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Gene: Tespa1 (thymocyte expressed, positive selection associated 1) Chinchilla lanigera

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Symbol:

Tespa1

Name:

thymocyte expressed, positive selection associated 1

RGD ID:

9021951

Description:

ENCODES a protein that exhibits phospholipase binding (ortholog); INVOLVED IN COP9 signalosome assembly (ortholog); positive regulation of T cell differentiation in thymus (ortholog); positive regulation of T cell receptor signaling pathway (ortholog); FOUND IN COP9 signalosome (ortholog); cytoplasm (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	2,084,868 - 2,108,335 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	2,084,931 - 2,108,328 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

COP9 signalosome assembly (ISO)

positive regulation of T cell differentiation in thymus (ISO)

positive regulation of T cell receptor signaling pathway (ISO)

protein localization (ISO)

regulation of T cell receptor signaling pathway (ISO)

T cell differentiation in thymus (ISO)

TCR signalosome assembly (ISO)

Cellular Component

COP9 signalosome (ISO)

cytoplasm (ISO)

cytosol (ISO)

TCR signalosome (ISO)

Molecular Function

phospholipase binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Tespa1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	2,084,868 - 2,108,335 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	2,084,931 - 2,108,328 (-)	NCBI	ChiLan1.0	ChiLan1.0

TESPA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	54,948,015 - 54,985,188 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	54,948,015 - 54,984,762 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	55,341,799 - 55,378,546 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	53,630,196 - 53,661,889 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	54,995,725 - 55,030,320 (-)	NCBI		Celera
Cytogenetic Map	12	q13.2	NCBI
HuRef	12	52,380,944 - 52,417,339 (-)	NCBI		HuRef
CHM1_1	12	55,308,992 - 55,345,430 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	54,914,643 - 54,951,806 (-)	NCBI		T2T-CHM13v2.0

Tespa1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	130,158,696 - 130,199,338 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	130,158,739 - 130,199,980 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	130,322,826 - 130,363,469 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	130,322,870 - 130,364,111 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	129,759,908 - 129,799,698 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	129,750,238 - 129,765,586 (+)	NCBI		MGSCv36	mm8
Celera	10	132,697,226 - 132,737,126 (+)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	77.85	NCBI

TESPA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	39,192,237 - 39,226,747 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	39,189,006 - 39,223,516 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	33,765,283 - 33,800,883 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	34,503,099 - 34,527,627 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	34,492,311 - 34,527,627 (+)	Ensembl	panpan1.1		panPan2

TESPA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	424,836 - 460,114 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	424,715 - 460,097 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	45,785,344 - 45,820,607 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	430,147 - 465,443 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	430,145 - 465,443 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	424,573 - 459,831 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	433,043 - 468,280 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	46,190,588 - 46,225,895 (-)	NCBI		UU_Cfam_GSD_1.0

Tespa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	60,858,971 - 60,887,735 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936891	512,671 - 534,025 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936891	512,882 - 549,676 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TESPA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	19,904,237 - 20,017,433 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	19,966,623 - 20,017,476 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	20,833,623 - 20,879,675 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TESPA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	51,044,269 - 51,079,210 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	51,042,095 - 51,070,939 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	194,955,965 - 194,991,852 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tespa1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624983	31,766 - 45,077 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624983	31,552 - 47,575 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013521032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01047214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01266984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000016085 ⟹ ENSCLAP00000015921

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955458	2,084,868 - 2,108,335 (-)	Ensembl

RefSeq Acc Id:

XM_013521032 ⟹ XP_013376486

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955458	2,084,931 - 2,108,328 (-)	NCBI

Sequence:

