Sacm1l (SAC1 like phosphatidylinositide phosphatase) - Rat Genome Database

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Gene: Sacm1l (SAC1 like phosphatidylinositide phosphatase) Rattus norvegicus
Analyze
Symbol: Sacm1l
Name: SAC1 like phosphatidylinositide phosphatase
RGD ID: 69223
Description: Enables phosphatidylinositol-3,5-bisphosphate phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; and phosphatidylinositol-4-phosphate phosphatase activity. Involved in neurotransmitter receptor transport to postsynaptic membrane; phosphatidylinositol dephosphorylation; and vesicle-mediated transport in synapse. Located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. Is active in glutamatergic synapse. Orthologous to human SACM1L (SAC1 like phosphatidylinositide phosphatase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: phosphatidylinositide phosphatase SAC1; phosphatidylinositol-3-phosphatase SAC1; phosphatidylinositol-4-phosphate phosphatase; Sac1; SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae); SAC1 (supressor of actin mutations 1, homolog)-like; SAC1 (supressor of actin mutations 1, homolog)-like (S. cerevisiae); SAC1 suppressor of actin mutations 1-like; SAC1 suppressor of actin mutations 1-like (yeast); suppressor of actin 1; suppressor of actin mutations 1-like protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,053,465 - 132,109,857 (+)NCBIGRCr8
mRatBN7.28123,176,017 - 123,232,413 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,172,536 - 123,232,413 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8128,765,500 - 128,828,247 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,964,469 - 127,027,208 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,793,995 - 124,856,731 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,607,166 - 132,663,502 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,607,166 - 132,663,502 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08131,759,866 - 131,816,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,302,927 - 128,359,950 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,322,663 - 128,379,687 (+)NCBI
Celera8122,286,384 - 122,342,572 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides. Dickson EJ, etal., J Cell Biol. 2016 Apr 11;213(1):33-48. doi: 10.1083/jcb.201508106. Epub 2016 Apr 4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity. Nemoto Y, etal., J Biol Chem 2000 Nov 3;275(44):34293-305.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
8. JNK3 couples the neuronal stress response to inhibition of secretory trafficking. Yang G, etal., Sci Signal. 2013 Jul 9;6(283):ra57. doi: 10.1126/scisignal.2003727.
Additional References at PubMed
PMID:22632720   PMID:24209621   PMID:25013167   PMID:29461204   PMID:30659099   PMID:31505169   PMID:31806350  


Genomics

Comparative Map Data
Sacm1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88132,053,465 - 132,109,857 (+)NCBIGRCr8
mRatBN7.28123,176,017 - 123,232,413 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8123,172,536 - 123,232,413 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8128,765,500 - 128,828,247 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08126,964,469 - 127,027,208 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08124,793,995 - 124,856,731 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08132,607,166 - 132,663,502 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8132,607,166 - 132,663,502 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08131,759,866 - 131,816,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48128,302,927 - 128,359,950 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18128,322,663 - 128,379,687 (+)NCBI
Celera8122,286,384 - 122,342,572 (+)NCBICelera
Cytogenetic Map8q32NCBI
SACM1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38345,689,396 - 45,745,409 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl345,689,056 - 45,745,412 (+)EnsemblGRCh38hg38GRCh38
GRCh37345,730,888 - 45,786,901 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36345,705,947 - 45,761,905 (+)NCBINCBI36Build 36hg18NCBI36
Build 34345,705,946 - 45,761,904NCBI
Celera345,668,700 - 45,724,522 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef345,775,115 - 45,830,941 (+)NCBIHuRef
CHM1_1345,680,731 - 45,736,559 (+)NCBICHM1_1
T2T-CHM13v2.0345,705,375 - 45,761,083 (+)NCBIT2T-CHM13v2.0
Sacm1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399123,358,818 - 123,421,665 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9123,358,824 - 123,421,665 (+)EnsemblGRCm39 Ensembl
GRCm389123,529,753 - 123,592,600 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9123,529,759 - 123,592,600 (+)EnsemblGRCm38mm10GRCm38
MGSCv379123,439,000 - 123,501,716 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369123,378,580 - 123,441,296 (+)NCBIMGSCv36mm8
Celera9123,982,316 - 124,047,496 (+)NCBICelera
Cytogenetic Map9F4NCBI
cM Map974.08NCBI
Sacm1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542026,229,840 - 26,280,516 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542026,231,597 - 26,280,516 (-)NCBIChiLan1.0ChiLan1.0
SACM1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2245,653,967 - 45,709,677 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1345,658,749 - 45,714,444 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0345,596,775 - 45,652,482 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1346,704,539 - 46,760,105 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl346,704,565 - 46,760,104 (+)Ensemblpanpan1.1panPan2
SACM1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,731,674 - 42,791,455 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,720,249 - 42,791,402 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,648,744 - 42,708,307 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02043,216,790 - 43,276,240 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2043,216,794 - 43,276,251 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12042,457,062 - 42,516,486 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,864,579 - 42,923,977 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02043,139,544 - 43,199,143 (-)NCBIUU_Cfam_GSD_1.0
Sacm1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118197,843,903 - 197,900,798 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936695196,238 - 253,128 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SACM1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1328,817,132 - 28,891,685 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11328,816,977 - 28,906,503 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21331,719,695 - 31,794,148 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SACM1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,159,701 - 7,214,368 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,159,809 - 7,214,555 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,951,795 - 160,006,471 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sacm1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473075,113,012 - 75,169,561 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473075,107,294 - 75,169,527 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sacm1l
352 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:444
Count of miRNA genes:245
Interacting mature miRNAs:302
Transcripts:ENSRNOT00000007223
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat

Markers in Region
D8Rat116  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28123,180,023 - 123,180,222 (+)MAPPERmRatBN7.2
Rnor_6.08132,611,122 - 132,611,318NCBIRnor6.0
Rnor_5.08131,763,822 - 131,764,018UniSTSRnor5.0
RGSC_v3.48128,306,882 - 128,307,079RGDRGSC3.4
RGSC_v3.48128,306,883 - 128,307,079UniSTSRGSC3.4
RGSC_v3.18128,326,536 - 128,326,932RGD
Celera8122,290,340 - 122,290,536UniSTS
SHRSP x BN Map884.17RGD
SHRSP x BN Map884.17UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 57 41 19 41 8 8 74 35 36 11 8
Low 2 3 5
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000007223   ⟹   ENSRNOP00000007223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,186,796 - 123,232,413 (+)Ensembl
Rnor_6.0 Ensembl8132,607,166 - 132,663,502 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109426   ⟹   ENSRNOP00000080652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,172,536 - 123,232,413 (+)Ensembl
RefSeq Acc Id: NM_001357497   ⟹   NP_001344426
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,053,465 - 132,109,857 (+)NCBI
mRatBN7.28123,176,017 - 123,232,413 (+)NCBI
RefSeq Acc Id: NM_053798   ⟹   NP_446250
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,053,465 - 132,109,857 (+)NCBI
mRatBN7.28123,176,017 - 123,232,413 (+)NCBI
Rnor_6.08132,607,166 - 132,663,502 (+)NCBI
Rnor_5.08131,759,866 - 131,816,202 (+)NCBI
RGSC_v3.48128,302,927 - 128,359,950 (+)RGD
Celera8122,286,384 - 122,342,572 (+)RGD
Sequence:
RefSeq Acc Id: XM_063264777   ⟹   XP_063120847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88132,068,271 - 132,109,857 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001344426 (Get FASTA)   NCBI Sequence Viewer  
  NP_446250 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120847 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL76757 (Get FASTA)   NCBI Sequence Viewer  
  EDL76758 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007223.6
  ENSRNOP00000080652
  ENSRNOP00000080652.1
GenBank Protein Q9ES21 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446250   ⟸   NM_053798
- Peptide Label: isoform 1
- UniProtKB: Q9ES21 (UniProtKB/Swiss-Prot),   A6I4B9 (UniProtKB/TrEMBL),   A0A8L2Q2L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007223   ⟸   ENSRNOT00000007223
RefSeq Acc Id: NP_001344426   ⟸   NM_001357497
- Peptide Label: isoform 1x
- UniProtKB: A0A8L2Q2L9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000080652   ⟸   ENSRNOT00000109426
RefSeq Acc Id: XP_063120847   ⟸   XM_063264777
- Peptide Label: isoform X1
Protein Domains
SAC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ES21-F1-model_v2 AlphaFold Q9ES21 1-587 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696410
Promoter ID:EPDNEW_R6935
Type:initiation region
Name:Sacm1l_1
Description:SAC1 like phosphatidylinositide phosphatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08132,607,110 - 132,607,170EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69223 AgrOrtholog
BioCyc Gene G2FUF-28612 BioCyc
BioCyc Pathway PWY-6368 [3-phosphoinositide degradation] BioCyc
BioCyc Pathway Image PWY-6368 BioCyc
Ensembl Genes ENSRNOG00000005149 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007223.6 UniProtKB/TrEMBL
  ENSRNOT00000109426 ENTREZGENE
  ENSRNOT00000109426.1 UniProtKB/TrEMBL
InterPro SAC_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116482 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116482 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Syja_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sacm1l PhenoGen
PROSITE SAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005149 RatGTEx
TIGR TC217389
UniProt A0A8I5ZR90_RAT UniProtKB/TrEMBL
  A0A8L2Q2L9 ENTREZGENE, UniProtKB/TrEMBL
  A6I4B9 ENTREZGENE, UniProtKB/TrEMBL
  Q9ES21 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-19 Sacm1l  SAC1 like phosphatidylinositide phosphatase  Sacm1l  SAC1 suppressor of actin mutations 1-like (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Sacm1l  SAC1 suppressor of actin mutations 1-like (yeast)  Sacm1l  SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sacm1l  SAC1 (supressor of actin mutations 1, homolog)-like (S. cerevisiae)       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the endoplasmic reticulum 68842
gene_expression expressed in cerebellar Purkinje cells 68842