Kcnt1 (potassium sodium-activated channel subfamily T member 1) - Rat Genome Database

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Gene: Kcnt1 (potassium sodium-activated channel subfamily T member 1) Rattus norvegicus
Analyze
Symbol: Kcnt1
Name: potassium sodium-activated channel subfamily T member 1
RGD ID: 621106
Description: Exhibits potassium channel activity. Involved in potassium ion transport. Localizes to integral component of membrane. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5 and developmental and epileptic encephalopathy 14. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: potassium channel subfamily T member 1; potassium channel subunit (Slack); potassium channel, sodium-activated subfamily T, member 1; potassium channel, subfamily T, member 1; rSlo2; sequence like a calcium-activated potassium channel subunit; Slack
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,682,964 - 8,736,615 (+)NCBI
Rnor_6.0 Ensembl33,310,954 - 3,365,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.033,310,641 - 3,366,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.038,673,033 - 8,726,493 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,050,340 - 4,088,029 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.134,050,339 - 4,088,029 (+)NCBI
Celera33,521,129 - 3,558,818 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10196543   PMID:18082331   PMID:18664322   PMID:19403831   PMID:19540251   PMID:25347289   PMID:26721627   PMID:28222129   PMID:28366665   PMID:30860870  


Genomics

Comparative Map Data
Kcnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.238,682,964 - 8,736,615 (+)NCBI
Rnor_6.0 Ensembl33,310,954 - 3,365,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.033,310,641 - 3,366,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.038,673,033 - 8,726,493 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,050,340 - 4,088,029 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.134,050,339 - 4,088,029 (+)NCBI
Celera33,521,129 - 3,558,818 (+)NCBICelera
Cytogenetic Map3p13NCBI
KCNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9135,702,185 - 135,795,508 (+)EnsemblGRCh38hg38GRCh38
GRCh389135,702,185 - 135,795,502 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379138,594,031 - 138,687,348 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369137,733,859 - 137,824,813 (+)NCBINCBI36hg18NCBI36
Build 349135,819,982 - 135,904,199NCBI
Celera9109,111,863 - 109,202,929 (+)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9108,055,583 - 108,146,760 (+)NCBIHuRef
CHM1_19138,742,378 - 138,833,497 (+)NCBICHM1_1
Kcnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,753,807 - 25,808,285 (+)NCBIGRCm39mm39
GRCm39 Ensembl225,753,746 - 25,808,285 (+)Ensembl
GRCm38225,863,791 - 25,918,273 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,863,734 - 25,918,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,719,374 - 25,773,793 (+)NCBIGRCm37mm9NCBIm37
MGSCv36225,699,870 - 25,740,282 (+)NCBImm8
Celera225,584,088 - 25,640,454 (+)NCBICelera
Cytogenetic Map2A3NCBI
Kcnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,712,516 - 4,765,657 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,712,772 - 4,765,657 (-)NCBIChiLan1.0ChiLan1.0
KCNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19135,813,431 - 135,853,461 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9135,763,956 - 135,852,482 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09106,773,184 - 106,867,490 (+)NCBIMhudiblu_PPA_v0panPan3
KCNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,532,073 - 49,581,332 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,532,922 - 49,593,633 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,784,630 - 48,845,057 (-)NCBI
ROS_Cfam_1.0950,411,434 - 50,471,850 (-)NCBI
UMICH_Zoey_3.1949,191,495 - 49,251,818 (-)NCBI
UNSW_CanFamBas_1.0949,485,623 - 49,546,068 (-)NCBI
UU_Cfam_GSD_1.0949,533,803 - 49,594,207 (-)NCBI
Kcnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,507,793 - 201,540,179 (+)NCBI
SpeTri2.0NW_0049366691,834,879 - 1,867,572 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21308,727,206 - 308,790,168 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1122,410,520 - 2,502,176 (-)NCBI
ChlSab1.1 Ensembl122,408,751 - 2,486,858 (-)Ensembl
Vero_WHO_p1.0NW_0236660582,716,197 - 2,752,847 (+)NCBI
Kcnt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247601,167,489 - 1,209,155 (+)NCBI

Position Markers
D3Rat57  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,717,349 - 8,717,520 (+)MAPPER
Rnor_6.033,345,114 - 3,345,312NCBIRnor6.0
Rnor_5.038,707,196 - 8,707,394UniSTSRnor5.0
RGSC_v3.434,069,683 - 4,069,882RGDRGSC3.4
RGSC_v3.434,069,684 - 4,069,882UniSTSRGSC3.4
RGSC_v3.134,069,464 - 4,069,918RGD
Celera33,540,473 - 3,540,671UniSTS
SHRSP x BN Map32.4499RGD
SHRSP x BN Map32.4499UniSTS
Cytogenetic Map3p13UniSTS
RH138010  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,735,810 - 8,735,947 (+)MAPPER
Rnor_6.033,363,603 - 3,363,739NCBIRnor6.0
Rnor_5.038,725,685 - 8,725,821UniSTSRnor5.0
RGSC_v3.434,088,173 - 4,088,309UniSTSRGSC3.4
Celera33,558,962 - 3,559,098UniSTS
Cytogenetic Map3p13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3125786001Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3128136884Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3128500807Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3132972944Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3137891710Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3139773425Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3195176874Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35711366000866Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35711366000866Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3263142133477544Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3263142148562146Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3328592928136884Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3328592928136884Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:78
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000023542, ENSRNOT00000061773
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 42 23 20
Low 1 19 6 16 6 2 2 22 6 19 11 2
Below cutoff 2 25 38 35 3 35 6 9 10 6 2 6

