Anxa4 (annexin A4) - Rat Genome Database

Name: Anxa4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Anxa4 (annexin A4) Chinchilla lanigera

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Symbol:

Anxa4

Name:

annexin A4

RGD ID:

8900090

Description:

ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent phospholipid binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN epithelial cell differentiation (ortholog); negative regulation of interleukin-8 production (ortholog); negative regulation of NF-kappaB transcription factor activity (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); nuclear membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ANXA4 (annexin A4)	NCBI	Ortholog
Mus musculus (house mouse):	Anxa4 (annexin A4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Anxa4 (annexin A4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ANXA4 (annexin A4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ANXA4 (annexin A4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Anxa4 (annexin A4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ANXA4 (annexin A4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ANXA4 (annexin A4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Anxa4 (annexin A4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	15,321,990 - 15,389,136 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	15,323,604 - 15,389,136 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

Animal Mammary Neoplasms (ISO)

carcinoma (ISO)

Experimental Liver Cirrhosis (ISO)

Experimental Mammary Neoplasms (ISO)

hepatocellular carcinoma (ISO)

Liver Neoplasms (ISO)

Neoplasm Metastasis (ISO)

pre-malignant neoplasm (ISO)

Prostatic Neoplasms (ISO)

renal cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

epithelial cell differentiation (ISO)

negative regulation of interleukin-8 production (ISO)

negative regulation of NF-kappaB transcription factor activity (ISO)

Notch signaling pathway (ISO)

regulation of transcription by RNA polymerase II (ISO)

Cellular Component

cell surface (ISO)

cytoplasm (ISO)

nuclear membrane (ISO)

nucleus (ISO)

perinuclear region of cytoplasm (ISO)

plasma membrane (ISO)

vesicle membrane (ISO)

Molecular Function

calcium ion binding (ISO)

calcium-dependent phospholipid binding (ISO)

calcium-dependent protein binding (ISO)

identical protein binding (ISO)

NF-kappaB binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Anxa4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	15,321,990 - 15,389,136 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	15,323,604 - 15,389,136 (-)	NCBI	ChiLan1.0	ChiLan1.0

ANXA4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	69,643,808 - 69,827,112 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	69,644,425 - 69,827,112 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	69,870,940 - 70,054,244 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	69,862,156 - 69,907,095 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	69,880,931 - 69,965,242	NCBI
Celera	2	69,820,355 - 69,904,776 (+)	NCBI		Celera
Cytogenetic Map	2	p13.3	NCBI
HuRef	2	69,705,143 - 69,789,596 (+)	NCBI		HuRef
CHM1_1	2	69,898,797 - 69,983,225 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	69,656,119 - 69,839,380 (+)	NCBI		T2T-CHM13v2.0

Anxa4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	86,713,822 - 86,770,616 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	86,713,822 - 86,770,566 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	86,736,840 - 86,793,634 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	86,736,840 - 86,793,584 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	86,686,834 - 86,743,578 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	86,702,481 - 86,759,190 (-)	NCBI		MGSCv36	mm8
Celera	6	88,676,474 - 88,732,953 (-)	NCBI		Celera
Cytogenetic Map	6	D1	NCBI
cM Map	6	37.75	NCBI

Anxa4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	120,741,750 - 120,798,534 (-)	NCBI		GRCr8
mRatBN7.2	4	119,184,378 - 119,241,183 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	119,184,374 - 119,241,161 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	124,657,022 - 124,714,488 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	120,431,755 - 120,489,223 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	119,056,020 - 119,113,477 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	118,538,775 - 118,595,591 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	118,538,777 - 118,595,580 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	183,108,900 - 183,164,913 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	120,889,617 - 120,947,662 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	121,134,099 - 121,192,143 (-)	NCBI
Celera	4	108,154,463 - 108,210,569 (-)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

ANXA4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	56,584,356 - 56,770,098 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	56,585,188 - 56,774,043 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	69,686,651 - 69,869,340 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	70,804,600 - 70,986,917 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	70,902,260 - 70,986,917 (+)	Ensembl	panpan1.1		panPan2

ANXA4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	68,418,678 - 68,466,181 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	68,431,056 - 68,466,174 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	68,322,864 - 68,356,727 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	69,440,630 - 69,488,848 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	69,440,673 - 69,488,845 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	69,173,313 - 69,207,038 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	69,436,246 - 69,470,031 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	69,733,550 - 69,767,485 (+)	NCBI		UU_Cfam_GSD_1.0

Anxa4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	14,523,602 - 14,588,420 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	13,982,677 - 14,047,690 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	13,982,926 - 14,047,690 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ANXA4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	72,622,358 - 72,694,212 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	72,623,311 - 72,654,591 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	76,061,048 - 76,092,442 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ANXA4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	37,297,960 - 37,384,187 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	37,297,652 - 37,344,884 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	74,614,745 - 74,700,151 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Anxa4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624762	3,562,446 - 3,641,770 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624762	3,562,656 - 3,641,465 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005385639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01024706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01024710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01015085	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000023003 ⟹ ENSCLAP00000022794

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955424	15,321,990 - 15,389,136 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000023004 ⟹ ENSCLAP00000022795

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955424	15,323,838 - 15,349,677 (-)	Ensembl

RefSeq Acc Id:

XM_005385639 ⟹ XP_005385696

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955424	15,323,604 - 15,389,136 (-)	NCBI

