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Gene: Lmf1 (lipase maturation factor 1) Chinchilla lanigera

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Symbol:

Lmf1

Name:

lipase maturation factor 1

RGD ID:

8864949

Description:

INVOLVED IN chylomicron remnant clearance (ortholog); endoplasmic reticulum to Golgi vesicle-mediated transport (ortholog); positive regulation of lipoprotein lipase activity (ortholog); ASSOCIATED WITH epilepsy (ortholog); familial lipase maturation factor 1 deficiency (ortholog); Hypertriglyceridemia (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	16,245,081 - 16,360,846 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	16,250,131 - 16,360,907 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

epilepsy (ISO)

familial lipase maturation factor 1 deficiency (ISO)

Hypertriglyceridemia (ISO)

idiopathic generalized epilepsy (ISO)

short-rib thoracic dysplasia 9 with or without polydactyly (ISO)

tuberous sclerosis 2 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chylomicron remnant clearance (ISO)

endoplasmic reticulum to Golgi vesicle-mediated transport (ISO)

positive regulation of lipoprotein lipase activity (ISO)

protein glycosylation (ISO)

protein maturation (ISO)

protein secretion (ISO)

regulation of cholesterol metabolic process (ISO)

regulation of triglyceride metabolic process (ISO)

triglyceride metabolic process (ISO)

Cellular Component

endoplasmic reticulum membrane (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Lmf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	16,245,081 - 16,360,846 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	16,250,131 - 16,360,907 (+)	NCBI	ChiLan1.0	ChiLan1.0

LMF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	853,634 - 981,613 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	853,634 - 981,318 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	903,634 - 1,031,613 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	843,635 - 960,985 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	16	1,107,225 - 1,239,539 (-)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	828,327 - 957,558 (-)	NCBI		HuRef
CHM1_1	16	903,220 - 1,030,220 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	860,524 - 992,407 (-)	NCBI		T2T-CHM13v2.0

Lmf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	25,798,143 - 25,886,381 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	25,798,059 - 25,881,800 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	25,579,174 - 25,662,831 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	25,579,085 - 25,662,826 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	25,716,119 - 25,799,668 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	25,306,789 - 25,390,323 (+)	NCBI		MGSCv36	mm8
Celera	17	26,111,464 - 26,194,783 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	12.7	NCBI

Lmf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	15,094,432 - 15,188,665 (+)	NCBI		GRCr8
mRatBN7.2	10	14,597,726 - 14,684,071 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	14,597,594 - 14,684,119 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	10	14,945,185 - 15,031,855 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	14,945,265 - 15,031,942 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	14,758,772 - 14,845,170 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	14,831,884 - 14,918,491 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	14,831,904 - 14,988,148 (+)	NCBI
Celera	10	14,268,567 - 14,354,506 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

LMF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	1,100,904 - 1,232,682 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	4,866,946 - 5,014,229 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	869,449 - 921,019 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	869,449 - 973,456 (-)	Ensembl	panpan1.1		panPan2

LMF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	39,682,229 - 39,768,311 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	39,696,442 - 39,762,709 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	40,947,818 - 41,030,692 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	40,026,289 - 40,109,210 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	40,026,316 - 40,106,371 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	39,702,701 - 39,795,437 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	39,675,594 - 39,758,228 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	40,154,171 - 40,237,062 (+)	NCBI		UU_Cfam_GSD_1.0

Lmf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	112,034,995 - 112,109,143 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	140,661 - 204,127 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	138,470 - 200,120 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LMF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	40,835,413 - 40,934,253 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	40,841,242 - 40,929,163 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	41,548,552 - 41,568,317 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LMF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	761,788 - 857,798 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	762,697 - 866,926 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	30,241,026 - 30,369,020 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lmf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624913	1,655,386 - 1,762,094 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624913	1,651,435 - 1,750,767 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005391597	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01037893	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01037894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01037895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01037896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01037897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01037898	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01272886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000018544 ⟹ ENSCLAP00000018364

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955442	16,245,081 - 16,360,846 (+)	Ensembl

RefSeq Acc Id:

XM_005391597 ⟹ XP_005391654

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955442	16,250,131 - 16,360,907 (+)	NCBI

Sequence:

