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Gene: Mup22 (major urinary protein 22) Mus musculus

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No known orthologs.

Symbol:

Mup22

Name:

major urinary protein 22

RGD ID:

7205601

MGI Page

MGI

Description:

Predicted to enable odorant binding activity. Predicted to be active in extracellular space.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Gm21320; major urinary protein 11-like; major urinary protein-like; predicted gene, 21320

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Alliance orthologs ³				less info ...
Rattus norvegicus (Norway rat):	Mup4l4 (major urinary protein 4 like 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Mup5 (major urinary protein 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Mup4 (major urinary protein 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Mup4l1 (major urinary protein 4 like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Mup18 (major urinary protein 18)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Mup4l3 (major urinary protein 4 like 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Mup4-ps6 (major urinary protein 4, pseudogene 6)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG44013	Alliance	DIOPT (InParanoid\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	60,773,585 - 60,777,596 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	60,773,588 - 60,777,462 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	60,817,586 - 60,821,597 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	60,817,589 - 60,821,463 (-)	Ensembl	GRCm38		mm10	GRCm38
Cytogenetic Map	4	B3	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mup22	Mouse	17beta-estradiol	decreases expression	EXP		6480464	Estradiol results in decreased expression of MUP22 mRNA	CTD	PMID:39298647
Mup22	Mouse	4,4'-sulfonyldiphenol	decreases expression	EXP		6480464	bisphenol S results in decreased expression of MUP22 mRNA	CTD	PMID:39298647
Mup22	Mouse	glyphosate	increases expression	EXP		6480464	Glyphosate results in increased expression of MUP22 protein	CTD	PMID:37208198

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mup22	Mouse	extracellular space	is_active_in	IBA	PANTHER:PTN001350062 more ...	2290270		GO_Central	GO_REF:0000033
Mup22	Mouse	extracellular space	located_in	ISO	Mup4l1 (Rattus norvegicus)	2290270		GO_Central	GO_REF:0000096

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mup22	Mouse	odorant binding	enables	IBA	PANTHER:PTN000152998 more ...	2290270		GO_Central	GO_REF:0000033

