DCTN1-AS1 (DCTN1 antisense RNA 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: DCTN1-AS1 (DCTN1 antisense RNA 1) Homo sapiens
Analyze
Symbol: DCTN1-AS1
Name: DCTN1 antisense RNA 1
RGD ID: 6770566
HGNC Page HGNC:44151
Description: INTERACTS WITH nickel atom
Type: ncrna (Ensembl: lncRNA)
RefSeq Status: VALIDATED
Previously known as: AC005041.9
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,385,503 - 74,398,668 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,385,474 - 74,393,882 (+)EnsemblGRCh38hg38GRCh38
GRCh37274,612,630 - 74,625,795 (+)NCBIGRCh37GRCh37hg19GRCh37
Celera274,444,035 - 74,452,198 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,349,158 - 74,357,321 (+)NCBIHuRef
CHM1_1274,542,272 - 74,550,435 (+)NCBICHM1_1
T2T-CHM13v2.0274,394,062 - 74,407,241 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
nickel atom  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in DCTN1-AS1
1 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2		 pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2		 uncertain significance
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh38/hg38 2p13.1-12(chr2:74375779-75517520)x1 copy number loss See cases [RCV000143456] Chr2:74375779..75517520 [GRCh38]
Chr2:74602906..75744646 [GRCh37]
Chr2:74456414..75598154 [NCBI36]
Chr2:2p13.1-12		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1042
Count of miRNA genes:655
Interacting mature miRNAs:749
Transcripts:ENST00000412957, ENST00000416630, ENST00000418990, ENST00000426715, ENST00000427343, ENST00000437991
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406992009GWAS640985_Hserum alanine aminotransferase measurement, response to combination chemotherapy QTL GWAS640985 (human)0.000002serum alanine aminotransferase measurement, response to combination chemotherapyserum alanine aminotransferase activity level (CMO:0000575)27439526274395263Human


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
907 2202 1853 1538 4592 1274 1720 3 319 1102 173 1786 4622 4423 47 3676 629 1551 1326 161 1

Sequence


Ensembl Acc Id: ENST00000412957
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl274,385,524 - 74,392,896 (+)Ensembl
Ensembl Acc Id: ENST00000416630
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl274,385,486 - 74,388,178 (+)Ensembl
Ensembl Acc Id: ENST00000418990
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl274,385,496 - 74,391,427 (+)Ensembl
Ensembl Acc Id: ENST00000426715
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl274,385,497 - 74,391,904 (+)Ensembl
Ensembl Acc Id: ENST00000427343
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl274,385,493 - 74,393,511 (+)Ensembl
Ensembl Acc Id: ENST00000437991
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl274,385,718 - 74,393,882 (+)Ensembl
Ensembl Acc Id: ENST00000664266
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl274,385,474 - 74,393,859 (+)Ensembl
Ensembl Acc Id: ENST00000664792
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl274,385,693 - 74,393,524 (+)Ensembl
RefSeq Acc Id: NR_024463
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,385,503 - 74,393,881 (+)NCBI
GRCh37274,612,845 - 74,621,008 (+)NCBI
HuRef274,349,158 - 74,357,321 (+)NCBI
CHM1_1274,542,272 - 74,550,435 (+)NCBI
T2T-CHM13v2.0274,394,062 - 74,402,454 (+)NCBI
Sequence:
RefSeq Acc Id: NR_158172
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,385,503 - 74,393,881 (+)NCBI
T2T-CHM13v2.0274,394,062 - 74,402,454 (+)NCBI
Sequence:
RefSeq Acc Id: NR_158173
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,385,503 - 74,393,881 (+)NCBI
T2T-CHM13v2.0274,394,062 - 74,402,454 (+)NCBI
Sequence:
RefSeq Acc Id: NR_158174
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,385,503 - 74,398,668 (+)NCBI
T2T-CHM13v2.0274,394,062 - 74,407,241 (+)NCBI
Sequence:
Promoters
RGD ID:15095454
Promoter ID:EPDNEWNC_H278
Type:initiation region
Name:DCTN1-AS1_1
Description:DCTN1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44151]
SO ACC ID:SO:0000170
Source:EPDNEWNC (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38274,385,509 - 74,385,569EPDNEWNC

Additional Information

Database Acc Id Source(s)
COSMIC DCTN1-AS1 COSMIC
Ensembl Genes ENSG00000237737 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000427343 ENTREZGENE
  ENST00000437991 ENTREZGENE
  ENST00000664266 ENTREZGENE
GTEx ENSG00000237737 GTEx
HGNC ID HGNC:44151 ENTREZGENE
Human Proteome Map DCTN1-AS1 Human Proteome Map
NCBI Gene DCTN1-AS1 ENTREZGENE
RNAcentral URS0000D77F4C RNACentral
  URS0000D77F6E RNACentral
  URS0000D78088 RNACentral
  URS0000D780AE RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-21 DCTN1-AS1  DCTN1 antisense RNA 1  DCTN1-AS1  DCTN1 antisense RNA 1 (non-protein coding)  Symbol and/or name change 5135510 APPROVED