Dapk2 (death-associated protein kinase 2) - Rat Genome Database

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Gene: Dapk2 (death-associated protein kinase 2) Rattus norvegicus
Analyze
Symbol: Dapk2
Name: death-associated protein kinase 2
RGD ID: 1304708
Description: Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and identical protein binding activity. Predicted to be involved in several processes, including anoikis; positive regulation of granulocyte chemotaxis; and regulation of apoptotic process. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and nucleus. Orthologous to human DAPK2 (death associated protein kinase 2); INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: death-associated kinase 2; LOC300799; MGC109553
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8875,601,621 - 75,720,619 (+)NCBIGRCr8
mRatBN7.2866,706,536 - 66,825,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl866,706,609 - 66,825,567 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx872,218,993 - 72,338,006 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0870,492,045 - 70,611,049 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0868,362,023 - 68,481,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0871,822,107 - 71,941,941 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl871,822,129 - 71,941,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0871,490,902 - 71,610,445 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4870,539,831 - 70,566,213 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1870,558,884 - 70,585,265 (+)NCBI
Celera866,187,713 - 66,213,741 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dapk2RatBloom syndrome  ISODAPK2 (Homo sapiens)8554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
Dapk2Ratcolorectal cancer  ISODAPK2 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial colorectal cancerClinVarPMID:28492532
Dapk2Ratnemaline myopathy 6  ISODAPK2 (Homo sapiens)8554872ClinVar Annotator: match by term: Nemaline myopathy 6ClinVarPMID:21681106 and PMID:24525055
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dapk2Ratacute promyelocytic leukemia  ISODAPK2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28978663
Dapk2RatHepatomegaly  ISODAPK2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28108177

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dapk2Rat1,1-dichloroethene increases expressionISODapk2 (Mus musculus)6480464vinylidene chloride results in increased expression of DAPK2 mRNACTDPMID:26682919
Dapk2Rat1,2-dimethylhydrazine multiple interactionsISODapk2 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of DAPK2 mRNACTDPMID:22206623
Dapk2Rat17beta-estradiol multiple interactionsISODAPK2 (Homo sapiens)6480464EGF protein promotes the reaction [Estradiol results in increased expression of DAPK2 mRNA]CTDPMID:24758408
Dapk2Rat17beta-estradiol decreases expressionISODapk2 (Mus musculus)6480464Estradiol results in decreased expression of DAPK2 mRNACTDPMID:19484750 and PMID:39298647
Dapk2Rat17beta-estradiol increases expressionISODAPK2 (Homo sapiens)6480464Estradiol results in increased expression of DAPK2 mRNACTDPMID:23373633 more ...
Dapk2Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionEXP 64804642 more ...CTDPMID:31020377 and PMID:32895711
Dapk2Rat2,3',4,4',5-Pentachlorobiphenyl affects expressionEXP 64804642 more ...CTDPMID:31020377
Dapk2Rat2,3',4,4',5-Pentachlorobiphenyl multiple interactionsEXP 64804641-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole inhibits the reaction [2 more ...CTDPMID:31020377 and PMID:32895711
Dapk2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of DAPK2 mRNA]CTDPMID:21215274
Dapk2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of DAPK2 mRNACTDPMID:33387578
Dapk2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of DAPK2 mRNACTDPMID:34747641
Dapk2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISODapk2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of DAPK2 mRNACTDPMID:15310856 more ...
Dapk2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISODapk2 (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of DAPK2 mRNACTDPMID:25975270
Dapk2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of DAPK2 mRNACTDPMID:21215274
Dapk2Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of DAPK2 mRNACTDPMID:21346803
Dapk2Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISODapk2 (Mus musculus)6480464tetrabromobisphenol A results in decreased expression of DAPK2 mRNACTDPMID:25172293
Dapk2Rat3-methylcholanthrene multiple interactionsISODapk2 (Mus musculus)6480464[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of DAPK2 mRNACTDPMID:23519560
Dapk2Rat4,4'-sulfonyldiphenol decreases expressionISODapk2 (Mus musculus)6480464bisphenol S results in decreased expression of DAPK2 mRNACTDPMID:39298647
Dapk2Rat4-amino-2,6-dinitrotoluene affects expressionEXP 64804644-amino-2 and 6-dinitrotoluene affects the expression of DAPK2 mRNACTDPMID:21346803
Dapk2Rat4-hydroxyphenyl retinamide increases expressionISODapk2 (Mus musculus)6480464Fenretinide results in increased expression of DAPK2 mRNACTDPMID:28973697

