Pcca (propionyl-Coenzyme A carboxylase, alpha polypeptide) - Rat Genome Database

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Gene: Pcca (propionyl-Coenzyme A carboxylase, alpha polypeptide) Mus musculus
Analyze
Symbol: Pcca
Name: propionyl-Coenzyme A carboxylase, alpha polypeptide
RGD ID: 733831
MGI Page MGI
Description: Enables propionyl-CoA carboxylase activity. Predicted to be involved in lipid catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; nervous system; orbito-sphenoid; sensory organ; and urinary system. Used to study propionic acidemia. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCA (propionyl-CoA carboxylase subunit alpha).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C79630; PCCase subunit alpha; propanoyl-CoA:carbon dioxide ligase subunit alpha; propionyl CoA-carboxylase alpha; propionyl-CoA carboxylase alpha chain, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914122,721,822 - 123,127,372 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14122,771,736 - 123,128,512 (+)EnsemblGRCm39 Ensembl
GRCm3814122,484,365 - 122,889,944 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14122,534,324 - 122,891,100 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714122,933,550 - 123,289,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614121,669,524 - 122,025,008 (+)NCBIMGSCv36mm8
Celera14121,094,262 - 121,448,288 (+)NCBICelera
Cytogenetic Map14E5NCBI
cM Map1465.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (ISO)
7,12-dimethyltetraphene  (EXP)
aconitine  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium trinitrate  (EXP)
cisplatin  (EXP)
clothianidin  (ISO)
cobalt dichloride  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diuron  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
gallic acid  (ISO)
genistein  (ISO)
glafenine  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (ISO)
inulin  (EXP)
ivermectin  (ISO)
L-methionine  (EXP)
menadione  (ISO)
methapyrilene  (ISO)
N-nitrosomorpholine  (ISO)
O-methyleugenol  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
PhIP  (ISO)
phlorizin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (EXP,ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
topotecan  (ISO)
tunicamycin  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
catalytic complex  (IEA,ISO)
mitochondrial matrix  (ISO,ISS)
mitochondrion  (HDA,IBA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Three novel splice mutations in the PCCA gene causing identical exon skipping in propionic acidemia patients. Richard E, etal., Hum Genet. 1997 Nov;101(1):93-6.
Additional References at PubMed
PMID:8211130   PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11461925   PMID:12477932   PMID:14681479   PMID:15226823   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16919269   PMID:18614015   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22496890   PMID:23648696   PMID:25654275   PMID:27083476   PMID:28130547  
PMID:28188211   PMID:28720782   PMID:29199018   PMID:29222160   PMID:29378828   PMID:30550785   PMID:30733279   PMID:31678161   PMID:32325033   PMID:33087718   PMID:33601422   PMID:36064721  
PMID:36114006   PMID:36417873   PMID:38355793   PMID:38811689  


Genomics

Comparative Map Data
Pcca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914122,721,822 - 123,127,372 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14122,771,736 - 123,128,512 (+)EnsemblGRCm39 Ensembl
GRCm3814122,484,365 - 122,889,944 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14122,534,324 - 122,891,100 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714122,933,550 - 123,289,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614121,669,524 - 122,025,008 (+)NCBIMGSCv36mm8
Celera14121,094,262 - 121,448,288 (+)NCBICelera
Cytogenetic Map14E5NCBI
cM Map1465.99NCBI
PCCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813100,089,093 - 100,530,435 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13100,089,015 - 100,530,437 (+)EnsemblGRCh38hg38GRCh38
GRCh3713100,741,347 - 101,182,689 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361399,539,338 - 99,980,690 (+)NCBINCBI36Build 36hg18NCBI36
Build 341399,539,402 - 99,980,687NCBI
Celera1381,585,804 - 82,027,260 (+)NCBICelera
Cytogenetic Map13q32.3NCBI
HuRef1381,336,606 - 81,778,760 (+)NCBIHuRef
CHM1_113100,711,146 - 101,152,990 (+)NCBICHM1_1
T2T-CHM13v2.01399,302,579 - 99,745,721 (+)NCBIT2T-CHM13v2.0
Pcca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815106,034,586 - 106,374,908 (+)NCBIGRCr8
mRatBN7.21599,627,955 - 99,969,555 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1599,627,982 - 99,968,266 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx15103,560,589 - 103,901,667 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015104,665,702 - 105,000,289 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015101,592,936 - 101,927,542 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015108,960,509 - 109,306,879 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15108,960,562 - 109,306,603 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015112,346,155 - 112,477,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.015112,502,385 - 112,687,789 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415107,659,723 - 108,028,929 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.115107,675,589 - 108,044,696 (+)NCBI
Celera1598,401,724 - 98,738,731 (+)NCBICelera
RH 3.4 Map15692.11RGD
Cytogenetic Map15q25NCBI
Pcca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540410,317,640 - 10,661,496 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540410,317,640 - 10,719,148 (-)NCBIChiLan1.0ChiLan1.0
PCCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214101,616,111 - 102,056,078 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113100,283,182 - 100,723,379 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01381,259,313 - 81,699,117 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113100,390,959 - 100,837,772 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13100,390,959 - 100,837,772 (+)Ensemblpanpan1.1panPan2
PCCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12249,965,134 - 50,428,025 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2250,023,369 - 50,428,027 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2249,745,683 - 50,208,149 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02250,406,847 - 50,870,032 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2250,464,478 - 50,870,032 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12250,114,652 - 50,516,893 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02250,090,509 - 50,553,146 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02250,127,751 - 50,590,508 (+)NCBIUU_Cfam_GSD_1.0
Pcca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945185,393,912 - 185,784,766 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647210,164,642 - 10,501,878 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647210,167,387 - 10,501,824 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCCA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1168,920,929 - 69,286,430 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11168,920,923 - 69,286,431 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21176,363,099 - 76,547,559 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCCA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1378,722,186 - 79,156,049 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl378,722,286 - 79,156,863 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604635,224,719 - 35,662,275 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479310,691,224 - 11,100,853 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479310,691,224 - 11,099,905 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pcca
9772 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1504
Count of miRNA genes:649
Interacting mature miRNAs:816
Transcripts:ENSMUST00000038374, ENSMUST00000128893, ENSMUST00000132444, ENSMUST00000135578, ENSMUST00000138836, ENSMUST00000140517, ENSMUST00000143240, ENSMUST00000147018, ENSMUST00000148172, ENSMUST00000152383, ENSMUST00000154206, ENSMUST00000156755, ENSMUST00000177312
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12792981Fbmd5_mfemoral bone mineral density 5, females only (mouse)1499838217125033054Mouse
10755523Hgb2_mhemoglobin 2 (mouse)14105884654125139656Mouse

Markers in Region
RH126703  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814122,582,591 - 122,582,819UniSTSGRCm38
MGSCv3714122,981,813 - 122,982,041UniSTSGRCm37
Celera14121,142,521 - 121,142,749UniSTS
Cytogenetic Map14E5UniSTS
cM Map1464.0UniSTS
Whitehead/MRC_RH141277.83UniSTS
AI315552  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814122,889,626 - 122,889,730UniSTSGRCm38
MGSCv3714123,288,848 - 123,288,952UniSTSGRCm37
Celera14121,447,970 - 121,448,074UniSTS
Cytogenetic Map14E5UniSTS
cM Map1464.0UniSTS
Whitehead/MRC_RH141280.33UniSTS
UniSTS:237256  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814122,889,563 - 122,889,786UniSTSGRCm38
MGSCv3714123,288,785 - 123,289,008UniSTSGRCm37
Celera14121,447,907 - 121,448,130UniSTS
Cytogenetic Map14E5UniSTS
cM Map1464.0UniSTS
Pcca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14E5UniSTS
cM Map1464.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001425592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001425597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_144844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_153443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_189332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_383133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC144798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC169511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK208044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY046947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY263345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB872161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB873421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB875292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB879802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB888537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB921346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC929570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC930830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC932701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC937211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC945946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC978755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000038374   ⟹   ENSMUSP00000038763
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,771,751 - 123,127,356 (+)Ensembl
GRCm38.p6 Ensembl14122,534,339 - 122,889,944 (+)Ensembl
Ensembl Acc Id: ENSMUST00000128893
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,975,312 - 123,051,005 (+)Ensembl
GRCm38.p6 Ensembl14122,737,900 - 122,813,593 (+)Ensembl
Ensembl Acc Id: ENSMUST00000132444   ⟹   ENSMUSP00000135087
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14123,027,811 - 123,127,232 (+)Ensembl
GRCm38.p6 Ensembl14122,790,399 - 122,889,820 (+)Ensembl
Ensembl Acc Id: ENSMUST00000135578   ⟹   ENSMUSP00000123422
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,771,757 - 122,887,696 (+)Ensembl
GRCm38.p6 Ensembl14122,534,345 - 122,650,284 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138836
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14123,124,315 - 123,127,240 (+)Ensembl
GRCm38.p6 Ensembl14122,886,903 - 122,889,828 (+)Ensembl
Ensembl Acc Id: ENSMUST00000140517
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14123,113,347 - 123,128,512 (+)Ensembl
GRCm38.p6 Ensembl14122,875,935 - 122,891,100 (+)Ensembl
Ensembl Acc Id: ENSMUST00000143240
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,840,331 - 122,901,739 (+)Ensembl
GRCm38.p6 Ensembl14122,602,919 - 122,664,327 (+)Ensembl
Ensembl Acc Id: ENSMUST00000147018   ⟹   ENSMUSP00000135557
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,951,441 - 122,975,407 (+)Ensembl
GRCm38.p6 Ensembl14122,714,029 - 122,737,995 (+)Ensembl
Ensembl Acc Id: ENSMUST00000148172
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,771,736 - 122,820,389 (+)Ensembl
GRCm38.p6 Ensembl14122,534,324 - 122,582,977 (+)Ensembl
Ensembl Acc Id: ENSMUST00000152383   ⟹   ENSMUSP00000135266
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,951,467 - 123,127,237 (+)Ensembl
GRCm38.p6 Ensembl14122,714,055 - 122,889,825 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154206   ⟹   ENSMUSP00000120027
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,771,743 - 122,854,221 (+)Ensembl
GRCm38.p6 Ensembl14122,534,331 - 122,616,809 (+)Ensembl
Ensembl Acc Id: ENSMUST00000156755
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,951,531 - 123,050,659 (+)Ensembl
GRCm38.p6 Ensembl14122,714,119 - 122,813,247 (+)Ensembl
Ensembl Acc Id: ENSMUST00000177312   ⟹   ENSMUSP00000135665
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,820,096 - 123,127,240 (+)Ensembl
GRCm38.p6 Ensembl14122,582,684 - 122,889,828 (+)Ensembl
RefSeq Acc Id: NM_001425592   ⟹   NP_001412521
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,771,743 - 123,127,372 (+)NCBI
RefSeq Acc Id: NM_001425593   ⟹   NP_001412522
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,771,743 - 123,127,372 (+)NCBI
RefSeq Acc Id: NM_001425594   ⟹   NP_001412523
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,771,743 - 123,127,372 (+)NCBI
RefSeq Acc Id: NM_001425595   ⟹   NP_001412524
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,771,743 - 123,127,372 (+)NCBI
RefSeq Acc Id: NM_001425596   ⟹   NP_001412525
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,721,822 - 123,127,372 (+)NCBI
RefSeq Acc Id: NM_001425597   ⟹   NP_001412526
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,771,743 - 123,127,372 (+)NCBI
RefSeq Acc Id: NM_144844   ⟹   NP_659093
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,771,743 - 123,127,372 (+)NCBI
GRCm3814122,534,328 - 122,889,944 (+)NCBI
MGSCv3714122,933,550 - 123,289,166 (+)RGD
Celera14121,094,262 - 121,448,288 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_153443
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,721,822 - 123,127,372 (+)NCBI
GRCm3814122,484,365 - 122,889,944 (+)NCBI
Sequence:
RefSeq Acc Id: NR_189332
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,771,743 - 123,127,372 (+)NCBI
RefSeq Acc Id: XM_036158399   ⟹   XP_036014292
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,771,711 - 123,127,242 (+)NCBI
Sequence:
RefSeq Acc Id: XR_383133
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,771,601 - 123,127,242 (+)NCBI
GRCm3814122,526,313 - 122,889,830 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001412521 (Get FASTA)   NCBI Sequence Viewer  
  NP_001412522 (Get FASTA)   NCBI Sequence Viewer  
  NP_001412523 (Get FASTA)   NCBI Sequence Viewer  
  NP_001412524 (Get FASTA)   NCBI Sequence Viewer  
  NP_001412525 (Get FASTA)   NCBI Sequence Viewer  
  NP_001412526 (Get FASTA)   NCBI Sequence Viewer  
  NP_659093 (Get FASTA)   NCBI Sequence Viewer  
  XP_036014292 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH06915 (Get FASTA)   NCBI Sequence Viewer  
  AAH49802 (Get FASTA)   NCBI Sequence Viewer  
  AAL02364 (Get FASTA)   NCBI Sequence Viewer  
  BAE28281 (Get FASTA)   NCBI Sequence Viewer  
  CBF60137 (Get FASTA)   NCBI Sequence Viewer  
  CBF60914 (Get FASTA)   NCBI Sequence Viewer  
  CBF62018 (Get FASTA)   NCBI Sequence Viewer  
  CBF64199 (Get FASTA)   NCBI Sequence Viewer  
  CBF68413 (Get FASTA)   NCBI Sequence Viewer  
  CBF95663 (Get FASTA)   NCBI Sequence Viewer  
  CBU85381 (Get FASTA)   NCBI Sequence Viewer  
  CBU85990 (Get FASTA)   NCBI Sequence Viewer  
  CBU86894 (Get FASTA)   NCBI Sequence Viewer  
  CBU89075 (Get FASTA)   NCBI Sequence Viewer  
  CBU93287 (Get FASTA)   NCBI Sequence Viewer  
  CBV09183 (Get FASTA)   NCBI Sequence Viewer  
  EDL00630 (Get FASTA)   NCBI Sequence Viewer  
  EDL00631 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000038763
  ENSMUSP00000038763.7
  ENSMUSP00000120027.2
  ENSMUSP00000123422.2
  ENSMUSP00000135087.2
  ENSMUSP00000135266.2
  ENSMUSP00000135557.2
  ENSMUSP00000135665.2
GenBank Protein Q91ZA3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_659093   ⟸   NM_144844
- Peptide Label: isoform 1 precursor
- UniProtKB: Q922N3 (UniProtKB/Swiss-Prot),   Q91ZA3 (UniProtKB/Swiss-Prot),   Q80VU5 (UniProtKB/Swiss-Prot),   Q3UGC8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000135665   ⟸   ENSMUST00000177312
Ensembl Acc Id: ENSMUSP00000135557   ⟸   ENSMUST00000147018
Ensembl Acc Id: ENSMUSP00000135087   ⟸   ENSMUST00000132444
Ensembl Acc Id: ENSMUSP00000135266   ⟸   ENSMUST00000152383
Ensembl Acc Id: ENSMUSP00000123422   ⟸   ENSMUST00000135578
Ensembl Acc Id: ENSMUSP00000120027   ⟸   ENSMUST00000154206
Ensembl Acc Id: ENSMUSP00000038763   ⟸   ENSMUST00000038374
RefSeq Acc Id: XP_036014292   ⟸   XM_036158399
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001412525   ⟸   NM_001425596
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001412526   ⟸   NM_001425597
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001412521   ⟸   NM_001425592
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001412523   ⟸   NM_001425594
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001412524   ⟸   NM_001425595
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001412522   ⟸   NM_001425593
- Peptide Label: isoform 3
Protein Domains
ATP-grasp   Biotin carboxylation   Biotinyl-binding   Lipoyl-binding   Propionyl-coenzyme A carboxylase BT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91ZA3-F1-model_v2 AlphaFold Q91ZA3 1-724 view protein structure

Promoters
RGD ID:8683278
Promoter ID:EPDNEW_M19669
Type:initiation region
Name:Pcca_1
Description:Mus musculus propionyl-Coenzyme A carboxylase, alpha polypeptide, transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3814122,534,331 - 122,534,391EPDNEW
RGD ID:6825254
Promoter ID:MM_KWN:17873
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_144844,   OTTMUST00000063411,   OTTMUST00000063412,   OTTMUST00000063414
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3614122,933,239 - 122,933,739 (+)MPROMDB
RGD ID:6825256
Promoter ID:MM_KWN:17879
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000063408
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3614123,274,316 - 123,274,816 (+)MPROMDB
RGD ID:6825258
Promoter ID:MM_KWN:17880
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver
Transcripts:OTTMUST00000063418
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3614123,285,686 - 123,286,186 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97499 AgrOrtholog
Ensembl Genes ENSMUSG00000041650 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000038374 ENTREZGENE
  ENSMUST00000038374.13 UniProtKB/Swiss-Prot
  ENSMUST00000132444.2 UniProtKB/TrEMBL
  ENSMUST00000135578.8 UniProtKB/TrEMBL
  ENSMUST00000147018.2 UniProtKB/TrEMBL
  ENSMUST00000152383.8 UniProtKB/TrEMBL
  ENSMUST00000154206.8 UniProtKB/TrEMBL
  ENSMUST00000177312.8 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.1490.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.700.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATP-grasp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP_grasp_subdomain_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BC-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_carboxylase_complex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_carboxylation_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_COase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCC_BT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rudment_hybrid_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:110821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97499 ENTREZGENE
NCBI Gene Pcca ENTREZGENE
PANTHER CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Biotin_carb_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_carb_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSase_L_D2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PCC_BT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pcca PhenoGen
PROSITE ATP_GRASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIOTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIOTINYL_LIPOYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50979 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Biotin_carb_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51246 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YWM4_MOUSE UniProtKB/TrEMBL
  D3YZC0_MOUSE UniProtKB/TrEMBL
  H3BJR0_MOUSE UniProtKB/TrEMBL
  H3BK61_MOUSE UniProtKB/TrEMBL
  H3BKW6_MOUSE UniProtKB/TrEMBL
  H3BL62_MOUSE UniProtKB/TrEMBL
  PCCA_MOUSE UniProtKB/Swiss-Prot
  Q3UGC8 ENTREZGENE, UniProtKB/TrEMBL
  Q80VU5 ENTREZGENE
  Q91ZA3 ENTREZGENE
  Q922N3 ENTREZGENE
UniProt Secondary Q80VU5 UniProtKB/Swiss-Prot
  Q922N3 UniProtKB/Swiss-Prot