LMF1 (lipase maturation factor 1) - Rat Genome Database

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Gene: LMF1 (lipase maturation factor 1) Canis lupus familiaris
Analyze
Symbol: LMF1
Name: lipase maturation factor 1
RGD ID: 12187593
Description: INVOLVED IN chylomicron remnant clearance (ortholog); endoplasmic reticulum to Golgi vesicle-mediated transport (ortholog); protein glycosylation (ortholog); ASSOCIATED WITH epilepsy (ortholog); familial lipase maturation factor 1 deficiency (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,682,229 - 39,768,311 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,696,442 - 39,762,709 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,947,818 - 41,030,692 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,026,289 - 40,109,210 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1639,702,701 - 39,795,437 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,675,594 - 39,758,228 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,154,171 - 40,237,062 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LMF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,682,229 - 39,768,311 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,696,442 - 39,762,709 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,947,818 - 41,030,692 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,026,289 - 40,109,210 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1639,702,701 - 39,795,437 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,675,594 - 39,758,228 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,154,171 - 40,237,062 (+)NCBIUU_Cfam_GSD_1.0
LMF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816853,634 - 981,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16853,634 - 981,318 (-)EnsemblGRCh38hg38GRCh38
GRCh3716903,634 - 1,031,613 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616843,635 - 960,985 (-)NCBINCBI36Build 36hg18NCBI36
Celera161,107,225 - 1,239,539 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16828,327 - 957,558 (-)NCBIHuRef
CHM1_116903,220 - 1,030,220 (-)NCBICHM1_1
T2T-CHM13v2.016860,524 - 992,407 (-)NCBIT2T-CHM13v2.0
Lmf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,798,143 - 25,886,381 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,798,059 - 25,881,800 (+)EnsemblGRCm39 Ensembl
GRCm381725,579,174 - 25,662,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,579,085 - 25,662,826 (+)EnsemblGRCm38mm10GRCm38
MGSCv371725,716,119 - 25,799,668 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,306,789 - 25,390,323 (+)NCBIMGSCv36mm8
Celera1726,111,464 - 26,194,783 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.7NCBI
Lmf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,094,432 - 15,188,665 (+)NCBIGRCr8
mRatBN7.21014,597,726 - 14,684,071 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,597,594 - 14,684,119 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01014,945,185 - 15,031,855 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,945,265 - 15,031,942 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,758,772 - 14,845,170 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,831,884 - 14,918,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,831,904 - 14,988,148 (+)NCBI
Celera1014,268,567 - 14,354,506 (+)NCBICelera
Cytogenetic Map10q12NCBI
Lmf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544216,245,081 - 16,360,846 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544216,250,131 - 16,360,907 (+)NCBIChiLan1.0ChiLan1.0
LMF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2181,100,904 - 1,232,682 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,866,946 - 5,014,229 (-)NCBINHGRI_mPanPan1
PanPan1.116869,449 - 921,019 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16869,449 - 973,456 (-)Ensemblpanpan1.1panPan2
Lmf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,034,995 - 112,109,143 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501140,661 - 204,127 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936501138,470 - 200,120 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LMF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,835,413 - 40,934,253 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1340,841,242 - 40,929,163 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,548,552 - 41,568,317 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LMF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.15761,788 - 857,798 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl5762,697 - 866,926 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606830,241,026 - 30,369,020 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lmf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249131,655,386 - 1,762,094 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249131,651,435 - 1,750,767 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LMF1
710 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 17 1 1 1 6 9 8 10 6
Low 4 5 5 5 5 5 6 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022420279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022420280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022420281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038479588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038540861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038540862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038604983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038604984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038669662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038669663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_547204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000031160   ⟹   ENSCAFP00000028992
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl639,696,442 - 39,762,709 (+)Ensembl
RefSeq Acc Id: XM_022420281   ⟹   XP_022275989
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1639,750,372 - 39,768,311 (+)NCBI
Dog10K_Boxer_Tasha641,012,971 - 41,030,692 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038479588   ⟹   XP_038335516
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1639,702,701 - 39,795,437 (+)NCBI
RefSeq Acc Id: XM_038540861   ⟹   XP_038396789
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0640,154,171 - 40,234,277 (+)NCBI
RefSeq Acc Id: XM_038540862   ⟹   XP_038396790
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0640,222,062 - 40,237,062 (+)NCBI
RefSeq Acc Id: XM_038604983   ⟹   XP_038460911
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0639,675,594 - 39,755,444 (+)NCBI
RefSeq Acc Id: XM_038604984   ⟹   XP_038460912
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0639,743,260 - 39,758,228 (+)NCBI
RefSeq Acc Id: XM_038669662   ⟹   XP_038525590
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0640,026,289 - 40,106,426 (+)NCBI
RefSeq Acc Id: XM_038669663   ⟹   XP_038525591
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0640,094,211 - 40,109,210 (+)NCBI
RefSeq Acc Id: XM_547204   ⟹   XP_547204
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1639,682,229 - 39,762,764 (+)NCBI
Dog10K_Boxer_Tasha640,947,818 - 41,027,908 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_547204   ⟸   XM_547204
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NE39 (UniProtKB/TrEMBL),   A0A8C0QXT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022275989   ⟸   XM_022420281
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000028992   ⟸   ENSCAFT00000031160
RefSeq Acc Id: XP_038335516   ⟸   XM_038479588
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038460911   ⟸   XM_038604983
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038460912   ⟸   XM_038604984
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038525590   ⟸   XM_038669662
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NE39 (UniProtKB/TrEMBL),   A0A8C0QXT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038525591   ⟸   XM_038669663
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038396789   ⟸   XM_038540861
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NE39 (UniProtKB/TrEMBL),   A0A8C0QXT7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038396790   ⟸   XM_038540862
- Peptide Label: isoform X2

Promoters
RGD ID:13683757
Promoter ID:EPDNEW_C1824
Type:multiple initiation site
Name:LMF1_1
Description:lipase maturation factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1639,682,239 - 39,682,299EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019603 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014577 UniProtKB/TrEMBL
  ENSCAFG00845024875 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031160.5 UniProtKB/TrEMBL
  ENSCAFT00030026908.1 UniProtKB/TrEMBL
  ENSCAFT00030026974.1 UniProtKB/TrEMBL
  ENSCAFT00030027057.1 UniProtKB/TrEMBL
  ENSCAFT00845043913.1 UniProtKB/TrEMBL
InterPro LMF UniProtKB/TrEMBL
NCBI Gene LMF1 ENTREZGENE
PANTHER LIPASE MATURATION FACTOR 1 UniProtKB/TrEMBL
  PTHR14463 UniProtKB/TrEMBL
Pfam LMF1 UniProtKB/TrEMBL
UniProt A0A8C0NE39 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QXT7 ENTREZGENE
  A0A8C0RK95_CANLF UniProtKB/TrEMBL
  A0A8C0RKA5_CANLF UniProtKB/TrEMBL
  A0A8I3PIZ6_CANLF UniProtKB/TrEMBL
  A0A8P0NKR6_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:54038 ENTREZGENE