Gene: Adam9 (ADAM metallopeptidase domain 9) Rattus rattus

Analyze

Symbol:

Adam9

Name:

ADAM metallopeptidase domain 9

RGD ID:

625964050

Description:

ENCODES a protein that exhibits collagen binding (ortholog); integrin binding (ortholog); laminin binding (ortholog); INVOLVED IN amyloid precursor protein catabolic process (ortholog); cell adhesion (ortholog); cell adhesion mediated by integrin (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Breast Cancer, Familial (ortholog); cervical cancer (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

disintegrin and metalloproteinase domain-containing protein 9

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Rrattus_CSIRO_v1 - Rrattus_CSIRO_v1 Assembly

Position:

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	61,442,803 - 61,525,097 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Breast Cancer, Familial (ISO)

cervical cancer (ISO)

cervix uteri carcinoma in situ (ISO)

chronic obstructive pulmonary disease (ISO)

clear cell renal cell carcinoma (ISO)

cone-rod dystrophy (ISO)

cone-rod dystrophy 3 (ISO)

cone-rod dystrophy 9 (ISO)

COVID-19 (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

high grade glioma (ISO)

lung squamous cell carcinoma (ISO)

nonpapillary renal cell carcinoma (ISO)

ovarian serous cystadenocarcinoma (ISO)

pancreatic cancer (ISO)

pancreatic ductal carcinoma (ISO)

Prostatic Neoplasms (ISO)

retinitis pigmentosa (ISO)

sarcoma (ISO)

status epilepticus (ISO)

stomach cancer (ISO)

thymoma (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

urinary bladder cancer (ISO)

Uterine Cervical Neoplasms (ISO)

uterine corpus endometrial carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amyloid precursor protein catabolic process (ISO)

cell adhesion (ISO)

cell adhesion mediated by integrin (ISO)

cell migration (ISO)

cell-cell adhesion mediated by integrin (ISO)

cell-matrix adhesion (ISO)

cellular response to lipopolysaccharide (ISO)

keratinocyte differentiation (ISO)

membrane protein ectodomain proteolysis (ISO)

membrane protein intracellular domain proteolysis (ISO)

monocyte activation (ISO)

positive regulation of cell adhesion mediated by integrin (ISO)

positive regulation of cell migration (ISO)

positive regulation of keratinocyte migration (ISO)

positive regulation of macrophage fusion (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of membrane protein ectodomain proteolysis (ISO)

positive regulation of protein secretion (ISO)

protein processing (ISO)

response to antineoplastic agent (ISO)

response to calcium ion (ISO)

response to glucocorticoid (ISO)

response to hydrogen peroxide (ISO)

response to laminar fluid shear stress (ISO)

response to manganese ion (ISO)

response to tumor necrosis factor (ISO)

transforming growth factor beta receptor signaling pathway (ISO)

Cellular Component

basolateral plasma membrane (ISO)

cell surface (ISO)

cytoplasm (ISO)

external side of plasma membrane (ISO)

extracellular region (ISO)

plasma membrane (ISO)

Molecular Function

collagen binding (ISO)

integrin binding (ISO)

laminin binding (ISO)

metalloendopeptidase activity (ISO)

metallopeptidase activity (ISO)

protein kinase C binding (ISO)

SH3 domain binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

epidermal growth factor/neuregulin signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Adam9
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	61,442,803 - 61,525,097 (+)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

ADAM9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	38,996,973 - 39,105,261 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	38,996,754 - 39,105,447 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	8	38,854,492 - 38,962,780 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	38,973,662 - 39,081,937 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	8	38,973,661 - 39,081,934	NCBI
Celera	8	37,806,051 - 37,914,424 (+)	NCBI		Celera
Cytogenetic Map	8	p11.22	NCBI
HuRef	8	37,387,348 - 37,495,887 (+)	NCBI		HuRef
CHM1_1	8	39,056,582 - 39,164,835 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	39,274,115 - 39,382,400 (+)	NCBI		T2T-CHM13v2.0

Adam9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	25,439,627 - 25,507,138 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	25,439,626 - 25,507,096 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	24,949,611 - 25,017,040 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	24,949,611 - 25,016,927 (-)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	8	26,060,083 - 26,127,394 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	26,415,170 - 26,482,339 (-)	NCBI		MGSCv36	mm8
Celera	8	26,416,905 - 26,484,530 (-)	NCBI		Celera
Cytogenetic Map	8	A2	NCBI
cM Map	8	13.7	NCBI

Adam9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	73,725,186 - 73,804,284 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	73,725,114 - 73,804,646 (+)	Ensembl				GRCr8
mRatBN7.2	16	67,022,538 - 67,101,647 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	67,022,655 - 67,100,917 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	72,299,877 - 72,378,087 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	75,705,845 - 75,783,765 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	70,952,385 - 71,031,826 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	16	73,638,943 - 73,717,156 (+)	NCBI
Lyon_Normotensive	16	75,012,079 - 75,090,291 (+)	NCBI
Lyon_Hypertensive	16	75,513,036 - 75,591,245 (+)	NCBI
F344_StmMcwi	16	71,678,603 - 71,756,970 (+)	NCBI
Rnor_6.0	16	71,810,377 - 71,887,926 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	71,810,377 - 71,887,926 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	16	71,459,144 - 71,536,608 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	71,446,498 - 71,526,108 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	64,927,252 - 65,004,785 (+)	NCBI		Celera
RGSC_v3.1	16	71,446,762 - 71,526,373 (+)	NCBI
Cytogenetic Map	16	q12.4	NCBI

Adam9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955463	14,545,589 - 14,645,419 (+)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955463	14,545,425 - 14,646,498 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADAM9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	57,559,148 - 57,667,461 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	33,276,626 - 33,384,700 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	38,298,194 - 38,406,706 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	35,473,280 - 35,581,192 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	35,473,278 - 35,581,192 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

ADAM9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	26,413,345 - 26,551,293 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	26,414,583 - 26,551,122 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	26,936,243 - 27,072,615 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	28,245,576 - 28,382,674 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	28,058,376 - 28,382,944 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	26,539,869 - 26,676,393 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	27,116,645 - 27,253,104 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	27,154,835 - 27,291,400 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Adam9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	14	63,408,734 - 63,495,742 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024404943	49,072,313 - 49,159,738 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936710	2,301,730 - 2,387,695 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936710	2,301,470 - 2,388,533 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADAM9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	47,523,771 - 47,601,710 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	15	47,523,768 - 47,601,722 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	54,595,430 - 54,674,618 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADAM9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	8	38,743,061 - 38,856,500 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666052	4,848,368 - 4,962,432 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	8	37,017,827 - 37,131,462 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	37,017,545 - 37,131,615 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Adam9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624780	4,482,696 - 4,612,475 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624780	4,480,647 - 4,612,477 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl	6	59,493,352 - 59,618,999 (+)	Ensembl

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_032918540	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAAIVD010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_032918540 ⟹ XP_032774431

Type:

CODING

Position:

Black Rat Assembly	Chr	Position (strand)	Source
Rrattus_CSIRO_v1	13	61,442,803 - 61,525,097 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_032774431	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_032774431 ⟸ XM_032918540

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	Adam9	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIA

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIA

Imported Disease Annotations - OMIM

RGD Manual Annotations