209 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361211,232,147 - 211,255,791 (-)NCBINCBI36Build 36hg18NCBI36
Celera1186,387,057 - 186,410,696 (-)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1183,840,467 - 183,864,032 (-)NCBIHuRef
CHM1_11214,437,848 - 214,461,486 (-)NCBICHM1_1
T2T-CHM13v2.01212,235,291 - 212,258,971 (-)NCBIT2T-CHM13v2.0
Angel2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391190,657,305 - 190,679,160 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1190,657,309 - 190,679,159 (+)EnsemblGRCm39 Ensembl
GRCm381190,925,108 - 190,946,963 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1190,925,112 - 190,946,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv371192,752,424 - 192,769,617 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361192,629,160 - 192,646,353 (+)NCBIMGSCv36mm8
Celera1197,853,114 - 197,870,579 (+)NCBICelera
Cytogenetic Map1H6NCBI
cM Map196.28NCBI
Angel2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554064,589,849 - 4,606,380 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554064,589,849 - 4,606,380 (+)NCBIChiLan1.0ChiLan1.0
ANGEL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2136,392,367 - 36,416,437 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1136,356,583 - 36,380,668 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01188,554,632 - 188,578,497 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11193,412,133 - 193,435,331 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1193,412,133 - 193,435,331 (-)Ensemblpanpan1.1panPan2
ANGEL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1711,112,077 - 11,130,736 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl711,114,059 - 11,152,197 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha710,686,404 - 10,705,716 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0710,817,075 - 10,836,911 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl710,818,475 - 10,858,587 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1710,738,709 - 10,757,956 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0710,841,569 - 10,860,879 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0710,964,881 - 10,984,711 (-)NCBIUU_Cfam_GSD_1.0
Angel2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934463,365,323 - 63,380,659 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936557605,569 - 623,291 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936557605,609 - 621,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANGEL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9130,453,920 - 130,474,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19130,453,912 - 130,476,383 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29143,380,854 - 143,399,675 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANGEL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12516,539,560 - 16,565,986 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2516,539,770 - 16,560,574 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605517,034,465 - 17,060,857 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Angel2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477118,336,190 - 18,353,087 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477118,334,720 - 18,353,080 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Angel2
94 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:460
Count of miRNA genes:251
Interacting mature miRNAs:304
Transcripts:ENSRNOT00000005084
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 33 48 32 19 32 4 4 74 35 38 11 4
Low 10 9 9 9 4 7 3 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005084   ⟹   ENSRNOP00000005084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13102,510,589 - 102,529,493 (+)Ensembl
Rnor_6.0 Ensembl13109,505,697 - 109,520,419 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109060   ⟹   ENSRNOP00000083532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl13102,515,191 - 102,529,493 (+)Ensembl
RefSeq Acc Id: NM_001135119   ⟹   NP_001128591
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,044,636 - 105,060,095 (+)NCBI
mRatBN7.213102,513,497 - 102,528,956 (+)NCBI
Rnor_6.013109,505,697 - 109,520,431 (+)NCBI
Rnor_5.013114,107,705 - 114,122,390 (+)NCBI
RGSC_v3.413107,013,927 - 107,030,231 (+)RGD
Celera13101,982,099 - 101,997,573 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401388   ⟹   NP_001388317
