Hapln2 (hyaluronan and proteoglycan link protein 2) - Rat Genome Database

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Gene: Hapln2 (hyaluronan and proteoglycan link protein 2) Mus musculus
Analyze
Symbol: Hapln2
Name: hyaluronan and proteoglycan link protein 2
RGD ID: 736584
MGI Page MGI
Description: Predicted to enable hyaluronic acid binding activity. Acts upstream of or within establishment of blood-nerve barrier and extracellular matrix assembly. Located in extracellular matrix. Is expressed in brain. Orthologous to human HAPLN2 (hyaluronan and proteoglycan link protein 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930401E20Rik; Br; brain link protein 1; Bral1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39387,927,865 - 87,934,818 (-)NCBIGRCm39mm39
GRCm39 Ensembl387,929,057 - 87,934,890 (-)Ensembl
GRCm38388,020,558 - 88,027,511 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,021,750 - 88,027,583 (-)EnsemblGRCm38mm10GRCm38
MGSCv37387,825,672 - 87,831,433 (-)NCBIGRCm37mm9NCBIm37
MGSCv36388,107,990 - 88,113,367 (-)NCBImm8
Celera388,060,940 - 88,066,702 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.78NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11027579   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12663660   PMID:14550776   PMID:14610273   PMID:14706451   PMID:16141072   PMID:16141073  
PMID:16537572   PMID:20181608   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23664614   PMID:30125937  