Sequence:

show sequence

GTCTCCACCCCGAAGTGGGGCGGATCCTCCCGGGATAAGACGCGCGGCCCGGCCCGACGTGCGT
GCGACCTCCGCGGCCGCAGAGGAAGAGCGCTGCCGGTCTGGTCTGGGCGCGGCAGGAACTTCTG
CTGGGTGATTGAACTTTGGATCTTGACACAGAAACATGGCCATGGCAACCAAAGGAGGCACTGT
CAAAGCTGCTTCAGGATTCAACGCCACTGAGGATGCCCAGGCCCTGAGGAAGGCCATGAAAGGA
CTTGGCACTGACGAAGACGCCATCATCAAAGTCCTGGCCTACCGCAACACGGCCCAGCGCCAGG
AAATCAGGACGGCCTACAAGACCACCATCGGCAGGGAGCTGATAGATGACTTGAAGTCTGAACT
GAGTGGCAACTTTGAGCAGGTGATCATAGGGATGATGACACCCACCGTGCTATACGATGTGCAA
GAGCTGCGAAGGGCCATGAAGGGAGCTGGCACGGATGAAGGCTGCCTGATCGAGATCCTGGCCT
CCCGGTCCCCGGAGGAGCTCCAGCGCATCAAGCAGACCTACCAGCATCAATACGGACGGAGCCT
TGAAGACGACATTTGCTCAGACACTTCATTCATGTTCCAGAGAGTGCTGGTGTCCCTGTCAGCT
GGAGGCAGGGACCAAGGGAATTACCTGGACGACGGTCTCGTGAAACAGGACGCCCAGGACCTGT
ATGATGCTGGAGAGAAGAAATGGGGAACAGATGAAGTGAAATTCCTAACCATCCTCTGTTCCCG
GAACCGAAATCATCTGTTGCATGTGTTTGATGAATACAAAAGGATATCAAAGAAGGATATTGAA
CAGAGTATCAAATCTGAGACATCTGGTAGCTTTGAAGATGCCCTGCTGGCTATAGTTAAGTGCA
TGAGGAACAAATCTGCATATTTTGCTGAAAGGCTTTATAAATCTATGAAGGGCTTGGGCACGGA
CGACAACACCCTCATTAGAGTGATGGTCTCCCGAGCAGAGATTGACATGCTGGACATCCGGGAC
AACTTCAAGAGGCTGTACGGAAAGTCTCTGTACTCGTTCATCAAGGGTGACACATCTGGAGACT
ACAGGAAGGTACTACTCATTCTCAGTGGAGGAGATGATTAAAGTAAAATCCCAGAAGGATAGGA
AGATCCTCAACAATGAATTTGTTTTTAAACTTCATTTTTCTACACTGCTATTAGCATTATCTCT
GAATGCTTATTTCCAATTAAAACACCCACAGTTGCTTCGTAGGATTAGACTATATTATTATCAT
CTGTAATTAGTCATTCTGATGCCTTAAAGCTGTACTTGCATTTCAAAGCTTACAAAACCTAAAT
GGAGATTTAAAATTAGAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005385696	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022794
	ENSCLAP00000022794.1
	ENSCLAP00000022795.1

RefSeq Acc Id:

XP_005385696 ⟸ XM_005385639

- UniProtKB:

A0A8C2YTT7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAMATKGGTVKAASGFNATEDAQALRKAMKGLGTDEDAIIKVLAYRNTAQRQEIRTAYKTTIGR
ELIDDLKSELSGNFEQVIIGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRSPEELQRIKQ
TYQHQYGRSLEDDICSDTSFMFQRVLVSLSAGGRDQGNYLDDGLVKQDAQDLYDAGEKKWGTDE
VKFLTILCSRNRNHLLHVFDEYKRISKKDIEQSIKSETSGSFEDALLAIVKCMRNKSAYFAERL
YKSMKGLGTDDNTLIRVMVSRAEIDMLDIRDNFKRLYGKSLYSFIKGDTSGDYRKVLLILSGGD
D

hide sequence

Ensembl Acc Id:

ENSCLAP00000022794 ⟸ ENSCLAT00000023003

Ensembl Acc Id:

ENSCLAP00000022795 ⟸ ENSCLAT00000023004

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015630	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000023003	ENTREZGENE
	ENSCLAT00000023003.1	UniProtKB/TrEMBL
	ENSCLAT00000023004.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.220.10	UniProtKB/TrEMBL
InterPro	Annexin	UniProtKB/TrEMBL
	Annexin_repeat	UniProtKB/TrEMBL
	Annexin_repeat_CS	UniProtKB/TrEMBL
	Annexin_sf	UniProtKB/TrEMBL
	ANX4	UniProtKB/TrEMBL
NCBI Gene	Anxa4	ENTREZGENE
PANTHER	ANNEXIN	UniProtKB/TrEMBL
	PTHR10502:SF28	UniProtKB/TrEMBL
Pfam	Annexin	UniProtKB/TrEMBL
PRINTS	ANNEXIN	UniProtKB/TrEMBL
	ANNEXINIV	UniProtKB/TrEMBL
PROSITE	ANNEXIN_1	UniProtKB/TrEMBL
	ANNEXIN_2	UniProtKB/TrEMBL
SMART	ANX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47874	UniProtKB/TrEMBL
UniProt	A0A8C2YTT2_CHILA	UniProtKB/TrEMBL
	A0A8C2YTT7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD