Trim69 (tripartite motif containing 69)

Gene: Trim69 (tripartite motif containing 69) Chinchilla lanigera

Analyze

Symbol:

Trim69

Name:

tripartite motif containing 69

RGD ID:

8999932

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN protein localization to centrosome (ortholog); ASSOCIATED WITH AGAT deficiency (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); nuclear speck (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

E3 ubiquitin-protein ligase TRIM69

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	8,376,370 - 8,394,540 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	8,376,449 - 8,394,651 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

AGAT deficiency (ISO)

Bloom syndrome (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 11 (ISO)

multisystem inflammatory syndrome in children (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

protein localization to centrosome (ISO)

Cellular Component

centrosome (ISO)

cytoplasm (ISO)

nuclear speck (ISO)

nucleus (ISO)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

ubiquitin protein ligase activity (ISO)

ubiquitin-protein transferase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Trim69
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	8,376,370 - 8,394,540 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	8,376,449 - 8,394,651 (-)	NCBI	ChiLan1.0	ChiLan1.0

TRIM69
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	44,736,528 - 44,767,827 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	44,728,988 - 44,767,829 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	45,028,726 - 45,060,025 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	42,815,852 - 42,847,317 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	42,816,013 - 42,847,317	NCBI
Celera	15	21,918,324 - 21,949,771 (+)	NCBI		Celera
Cytogenetic Map	15	q21.1	NCBI
HuRef	15	21,852,178 - 21,883,615 (+)	NCBI		HuRef
CHM1_1	15	45,146,891 - 45,178,340 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	42,544,526 - 42,575,817 (+)	NCBI		T2T-CHM13v2.0

Trim69
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	121,991,189 - 122,009,503 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	121,991,181 - 122,009,508 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	122,160,708 - 122,179,022 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	122,160,700 - 122,179,027 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	121,986,436 - 122,004,763 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	121,852,141 - 121,870,468 (+)	NCBI		MGSCv36	mm8
Celera	2	123,308,034 - 123,327,541 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	60.55	NCBI

Trim69
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	129,565,060 - 129,585,629 (+)	NCBI		GRCr8
mRatBN7.2	3	109,111,468 - 109,135,255 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	109,111,468 - 109,132,037 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	112,785,242 - 112,805,687 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	121,380,762 - 121,401,207 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	119,041,138 - 119,061,583 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	114,103,011 - 114,123,293 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	114,102,875 - 114,126,523 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	120,642,563 - 120,663,689 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	108,943,306 - 108,963,931 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	108,848,878 - 108,869,504 (+)	NCBI
Celera	3	108,009,507 - 108,030,026 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

TRIM69
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	33,977,895 - 34,016,873 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	38,140,424 - 38,179,170 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	23,691,927 - 23,724,349 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	41,861,525 - 41,893,069 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	41,861,525 - 41,893,069 (+)	Ensembl	panpan1.1		panPan2

TRIM69
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	11,363,995 - 11,408,494 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	11,364,075 - 11,408,469 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	11,420,364 - 11,464,924 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	11,500,574 - 11,545,062 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	11,489,319 - 11,545,035 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	11,407,221 - 11,451,416 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	11,529,971 - 11,574,490 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	11,649,226 - 11,693,502 (+)	NCBI		UU_Cfam_GSD_1.0

Trim69
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	89,817,448 - 89,854,180 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	7,665,218 - 7,702,243 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	7,664,655 - 7,702,243 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRIM69
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	126,775,217 - 126,814,508 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	126,775,856 - 126,788,628 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	141,375,185 - 141,415,242 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRIM69
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	38,284,883 - 38,313,874 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	38,284,940 - 38,299,867 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	102,747,263 - 102,775,295 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trim69
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	14,224,366 - 14,252,976 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	14,228,511 - 14,253,128 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005376746	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01009402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01009403	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01009404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01009405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01009406	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01053402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000019218 ⟹ ENSCLAP00000019033

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955409	8,376,370 - 8,394,540 (-)	Ensembl

RefSeq Acc Id:

XM_005376746 ⟹ XP_005376803

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955409	8,376,449 - 8,394,651 (-)	NCBI

Sequence:

show sequence

AGCCCATCCCTAGCAAGCTAACAGGTCCGGCTGCGGGCCGCCGCCGCCCTGAGCTGCGGAGCTG
ATTCAAGTGGCCTGCTCTGCCCCCTGGTGGCCAGATGATCGAGCTTCATGGAGGCACCCTCCAC
AACCTCCTCCGACATCCACCCAGGCGCCCAGGAAGACGACGACTCCGTCTCAGTCACCCGCATC
CCCTCGAAAGTGGCGATGCAGGACATTACTACAGAGCTGCACTGCCCGCTGTGCAAGGACTGGT
TCAGTGACCCCCTCATGCTCAGCTGCGGCCACAACTTCTGCCAAGCCTGCATCCAAAACTTCTG
GAAGCTGGAAGCCAAGGAAACGTTCTGTCCCGAGTGCAAGATGCTGTGTCAGTACAGCAACTGC
ACGTTCAACCTGGTGCTGGAGAAGCTGGTGGAGAAGGTGAAGAGGCTGCCCCTGCTCAAGGACC
AGCCGCAGTGCTCAGAGCACGGCGAGAACCTGAAGCTGTTCAGCAAGCCGGACGGGAAGCTGGT
CTGCTTCCAGTGCAAGGACGCGCGGCTGTCCACGGGGCCCTCCAAGGAGTTCCTGCAAATCCCG
GACGCCGTGCGGCTCTTCACGGAGGAACTTGCCATTTACCAGGATGAACTGGAGACAACCCTGA
AGGAACTTCAGTCTCTCAGGAACAAGCAGAAGGATGCTATTGCTTCTTGCAAGGAGGACAAGGT
GCACCTGCAGGAGCACGTGTCCTTGGAGTTTCTCAAACTGCATCAGTTCCTGCACAATAAAGAA
AAGGACATTGTCAGCGCCCTCCGGGAGGAAGGGAGAGCCTTGAGTGAGGAGATGGAGCTGGGCC
TGAGCCAGCTCCGGGAGCAGTGTGTCCAGGCCAAAGACATGCTGGCGAGCATCAAGACCCGGAT
GGAGCAGCAGAACGCCTTCGAATTCCTCAAGGACATCACACATCTCTTGAATAGCTTGGATAAA
GGAACTCGGCAGCTGGTGCCCCGAGGGCTGATTTCCAGGAAGCTGGCCCCGGGCCTGTTCAGAG
GTCCCATCCAGTACATGGTCTGGAAGGAAATGCAGTTCACTCTCTCTCCAGGTCTCTGTCCGTT
AACTCTGGACCCTAAAACAGCTCACCCAAATCTAGTGCTCTCCAAAGACCGGACCAGCGTGTGG
CATGGTGACGTGAAGCAGCTCATGCCCAACGATGCGGAGAGGTTCGATTCGAGCGTGGCGGTGC
TAGGCTCCAAAGGCTTCACATCTGGAAAGTGGTACTGGGAAGTGGAAGTAGCCAAGAAGACGAA
GTGGACAGTGGGTGTGGCCAGGGAGTCCATCATCCGGAAGGGCAACTGTCCTCTGACTCCCGAG
CGAGGGTTCTGGCTCCTGAGACTCAGGAACCAAACCGACCTAAAGGCTCTGGATTTGCCTTCTT
GCAGTCTGCCGCTGACGCACAACCTCACCAAGGTGGGCATTTACCTGGACTACGAGGGCGGGCA
GGTGTCCTTCTACAGTGCGAACACCATGAGCCACATTTACACCTTCCACAGCACTTTCACAGAG
AAACTTTATCCCTACTTCTGCCCCTGCCTTAACGACGGCGGGGAGAACAAAGAGCCGCTGCGGA
TCCTGCACCCACAGTGAGAGCTCACCCTGTTGTGTGCATTCACGGTGTTATTAAAGAAGTATTG
GAATCGTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005376803	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000019033
	ENSCLAP00000019033.1

RefSeq Acc Id:

XP_005376803 ⟸ XM_005376746

- UniProtKB:

A0A8C2VVJ5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAPSTTSSDIHPGAQEDDDSVSVTRIPSKVAMQDITTELHCPLCKDWFSDPLMLSCGHNFCQA
CIQNFWKLEAKETFCPECKMLCQYSNCTFNLVLEKLVEKVKRLPLLKDQPQCSEHGENLKLFSK
PDGKLVCFQCKDARLSTGPSKEFLQIPDAVRLFTEELAIYQDELETTLKELQSLRNKQKDAIAS
CKEDKVHLQEHVSLEFLKLHQFLHNKEKDIVSALREEGRALSEEMELGLSQLREQCVQAKDMLA
SIKTRMEQQNAFEFLKDITHLLNSLDKGTRQLVPRGLISRKLAPGLFRGPIQYMVWKEMQFTLS
PGLCPLTLDPKTAHPNLVLSKDRTSVWHGDVKQLMPNDAERFDSSVAVLGSKGFTSGKWYWEVE
VAKKTKWTVGVARESIIRKGNCPLTPERGFWLLRLRNQTDLKALDLPSCSLPLTHNLTKVGIYL
DYEGGQVSFYSANTMSHIYTFHSTFTEKLYPYFCPCLNDGGENKEPLRILHPQ

hide sequence

RefSeq Acc Id:

ENSCLAP00000019033 ⟸ ENSCLAT00000019218

Protein Domains

B30.2/SPRY RING-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000013033	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000019218	ENTREZGENE
	ENSCLAT00000019218.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.920	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	B30.2/SPRY	UniProtKB/TrEMBL
	B30.2/SPRY_sf	UniProtKB/TrEMBL
	Butyrophylin_SPRY	UniProtKB/TrEMBL
	ConA-like_dom_sf	UniProtKB/TrEMBL
	PRY	UniProtKB/TrEMBL
	SPRY_dom	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
NCBI Gene	Trim69	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE TRIM	UniProtKB/TrEMBL
	E3 UBIQUITIN-PROTEIN LIGASE TRIM69	UniProtKB/TrEMBL
Pfam	PRY	UniProtKB/TrEMBL
	SPRY	UniProtKB/TrEMBL
	zf-C3HC4_4	UniProtKB/TrEMBL
PRINTS	BUTYPHLNCDUF	UniProtKB/TrEMBL
PROSITE	B302_SPRY	UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
SMART	PRY	UniProtKB/TrEMBL
	RING	UniProtKB/TrEMBL
	SPRY	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	SSF49899	UniProtKB/TrEMBL
UniProt	A0A8C2VVJ5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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