MIR4475 (microRNA 4475) - Rat Genome Database

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Gene: MIR4475 (microRNA 4475) Homo sapiens
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Symbol: MIR4475
Name: microRNA 4475
RGD ID: 5133946
HGNC Page HGNC:41697
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38936,823,539 - 36,823,599 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl936,823,539 - 36,823,599 (-)EnsemblGRCh38hg38GRCh38
GRCh37936,823,536 - 36,823,596 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map9p13.2NCBI
HuRef936,774,902 - 36,774,962 (-)NCBIHuRef
CHM1_1936,824,636 - 36,824,696 (-)NCBICHM1_1
T2T-CHM13v2.0936,847,103 - 36,847,163 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR4475Humanaflatoxin B1 decreases methylationEXP 6480464Aflatoxin B1 results in decreased methylation of MIR4475 promoterCTDPMID:30157460
MIR4475Humanbenzo[a]pyrene affects methylationEXP 6480464Benzo(a)pyrene affects the methylation of MIR4475 promoterCTDPMID:30157460
MIR4475Humanparaquat decreases expressionEXP 6480464Paraquat results in decreased expression of MIR4475 mRNACTDPMID:28619522

PMID:16381832   PMID:20733160  



.

1 to 10 of 32 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p13.3-13.1(chr9:33225730-38529813)x3 copy number gain See cases [RCV000133829] Chr9:33225730..38529813 [GRCh38]
Chr9:33225728..38529810 [GRCh37]
Chr9:33215728..38519810 [NCBI36]
Chr9:9p13.3-13.1		 pathogenic
GRCh38/hg38 9p13.3-13.1(chr9:35623500-38815474)x3 copy number gain See cases [RCV000134038] Chr9:35623500..38815474 [GRCh38]
Chr9:35623497..38815471 [GRCh37]
Chr9:35613497..38805471 [NCBI36]
Chr9:9p13.3-13.1		 pathogenic
GRCh38/hg38 9p24.3-q21.11(chr9:13997-68401065)x3 copy number gain See cases [RCV000135344] Chr9:13997..68401065 [GRCh38]
Chr9:13997..71015981 [GRCh37]
Chr9:3997..70205801 [NCBI36]
Chr9:9p24.3-q21.11		 pathogenic
GRCh38/hg38 9p13.2(chr9:36390138-36924289)x3 copy number gain See cases [RCV000134983] Chr9:36390138..36924289 [GRCh38]
Chr9:36390135..36924286 [GRCh37]
Chr9:36380135..36914286 [NCBI36]
Chr9:9p13.2		 likely benign|uncertain significance
GRCh38/hg38 9p24.3-q21.12(chr9:193412-70630731)x3 copy number gain See cases [RCV000136152] Chr9:193412..70630731 [GRCh38]
Chr9:220253..73245647 [GRCh37]
Chr9:210253..72435467 [NCBI36]
Chr9:9p24.3-q21.12		 pathogenic
GRCh38/hg38 9p24.3-q21.13(chr9:193412-74615913)x3 copy number gain See cases [RCV000135954] Chr9:193412..74615913 [GRCh38]
Chr9:204193..77230829 [GRCh37]
Chr9:194193..76420649 [NCBI36]
Chr9:9p24.3-q21.13		 pathogenic
GRCh38/hg38 9p24.1-13.2(chr9:7162304-37038771)x3 copy number gain See cases [RCV000137741] Chr9:7162304..37038771 [GRCh38]
Chr9:7162304..37038768 [GRCh37]
Chr9:7152304..37028768 [NCBI36]
Chr9:9p24.1-13.2		 pathogenic
GRCh38/hg38 9p24.3-q21.11(chr9:204104-66233120)x4 copy number gain See cases [RCV000137888] Chr9:204104..66233120 [GRCh38]
Chr9:204104..47212321 [GRCh37]
Chr9:194104..47002141 [NCBI36]
Chr9:9p24.3-q21.11		 pathogenic|conflicting data from submitters
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
1 to 10 of 32 rows

Predicted Targets
Summary Value
Count of predictions:16744
Count of gene targets:8143
Count of transcripts:14754
Interacting mature miRNAs:hsa-miR-4475
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.




adipose tissue
alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
1 3 2 4 3 4 2 15 2 1 20 17 3 1 3 2


RefSeq Transcripts NR_039686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AL450267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000580479
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl936,823,539 - 36,823,599 (-)Ensembl
RefSeq Acc Id: NR_039686
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38936,823,539 - 36,823,599 (-)NCBI
GRCh37936,823,536 - 36,823,596 (-)ENTREZGENE
HuRef936,774,902 - 36,774,962 (-)ENTREZGENE
CHM1_1936,824,636 - 36,824,696 (-)NCBI
T2T-CHM13v2.0936,847,103 - 36,847,163 (-)NCBI
Sequence:


1 to 10 of 10 rows
Database
Acc Id
Source(s)
COSMIC MIR4475 COSMIC
Ensembl Genes ENSG00000266255 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000580479 ENTREZGENE
GTEx ENSG00000266255 GTEx
HGNC ID HGNC:41697 ENTREZGENE
Human Proteome Map MIR4475 Human Proteome Map
miRBase MI0016827 ENTREZGENE
NCBI Gene 100616289 ENTREZGENE
RNAcentral URS0000759E95 RNACentral
  URS000075DCF4 RNACentral
1 to 10 of 10 rows