PMID:30782214

Variants in Mup22
77 total Variants

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1301586	Stheal3_m	soft tissue heal 3 (mouse)			Not determined		4	28658442	62658566	Mouse
11532714	Sluc43_m	susceptibility to lung cancer 43 (mouse)					4	46642108	123127211	Mouse
39128211	Lwq22_m	liver weight QTL 22 (mouse)					4	17892616	88982216	Mouse
25314308	Mlh1fc1_m	MLH1 foci count 1 (mouse)					4	48500000	76918237	Mouse
26884434	Zlq1_m	zygomatic length QTL 1, 5 week (mouse)					4	53700000	103257197	Mouse
1301786	Bpq3_m	blood pressure QTL 3 (mouse)			Not determined		4	42402240	76402381	Mouse
10412178	Habiir2_m	hyperoxic acute lung injury imprinted region 2 (mouse)			Not determined		4	39452126	63283678	Mouse
1300574	Im2_m	immunoregulatory 2 (mouse)			Not determined		4	28077682	62077816	Mouse
1301213	Lgth3_m	body length 3 (mouse)			Not determined		4	50100262	84100408	Mouse
26884437	Sklq13_m	skull length QTL 13, 16 week (mouse)					4	57700000	155684457	Mouse
4142318	Lyr2_m	lymphoma resistance 2 (mouse)			Not determined			14010457	63283678	Mouse
1357895	Ctrcts_m	cataract severity (mouse)			Not determined		4	45709925	138342753	Mouse
1301190	Cd4ts2_m	CD4 T cell subset 2 (mouse)			Not determined		4	60145277	94145424	Mouse
1357507	Synch2_m	synechia 2 (mouse)			Not determined		4	60145277	94145424	Mouse
1357443	Lhyp_m	lung hyperpermeability (mouse)			Not determined		4	60454011	66764818	Mouse
1357453	Kidq4_m	kidney weight QTL 4 (mouse)			Not determined		4	17892616	88982216	Mouse
13207572	Spir2_m	Streptococcus pneumoniae infection resistance 2 (mouse)					4	50682795	88510637	Mouse
4142047	Mvwf3_m	modifier of von Willebrand factor 3 (mouse)			Not determined			14010457	117072206	Mouse
11567249	Elorr3_m	ethanol induced loss of righting response 3 (mouse)					4	3722677	156268235	Mouse
1357877	Synch1_m	synechia 1 (mouse)			Not determined		4	28709925	62710107	Mouse
10449022	Aanq1_m	aristolochic acid nephrotoxicity QTL 1 (mouse)					4	46603826	80603826	Mouse
1300977	Mopkd1_m	modifier of polycystic kidney disease progression 1 (mouse)			Not determined		4	36550839	70550967	Mouse
27095934	Ulnl2_m	ulna length 2, 5 week (mouse)					4	57700000	94788237	Mouse
10043964	Obq26_m	obesity QTL 26 (mouse)			Not determined		4	59047251	93047251	Mouse
1301941	Mmtg1_m	modifier of mammary tumor growth 1 (mouse)			Not determined		4	45658442	83099157	Mouse
13524841	Hbasrq1_m	habituation of the acoustic startle response QTL 1 (mouse)					4	54471589	88471589	Mouse
4141911	W6q15_m	weight 6 weeks QTL 15 (mouse)			Not determined			17892616	88982216	Mouse
13524838	Hbasrq1a_m	habituation of the acoustic startle response QTL 1a (mouse)					4	54471589	88471589	Mouse
12879977	Bod2_m	bone length and organs 2 (mouse)					4	46283531	80283678	Mouse
10043880	Adip23_m	adiposity 23 (mouse)			Not determined		4	46283531	80283678	Mouse
1301792	Hdlq10_m	HDL QTL 10 (mouse)			Not determined		4	35859707	69859853	Mouse
1558948	Ath8_m	atherosclerosis 8 (mouse)			Not determined		4	45658442	105156995	Mouse
4141900	Skts-fp1_m	skin tumor susceptibility in FVB and PWK 1 (mouse)			Not determined		4	53550839	124055180	Mouse
1301990	Arvm1_m	autoimmune renal vasculitis 1 (mouse)			Not determined		4	29332646	63332776	Mouse
1300966	Pabr2_m	plasma apolipoprotein B (human) regulator 2 (mouse)			Not determined		4	46332646	105801860	Mouse
1302116	Bbaa1_m	B.burgdorferi-associated arthritis 1 (mouse)			Not determined		4	38250930	72251078	Mouse
1301995	Lprm1_m	lymphoproliferation modifier 1 (mouse)			Not determined		4	50100262	84100408	Mouse
1301033	Abbp2_m	A/J and C57BL/6 blood pressure 2 (mouse)			Not determined		4	53550839	93763305	Mouse
26884449	Sklq2_m	skull length QTL 2, 5 week (mouse)					4	36700000	128993793	Mouse
27226724	Tibw2_m	tibia width 2, proximal, 10 week (mouse)					4	43000000	108357197	Mouse
27095905	Scvln3_m	sacral vertebrae length 2, 5 week (mouse)					4	55600000	128993793	Mouse
11532688	Mh_m	modifier of hemostasis (mouse)					4	48304775	82304775	Mouse

RH125017

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	11	55,123,905 - 55,123,988	UniSTS	GRCm38
MGSCv37	11	54,937,407 - 54,937,490	UniSTS	GRCm37
Celera	11	59,713,823 - 59,713,906	UniSTS
Cytogenetic Map	4	B3	UniSTS
cM Map	4	27.8	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	NM_001347154	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003688785	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CU463345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000211875 ⟹ ENSMUSP00000148722

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	60,773,588 - 60,777,462 (-)	Ensembl
GRCm38.p6 Ensembl	4	60,817,589 - 60,821,463 (-)	Ensembl

