Nfkbiz (NFKB inhibitor zeta) - Rat Genome Database

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Gene: Nfkbiz (NFKB inhibitor zeta) Chinchilla lanigera
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Symbol: Nfkbiz
Name: NFKB inhibitor zeta
RGD ID: 8811079
Description: ENCODES a protein that exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); transcription coregulator activity (ortholog); INVOLVED IN adaptive immune response (ortholog); B cell proliferation (ortholog); B cell receptor apoptotic signaling pathway (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); Experimental Liver Cirrhosis (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN cytoplasmic ribonucleoprotein granule (ortholog); nuclear speck (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NF-kappa-B inhibitor zeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554273,350,174 - 3,360,379 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554273,350,174 - 3,358,609 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (ISO)
B cell proliferation  (ISO)
B cell receptor apoptotic signaling pathway  (ISO)
B cell receptor signaling pathway  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to interleukin-17  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
chromatin organization  (ISO)
chromatin remodeling  (ISO)
chronic inflammatory response  (ISO)
cytokine-mediated signaling pathway  (ISO)
defense response to Gram-negative bacterium  (ISO)
epithelial cell apoptotic process  (ISO)
establishment of skin barrier  (ISO)
execution phase of apoptosis  (ISO)
gene expression  (ISO)
homeostasis of number of cells within a tissue  (ISO)
immunoglobulin mediated immune response  (ISO)
inflammatory response  (ISO)
inflammatory response to wounding  (ISO)
isotype switching  (ISO)
keratinocyte activation  (ISO)
keratinocyte differentiation  (ISO)
keratinocyte proliferation  (ISO)
lymphocyte activation involved in immune response  (ISO)
mRNA transcription by RNA polymerase II  (ISO)
plasma cell differentiation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of T-helper 17 cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of immune response  (ISO)
response to cisplatin  (ISO)
response to cytokine  (ISO)
response to folic acid  (ISO)
response to Gram-positive bacterium  (ISO)
response to lipopolysaccharide  (ISO)
response to xenobiotic stimulus  (ISO)
skin development  (ISO)
skin epidermis development  (ISO)
spleen development  (ISO)
T cell differentiation  (ISO)
T cell mediated immunity  (ISO)
T cell receptor signaling pathway  (ISO)
T-helper 1 cell differentiation  (ISO)
T-helper 17 cell differentiation  (ISO)
toll-like receptor signaling pathway  (ISO)
transcription by RNA polymerase II  (ISO)
transcription preinitiation complex assembly  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Nfkbiz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554273,350,174 - 3,360,379 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554273,350,174 - 3,358,609 (+)NCBIChiLan1.0ChiLan1.0
NFKBIZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383101,827,990 - 101,861,022 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3101,827,991 - 101,861,022 (+)EnsemblGRCh38hg38GRCh38
GRCh373101,546,834 - 101,579,866 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363103,029,547 - 103,062,556 (+)NCBINCBI36Build 36hg18NCBI36
Build 343103,051,047 - 103,062,555NCBI
Celera399,940,218 - 99,973,254 (+)NCBICelera
Cytogenetic Map3q12.3NCBI
HuRef398,915,528 - 98,948,489 (+)NCBIHuRef
CHM1_13101,510,104 - 101,543,165 (+)NCBICHM1_1
T2T-CHM13v2.03104,540,783 - 104,573,840 (+)NCBIT2T-CHM13v2.0
Nfkbiz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391655,631,740 - 55,659,018 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1655,631,738 - 55,659,262 (-)EnsemblGRCm39 Ensembl
GRCm381655,811,375 - 55,838,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1655,811,375 - 55,838,899 (-)EnsemblGRCm38mm10GRCm38
MGSCv371655,811,490 - 55,838,754 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361655,736,329 - 55,763,805 (-)NCBIMGSCv36mm8
Celera1656,126,905 - 56,154,128 (-)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1633.65NCBI
Nfkbiz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81158,251,720 - 58,279,767 (+)NCBIGRCr8
mRatBN7.21144,782,676 - 44,810,722 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1144,782,676 - 44,810,723 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1153,559,179 - 53,587,222 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01146,220,825 - 46,248,868 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01145,344,968 - 45,373,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01147,243,342 - 47,271,487 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1147,243,342 - 47,271,487 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01150,420,563 - 50,447,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41145,776,027 - 45,811,515 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11145,851,817 - 45,867,783 (+)NCBI
Celera1144,534,358 - 44,562,504 (+)NCBICelera
Cytogenetic Map11q12NCBI
NFKBIZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2299,765,320 - 99,798,852 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1399,770,109 - 99,803,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0398,914,957 - 98,948,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13105,616,645 - 105,628,300 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3105,616,645 - 105,628,300 (+)Ensemblpanpan1.1panPan2
NFKBIZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1338,147,160 - 8,154,401 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl338,073,840 - 8,154,561 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha338,299,319 - 8,308,950 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0338,263,750 - 8,294,332 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl338,283,254 - 8,294,324 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1338,171,804 - 8,181,424 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0338,218,093 - 8,227,719 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0338,558,667 - 8,568,280 (+)NCBIUU_Cfam_GSD_1.0
Nfkbiz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602148,703,296 - 148,734,803 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366301,601,010 - 1,632,745 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366301,601,006 - 1,633,844 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKBIZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13157,261,419 - 157,272,688 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113157,261,419 - 157,273,119 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213166,743,487 - 166,777,576 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFKBIZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12279,044,624 - 79,077,736 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2279,044,619 - 79,055,776 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604187,478,007 - 87,510,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkbiz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478915,612,335 - 15,624,152 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478915,612,311 - 15,623,878 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000011794   ⟹   ENSCLAP00000011657
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554273,350,174 - 3,360,379 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000011795   ⟹   ENSCLAP00000011658
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554273,350,174 - 3,360,379 (+)Ensembl
RefSeq Acc Id: XM_013515204   ⟹   XP_013370658
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554273,350,174 - 3,358,609 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013370658 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000011657.1
  ENSCLAP00000011658
  ENSCLAP00000011658.1
RefSeq Acc Id: XP_013370658   ⟸   XM_013515204
- UniProtKB: A0A8C2VE88 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000011658   ⟸   ENSCLAT00000011795
Ensembl Acc Id: ENSCLAP00000011657   ⟸   ENSCLAT00000011794
Protein Domains
OCA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008036 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000011794.1 UniProtKB/TrEMBL
  ENSCLAT00000011795 ENTREZGENE
  ENSCLAT00000011795.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  OCA UniProtKB/TrEMBL
NCBI Gene Nfkbiz ENTREZGENE
PANTHER ANKYRIN REPEAT FAMILY A UniProtKB/TrEMBL
  NF-KAPPA-B INHIBITOR ZETA UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  OCA UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
UniProt A0A8C2VBP2_CHILA UniProtKB/TrEMBL
  A0A8C2VE88 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Nfkbiz  NFKB inhibitor zeta    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta  Symbol and/or name change 5135510 APPROVED