Kcnt1 (potassium sodium-activated channel subfamily T member 1) - Rat Genome Database

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Gene: Kcnt1 (potassium sodium-activated channel subfamily T member 1) Rattus norvegicus
Analyze
Symbol: Kcnt1
Name: potassium sodium-activated channel subfamily T member 1
RGD ID: 621106
Description: Enables chloride-activated potassium channel activity and intracellular sodium-activated potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5 and developmental and epileptic encephalopathy 14. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: potassium channel subfamily T member 1; potassium channel subunit (Slack); potassium channel, sodium-activated subfamily T, member 1; potassium channel, subfamily T, member 1; rSlo2; sequence like a calcium-activated potassium channel subunit; Slack
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,081,071 - 29,136,902 (+)NCBIGRCr8
mRatBN7.238,682,964 - 8,736,615 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,682,113 - 8,736,667 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,752,260 - 11,789,926 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,335,474 - 20,373,140 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,590,792 - 18,628,457 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,310,641 - 3,366,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,310,954 - 3,365,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.038,673,033 - 8,726,493 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,050,340 - 4,088,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,050,339 - 4,088,029 (+)NCBI
Celera33,521,129 - 3,558,818 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Localization of the Slack potassium channel in the rat central nervous system. Bhattacharjee A, etal., J Comp Neurol 2002 Dec 16;454(3):241-54.
2. Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP. Bhattacharjee A, etal., J Neurosci 2003 Dec 17;23(37):11681-91.
3. Na+-activated K+ channels express a large delayed outward current in neurons during normal physiology. Budelli G, etal., Nat Neurosci. 2009 Jun;12(6):745-50. doi: 10.1038/nn.2313. Epub 2009 May 3.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. The sodium-activated potassium channel is encoded by a member of the Slo gene family. Yuan A, etal., Neuron 2003 Mar 6;37(5):765-73.
Additional References at PubMed
PMID:10196543   PMID:18082331   PMID:18664322   PMID:19403831   PMID:19540251   PMID:25347289   PMID:26721627   PMID:28222129   PMID:28366665   PMID:30860870   PMID:36898835   PMID:37889366  


Genomics

Comparative Map Data
Kcnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,081,071 - 29,136,902 (+)NCBIGRCr8
mRatBN7.238,682,964 - 8,736,615 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,682,113 - 8,736,667 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,752,260 - 11,789,926 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,335,474 - 20,373,140 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,590,792 - 18,628,457 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,310,641 - 3,366,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,310,954 - 3,365,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.038,673,033 - 8,726,493 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,050,340 - 4,088,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,050,339 - 4,088,029 (+)NCBI
Celera33,521,129 - 3,558,818 (+)NCBICelera
Cytogenetic Map3p13NCBI
KCNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389135,702,185 - 135,795,502 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9135,702,185 - 135,795,508 (+)EnsemblGRCh38hg38GRCh38
GRCh379138,594,031 - 138,687,348 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369137,733,859 - 137,824,813 (+)NCBINCBI36Build 36hg18NCBI36
Build 349135,819,982 - 135,904,199NCBI
Celera9109,111,863 - 109,202,929 (+)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,055,583 - 108,146,760 (+)NCBIHuRef
CHM1_19138,742,378 - 138,833,497 (+)NCBICHM1_1
T2T-CHM13v2.09147,929,033 - 148,022,602 (+)NCBIT2T-CHM13v2.0
Kcnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,753,807 - 25,808,285 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,753,746 - 25,808,285 (+)EnsemblGRCm39 Ensembl
GRCm38225,863,791 - 25,918,273 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,863,734 - 25,918,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,719,374 - 25,773,793 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,699,870 - 25,740,282 (+)NCBIMGSCv36mm8
Celera225,584,088 - 25,640,454 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.27NCBI
Kcnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,712,516 - 4,765,657 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,712,772 - 4,765,657 (-)NCBIChiLan1.0ChiLan1.0
KCNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2113,589,397 - 3,685,539 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan193,591,730 - 3,687,241 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09106,773,184 - 106,867,490 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19135,813,431 - 135,853,461 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9135,763,956 - 135,852,482 (+)Ensemblpanpan1.1panPan2
KCNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,532,073 - 49,581,332 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,532,922 - 49,593,633 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,784,630 - 48,845,057 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,411,434 - 50,471,850 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,411,452 - 50,472,234 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,191,495 - 49,251,818 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,485,623 - 49,546,068 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,533,803 - 49,594,207 (-)NCBIUU_Cfam_GSD_1.0
Kcnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,507,793 - 201,540,179 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,834,582 - 1,871,791 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,834,879 - 1,867,572 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21308,727,206 - 308,790,168 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1122,410,520 - 2,502,176 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl122,408,751 - 2,486,858 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660582,716,197 - 2,752,847 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,167,641 - 1,209,802 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,167,489 - 1,209,155 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnt1
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:78
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000023542, ENSRNOT00000061773
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat

Markers in Region
D3Rat57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,717,349 - 8,717,520 (+)MAPPERmRatBN7.2
Rnor_6.033,345,114 - 3,345,312NCBIRnor6.0
Rnor_5.038,707,196 - 8,707,394UniSTSRnor5.0
RGSC_v3.434,069,683 - 4,069,882RGDRGSC3.4
RGSC_v3.434,069,684 - 4,069,882UniSTSRGSC3.4
RGSC_v3.134,069,464 - 4,069,918RGD
Celera33,540,473 - 3,540,671UniSTS
SHRSP x BN Map32.4499RGD
SHRSP x BN Map32.4499UniSTS
Cytogenetic Map3p13UniSTS
RH138010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,735,810 - 8,735,947 (+)MAPPERmRatBN7.2
Rnor_6.033,363,603 - 3,363,739NCBIRnor6.0
Rnor_5.038,725,685 - 8,725,821UniSTSRnor5.0
RGSC_v3.434,088,173 - 4,088,309UniSTSRGSC3.4
Celera33,558,962 - 3,559,098UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 31 113 91 90 59 25 59 6 200 79 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001413123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF089730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY884213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023542   ⟹   ENSRNOP00000023542
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,698,005 - 8,736,667 (+)Ensembl
Rnor_6.0 Ensembl33,325,770 - 3,363,459 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000061773   ⟹   ENSRNOP00000058487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,682,113 - 8,736,667 (+)Ensembl
Rnor_6.0 Ensembl33,310,954 - 3,365,340 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104747   ⟹   ENSRNOP00000089937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,698,005 - 8,736,667 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110074   ⟹   ENSRNOP00000096324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,683,345 - 8,736,667 (+)Ensembl
RefSeq Acc Id: NM_001413123   ⟹   NP_001400052
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,081,339 - 29,134,757 (+)NCBI
mRatBN7.238,683,226 - 8,736,615 (+)NCBI
RefSeq Acc Id: NM_021853   ⟹   NP_068625
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,096,096 - 29,134,757 (+)NCBI
mRatBN7.238,697,981 - 8,736,615 (+)NCBI
Rnor_6.033,325,770 - 3,363,459 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
RGSC_v3.434,050,340 - 4,088,029 (+)RGD
Celera33,521,129 - 3,558,818 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233697   ⟹   XP_006233759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,847 - 29,136,902 (+)NCBI
mRatBN7.238,696,856 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233698   ⟹   XP_006233760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,846 - 29,136,902 (+)NCBI
mRatBN7.238,696,856 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233699   ⟹   XP_006233761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,849 - 29,136,902 (+)NCBI
mRatBN7.238,696,858 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233700   ⟹   XP_006233762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,847 - 29,136,902 (+)NCBI
mRatBN7.238,696,857 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233701   ⟹   XP_006233763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,847 - 29,136,902 (+)NCBI
mRatBN7.238,696,856 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233702   ⟹   XP_006233764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,850 - 29,136,902 (+)NCBI
mRatBN7.238,696,859 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233703   ⟹   XP_006233765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,850 - 29,136,902 (+)NCBI
mRatBN7.238,696,858 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233704   ⟹   XP_006233766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,081,071 - 29,136,902 (+)NCBI
mRatBN7.238,682,964 - 8,736,615 (+)NCBI
Rnor_6.033,310,641 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233706   ⟹   XP_006233768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,843 - 29,133,596 (+)NCBI
mRatBN7.238,696,854 - 8,735,450 (+)NCBI
Rnor_6.033,325,462 - 3,363,177 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233707   ⟹   XP_006233769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,081,076 - 29,136,902 (+)NCBI
mRatBN7.238,682,968 - 8,736,615 (+)NCBI
Rnor_6.033,310,643 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761624   ⟹   XP_008759846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,081,073 - 29,136,902 (+)NCBI
mRatBN7.238,682,968 - 8,736,615 (+)NCBI
Rnor_6.033,310,641 - 3,366,558 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105771   ⟹   XP_038961699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,117,020 - 29,136,902 (+)NCBI
mRatBN7.238,718,882 - 8,736,615 (+)NCBI
RefSeq Acc Id: XM_063284465   ⟹   XP_063140535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,843 - 29,133,596 (+)NCBI
RefSeq Acc Id: XR_005501975
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,095,838 - 29,125,391 (+)NCBI
mRatBN7.238,696,851 - 8,727,246 (+)NCBI
RefSeq Acc Id: NP_068625   ⟸   NM_021853
- Peptide Label: isoform 1
- Sequence:
RefSeq Acc Id: XP_006233766   ⟸   XM_006233704
- Peptide Label: isoform X8
- UniProtKB: A6JTB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233769   ⟸   XM_006233707
- Peptide Label: isoform X10
- UniProtKB: D3ZNI9 (UniProtKB/TrEMBL),   A6JTB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233768   ⟸   XM_006233706
- Peptide Label: isoform X9
- UniProtKB: A6JTB5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233759   ⟸   XM_006233697
- Peptide Label: isoform X1
- UniProtKB: Q9Z258 (UniProtKB/Swiss-Prot),   Q5D6C6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233763   ⟸   XM_006233701
- Peptide Label: isoform X5
- UniProtKB: Q9Z258 (UniProtKB/Swiss-Prot),   Q5D6C6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233761   ⟸   XM_006233699
- Peptide Label: isoform X3
- UniProtKB: Q9Z258 (UniProtKB/Swiss-Prot),   Q5D6C6 (UniProtKB/Swiss-Prot),   F1LSG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233765   ⟸   XM_006233703
- Peptide Label: isoform X7
- UniProtKB: Q9Z258 (UniProtKB/Swiss-Prot),   Q5D6C6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233760   ⟸   XM_006233698
- Peptide Label: isoform X2
- UniProtKB: Q9Z258 (UniProtKB/Swiss-Prot),   Q5D6C6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233762   ⟸   XM_006233700
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A9R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233764   ⟸   XM_006233702
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A9R0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759846   ⟸   XM_008761624
- Peptide Label: isoform X13
- UniProtKB: A0A8I6ALJ8 (UniProtKB/TrEMBL),   A6JTB4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023542   ⟸   ENSRNOT00000023542
Ensembl Acc Id: ENSRNOP00000058487   ⟸   ENSRNOT00000061773
RefSeq Acc Id: XP_038961699   ⟸   XM_039105771
- Peptide Label: isoform X12
Ensembl Acc Id: ENSRNOP00000096324   ⟸   ENSRNOT00000110074
Ensembl Acc Id: ENSRNOP00000089937   ⟸   ENSRNOT00000104747
RefSeq Acc Id: NP_001400052   ⟸   NM_001413123
- Peptide Label: isoform 2
RefSeq Acc Id: XP_063140535   ⟸   XM_063284465
- Peptide Label: isoform X11
Protein Domains
Calcium-activated potassium channel BK alpha   Potassium channel   RCK N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z258-F1-model_v2 AlphaFold Q9Z258 1-1237 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621106 AgrOrtholog
BioCyc Gene G2FUF-50409 BioCyc
Ensembl Genes ENSRNOG00000017283 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023542.6 UniProtKB/TrEMBL
  ENSRNOT00000061773.4 UniProtKB/TrEMBL
  ENSRNOT00000104747.1 UniProtKB/TrEMBL
  ENSRNOT00000110074.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro K_chnl_BK_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_Slo-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60444 UniProtKB/Swiss-Prot
NCBI Gene 60444 ENTREZGENE
PANTHER CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  POTASSIUM CHANNEL SUBFAMILY T MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BK_channel_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Slo-like_RCK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnt1 PhenoGen
PROSITE RCK_N UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017283 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A9R0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALJ8 ENTREZGENE, UniProtKB/TrEMBL
  A6JTB4 ENTREZGENE, UniProtKB/TrEMBL
  A6JTB5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZNI9 ENTREZGENE, UniProtKB/TrEMBL
  F1LSG1 ENTREZGENE, UniProtKB/TrEMBL
  KCNT1_RAT UniProtKB/Swiss-Prot
  Q5D6C6 ENTREZGENE
  Q9Z258 ENTREZGENE
UniProt Secondary Q5D6C6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnt1  potassium sodium-activated channel subfamily T member 1  Kcnt1  potassium channel, sodium-activated subfamily T, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnt1  potassium channel, sodium-activated subfamily T, member 1  Kcnt1  potassium channel, subfamily T, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Kcnt1  potassium channel, subfamily T, member 1  Slack  potassium channel subunit (Slack)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Slack  potassium channel subunit (Slack)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by intracellular Na(+), high conductance, and prominent subconductance states 633994