RefSeq Acc Id:

NM_001347154 ⟹ NP_001334083

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	60,773,585 - 60,777,589 (-)	NCBI
GRCm38	4	60,817,586 - 60,821,590 (-)	NCBI

Sequence:

show sequence

CAAAGCCTAACAGAGGTAGAGGAGACCCATACGGGAAGAGGGAAAAAAAAAAAAAAAAACGCTGAACCCAGAGAGTATATAAGGACAAGCAAAGGGGCTGGGGAGTGGAGTGTAGCCACGATCACAAG
AAAGACGTGGTCCTGACAGACAGACAATCCTATTCCCTACCAAAATGAAGATGCTGCTGCTGCTGCTGTGTTTGGGACTGACCCTAGTCTGTGTCCATGCAGAAGAAGCTAGTTCTACGGGAAGGAAC
TTTAATGTAGAAAAGATTAATGGGGAATGGCATACTATTATCCTGGCCTCTGACAAAAGAGAAAAGATAGAAGATAATGGCAACTTTAGACTTTTTCTGGAGCAAATCCATGTCTTGGAGAAATCCTT
AGTTCTTAAATTCCATACTGTAAGAGATGAAGAGTGCTCCGAATTATCTATGGTTGCTGACAAAACAGAAAAGGCTGGTGAATATTCTGTGACGTATGATGGATTCAATACATTTACTATACCTAAGA
CAGACTATGATAACTTTCTTATGGCTCATCTCATTAACGAAAAGGATGGGGAAACCTTCCAGCTGATGGGGCTCTATGGCCGAGAACCAGATTTGAGTTCAGACATCAAGGAAAGGTTTGCACAACTA
TGTGAGGAGCATGGAATCCTTAGAGAAAATATCATTGACCTATCCAATGCCAATCGCTGCCTCCAGGCCCGAGAATGAAGAATGGCCTGAGCCTCCAGTGTTGAGTGGAGACTTCTCACCAGGACTCC
ACCATCATCCCTTCCTATCCATACAGCATCCCCAGTATAAATTCTGTGATCTGCATTCCATCCTGTCTCACTGAGAAGTCCAATTCCAGTCTATCCACATGTTACCTAGGATACCTCATCAAGAATCA
AAGACTTCTTTAAATTTCTCTTTGATATACCCATGACAATTTTTCATGAATTTCTTCCTCTTCCTGTTCAATAAATGATTACCCTTGCACTTAAA

hide sequence

RefSeq Acc Id:

XM_003688785 ⟹ XP_003688833

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	60,773,585 - 60,777,596 (-)	NCBI
GRCm38	4	60,817,586 - 60,821,597 (-)	NCBI

Sequence:

show sequence

CATTCCACAAAGCCTAACAGAGGTAGAGGAGACCCATACGGGAAGAGGGAAAAAAAAAAAAAAAAACGCTGAACCCAGAGAGTATATAAGGACAAGCAAAGGGGCTGGGGAGTGGAGTGTAGCCACGA
TCACAAGAAAGACGTGGTCCTGACAGACAGACAATCCTATTCCCTACCAAAATGAAGATGCTGCTGCTGCTGCTGTGTTTGGGACTGACCCTAGTCTGTGTCCATGCAGAAGAAGCTAGTTCTACGGG
AAGGAACTTTAATGTAGAAAAGATTAATGGGGAATGGCATACTATTATCCTGGCCTCTGACAAAAGAGAAAAGATAGAAGATAATGGCAACTTTAGACTTTTTCTGGAGCAAATCCATGTCTTGGAGA
AATCCTTAGTTCTTAAATTCCATACTGTAAGAGATGAAGAGTGCTCCGAATTATCTATGGTTGCTGACAAAACAGAAAAGGCTGGTGAATATTCTGTGACGTATGATGGATTCAATACATTTACTATA
CCTAAGACAGACTATGATAACTTTCTTATGGCTCATCTCATTAACGAAAAGGATGGGGAAACCTTCCAGCTGATGGGGCTCTATGGCCGAGAACCAGATTTGAGTTCAGACATCAAGGAAAGGTTTGC
ACAACTATGTGAGGAGCATGGAATCCTTAGAGAAAATATCATTGACCTATCCAATGCCATGGACCTGGTACCTGAACATGTTCTTGTTCTCACACTACAGATCGCTGCCTCCAGGCCCGAGAATGAAG
AATGGCCTGAGCCTCCAGTGTTGAGTGGAGACTTCTCACCAGGACTCCACCATCATCCCTTCCTATCCATACAGCATCCCCAGTATAAATTCTGTGATCTGCATTCCATCCTGTCTCACTGAGAAGTC
CAATTCCAGTCTATCCACATGTTACCTAGGATACCTCATCAAGAATCAAAGACTTCTTTAAATTTCTCTTTGATATACCCATGACAATTTTTCATGAATTTCTTCCTCTTCCTGTTCAATAAATGATT
ACCCTTGCACTTAAA

hide sequence


Protein RefSeqs	NP_001334083	(Get FASTA)	NCBI Sequence Viewer
	XP_003688833	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000148722
	ENSMUSP00000148722.2

RefSeq Acc Id:

XP_003688833 ⟸ XM_003688785

- Peptide Label:

isoform X1

- Sequence:

show sequence

MKMLLLLLCLGLTLVCVHAEEASSTGRNFNVEKINGEWHTIILASDKREKIEDNGNFRLFLEQIHVLEKSLVLKFHTVRDEECSELSMVADKTEKAGEYSVTYDGFNTFTIPKTDYDNFLMAHLINEK
DGETFQLMGLYGREPDLSSDIKERFAQLCEEHGILRENIIDLSNAMDLVPEHVLVLTLQIAASRPENEEWPEPPVLSGDFSPGLHHHPFLSIQHPQYKFCDLHSILSH

hide sequence

RefSeq Acc Id:	NP_001334083 ⟸ NM_001347154
- Peptide Label:	precursor
- UniProtKB:	Q99JF6 (UniProtKB/Swiss-Prot), P11589 (UniProtKB/Swiss-Prot), Q4FZE8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSMUSP00000148722 ⟸ ENSMUST00000211875

Protein Domains

Lipocalin/cytosolic fatty-acid binding

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4FZE8-F1-model_v2	AlphaFold	Q4FZE8	1-181	view protein structure

Database	Acc Id	Source(s)
Ensembl Genes	ENSMUSG00000110439	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000211875	ENTREZGENE
	ENSMUST00000211875.2	UniProtKB/TrEMBL
Gene3D-CATH	2.40.128.20	UniProtKB/TrEMBL
InterPro	Calycin	UniProtKB/TrEMBL
	Lipocalin	UniProtKB/TrEMBL
	Lipocalin_CS	UniProtKB/TrEMBL
	Lipocln_cytosolic_FA-bd_dom	UniProtKB/TrEMBL
	Maj_urinary	UniProtKB/TrEMBL
KEGG Report	mmu:100861909	UniProtKB/TrEMBL
MGD	MGI:5434675	ENTREZGENE
NCBI Gene	Gm21320	ENTREZGENE
PANTHER	MAJOR URINARY PROTEIN 1-RELATED	UniProtKB/TrEMBL
	PTHR11430	UniProtKB/TrEMBL
Pfam	Lipocalin	UniProtKB/TrEMBL
PhenoGen	Mup22	PhenoGen
PRINTS	LIPOCALIN	UniProtKB/TrEMBL
	MAJORURINARY	UniProtKB/TrEMBL
PROSITE	LIPOCALIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50814	UniProtKB/TrEMBL
UniProt	P11589	ENTREZGENE
	Q4FZE8	ENTREZGENE, UniProtKB/TrEMBL
	Q99JF6	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-11-13	Mup22	major urinary protein 22	Gm21320	predicted gene, 21320	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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