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,041,728 - 105,060,640 (+)NCBI
mRatBN7.213102,510,589 - 102,529,501 (+)NCBI
RefSeq Acc Id: XM_006250462   ⟹   XP_006250524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,044,825 - 105,060,637 (+)NCBI
mRatBN7.213102,513,686 - 102,529,501 (+)NCBI
Rnor_6.013109,505,935 - 109,520,976 (+)NCBI
Rnor_5.013114,107,705 - 114,122,390 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090820   ⟹   XP_038946748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,042,025 - 105,060,637 (+)NCBI
mRatBN7.213102,510,970 - 102,529,501 (+)NCBI
RefSeq Acc Id: XM_039090821   ⟹   XP_038946749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,042,026 - 105,060,637 (+)NCBI
mRatBN7.213102,510,894 - 102,529,501 (+)NCBI
RefSeq Acc Id: XM_039090822   ⟹   XP_038946750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,042,319 - 105,060,637 (+)NCBI
mRatBN7.213102,511,182 - 102,529,501 (+)NCBI
RefSeq Acc Id: XM_039090823   ⟹   XP_038946751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,042,612 - 105,060,637 (+)NCBI
mRatBN7.213102,511,473 - 102,529,501 (+)NCBI
RefSeq Acc Id: XM_039090824   ⟹   XP_038946752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,041,727 - 105,056,927 (+)NCBI
mRatBN7.213102,509,111 - 102,525,791 (+)NCBI
RefSeq Acc Id: XM_039090825   ⟹   XP_038946753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813105,050,698 - 105,060,637 (+)NCBI
mRatBN7.213102,519,559 - 102,529,501 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001128591   ⟸   NM_001135119
- Peptide Label: isoform 1
- UniProtKB: A6JGX6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250524   ⟸   XM_006250462
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZZF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005084   ⟸   ENSRNOT00000005084
RefSeq Acc Id: XP_038946752   ⟸   XM_039090824
- Peptide Label: isoform X3
- UniProtKB: A6JGX7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946749   ⟸   XM_039090821
- Peptide Label: isoform X1
- UniProtKB: A6JGX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946748   ⟸   XM_039090820
- Peptide Label: isoform X1
- UniProtKB: A6JGX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946750   ⟸   XM_039090822
- Peptide Label: isoform X1
- UniProtKB: A6JGX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946751   ⟸   XM_039090823
- Peptide Label: isoform X1
- UniProtKB: A6JGX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946753   ⟸   XM_039090825
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000083532   ⟸   ENSRNOT00000109060
RefSeq Acc Id: NP_001388317   ⟸   NM_001401388
- Peptide Label: isoform 2
- UniProtKB: F1LT13 (UniProtKB/TrEMBL)
Protein Domains
Endonuclease/exonuclease/phosphatase   Protein angel homolog 2 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LT13-F1-model_v2 AlphaFold F1LT13 1-522 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305056 AgrOrtholog
BioCyc Gene G2FUF-16873 BioCyc
Ensembl Genes ENSRNOG00000003795 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005084 ENTREZGENE
  ENSRNOT00000005084.8 UniProtKB/TrEMBL
  ENSRNOT00000109060.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.10.10 UniProtKB/TrEMBL
InterPro ANGEL2_N UniProtKB/TrEMBL
  Endo/exonu/phosph_ase_sf UniProtKB/TrEMBL
  Endo/exonuclease/phosphatase UniProtKB/TrEMBL
KEGG Report rno:305035 UniProtKB/TrEMBL
NCBI Gene 305035 ENTREZGENE
PANTHER CARBON CATABOLITE REPRESSOR PROTEIN 4 UniProtKB/TrEMBL
  PROTEIN ANGEL HOMOLOG 2 UniProtKB/TrEMBL
Pfam DUF5922 UniProtKB/TrEMBL
  Exo_endo_phos UniProtKB/TrEMBL
PhenoGen Angel2 PhenoGen
RatGTEx ENSRNOG00000003795 RatGTEx
Superfamily-SCOP Exo_endo_phos UniProtKB/TrEMBL
UniProt A0A8I5ZZF9 ENTREZGENE, UniProtKB/TrEMBL
  A6JGX6 ENTREZGENE, UniProtKB/TrEMBL
  A6JGX7 ENTREZGENE, UniProtKB/TrEMBL
  F1LT13 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-06 Angel2  angel homolog 2  Angel2  angel homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Angel2  angel homolog 2 (Drosophila)   Angel2_predicted  angel homolog 2 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Angel2_predicted  angel homolog 2 (Drosophila) (predicted)  RGD1305056_predicted  similar to D1Ertd396e protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1305056_predicted  similar to D1Ertd396e protein (predicted)  LOC305035_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC305035_predicted  similar to D1Ertd396e protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL