Srpk3 (SRSF protein kinase 3) - Rat Genome Database

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Gene: Srpk3 (SRSF protein kinase 3) Rattus norvegicus
Analyze
Symbol: Srpk3
Name: SRSF protein kinase 3
RGD ID: 727856
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in muscle tissue development. Predicted to act upstream of or within protein phosphorylation and skeletal muscle tissue development. Orthologous to human SRPK3 (SRSF protein kinase 3); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Mssk1; muscle-specific serine kinase 1; serine arginine rich protein-specific kinase 3; serine/arginine-rich protein specific kinase 3; serine/threonine kinase 23; serine/threonine-protein kinase SRPK3; SFRS protein kinase 3; Stk23
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,510,452 - 151,515,208 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,510,539 - 151,515,198 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,651,811 - 153,656,371 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X157,215,041 - 157,219,601 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X154,886,865 - 154,891,425 (+)NCBIRnor_WKY
Rnor_6.0X157,008,773 - 157,014,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,008,824 - 157,013,443 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,757,658 - 152,762,297 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,696,742 - 159,701,302 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X159,771,842 - 159,776,400 (+)NCBI
Celera1136,374,344 - 136,378,904 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. Brenner V, etal., Genomics 1997 Aug 15;44(1):8-14.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16140986  


Genomics

Comparative Map Data
Srpk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,510,452 - 151,515,208 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,510,539 - 151,515,198 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX153,651,811 - 153,656,371 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X157,215,041 - 157,219,601 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X154,886,865 - 154,891,425 (+)NCBIRnor_WKY
Rnor_6.0X157,008,773 - 157,014,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,008,824 - 157,013,443 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,757,658 - 152,762,297 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,696,742 - 159,701,302 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X159,771,842 - 159,776,400 (+)NCBI
Celera1136,374,344 - 136,378,904 (-)NCBICelera
Cytogenetic MapXq37NCBI
SRPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,781,041 - 153,785,730 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX153,776,412 - 153,785,732 (+)EnsemblGRCh38hg38GRCh38
GRCh37X153,046,496 - 153,051,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,699,704 - 152,704,381 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X152,567,364 - 152,572,031NCBI
CeleraX153,280,137 - 153,284,868 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,703,520 - 141,708,215 (+)NCBIHuRef
CHM1_1X152,920,866 - 152,925,596 (+)NCBICHM1_1
T2T-CHM13v2.0X152,054,705 - 152,059,393 (+)NCBIT2T-CHM13v2.0
Srpk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,817,966 - 72,822,531 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,818,011 - 72,822,531 (+)EnsemblGRCm39 Ensembl
GRCm38X73,772,608 - 73,778,925 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,774,405 - 73,778,925 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X71,019,761 - 71,024,264 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X70,027,142 - 70,031,645 (+)NCBIMGSCv36mm8
CeleraX65,026,695 - 65,031,198 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
Srpk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580496,451 - 500,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955580496,447 - 500,709 (+)NCBIChiLan1.0ChiLan1.0
SRPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,217,064 - 153,222,305 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,216,794 - 153,222,273 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X143,331,213 - 143,336,426 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SRPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,594,992 - 121,599,333 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,594,864 - 121,599,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX106,924,169 - 106,928,495 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X124,736,478 - 124,740,804 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX124,736,435 - 124,740,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,505,752 - 120,510,078 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X123,020,752 - 123,025,078 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X122,782,946 - 122,787,273 (+)NCBIUU_Cfam_GSD_1.0
Srpk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X118,923,482 - 118,928,430 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809661,264 - 666,188 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936809661,264 - 666,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,524,083 - 124,528,945 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,524,102 - 124,528,607 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,088,688 - 142,093,193 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,207,636 - 128,212,624 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,207,989 - 128,212,410 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606566,075,229 - 66,079,982 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srpk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946462,114 - 465,841 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624946462,108 - 465,831 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:41
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000026211
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 3 8 11 1 8
Low 1 22 6 16 6 32 16 30 11
Below cutoff 17 17 17 22 18 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000082711   ⟹   ENSRNOP00000075400
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX151,510,539 - 151,515,198 (+)Ensembl
Rnor_6.0 EnsemblX157,008,824 - 157,013,443 (-)Ensembl
RefSeq Acc Id: NM_184045   ⟹   NP_908934
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,510,641 - 151,515,201 (+)NCBI
Rnor_6.0X157,008,778 - 157,013,338 (-)NCBI
Rnor_5.01152,757,658 - 152,762,297 (-)NCBI
RGSC_v3.4X159,696,742 - 159,701,302 (+)RGD
Celera1136,374,344 - 136,378,904 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229558   ⟹   XP_006229620
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,510,452 - 151,515,208 (+)NCBI
Rnor_6.0X157,008,773 - 157,014,342 (-)NCBI
Rnor_5.01152,757,658 - 152,762,297 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229559   ⟹   XP_006229621
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,510,454 - 151,515,208 (+)NCBI
Rnor_6.0X157,008,773 - 157,014,341 (-)NCBI
Rnor_5.01152,757,658 - 152,762,297 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229560   ⟹   XP_006229622
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,510,460 - 151,515,208 (+)NCBI
Rnor_6.0X157,008,773 - 157,014,338 (-)NCBI
Rnor_5.01152,757,658 - 152,762,297 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229561   ⟹   XP_006229623
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,510,462 - 151,515,208 (+)NCBI
Rnor_6.0X157,008,773 - 157,014,338 (-)NCBI
Rnor_5.01152,757,658 - 152,762,297 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773617   ⟹   XP_008771839
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,510,457 - 151,515,208 (+)NCBI
Rnor_6.0X157,008,773 - 157,014,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773618   ⟹   XP_008771840
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X151,510,464 - 151,515,208 (+)NCBI
Rnor_6.0X157,008,773 - 157,013,608 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_908934   ⟸   NM_184045
- UniProtKB: G3V8I2 (UniProtKB/TrEMBL),   Q6V9W0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229620   ⟸   XM_006229558
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006229621   ⟸   XM_006229559
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006229623   ⟸   XM_006229561
- Peptide Label: isoform X4
- UniProtKB: A0A0G2KAH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229622   ⟸   XM_006229560
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008771839   ⟸   XM_008773617
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008771840   ⟸   XM_008773618
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSRNOP00000075400   ⟸   ENSRNOT00000082711
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAH6-F1-model_v2 AlphaFold A0A0G2KAH6 1-590 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727856 AgrOrtholog
BioCyc Gene G2FUF-662 BioCyc
Ensembl Genes ENSRNOG00000054548 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000075400 ENTREZGENE
  ENSRNOP00000075400.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082711 ENTREZGENE
  ENSRNOT00000082711.2 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:293854 UniProtKB/TrEMBL
NCBI Gene 293854 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Srpk3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2KAH6 ENTREZGENE, UniProtKB/TrEMBL
  G3V8I2 ENTREZGENE, UniProtKB/TrEMBL
  Q6V9W0 ENTREZGENE
UniProt Secondary Q6V9W0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Srpk3  SRSF protein kinase 3  Srpk3  SFRS protein kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-22 Srpk3  SFRS protein kinase 3  Srpk3  Srsf protein kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-07-13 Srpk3  Srsf protein kinase 3  Srpk3  SFRS protein kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Srpk3  SFRS protein kinase 3  Srpk3  serine/arginine-rich protein specific kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-08-20 Srpk3  serine/arginine-rich protein specific kinase 3  Stk23  serine/threonine kinase 23  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Stk23  serine/threonine kinase 23      Symbol and Name status set to approved 1299863 APPROVED