Genomics

Comparative Map Data
Hapln2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39387,927,865 - 87,934,818 (-)NCBIGRCm39mm39
GRCm39 Ensembl387,929,057 - 87,934,890 (-)Ensembl
GRCm38388,020,558 - 88,027,511 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,021,750 - 88,027,583 (-)EnsemblGRCm38mm10GRCm38
MGSCv37387,825,672 - 87,831,433 (-)NCBIGRCm37mm9NCBIm37
MGSCv36388,107,990 - 88,113,367 (-)NCBImm8
Celera388,060,940 - 88,066,702 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.78NCBI
HAPLN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1156,619,331 - 156,625,725 (+)EnsemblGRCh38hg38GRCh38
GRCh381156,601,504 - 156,626,608 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371156,589,207 - 156,595,517 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,855,710 - 154,862,141 (+)NCBINCBI36hg18NCBI36
Build 341153,402,158 - 153,408,590NCBI
Celera1129,659,883 - 129,666,327 (+)NCBI
Cytogenetic Map1q23.1NCBI
HuRef1127,946,689 - 127,953,128 (+)NCBIHuRef
CHM1_11157,985,292 - 157,991,726 (+)NCBICHM1_1
Hapln2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22173,488,909 - 173,496,824 (-)NCBI
Rnor_6.0 Ensembl2187,396,349 - 187,401,786 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02187,395,104 - 187,402,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02206,798,121 - 206,804,794 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,104,684 - 180,110,113 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,054,791 - 180,060,219 (-)NCBI
Celera2167,438,414 - 167,443,845 (-)NCBICelera
Cytogenetic Map2q34NCBI
Hapln2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,709,013 - 2,710,588 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,705,903 - 2,710,763 (+)NCBIChiLan1.0ChiLan1.0
HAPLN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11135,785,754 - 135,792,652 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,785,754 - 135,792,652 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01131,962,801 - 131,969,331 (+)NCBIMhudiblu_PPA_v0panPan3
HAPLN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,340,493 - 41,346,607 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,341,883 - 41,344,117 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha740,827,781 - 40,833,885 (-)NCBI
ROS_Cfam_1.0741,203,438 - 41,209,543 (-)NCBI
UMICH_Zoey_3.1740,987,110 - 40,991,416 (-)NCBI
UNSW_CanFamBas_1.0741,038,338 - 41,044,441 (-)NCBI
UU_Cfam_GSD_1.0741,322,006 - 41,328,109 (-)NCBI
Hapln2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,761,897 - 26,777,432 (+)NCBI
SpeTri2.0NW_0049365805,792,421 - 5,811,096 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAPLN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,462,308 - 93,467,802 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,462,306 - 93,468,394 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,125,801 - 102,128,123 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAPLN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,237,940 - 7,244,840 (-)NCBI
ChlSab1.1 Ensembl207,238,281 - 7,240,183 (-)Ensembl
Vero_WHO_p1.0NW_0236660386,533,760 - 6,540,524 (-)NCBI
Hapln2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248851,799,303 - 1,805,977 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7521114102782718Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316000000109800000Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316450000130370000Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328900000119100000Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)341000000116000000Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)344000000101700000Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)352000000102400000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356796681100556821Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35900000093000000Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36183275495832934Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366139351100139488Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)368000000128600000Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369661247103661247Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369718176100747974Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370301597104301735Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372232660106232787Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372232660106232787Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375555995109556242Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379641414113641521Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381177336115177481Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382239727116239868Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383556675117556821Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383556675117556821Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383556675117556821Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383556675117556821Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383556675117556821Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383556675117556821Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383556675117556821Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383975596117975728Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384981602118981751Mouse
14746984Manh54_mmandible shape 54 (mouse)385381836119381836Mouse
10043981Cia5a_mcollagen induced arthritis QTL 5a (mouse)Not determined38726314789232787Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387301597125522587Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387320699121320699Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:662
Count of miRNA genes:432
Interacting mature miRNAs:500
Transcripts:ENSMUST00000005014, ENSMUST00000160150, ENSMUST00000160737, ENSMUST00000162352
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000005014   ⟹   ENSMUSP00000005014
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl388,022,061 - 88,027,478 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160150   ⟹   ENSMUSP00000125271
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl388,023,534 - 88,027,492 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160737
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl388,021,750 - 88,027,583 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162352
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl388,022,638 - 88,023,673 (-)Ensembl
RefSeq Acc Id: NM_022031   ⟹   NP_071314
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39387,929,057 - 87,934,818 (-)NCBI
GRCm38388,021,750 - 88,027,511 (-)NCBI
MGSCv37387,825,672 - 87,831,433 (-)RGD
Celera388,060,940 - 88,066,702 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006502148   ⟹   XP_006502211
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39387,927,865 - 87,934,602 (-)NCBI
GRCm38388,020,558 - 88,027,298 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_071314   ⟸   NM_022031
- Peptide Label: precursor
- UniProtKB: Q9ESM3 (UniProtKB/Swiss-Prot),   B2RRU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006502211   ⟸   XM_006502148
- Peptide Label: isoform X1
- UniProtKB: Q9ESM3 (UniProtKB/Swiss-Prot),   B2RRU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000125271   ⟸   ENSMUST00000160150
RefSeq Acc Id: ENSMUSP00000005014   ⟸   ENSMUST00000005014
Protein Domains
Ig-like   Ig-like V-type   Link

Promoters
RGD ID:6833938
Promoter ID:MM_KWN:34813
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney
Transcripts:OTTMUST00000067278
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36387,827,116 - 87,827,682 (-)MPROMDB
RGD ID:6881086
Promoter ID:EPDNEW_M3994
Type:multiple initiation site
Name:Hapln2_1
Description:Mus musculus hyaluronan and proteoglycan link protein 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38388,027,488 - 88,027,548EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2137300 AgrOrtholog
Ensembl Genes ENSMUSG00000004894 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000005014 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000125271 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000005014 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000160150 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Link_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:73940 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2137300 ENTREZGENE
NCBI Gene 73940 ENTREZGENE
Pfam V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xlink UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hapln2 PhenoGen
PRINTS LINKMODULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RRU7 ENTREZGENE, UniProtKB/TrEMBL
  E0CXI3_MOUSE UniProtKB/TrEMBL
  HPLN2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE