Nek3 (NIMA related kinase 3) - Rat Genome Database

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Gene: Nek3 (NIMA related kinase 3) Chinchilla lanigera
Analyze
Symbol: Nek3
Name: NIMA related kinase 3
RGD ID: 8730120
Description: INVOLVED IN establishment of cell polarity (ortholog); neuron projection morphogenesis (ortholog); protein phosphorylation (ortholog); ASSOCIATED WITH chromosome 13q14 deletion syndrome (ortholog); hereditary breast ovarian cancer syndrome (ortholog); intellectual disability (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NIMA-related kinase 3; serine/threonine-protein kinase Nek3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554315,378,896 - 5,412,221 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554315,382,992 - 5,412,206 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Nek3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554315,378,896 - 5,412,221 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554315,382,992 - 5,412,206 (-)NCBIChiLan1.0ChiLan1.0
NEK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381352,132,647 - 52,159,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1352,132,639 - 52,159,597 (-)EnsemblGRCh38hg38GRCh38
GRCh371352,706,783 - 52,733,995 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361351,604,780 - 51,631,997 (-)NCBINCBI36Build 36hg18NCBI36
Build 341351,604,779 - 51,631,511NCBI
Celera1333,755,426 - 33,782,643 (-)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1333,494,915 - 33,522,031 (-)NCBIHuRef
CHM1_11352,674,859 - 52,702,079 (-)NCBICHM1_1
T2T-CHM13v2.01351,347,480 - 51,374,691 (-)NCBIT2T-CHM13v2.0
Nek3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,618,299 - 22,657,009 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,618,299 - 22,656,451 (-)EnsemblGRCm39 Ensembl
GRCm38822,128,283 - 22,166,997 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,128,283 - 22,166,435 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,238,755 - 23,276,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,593,828 - 23,631,947 (-)NCBIMGSCv36mm8
Celera823,623,168 - 23,659,067 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.07NCBI
Nek3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,569,465 - 76,594,921 (+)NCBIGRCr8
mRatBN7.21669,867,020 - 69,892,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,867,047 - 69,892,508 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01674,781,371 - 74,806,567 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,785,281 - 74,806,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,412,402 - 74,437,059 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,524,839 - 74,547,785 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11674,525,103 - 74,569,327 (+)NCBI
Celera1667,751,672 - 67,777,870 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
NEK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21453,564,420 - 53,592,624 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11352,208,697 - 52,236,903 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01333,261,186 - 33,288,316 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11352,003,518 - 52,030,538 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1352,003,518 - 52,030,212 (-)Ensemblpanpan1.1panPan2
NEK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.125118,558 - 130,901 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha25237,734 - 250,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.025221,349 - 233,911 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.125102,210 - 114,767 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.025116,905 - 129,452 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.025184,724 - 197,292 (-)NCBIUU_Cfam_GSD_1.0
Nek3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945161,356,381 - 161,383,259 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365654,840,894 - 4,863,301 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365654,840,416 - 4,863,349 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,772,844 - 15,798,420 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,772,578 - 15,798,424 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21116,097,410 - 16,123,551 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1330,018,641 - 30,048,787 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl330,018,635 - 30,045,216 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605713,765,557 - 13,795,721 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nek3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247481,944,152 - 1,977,187 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247481,939,806 - 1,976,484 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000009538   ⟹   ENSCLAP00000009409
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554315,378,896 - 5,412,221 (-)Ensembl
RefSeq Acc Id: XM_005387620   ⟹   XP_005387677
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554315,382,992 - 5,412,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515774   ⟹   XP_013371228
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554315,382,992 - 5,412,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515775   ⟹   XP_013371229
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554315,382,992 - 5,412,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515776   ⟹   XP_013371230
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554315,382,992 - 5,412,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515777   ⟹   XP_013371231
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554315,382,992 - 5,412,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515778   ⟹   XP_013371232
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554315,382,992 - 5,412,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515779   ⟹   XP_013371233
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554315,382,992 - 5,412,206 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005387677   ⟸   XM_005387620
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YMF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013371228   ⟸   XM_013515774
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YMF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013371231   ⟸   XM_013515777
- Peptide Label: isoform X5
- UniProtKB: A0A8C2YMF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013371229   ⟸   XM_013515775
- Peptide Label: isoform X3
- UniProtKB: A0A8C2YMF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013371230   ⟸   XM_013515776
- Peptide Label: isoform X4
- UniProtKB: A0A8C2YMF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013371233   ⟸   XM_013515779
- Peptide Label: isoform X7
- UniProtKB: A0A8C2YMF3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013371232   ⟸   XM_013515778
- Peptide Label: isoform X6
- UniProtKB: A0A8C2YMF3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000009409   ⟸   ENSCLAT00000009538
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006532 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009538 ENTREZGENE
  ENSCLAT00000009538.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Nek3 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE NEK3 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE NEK3 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2YMF3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Nek3  NIMA related kinase 3    NIMA-related kinase 3  Symbol and/or name change 5135510 APPROVED