Otop3 (otopetrin 3) - Rat Genome Database

Name: Otop3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Otop3 (otopetrin 3) Chinchilla lanigera

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Symbol:

Otop3

Name:

otopetrin 3

RGD ID:

9048711

Description:

ENCODES a protein that exhibits proton channel activity (ortholog); INVOLVED IN proton transmembrane transport (ortholog); FOUND IN plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

otopetrin-3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	OTOP3 (otopetrin 3)	NCBI	Ortholog
Mus musculus (house mouse):	Otop3 (otopetrin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Otop3 (otopetrin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	OTOP3 (otopetrin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	OTOP3 (otopetrin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Otop3 (otopetrin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	OTOP3 (otopetrin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	OTOP3 (otopetrin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Otop3 (otopetrin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955553	1,806,313 - 1,817,698 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955553	1,806,313 - 1,817,515 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

proton transmembrane transport (ISO)

Cellular Component

plasma membrane (ISO)

Molecular Function

protein binding (ISO)

proton channel activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Otop3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955553	1,806,313 - 1,817,698 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955553	1,806,313 - 1,817,515 (+)	NCBI	ChiLan1.0	ChiLan1.0

OTOP3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	74,935,802 - 74,949,992 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	74,935,898 - 74,949,992 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	72,931,897 - 72,946,087 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	70,443,492 - 70,457,106 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	70,443,491 - 70,457,106	NCBI
Celera	17	69,525,122 - 69,538,736 (+)	NCBI		Celera
Cytogenetic Map	17	q25.1	NCBI
HuRef	17	68,342,265 - 68,356,433 (+)	NCBI		HuRef
CHM1_1	17	72,996,714 - 73,010,911 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	75,827,605 - 75,841,795 (+)	NCBI		T2T-CHM13v2.0

Otop3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	115,225,557 - 115,237,753 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	115,225,557 - 115,237,753 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	115,334,731 - 115,346,927 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	115,334,731 - 115,346,927 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	115,196,048 - 115,208,240 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	115,150,869 - 115,163,016 (+)	NCBI		MGSCv36	mm8
Celera	11	127,100,606 - 127,112,806 (+)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	80.84	NCBI

Otop3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	101,076,307 - 101,087,704 (+)	NCBI		GRCr8
mRatBN7.2	10	100,577,346 - 100,588,729 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	100,577,392 - 100,588,726 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	105,637,549 - 105,648,857 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	105,100,608 - 105,111,926 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	100,498,380 - 100,509,713 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	103,887,045 - 103,898,331 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	103,891,369 - 103,898,331 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	104,393,465 - 104,404,614 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	105,412,853 - 105,423,998 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	105,431,699 - 105,438,014 (+)	NCBI
Celera	10	99,152,946 - 99,164,011 (+)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

OTOP3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	90,971,951 - 90,987,154 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	95,794,959 - 95,810,148 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	68,880,492 - 68,895,449 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	74,437,267 - 74,451,832 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	74,437,350 - 74,451,832 (+)	Ensembl	panpan1.1		panPan2

OTOP3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	5,505,848 - 5,515,157 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	5,506,350 - 5,513,846 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	6,184,104 - 6,197,277 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	6,176,417 - 6,189,531 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	6,176,917 - 6,189,452 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	6,213,582 - 6,226,662 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	6,323,913 - 6,337,105 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	6,384,354 - 6,397,454 (-)	NCBI		UU_Cfam_GSD_1.0

Otop3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	6,127,786 - 6,138,177 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	273,866 - 283,663 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	273,866 - 283,663 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OTOP3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	6,311,696 - 6,322,080 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	6,311,308 - 6,323,038 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	6,296,146 - 6,323,574 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OTOP3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	46,730,412 - 46,745,104 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	46,730,972 - 46,745,021 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	17,516,315 - 17,531,400 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Otop3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	4,772,661 - 4,782,681 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	4,772,600 - 4,783,535 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005412263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01072900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01310917	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000010078 ⟹ ENSCLAP00000009948

