Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Klc3 | Mouse | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of KLC3 mRNA | CTD | PMID:22206623 | Klc3 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of KLC3 mRNA | CTD | PMID:22298810 | Klc3 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KLC3 mRNA | CTD | PMID:32109520 and PMID:33387578 | Klc3 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | KLC3 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KLC3 mRNA | CTD | PMID:27913140 | Klc3 | Mouse | 4,4'-sulfonyldiphenol | affects methylation | EXP | | 6480464 | bisphenol S affects the methylation of KLC3 exon and bisphenol S affects the methylation of KLC3 gene | CTD | PMID:31683443 and PMID:33297965 | Klc3 | Mouse | 4-hydroxyphenyl retinamide | increases expression | EXP | | 6480464 | Fenretinide results in increased expression of KLC3 mRNA | CTD | PMID:28973697 | Klc3 | Mouse | 6-propyl-2-thiouracil | decreases expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of KLC3 mRNA | CTD | PMID:25825206 | Klc3 | Mouse | actinomycin D | multiple interactions | ISO | KLC3 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of KLC3 mRNA | CTD | PMID:38460933 | Klc3 | Mouse | all-trans-retinoic acid | multiple interactions | EXP | | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of KLC3 mRNA | CTD | PMID:36189433 | Klc3 | Mouse | ammonium chloride | affects expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of KLC3 mRNA | CTD | PMID:16483693 | Klc3 | Mouse | amphetamine | decreases expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | Amphetamine results in decreased expression of KLC3 mRNA | CTD | PMID:30779732 | Klc3 | Mouse | Aroclor 1254 | increases expression | EXP | | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of KLC3 mRNA | CTD | PMID:23650126 | Klc3 | Mouse | arsenous acid | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of KLC3 mRNA | CTD | PMID:20458559 | Klc3 | Mouse | benzo[a]pyrene | affects methylation | ISO | KLC3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of KLC3 5' UTR and Benzo(a)pyrene affects the methylation of KLC3 promoter | CTD | PMID:27901495 | Klc3 | Mouse | beta-lapachone | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of KLC3 mRNA | CTD | PMID:38218311 | Klc3 | Mouse | bisphenol A | decreases expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of KLC3 mRNA | CTD | PMID:25181051 | Klc3 | Mouse | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of KLC3 mRNA | CTD | PMID:32156529 | Klc3 | Mouse | bisphenol F | decreases expression | EXP | | 6480464 | bisphenol F results in decreased expression of KLC3 mRNA | CTD | PMID:38685157 | Klc3 | Mouse | bromobenzene | affects binding | ISO | Klc3 (Rattus norvegicus) | 6480464 | bromobenzene metabolite binds to KLC3 protein | CTD | PMID:17305373 | Klc3 | Mouse | butanal | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of KLC3 mRNA | CTD | PMID:26079696 | Klc3 | Mouse | C60 fullerene | increases expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | fullerene C60 results in increased expression of KLC3 mRNA | CTD | PMID:19167457 | Klc3 | Mouse | camptothecin | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | Camptothecin results in increased expression of KLC3 mRNA | CTD | PMID:38460933 | Klc3 | Mouse | CGP 52608 | multiple interactions | ISO | KLC3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to KLC3 gene] | CTD | PMID:28238834 | Klc3 | Mouse | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of KLC3 mRNA | CTD | PMID:37019170 | Klc3 | Mouse | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLC3 mRNA | CTD | PMID:20938992 | Klc3 | Mouse | copper(II) sulfate | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of KLC3 mRNA | CTD | PMID:19549813 | Klc3 | Mouse | Cuprizon | increases expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of KLC3 mRNA | CTD | PMID:26577399 | Klc3 | Mouse | dextran sulfate | increases expression | EXP | | 6480464 | Dextran Sulfate results in increased expression of KLC3 mRNA | CTD | PMID:35093514 | Klc3 | Mouse | diarsenic trioxide | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of KLC3 mRNA | CTD | PMID:20458559 | Klc3 | Mouse | diuron | decreases expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | Diuron results in decreased expression of KLC3 mRNA | CTD | PMID:21551480 | Klc3 | Mouse | endosulfan | affects expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | Endosulfan affects the expression of KLC3 mRNA | CTD | PMID:29391264 | Klc3 | Mouse | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLC3 mRNA | CTD | PMID:20938992 | Klc3 | Mouse | FR900359 | increases phosphorylation | ISO | KLC3 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of KLC3 protein | CTD | PMID:37730182 | Klc3 | Mouse | gentamycin | decreases expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | Gentamicins results in decreased expression of KLC3 mRNA | CTD | PMID:22061828 | Klc3 | Mouse | inulin | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of KLC3 mRNA | CTD | PMID:36331819 | Klc3 | Mouse | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of KLC3 mRNA | CTD | PMID:20938992 | Klc3 | Mouse | mono(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of KLC3 mRNA | CTD | PMID:36189433 | Klc3 | Mouse | Nutlin-3 | multiple interactions | ISO | KLC3 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of KLC3 mRNA | CTD | PMID:38460933 | Klc3 | Mouse | ozone | multiple interactions | ISO | KLC3 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of KLC3 mRNA | CTD | PMID:35430440 | Klc3 | Mouse | paracetamol | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of KLC3 mRNA | CTD | PMID:26690555 | Klc3 | Mouse | PCB138 | decreases expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:23829299 | Klc3 | Mouse | pentanal | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | pentanal results in increased expression of KLC3 mRNA | CTD | PMID:26079696 | Klc3 | Mouse | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of KLC3 mRNA | CTD | PMID:36331819 | Klc3 | Mouse | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLC3 mRNA | CTD | PMID:19710929 | Klc3 | Mouse | propanal | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of KLC3 mRNA | CTD | PMID:26079696 | Klc3 | Mouse | silicon dioxide | decreases expression | ISO | KLC3 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of KLC3 mRNA | CTD | PMID:23806026 | Klc3 | Mouse | sodium arsenite | decreases expression | ISO | KLC3 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of KLC3 mRNA | CTD | PMID:29301061 | Klc3 | Mouse | sodium arsenite | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of KLC3 mRNA | CTD | PMID:38568856 | Klc3 | Mouse | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of KLC3 mRNA | CTD | PMID:17484886 | Klc3 | Mouse | thiram | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | Thiram results in increased expression of KLC3 mRNA | CTD | PMID:38568856 | Klc3 | Mouse | titanium dioxide | decreases expression | EXP | | 6480464 | titanium dioxide results in decreased expression of KLC3 mRNA | CTD | PMID:29264374 | Klc3 | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of KLC3 promoter alternative form | CTD | PMID:35295148 | Klc3 | Mouse | titanium dioxide | increases methylation | EXP | | 6480464 | titanium dioxide results in increased methylation of KLC3 promoter alternative form | CTD | PMID:35295148 | Klc3 | Mouse | trichloroethene | increases expression | ISO | Klc3 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of KLC3 mRNA | CTD | PMID:33387578 | Klc3 | Mouse | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of KLC3 mRNA | CTD | PMID:30912803 | Klc3 | Mouse | valproic acid | affects expression | ISO | KLC3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of KLC3 mRNA | CTD | PMID:25979313 | Klc3 | Mouse | valproic acid | increases expression | ISO | KLC3 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of KLC3 mRNA | CTD | PMID:28001369 | Klc3 | Mouse | valproic acid | increases methylation | ISO | KLC3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of KLC3 gene | CTD | PMID:29154799 | |