1 to 20 of 102 rows

Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dapk2Ratanoikis involved_inISODAPK2 (Homo sapiens)1624291 PMID:18957423RGDPMID:18957423
Dapk2Ratanoikis involved_inIEAUniProtKB:Q9UIK4 and ensembl:ENSP000004082771600115GO_REF:0000107EnsemblGO_REF:0000107
Dapk2Ratintracellular signal transduction involved_inISODAPK2 (Homo sapiens)1624291 PMID:10376525RGDPMID:10376525
Dapk2Ratintracellular signal transduction involved_inIEAUniProtKB:Q9UIK4 and ensembl:ENSP000004082771600115GO_REF:0000107EnsemblGO_REF:0000107
Dapk2Ratintracellular signal transduction involved_inIBAMGI:1203520 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dapk2Ratneutrophil migration involved_inISODapk2 (Mus musculus)1624291 PMID:24163421RGDPMID:24163421
Dapk2Ratpositive regulation of apoptotic process involved_inIBAPANTHER:PTN000678761 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dapk2Ratpositive regulation of eosinophil chemotaxis involved_inISODAPK2 (Homo sapiens)1624291 PMID:24163421RGDPMID:24163421
Dapk2Ratpositive regulation of eosinophil chemotaxis involved_inIEAUniProtKB:Q9UIK4 and ensembl:ENSP000004082771600115GO_REF:0000107EnsemblGO_REF:0000107
Dapk2Ratpositive regulation of neutrophil chemotaxis involved_inISODAPK2 (Homo sapiens)1624291 PMID:24163421RGDPMID:24163421
Dapk2Ratpositive regulation of neutrophil chemotaxis involved_inIEAUniProtKB:Q9UIK4 and ensembl:ENSP000004082771600115GO_REF:0000107EnsemblGO_REF:0000107
Dapk2Ratprotein phosphorylation involved_inISODAPK2 (Homo sapiens)1624291 PMID:10376525RGDPMID:10376525
Dapk2Ratregulation of intrinsic apoptotic signaling pathway involved_inISODAPK2 (Homo sapiens)1624291 PMID:10376525RGDPMID:10376525
Dapk2Ratregulation of intrinsic apoptotic signaling pathway involved_inIEAUniProtKB:Q9UIK4 and ensembl:ENSP000004082771600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 14 of 14 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dapk2Ratcytoplasm is_active_inIBAMGI:1916885 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dapk2Ratcytoplasm located_inIEAUniProtKB:Q9UIK4 and ensembl:ENSP000004082771600115GO_REF:0000107EnsemblGO_REF:0000107
Dapk2Ratcytoplasm located_inISODAPK2 (Homo sapiens)1624291 PMID:10376525 and PMID:10629061RGDPMID:10376525 and PMID:10629061
Dapk2RatGolgi apparatus located_inIEAUniProtKB:Q9UIK4 and ensembl:ENSP000004082771600115GO_REF:0000107EnsemblGO_REF:0000107
Dapk2RatGolgi apparatus located_inISODAPK2 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Dapk2Ratnucleus is_active_inIBAMGI:1203520 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dapk2RatATP binding enablesISODAPK2 (Homo sapiens)1624291 PMID:10376525RGDPMID:10376525
Dapk2RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Dapk2RatATP binding enablesIEAUniProtKB:Q9UIK4 and ensembl:ENSP000004082771600115GO_REF:0000107EnsemblGO_REF:0000107
Dapk2RatATP binding enablesIEAInterPro:IPR000719 and InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Dapk2RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Dapk2Ratcalmodulin binding enablesISODAPK2 (Homo sapiens)1624291 PMID:10376525RGDPMID:10376525
Dapk2Ratcalmodulin binding enablesIEAUniProtKB:Q9UIK4 and ensembl:ENSP000004082771600115GO_REF:0000107EnsemblGO_REF:0000107
Dapk2Ratidentical protein binding enablesISODAPK2 (Homo sapiens)1624291UniProtKB:Q9UIK4 more ...RGDPMID:10629061 and PMID:11230133
Dapk2Ratidentical protein binding enablesIEAUniProtKB:Q9UIK4 and ensembl:ENSP000004082771600115GO_REF:0000107EnsemblGO_REF:0000107
Dapk2Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Dapk2Ratnucleotide binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Dapk2Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Dapk2Ratprotein binding enablesISODAPK2 (Homo sapiens) and UniProtKB:Q9UIK4-21624291UniProtKB:P18848 and PMID:21408167RGDPMID:21408167
Dapk2Ratprotein binding enablesISODAPK2 (Homo sapiens)1624291UniProtKB:P62258 more ...RGDPMID:25416956 more ...
Dapk2Ratprotein kinase activity enablesIEAInterPro:IPR000719 and InterPro:IPR0082711600115GO_REF:0000002InterProGO_REF:0000002
Dapk2Ratprotein serine/threonine kinase activity enablesIBAMGI:1203520 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dapk2Ratprotein serine/threonine kinase activity enablesIEAUniProtKB-KW:KW-07231600115GO_REF:0000043UniProtGO_REF:0000043
1 to 17 of 17 rows