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955553	1,806,313 - 1,817,698 (+)	Ensembl

RefSeq Acc Id:

XM_005412263 ⟹ XP_005412320

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955553	1,806,313 - 1,817,515 (+)	NCBI

Sequence:

show sequence

GAGGGCGCCAGAGCCGCACCTGGATGGACGGCCAGCGCTGCACTGTCGGTGGTCAGCCCGCGGC
GATGCCCTCCCAGGCTTCAGCCCCTGCTGACACTCCACCCATGGCCTCTCTAGAAGCACAGGAG
ACTGAAGCAACTCCAGTCAAGGAGGATCAGATGGACTTGGAGGCCAAGGAGACAGGGTACCCAG
GCCCAGCACGGCAGCAGTCCTGGCTGGGGCGCCATTGGTTCCTGCTGCTGCGGCGGGACCGGCA
GGCGCAGAAGGCTGGGCAGCTCTTCTCGGGGCTCCTGGCCCTCAACGTGGTGTTCTTGGGTGGG
GCCTTCATTGGCAGCATGATCTTCAACAATGTGTCCATCACCCTGGGCGATGTGTGGATCCTGC
TGGCTGCACTGAAGGCACTGTCCCTCCTCTGGCTCCTGTACTACACAGTGGGCACCACGCGGCG
GCCCCATGCAGTGCTCCATCGAGACCCTCATGCGGGACCCGTCTGGGTGCGGGGCTCTCTGGTG
CTCTTTGGCAGCTGCACCATCTGCCTCAATGTCTTCCGCATCGGCTATGACGTGAGCCACAGCC
ACTGCAAGTCACAGGTGGAGCTTGTCTTCCCAGCCATCGAGATCGTCTTCATGGGCTTCCAGAC
CTGGGTGCTCTGGAAACATTGTAAGGACTGCGTTCAAATCCAGACCAATCTCACTAGGTGTGGC
TTGATGCTGACCCTGGCCACAAACCTGCTGCTGTGGGTTCTGGCCGTGACCAACGACTCCATGC
ACCAAGAGATCGAGGCTGAGCTCAACGCCATCATGGAGAAGTTCTCAGGCAACGGCACCAACAC
CTGTCTGTGCCTCAACGGCACAGTGTGCGAGGTCTTCCGGAAGGGCTACCTGATGCTCTATCCC
TTCAGCACTGAGTATTGCCTCATCTGCTGCGCTGTGCTCTTCGTCATGTGGAAGAATGTAGGCC
GCCGGCTGGCAGCCCACGTGGGCGCGCACCCCAGCTCCCCGCCCTTCCGCCTACACGGGGCCAT
CTTTGGGCCGCTGCTGGGCCTGCTGGTGCTGGTGGCAGGCATGTGCGTCTTTGTGCTCTTCCAG
ATCGAGGCGAGTGGCCCCAACATTGCCCGCCAGTACTTTACCCTCTACTACGCCTTCTACGTGG
CTGTGCTGCCGGCCATGAGCCTGGCATGCCTGGCAGGCACGGCTATCCACGGGCTGGAGGAGCG
TGAGCTGGACACACTCAAGAACCCTACTCGCAGCCTGGATGTGGTGCTGCTGATGGGCGCTGCC
CTCGGCCAGATGGGCATCGCCTACTTCTCCATCGTGGCCATTGTAGCCACTCACCCCAGTGAGC
TGCTCAACCAGCTCATCCTGGCCTACTCGCTGCTGCTCATCCTGCAGCACATCAGCCAGAACCT
CTTCATCATCGAGGGCCTGCACCGCCGCCCACTGTGGGAGGCGGCTCCCCGGGGCCTGGCAGAG
AAGCCAGAGGCCGAGCACTCCCGCAGGGGCTCCCTGCTGGAGCTGGGCCAGGACCTGCGGAGGG
CCTCCCTGGCCTACATCCACTCCTACAGCCACCTCAACTGGAGGCGGCGCATCCTCAAGGAGAT
CTCACTCTTTCTCATCCTCTGCAATATCACACTGTGGATGATGCCTGCGTTTGGCATCCACCCG
GAGTTCGAAAATGGCCTGGAGAAGGAATTCTACGGCTATCGAACATGGTTCACCATTGTCAATT
TTGGCCTGCCCCTGGGGGTCTTCTACCGCATGCACTCTGTCGGGGGGCTGGTAGAGGTCTACTT
GGGGGCCTGAGCTTTCCAAAACACCCACTCTCAGCAGCACCCCAAAAAACCAAGGCAGGGGAAA
TGCCAAGTCTCTGGGCAGCTGGCTCATTCCAAGAGGTGCAGAGGCCCCCCAAGCCTGCCCCTTC
CTGAGAGAGGAGGGTACTGCCGGTAGCCCAAGACCAAGGCCAGAGCCTAGATACAGCTTTGGAT
GCCCACTCCCAGGCCTGGGCACATGCCTGCCTCCTGTCTTACCATCACAATCTGTGCAGCATAG
GCTGCATGCACCTCAGAAAGCTGTCAAGGACCCCCACCGCTACTCTCGGAAAGAGTCAGATCTA
AATAATAGAACCAGGGGTGCAGGAGGGGGCACCCTTCTCCAGCCAGGCCTCAGGGCCGGCCTCC
TCCTACGAGGGCCATGGAGTCCAAGCTTGGCCCAGAACATCCAGGGAGATCAGAGGTCCAGCTC
CAAGCTCTGCAAGCAGCCCTGCCCCGCTCTCCCCACACGCCCAGTCTTCTAATGAGCTAATTAA
TTAGCTGCCAGGCGGGGCTCAACAGCTCTCTCTTGCTACCATAAACACTGTTTGTTTGATCGAT
TGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005412320	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000009948
	ENSCLAP00000009948.1

