Cerkl (CERK like autophagy regulator) - Rat Genome Database

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Gene: Cerkl (CERK like autophagy regulator) Chinchilla lanigera
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Symbol: Cerkl
Name: CERK like autophagy regulator
RGD ID: 8723813
Description: ENCODES a protein that exhibits ceramide kinase activity (ortholog); sphingolipid binding (ortholog); INVOLVED IN negative regulation of apoptotic process (ortholog); sphingolipid biosynthetic process (ortholog); ASSOCIATED WITH cone dystrophy (ortholog); cone-rod dystrophy (ortholog); fundus dystrophy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ceramide kinase like; ceramide kinase-like
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540315,620,047 - 15,727,957 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Cerkl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540315,620,047 - 15,727,957 (+)NCBIChiLan1.0ChiLan1.0
CERKL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382181,536,672 - 181,657,105 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2181,535,041 - 181,680,665 (-)EnsemblGRCh38hg38GRCh38
GRCh372182,401,399 - 182,521,832 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362182,109,650 - 182,229,996 (-)NCBINCBI36Build 36hg18NCBI36
Build 342182,226,911 - 182,347,257NCBI
Celera2175,997,484 - 176,117,888 (-)NCBICelera
Cytogenetic Map2q31.3NCBI
HuRef2174,258,264 - 174,378,426 (-)NCBIHuRef
CHM1_12182,406,604 - 182,527,616 (-)NCBICHM1_1
T2T-CHM13v2.02182,026,827 - 182,147,207 (-)NCBIT2T-CHM13v2.0
Cerkl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39279,162,835 - 79,259,332 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl279,160,887 - 79,287,129 (-)EnsemblGRCm39 Ensembl
GRCm38279,332,491 - 79,428,988 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl279,330,543 - 79,456,785 (-)EnsemblGRCm38mm10GRCm38
MGSCv37279,172,648 - 79,269,145 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36279,132,873 - 79,133,959 (+)NCBIMGSCv36mm8
Celera280,991,252 - 81,088,535 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map247.43NCBI
Cerkl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8384,641,121 - 84,747,999 (-)NCBIGRCr8
mRatBN7.2364,238,714 - 64,344,695 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl364,237,522 - 64,340,675 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0366,268,835 - 66,395,615 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl366,268,947 - 66,394,764 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0372,830,404 - 72,955,341 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4362,103,856 - 62,204,116 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera363,698,857 - 63,800,301 (-)NCBICelera
Cytogenetic Map3q24NCBI
CERKL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21384,186,541 - 84,308,125 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B84,202,998 - 84,323,098 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B68,800,462 - 68,921,793 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B186,611,147 - 186,731,484 (-)NCBIpanpan1.1PanPan1.1panPan2
CERKL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13624,708,109 - 24,839,240 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3624,710,035 - 24,859,028 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3624,731,428 - 24,862,131 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03624,871,001 - 25,001,556 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3624,872,357 - 25,001,556 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13624,960,221 - 25,091,171 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03624,925,686 - 25,056,169 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03625,060,795 - 25,191,691 (-)NCBIUU_Cfam_GSD_1.0
Cerkl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303141,741,059 - 141,850,691 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650910,294,988 - 10,404,609 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650910,294,247 - 10,404,743 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CERKL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1587,029,306 - 87,159,566 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11587,029,237 - 87,159,555 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21596,602,544 - 96,649,976 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CERKL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11067,055,654 - 67,185,927 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1067,056,078 - 67,185,580 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040132,389,417 - 132,524,424 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cerkl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248443,354,823 - 3,474,036 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_013512521   ⟹   XP_013367975
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540315,620,047 - 15,727,957 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013367975 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000023656.1
RefSeq Acc Id: XP_013367975   ⟸   XM_013512521
- Sequence:
Protein Domains
DAGKc


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016232 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000023881.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.40 UniProtKB/TrEMBL
InterPro ATP-NAD_kinase_N UniProtKB/TrEMBL
  CERK_C UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/TrEMBL
  Lipid_Phosphate_FormReg UniProtKB/TrEMBL
  NAD/diacylglycerol_kinase_sf UniProtKB/TrEMBL
NCBI Gene Cerkl ENTREZGENE
PANTHER CERAMIDE KINASE-LIKE PROTEIN UniProtKB/TrEMBL
  SPHINGOSINE KINASE UniProtKB/TrEMBL
Pfam CERK_C UniProtKB/TrEMBL
  DAGK_cat UniProtKB/TrEMBL
PROSITE DAGK UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/TrEMBL
UniProt A0A8C2W152_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-10-22 Cerkl  CERK like autophagy regulator  Cerkl  ceramide kinase like  Symbol and/or name change 5135510 APPROVED
2016-08-16 Cerkl  ceramide kinase like    ceramide kinase-like  Symbol and/or name change 5135510 APPROVED