show sequence

TACCGTGCACCGCCCCCCCTCGCGCTTGCGCCGAGAGGGCCCAGCAATGGCTGCGCCCGAGGGG
TCCCTGAGGAAACGGAAGGTCGCGGACGCGGGCCGGGCTCCGGTATCGCTGCCCGAGCCCGAGC
CGGAGTCTAATGCCGCGGCCCGCCCCACCCGTCTCCGTGCGGGGACCTTCTGGCTGACCAGGAT
CGTGCTCTTGAAGGCCCTCGCTTTAGTTTACTTTGTGGCATTCCTGGTGGCTTTCAATCAGAAC
AAGCAGCTGATTGGTGAACGGGGCTTGCTGCCCTGCAAGGCATACCTGAAGAGCATCCAGCAGT
ACTTCCATGGAAAGATTGGCTGGGATGCCTGGAACTACGCCCCAACCATCCTCTGGCTGCTGGA
CTGGTCAGACATGAACTTCAACCTGGACCTCCTTGCTGTTCTCGGATTGGGCATTTCCTCCTTC
ATCTTGATAACTGGCTGTGCCAACATGATCCTCATGGCAATGCTGTGGGTCTTCTACCTATCCC
TGGTCAACGTGGGACAGGTCTGGTATTCTTTTGGATGGGAGTCACAGCTGCTGGAAACAGGGTT
CCTGGGAATCTTCCTCTGCCCCCTTTGGACACTGTCCCGGCTGCCCAAATATACACCCACATCC
CGAGTTGTCCTGTGGGGCTTCCGGTGGCTGATTTTCAGGATCATGCTTGGAGCAGGCCTGATCA
AAATCCGGGGTGACAAGTGCTGGTGGGACCTCACCTGTATGGACTACCACTACGAGACACAGCC
TGTGCCCAACCCCCTGGCCTACTTCCTGCACCAGTCACCCTGGTGGTTCCACCGCTTTGAGACG
TTCAGCAACCACGTCCTGGAGCTGCTGGTGCCCTTCTTTGTGTTCCTTGGGCGCCGCCTGTGCC
TCCTCCATGGGGTGCTGCAGATCTTCTTTCAGGTGGTCCTTATCCTCAGCGGGAACCTGAGCTT
TCTGAACTGGCTGACCATCGTGCCTAGCCTCTCCTGCTTTGACGATGCCACACTGGGGTTCCTG
TTCCCTTCAGGGCCAGGCGGCCTGAAAGACCGAGTCCTAAAAATGCAGAAGGAAGAAGCTGAAG
GGGCCAACCCTAAGCCAAGATATGGCTGCTTGGTGCGGCGTGTGGCCAATCTCTCGCTGGGCAT
CCTGCTGGCTTGGCTTAGTGTGCCTGTGGTCATCAACCTGCTGAGCTCCAAGCAGGTCATGAAT
ACCTCCTTCAATCCACTGCGGATCGTCAACACCTATGGGGCCTTTGGAAGCATCACCAAGGAGA
GGACAGAGGTGATCCTGCAGGGCACAGCCAGCACCAACGCCAGTGCCCCTGATGCCGTGTGGGA
GGACTATGAGTTCAAGTGTAAACCAGGCAACCCCTGGAGGCGGCCATGCCTGATCTCCCCATAC
CATTACCGCCTGGACTGGCTCATGTGGTTTGCAGCCTTCCAGACCTACGAGCAGAATGAGTGGA
TCCTGCACCTAGCTGGCAAGCTCCTGGCCAACAATGCTGAAGCTCTGTCCCTGCTGGCCCTCAA
CCCCTTCGAAGGCCGGGCACCCCCCAGGTGGGTCCGCGGAGAGCACTGGCGTTACCGGTTCAGC
CGCCCCGGAGGCAAGCACGCCTCAGAAGGCAAGTGGTGGGCACGCAAGCGGATCGGCTCCTACT
TTCCCCCACTGCGCTTGGAGGACCTAAAGAACTACTTCAAGGCACGAGGGTGGCCCCTGGAAGA
ACCCATGTAGCCTTCCTCCCTGCAATAAAGGTCAGAGCCAGCACCCTGCTCTGCGTGGAATCCC
ACCAGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005391654	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000018364
	ENSCLAP00000018364.1

RefSeq Acc Id:

XP_005391654 ⟸ XM_005391597

- UniProtKB:

A0A8C2VNV6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAPEGSLRKRKVADAGRAPVSLPEPEPESNAAARPTRLRAGTFWLTRIVLLKALALVYFVAFL
VAFNQNKQLIGERGLLPCKAYLKSIQQYFHGKIGWDAWNYAPTILWLLDWSDMNFNLDLLAVLG
LGISSFILITGCANMILMAMLWVFYLSLVNVGQVWYSFGWESQLLETGFLGIFLCPLWTLSRLP
KYTPTSRVVLWGFRWLIFRIMLGAGLIKIRGDKCWWDLTCMDYHYETQPVPNPLAYFLHQSPWW
FHRFETFSNHVLELLVPFFVFLGRRLCLLHGVLQIFFQVVLILSGNLSFLNWLTIVPSLSCFDD
ATLGFLFPSGPGGLKDRVLKMQKEEAEGANPKPRYGCLVRRVANLSLGILLAWLSVPVVINLLS
SKQVMNTSFNPLRIVNTYGAFGSITKERTEVILQGTASTNASAPDAVWEDYEFKCKPGNPWRRP
CLISPYHYRLDWLMWFAAFQTYEQNEWILHLAGKLLANNAEALSLLALNPFEGRAPPRWVRGEH
WRYRFSRPGGKHASEGKWWARKRIGSYFPPLRLEDLKNYFKARGWPLEEPM

hide sequence

Ensembl Acc Id:

ENSCLAP00000018364 ⟸ ENSCLAT00000018544

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000012588	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000018544	ENTREZGENE
	ENSCLAT00000018544.1	UniProtKB/TrEMBL
InterPro	LMF	UniProtKB/TrEMBL
NCBI Gene	Lmf1	ENTREZGENE
PANTHER	LIPASE MATURATION FACTOR 1	UniProtKB/TrEMBL
	PTHR14463	UniProtKB/TrEMBL
Pfam	LMF1	UniProtKB/TrEMBL
UniProt	A0A8C2VNV6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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