RefSeq Acc Id:

XP_005412320 ⟸ XM_005412263

- UniProtKB:

A0A8C2YMP6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDGQRCTVGGQPAAMPSQASAPADTPPMASLEAQETEATPVKEDQMDLEAKETGYPGPARQQSW
LGRHWFLLLRRDRQAQKAGQLFSGLLALNVVFLGGAFIGSMIFNNVSITLGDVWILLAALKALS
LLWLLYYTVGTTRRPHAVLHRDPHAGPVWVRGSLVLFGSCTICLNVFRIGYDVSHSHCKSQVEL
VFPAIEIVFMGFQTWVLWKHCKDCVQIQTNLTRCGLMLTLATNLLLWVLAVTNDSMHQEIEAEL
NAIMEKFSGNGTNTCLCLNGTVCEVFRKGYLMLYPFSTEYCLICCAVLFVMWKNVGRRLAAHVG
AHPSSPPFRLHGAIFGPLLGLLVLVAGMCVFVLFQIEASGPNIARQYFTLYYAFYVAVLPAMSL
ACLAGTAIHGLEERELDTLKNPTRSLDVVLLMGAALGQMGIAYFSIVAIVATHPSELLNQLILA
YSLLLILQHISQNLFIIEGLHRRPLWEAAPRGLAEKPEAEHSRRGSLLELGQDLRRASLAYIHS
YSHLNWRRRILKEISLFLILCNITLWMMPAFGIHPEFENGLEKEFYGYRTWFTIVNFGLPLGVF
YRMHSVGGLVEVYLGA

hide sequence

Ensembl Acc Id:

ENSCLAP00000009948 ⟸ ENSCLAT00000010078

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000006891	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000010078	ENTREZGENE
	ENSCLAT00000010078.1	UniProtKB/TrEMBL
InterPro	Otopetrin	UniProtKB/TrEMBL
NCBI Gene	Otop3	ENTREZGENE
PANTHER	PROTON CHANNEL OTOP3	UniProtKB/TrEMBL
	PTHR21522	UniProtKB/TrEMBL
Pfam	Otopetrin	UniProtKB/TrEMBL
UniProt	A0A8C2YMP6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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