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF089730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY884213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000023542   ⟹   ENSRNOP00000023542
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl33,325,770 - 3,363,459 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000061773   ⟹   ENSRNOP00000058487
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl33,310,954 - 3,365,340 (+)Ensembl
RefSeq Acc Id: NM_021853   ⟹   NP_068625
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,698,005 - 8,735,667 (+)NCBI
Rnor_6.033,325,770 - 3,363,459 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
RGSC_v3.434,050,340 - 4,088,029 (+)RGD
Celera33,521,129 - 3,558,818 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233697   ⟹   XP_006233759
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,696,856 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233698   ⟹   XP_006233760
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,696,856 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233699   ⟹   XP_006233761
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,696,858 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233700   ⟹   XP_006233762
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,696,857 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233701   ⟹   XP_006233763
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,696,856 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233702   ⟹   XP_006233764
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,696,859 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233703   ⟹   XP_006233765
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,696,858 - 8,736,615 (+)NCBI
Rnor_6.033,325,462 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233704   ⟹   XP_006233766
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,682,964 - 8,736,615 (+)NCBI
Rnor_6.033,310,641 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233705   ⟹   XP_006233767
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,682,968 - 8,736,615 (+)NCBI
Rnor_6.033,310,641 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233706   ⟹   XP_006233768
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,696,854 - 8,735,450 (+)NCBI
Rnor_6.033,325,462 - 3,363,177 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233707   ⟹   XP_006233769
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,682,968 - 8,736,615 (+)NCBI
Rnor_6.033,310,643 - 3,366,558 (+)NCBI
Rnor_5.038,673,033 - 8,726,493 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761624   ⟹   XP_008759846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,682,968 - 8,736,615 (+)NCBI
Rnor_6.033,310,641 - 3,366,558 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592015   ⟹   XP_017447504
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.033,325,462 - 3,363,199 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105771   ⟹   XP_038961699
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,718,882 - 8,736,615 (+)NCBI
RefSeq Acc Id: XR_005501975
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.238,696,851 - 8,727,246 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_068625   ⟸   NM_021853
- UniProtKB: Q9Z258 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233766   ⟸   XM_006233704
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_006233769   ⟸   XM_006233707
- Peptide Label: isoform X11
- Sequence:
RefSeq Acc Id: XP_006233767   ⟸   XM_006233705
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_006233768   ⟸   XM_006233706
- Peptide Label: isoform X10
- Sequence:
RefSeq Acc Id: XP_006233759   ⟸   XM_006233697
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006233763   ⟸   XM_006233701
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006233761   ⟸   XM_006233699
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006233765   ⟸   XM_006233703
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006233760   ⟸   XM_006233698
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006233762   ⟸   XM_006233700
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006233764   ⟸   XM_006233702
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008759846   ⟸   XM_008761624
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_017447504   ⟸   XM_017592015
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: ENSRNOP00000023542   ⟸   ENSRNOT00000023542
RefSeq Acc Id: ENSRNOP00000058487   ⟸   ENSRNOT00000061773
RefSeq Acc Id: XP_038961699   ⟸   XM_039105771
- Peptide Label: isoform X12
Protein Domains
BK_channel_a   Ion_trans_2   RCK N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621106 AgrOrtholog
Ensembl Genes ENSRNOG00000017283 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023542 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000058487 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023542 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000061773 UniProtKB/TrEMBL
InterPro K_chnl_BK_asu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60444 UniProtKB/Swiss-Prot
NCBI Gene 60444 ENTREZGENE
Pfam BK_channel_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnt1 PhenoGen
UniProt D3ZNI9_RAT UniProtKB/TrEMBL
  F1LSG1_RAT UniProtKB/TrEMBL
  KCNT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q5D6C6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnt1  potassium sodium-activated channel subfamily T member 1  Kcnt1  potassium channel, sodium-activated subfamily T, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnt1  potassium channel, sodium-activated subfamily T, member 1  Kcnt1  potassium channel, subfamily T, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Kcnt1  potassium channel, subfamily T, member 1  Slack  potassium channel subunit (Slack)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Slack  potassium channel subunit (Slack)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by intracellular Na(+), high conductance, and prominent subconductance states 633994