show sequence

GCTGGCAACAGCGGTTGAATGAGAACAGAGACAAAGGCACAATTTACACCATGAGATTGTCCTA
CTCTCCTGGCCCCTCTCCCCAAATTTGGGAAGGGCTCTGCTCAGCTGTGAGAACTGCTTTACCT
CAAACTCGGCTCTCTACCAGCAGACAGATTCTGCTTGAAGCATAGCAACAGAGAAGAGGAGAGG
CCTGTCTGACCCACATCCCTGGGAGGAGGTGGAGAGCTGTGAAGATTGGGCCTTAGAGACCAAG
AGACTAAGGGGCAGGAGAAAGTCTGCATTATATAAAGGAAGAAAGTGCATGCACAGGACCTGGA
ATTTACAACTCTGAGTCCATTTACAACCACTAACACTCTATGTGACTCCAGACTTGAGACCAGT
TGTTGCCTTTTCAAGGAACAAATTATCCCACCGCACCTGAATTGCTTAGCAAATGACCGCCCTT
CACAGACATCATTAAGGTGGTGGGAGATCCTGACGTGTGAACCGGGACCATGGAGGCCTCTGTG
CTGAGCCCCACCTCCTGGGAGAAGCGGCAAGCTTGGCTCCGTCAGAGCCGTAACTGGCAGACGC
AGGTCCTGGAAGAGGAAGCTGCAGCCGCCCTGCAGGATGTCCCAGACCCTGAGCCTTCAAGCCT
AGATGATGTTTTCCATGAAGGAAATCCAATCAACAAGATTGAAAACTGGCTTCAGGACTGCAGA
GACTCTGAAGAGGGGTTTTCTGAGGAATCTAGACAACCCATCTACAATGGGTTCTCCAGCCATG
GAACCAGTTTTGAAGATGACTTGATGCTTGGAGCAGAGGCCACACTGCTGGCCGCTAATGACAA
ACTCTTCTCCAGGAGTTTCCTCCAGACATCCAAGCCTTGCCAGCTACTTGATCTTGGCTGTAGT
TTGGCTTCCAGCTGCATGACTGGTGGAACCAACAAGACTAGTTCAAGCATTTCAGAGATTCTAG
ACCAGGTGCAAGAGGATGCAGAAGATGTCCTCTTCAGTCTAGGCTTTGGCCAAGAGGACCACAA
AGACACTACTCGGATCCCCGCAAGATTTTTCACCAACCCCTCTCAGGCCAAGGGCATTGATTTC
CAGCTCTTCTTAAAGGCACAGGTGCGGAGGATCGAGATGGAGGACCCCTGCCTCATGCTGGCCA
GCAGGTTTAAGCAGGTGCAAACACTGGCTGCTACTGCGGATGCCTTCTTCTGTCTCTACTCCTA
TGTGTCCAAGACACCTGTTCAAAAGTTCACACCATCCCACATGTTCTGGAACTGCGACCCAACC
GATGTGCCATCCATCAGGATTTTGGCCCCAGAGCCTGAACCCCACTCACCGAGGGAGCGCCTGC
GGAAAGCCATCTCCAAAATGTGCCTGTACACAGGTTCCCGAGACCAGCTGTCACCATCCCACAA
CACCCCCAAGAGGAACAGTTTGGACCAAGTGGTTTGGGAAGTGATGGACAGAGTGAGAGGAGAG
AAGGTAAATCTCCAGCAAGGCTCTGAGTTTGGGCAAGGCCCACAGGCAGGTACTGAGCCCCCTA
CAGGAAACACAGAGCTGCCCGCTTCTTCCTCTCCATGTGCCCTTTGCCCCAAAGTGGAAACATG
GCAAAGGATGTCCGCAGTGCTGGCACCATCACAGACTCTGGACTCTAACCCTGAGGAGCCCTAC
TGCACACAATCTGTAGCAGGAGCATTTCCACAGTGGAGCATAAACCCTGTGGAGGTCATAAGAG
AGCCGTGTGGCCTGCAGTCCACTGATATGGAAGACCATTCAGCCAAGAATGAGACTTTCTGGAA
AAGAAAGACCAAAGCAAGAAAGAGTCTATTTTAAAACACTCCTCTGGACAAAAAGGGTTAGTCA
CTGCGCCTGTCCGTCATCCAGCAACAAAGGAAGAAGAGCCGAGACAGAACAGAACTGCACCAAT
CCCTAACCCAGCAGCTTCAGGGCACATTTGACTTAGAAGAGATGAGTGAATTGGAGGTGAGGGA
GAGACTGCAAAAGAAAAGCTCTGAATGCTTGTGCAGAAAATGAAAGAGTCGAGCCCTTGAGCAA
AGGAGATACAGGTATTTTGTTCTTGGCCAATGTACTACTTCATGAATTAAACTCAGGTACTTGT
CGGGATGGGTTAATAAAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013376486	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000015921
	ENSCLAP00000015921.1

RefSeq Acc Id:

XP_013376486 ⟸ XM_013521032

- UniProtKB:

A0A8C2VK93 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEASVLSPTSWEKRQAWLRQSRNWQTQVLEEEAAAALQDVPDPEPSSLDDVFHEGNPINKIENW
LQDCRDSEEGFSEESRQPIYNGFSSHGTSFEDDLMLGAEATLLAANDKLFSRSFLQTSKPCQLL
DLGCSLASSCMTGGTNKTSSSISEILDQVQEDAEDVLFSLGFGQEDHKDTTRIPARFFTNPSQA
KGIDFQLFLKAQVRRIEMEDPCLMLASRFKQVQTLAATADAFFCLYSYVSKTPVQKFTPSHMFW
NCDPTDVPSIRILAPEPEPHSPRERLRKAISKMCLYTGSRDQLSPSHNTPKRNSLDQVVWEVMD
RVRGEKVNLQQGSEFGQGPQAGTEPPTGNTELPASSSPCALCPKVETWQRMSAVLAPSQTLDSN
PEEPYCTQSVAGAFPQWSINPVEVIREPCGLQSTDMEDHSAKNETFWKRKTKARKSLF

hide sequence

Ensembl Acc Id:

ENSCLAP00000015921 ⟸ ENSCLAT00000016085

Protein Domains

ITPR-interacting

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000010955	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000016085	ENTREZGENE
	ENSCLAT00000016085.1	UniProtKB/TrEMBL
InterPro	ITPR-bd	UniProtKB/TrEMBL
	TESPA1-like	UniProtKB/TrEMBL
NCBI Gene	Tespa1	ENTREZGENE
PANTHER	PTHR17469	UniProtKB/TrEMBL
	PTHR17469:SF1	UniProtKB/TrEMBL
Pfam	KRAP_IP3R_bind	UniProtKB/TrEMBL
SMART	KRAP_IP3R_bind	UniProtKB/TrEMBL
UniProt	A0A8C2VK93	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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