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
PMID:10376525   PMID:10629061   PMID:11230133   PMID:18957423   PMID:24163421   PMID:26334104   PMID:37735821  



Dapk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8875,601,621 - 75,720,619 (+)NCBIGRCr8
mRatBN7.2866,706,536 - 66,825,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl866,706,609 - 66,825,567 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx872,218,993 - 72,338,006 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0870,492,045 - 70,611,049 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0868,362,023 - 68,481,089 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0871,822,107 - 71,941,941 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl871,822,129 - 71,941,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0871,490,902 - 71,610,445 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4870,539,831 - 70,566,213 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1870,558,884 - 70,585,265 (+)NCBI
Celera866,187,713 - 66,213,741 (+)NCBICelera
Cytogenetic Map8q24NCBI
DAPK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381563,907,036 - 64,046,485 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1563,907,036 - 64,072,033 (-)EnsemblGRCh38hg38GRCh38
GRCh371564,199,235 - 64,338,684 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361561,986,288 - 62,125,574 (-)NCBINCBI36Build 36hg18NCBI36
Build 341561,986,288 - 62,125,574NCBI
Celera1541,078,636 - 41,217,972 (-)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1541,023,955 - 41,163,206 (-)NCBIHuRef
CHM1_11564,318,568 - 64,458,052 (-)NCBICHM1_1
T2T-CHM13v2.01561,714,186 - 61,853,651 (-)NCBIT2T-CHM13v2.0
Dapk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39966,065,364 - 66,179,524 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl966,065,505 - 66,179,524 (+)EnsemblGRCm39 Ensembl
GRCm38966,158,226 - 66,272,242 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl966,158,223 - 66,272,242 (+)EnsemblGRCm38mm10GRCm38
MGSCv37966,006,033 - 66,120,049 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36965,956,271 - 66,070,248 (+)NCBIMGSCv36mm8
Celera963,393,700 - 63,507,514 (+)NCBICelera
Cytogenetic Map9CNCBI
cM Map935.75NCBI
Dapk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545011,348,566 - 11,455,582 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545011,348,566 - 11,443,908 (+)NCBIChiLan1.0ChiLan1.0
DAPK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21653,162,740 - 53,301,906 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11557,338,037 - 57,477,043 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01542,860,484 - 42,999,489 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11561,152,553 - 61,284,994 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1561,152,553 - 61,284,990 (-)Ensemblpanpan1.1panPan2
DAPK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13028,440,616 - 28,565,089 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3028,441,161 - 28,565,566 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3028,360,544 - 28,485,020 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03028,614,566 - 28,741,234 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3028,614,643 - 28,740,679 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13028,551,372 - 28,675,829 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03028,613,775 - 28,738,321 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03028,852,337 - 28,976,558 (-)NCBIUU_Cfam_GSD_1.0
Dapk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640106,565,063 - 106,678,970 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647124,412,029 - 24,527,023 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647124,412,035 - 24,527,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAPK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1107,997,293 - 108,132,781 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11107,997,274 - 108,131,723 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21118,993,426 - 119,044,831 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAPK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12619,492,112 - 19,637,453 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048121,762,688 - 121,899,318 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dapk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247818,513,700 - 8,617,883 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247818,507,508 - 8,606,931 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Dapk2
519 total Variants

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:50
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000023372
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 56 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat

1 to 10 of 56 rows
RH129839  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2866,825,313 - 66,825,493 (+)MAPPERmRatBN7.2
Rnor_6.0871,941,688 - 71,941,867NCBIRnor6.0
Rnor_5.0871,610,192 - 71,610,371UniSTSRnor5.0
RGSC_v3.4870,565,960 - 70,566,139UniSTSRGSC3.4
Celera866,213,488 - 66,213,667UniSTS
RH 3.4 Map8839.5UniSTS
Cytogenetic Map8q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000023372   ⟹   ENSRNOP00000023372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl871,914,867 - 71,941,409 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089147   ⟹   ENSRNOP00000070087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl866,706,640 - 66,825,567 (+)Ensembl
Rnor_6.0 Ensembl871,822,129 - 71,941,910 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098258   ⟹   ENSRNOP00000085631
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl866,706,609 - 66,813,431 (+)Ensembl
RefSeq Acc Id: NM_001013109   ⟹   NP_001013127
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,694,648 - 75,720,619 (+)NCBI
mRatBN7.2866,799,592 - 66,825,567 (+)NCBI
Rnor_6.0871,914,769 - 71,941,941 (+)NCBI
Rnor_5.0871,490,902 - 71,610,445 (+)NCBI
RGSC_v3.4870,539,831 - 70,566,213 (+)RGD
Celera866,187,713 - 66,213,741 (+)RGD
Sequence:
RefSeq Acc Id: NM_001395735   ⟹   NP_001382664
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,601,672 - 75,720,619 (+)NCBI
mRatBN7.2866,706,590 - 66,825,567 (+)NCBI
RefSeq Acc Id: XM_008766241   ⟹   XP_008764463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,601,647 - 75,711,542 (+)NCBI
mRatBN7.2866,706,562 - 66,816,333 (+)NCBI
Rnor_6.0871,822,107 - 71,931,508 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081122   ⟹   XP_038937050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,601,621 - 75,711,542 (+)NCBI
mRatBN7.2866,706,536 - 66,816,333 (+)NCBI
RefSeq Acc Id: XM_039081125   ⟹   XP_038937053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,668,122 - 75,711,542 (+)NCBI
mRatBN7.2866,773,055 - 66,816,333 (+)NCBI
RefSeq Acc Id: XM_039081126   ⟹   XP_038937054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,668,208 - 75,711,542 (+)NCBI
mRatBN7.2866,773,151 - 66,816,333 (+)NCBI
RefSeq Acc Id: XM_063265164   ⟹   XP_063121234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,601,656 - 75,720,071 (+)NCBI
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: NP_001013127   ⟸   NM_001013109
- Peptide Label: isoform 2
- UniProtKB: Q5BJN2 (UniProtKB/TrEMBL),   F1LS59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764463   ⟸   XM_008766241
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GD46 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070087   ⟸   ENSRNOT00000089147
Ensembl Acc Id: ENSRNOP00000023372   ⟸   ENSRNOT00000023372
RefSeq Acc Id: XP_038937050   ⟸   XM_039081122
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GD46 (UniProtKB/TrEMBL)
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX07-F1-model_v2 AlphaFold A0A0G2JX07 1-365 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696086
Promoter ID:EPDNEW_R6610
Type:initiation region
Name:Dapk2_1
Description:death-associated protein kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0871,822,139 - 71,822,199EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-30031 BioCyc
Ensembl Genes ENSRNOG00000017332 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089147 ENTREZGENE
  ENSRNOT00000089147.2 UniProtKB/TrEMBL
  ENSRNOT00000098258 ENTREZGENE
  ENSRNOT00000098258.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Single helix bin UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7325495 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
MGC_CLONE MGC:109553 IMAGE-MGC_LOAD
NCBI Gene 300799 ENTREZGENE
PANTHER DEATH-ASSOCIATED PROTEIN KINASE 2 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE 17 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Dapk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017332 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2JX07 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GD46 ENTREZGENE, UniProtKB/TrEMBL
  A6J5H8 ENTREZGENE, UniProtKB/TrEMBL
  F1LS59 ENTREZGENE
  Q5BJN2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LS59 UniProtKB/TrEMBL
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-01 Dapk2  death-associated protein kinase 2  Dapk2  death-associated kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Dapk2  death-associated kinase 2  Dapk2_predicted  death-associated kinase 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dapk2_predicted  death-associated kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED