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Gene: TRIL (TLR4 interactor with leucine rich repeats) Homo sapiens

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Symbol:

TRIL

Name:

TLR4 interactor with leucine rich repeats

RGD ID:

4143834

HGNC Page

HGNC:22200

Description:

Enables lipopolysaccharide binding activity. Involved in regulation of cytokine production involved in immune response and toll-like receptor 4 signaling pathway. Part of lipopolysaccharide receptor complex.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

KIAA0644; TLR4 interactor with leucine-rich repeats

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	28,953,358 - 28,958,330 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	28,953,358 - 28,958,330 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	28,992,974 - 28,997,946 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	28,959,499 - 28,964,554 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	28,982,554 - 28,987,608 (-)	NCBI		Celera
Cytogenetic Map	7	p14.3	NCBI
HuRef	7	28,874,840 - 28,879,894 (-)	NCBI		HuRef
CHM1_1	7	28,993,172 - 28,998,227 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	29,090,882 - 29,095,853 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	29,043,206 - 29,048,260 (-)	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

basal cell carcinoma (EXP)

pleomorphic xanthoastrocytoma (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (EXP)

(2,4,5-trichlorophenoxy)acetic acid (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (ISO)

aldrin (ISO)

all-trans-retinoic acid (EXP)

antirheumatic drug (EXP)

arsenous acid (EXP)

atrazine (EXP,ISO)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

carbon nanotube (ISO)

cefaloridine (ISO)

chloroprene (ISO)

clobetasol (ISO)

dexamethasone (EXP,ISO)

diarsenic trioxide (EXP)

dioxygen (ISO)

diquat (ISO)

dorsomorphin (EXP)

ethanol (ISO)

folic acid (ISO)

furan (ISO)

genistein (ISO)

hydrogen cyanide (ISO)

indometacin (EXP)

iron dichloride (EXP)

methylmercury chloride (EXP)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nickel atom (EXP)

oxaliplatin (ISO)

ozone (ISO)

paracetamol (EXP)

paraquat (ISO)

pentanal (EXP)

phenylmercury acetate (EXP)

pioglitazone (ISO)

potassium cyanide (ISO)

SB 431542 (EXP)

testosterone enanthate (EXP)

thioacetamide (ISO)

titanium dioxide (ISO)

topotecan (ISO)

tremolite asbestos (ISO)

trichostatin A (EXP)

trimellitic anhydride (ISO)

urethane (EXP)

valproic acid (EXP)

vinclozolin (ISO)

XL147 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

inflammatory response (IEA)

innate immune response (IEA)

regulation of cytokine production involved in immune response (IBA,IDA)

toll-like receptor 4 signaling pathway (IBA,IDA)

Cellular Component

extracellular matrix (IBA)

extracellular space (IBA)

lipopolysaccharide receptor complex (IBA,IDA)

membrane (IEA)

Molecular Function

lipopolysaccharide binding (IBA,IDA)

protein binding (IPI)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Pleomorphic xanthoastrocytoma (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9734811	PMID:9776767	PMID:12477932	PMID:12690205	PMID:19710467	PMID:19834535	PMID:21873635	PMID:21911501	PMID:34475212	PMID:35253622

Genomics

Comparative Map Data

TRIL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	28,953,358 - 28,958,330 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	28,953,358 - 28,958,330 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	28,992,974 - 28,997,946 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	28,959,499 - 28,964,554 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	28,982,554 - 28,987,608 (-)	NCBI		Celera
Cytogenetic Map	7	p14.3	NCBI
HuRef	7	28,874,840 - 28,879,894 (-)	NCBI		HuRef
CHM1_1	7	28,993,172 - 28,998,227 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	29,090,882 - 29,095,853 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	29,043,206 - 29,048,260 (-)	NCBI

Tril
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	53,792,453 - 53,797,810 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	53,792,453 - 53,797,815 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	53,815,468 - 53,820,825 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	53,815,468 - 53,820,830 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	53,765,462 - 53,770,819 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	53,745,046 - 53,750,272 (-)	NCBI		MGSCv36	mm8
Celera	6	54,342,086 - 54,347,443 (-)	NCBI		Celera
Cytogenetic Map	6	B3	NCBI
cM Map	6	26.07	NCBI

Tril
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	84,252,781 - 84,257,626 (-)	NCBI		GRCr8
mRatBN7.2	4	82,922,327 - 82,927,172 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	82,922,328 - 82,927,172 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	88,143,247 - 88,148,092 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	83,918,647 - 83,923,492 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	82,341,689 - 82,346,533 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	83,967,695 - 83,972,540 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	83,967,696 - 83,972,540 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	148,630,039 - 148,634,884 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	82,177,050 - 82,181,895 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	82,463,912 - 82,466,627 (-)	NCBI
Celera	4	77,801,789 - 77,806,634 (-)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI

Tril
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	30,500,276 - 30,502,735 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955410	30,497,953 - 30,503,444 (-)	NCBI	ChiLan1.0	ChiLan1.0

TRIL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	33,783,690 - 33,789,076 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	82,108,386 - 82,113,451 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	29,596,977 - 29,600,989 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	29,189,813 - 29,194,998 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	29,192,063 - 29,194,498 (-)	Ensembl	panpan1.1		panPan2

TRIL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	41,999,558 - 42,004,418 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	42,001,920 - 42,004,397 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	41,434,793 - 41,440,404 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	41,941,504 - 41,947,124 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	41,943,870 - 41,946,344 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	42,058,720 - 42,064,344 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	41,737,368 - 41,742,599 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	42,095,691 - 42,100,927 (-)	NCBI		UU_Cfam_GSD_1.0

Tril
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	86,241,805 - 86,247,016 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936478	5,453,532 - 5,459,071 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRIL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	18	43,725,910 - 43,833,993 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	48,131,829 - 48,260,547 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRIL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	29,416,135 - 29,421,192 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666042	75,330,871 - 75,336,064 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tril
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624739	1,664,432 - 1,666,867 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624739	1,663,916 - 1,668,258 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TRIL
60 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 7p22.3-14.1(chr7:54185-41875885)x3	copy number gain	See cases [RCV000051159]	Chr7:54185..41875885 [GRCh38] Chr7:54185..41915483 [GRCh37] Chr7:149268..41882008 [NCBI36] Chr7:7p22.3-14.1	pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1	copy number loss	See cases [RCV000052250]	Chr7:53985..159282531 [GRCh38] Chr7:53985..159075220 [GRCh37] Chr7:149068..158767981 [NCBI36] Chr7:7p22.3-q36.3	pathogenic
GRCh38/hg38 7p15.2-14.3(chr7:25511691-30421133)x1	copy number loss	See cases [RCV000052310]	Chr7:25511691..30421133 [GRCh38] Chr7:25551310..30460749 [GRCh37] Chr7:25517835..30427274 [NCBI36] Chr7:7p15.2-14.3	pathogenic
GRCh38/hg38 7p22.3-14.2(chr7:54185-37089712)x3	copy number gain	See cases [RCV000053530]	Chr7:54185..37089712 [GRCh38] Chr7:54185..37129317 [GRCh37] Chr7:149268..37095842 [NCBI36] Chr7:7p22.3-14.2	pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1	copy number loss	See cases [RCV000135401]	Chr7:54185..159282390 [GRCh38] Chr7:54185..159075079 [GRCh37] Chr7:149268..158767840 [NCBI36] Chr7:7p22.3-q36.3	pathogenic
GRCh38/hg38 7p21.1-14.3(chr7:20561456-32005143)x1	copy number loss	See cases [RCV000136775]	Chr7:20561456..32005143 [GRCh38] Chr7:20601079..32044755 [GRCh37] Chr7:20567604..32011280 [NCBI36] Chr7:7p21.1-14.3	pathogenic
GRCh37/hg19 7p15.3-14.3(chr7:22935369-32621975)x1	copy number loss	See cases [RCV000240125]	Chr7:22935369..32621975 [GRCh37] Chr7:7p15.3-14.3	pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1	copy number loss	See cases [RCV000446044]	Chr7:43360..159119707 [GRCh37] Chr7:7p22.3-q36.3	pathogenic
TMEM106B-BRAF fusion	deletion	Pleomorphic xanthoastrocytoma [RCV000454357]	Chr7:12258147..140494267 [GRCh37] Chr7:7p21.3-q34	pathogenic
GRCh37/hg19 7p21.3-14.2(chr7:11562624-36395416)x3	copy number gain	See cases [RCV000446478]	Chr7:11562624..36395416 [GRCh37] Chr7:7p21.3-14.2	pathogenic
GRCh37/hg19 7p21.3-12.1(chr7:11048840-52863626)x3	copy number gain	See cases [RCV000512091]	Chr7:11048840..52863626 [GRCh37] Chr7:7p21.3-12.1	pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)	copy number gain	See cases [RCV000510686]	Chr7:43361..159119707 [GRCh37] Chr7:7p22.3-q36.3	pathogenic
GRCh37/hg19 7p22.3-14.3(chr7:704573-29257946)x3	copy number gain	See cases [RCV000510275]	Chr7:704573..29257946 [GRCh37] Chr7:7p22.3-14.3	pathogenic
GRCh37/hg19 7p15.2-14.3(chr7:27720090-29219094)x3	copy number gain	See cases [RCV000511380]	Chr7:27720090..29219094 [GRCh37] Chr7:7p15.2-14.3	uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3	copy number gain	See cases [RCV000511549]	Chr7:43361..159119707 [GRCh37] Chr7:7p22.3-q36.3	pathogenic
NM_014817.4(TRIL):c.371C>T (p.Pro124Leu)	single nucleotide variant	not specified [RCV004294089]	Chr7:28957676 [GRCh38] Chr7:28997292 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.952C>G (p.Pro318Ala)	single nucleotide variant	not specified [RCV004308978]	Chr7:28957095 [GRCh38] Chr7:28996711 [GRCh37] Chr7:7p14.3	uncertain significance
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv	inversion	Childhood apraxia of speech [RCV000234948]	Chr7:21001537..114528369 [GRCh37] Chr7:7p15.3-q31.1	pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3	copy number gain	not provided [RCV000746280]	Chr7:44935..159126310 [GRCh37] Chr7:7p22.3-q36.3	pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3	copy number gain	not provided [RCV000746278]	Chr7:10704..159122532 [GRCh37] Chr7:7p22.3-q36.3	pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3	copy number gain	not provided [RCV000848126]	Chr7:10365..159119707 [GRCh37] Chr7:7p22.3-q36.3	pathogenic
NM_014817.4(TRIL):c.2252T>C (p.Met751Thr)	single nucleotide variant	not specified [RCV004306908]	Chr7:28955795 [GRCh38] Chr7:28995411 [GRCh37] Chr7:7p14.3	uncertain significance
GRCh37/hg19 7p15.3-14.3(chr7:23877135-33139446)x1	copy number loss	not provided [RCV001005924]	Chr7:23877135..33139446 [GRCh37] Chr7:7p15.3-14.3	pathogenic
NM_014817.4(TRIL):c.1072G>C (p.Gly358Arg)	single nucleotide variant	not specified [RCV004307703]	Chr7:28956975 [GRCh38] Chr7:28996591 [GRCh37] Chr7:7p14.3	uncertain significance
NC_000007.13:g.23236782_30690453del7453672	deletion	Silver Russell Syndrome-related disorder [RCV000785664]	Chr7:23236782..30690453 [GRCh37] Chr7:7p15.3-14.3	pathogenic
GRCh37/hg19 7p15.1-14.3(chr7:28487175-32037495)x3	copy number gain	not provided [RCV001005926]	Chr7:28487175..32037495 [GRCh37] Chr7:7p15.1-14.3	likely pathogenic
Single allele	complex	Ring chromosome 7 [RCV002280646]	Chr7:43360..159119707 [GRCh37] Chr7:7p22.3-q36.3	pathogenic
GRCh37/hg19 7p21.3-14.2(chr7:10745750-35305167)	copy number gain	not specified [RCV002053668]	Chr7:10745750..35305167 [GRCh37] Chr7:7p21.3-14.2	likely pathogenic
GRCh37/hg19 7p15.2-14.1(chr7:27507832-39072473)	copy number gain	not specified [RCV002053677]	Chr7:27507832..39072473 [GRCh37] Chr7:7p15.2-14.1	likely pathogenic
GRCh37/hg19 7p15.3-14.3(chr7:25451740-33864069)	copy number loss	Cyclical vomiting syndrome [RCV002280775]	Chr7:25451740..33864069 [GRCh37] Chr7:7p15.3-14.3	pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1	copy number loss	See cases [RCV002287832]	Chr7:56604613..96692931 [GRCh37] Chr7:7p22.3-q36.3	uncertain significance
NM_014817.4(TRIL):c.2338A>G (p.Ile780Val)	single nucleotide variant	not specified [RCV004115308]	Chr7:28955709 [GRCh38] Chr7:28995325 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2284T>A (p.Phe762Ile)	single nucleotide variant	not specified [RCV004088255]	Chr7:28955763 [GRCh38] Chr7:28995379 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.370C>T (p.Pro124Ser)	single nucleotide variant	not specified [RCV004101162]	Chr7:28957677 [GRCh38] Chr7:28997293 [GRCh37] Chr7:7p14.3	uncertain significance
GRCh37/hg19 7p15.2-14.3(chr7:27133786-34466477)x1	copy number loss	not provided [RCV002475752]	Chr7:27133786..34466477 [GRCh37] Chr7:7p15.2-14.3	pathogenic
NM_014817.4(TRIL):c.1460G>A (p.Arg487Gln)	single nucleotide variant	not specified [RCV004238646]	Chr7:28956587 [GRCh38] Chr7:28996203 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2210A>G (p.His737Arg)	single nucleotide variant	not specified [RCV004193484]	Chr7:28955837 [GRCh38] Chr7:28995453 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.649C>T (p.Pro217Ser)	single nucleotide variant	not specified [RCV004220808]	Chr7:28957398 [GRCh38] Chr7:28997014 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1876C>T (p.Arg626Cys)	single nucleotide variant	not specified [RCV004192875]	Chr7:28956171 [GRCh38] Chr7:28995787 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1244C>T (p.Ala415Val)	single nucleotide variant	not specified [RCV004242550]	Chr7:28956803 [GRCh38] Chr7:28996419 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2171G>A (p.Arg724Lys)	single nucleotide variant	not specified [RCV004136937]	Chr7:28955876 [GRCh38] Chr7:28995492 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2237G>A (p.Arg746Gln)	single nucleotide variant	not specified [RCV004098706]	Chr7:28955810 [GRCh38] Chr7:28995426 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.286C>T (p.Arg96Cys)	single nucleotide variant	not specified [RCV004162633]	Chr7:28957761 [GRCh38] Chr7:28997377 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2054C>T (p.Pro685Leu)	single nucleotide variant	not specified [RCV004151321]	Chr7:28955993 [GRCh38] Chr7:28995609 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.56T>G (p.Leu19Arg)	single nucleotide variant	not specified [RCV004111527]	Chr7:28957991 [GRCh38] Chr7:28997607 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1661G>T (p.Arg554Leu)	single nucleotide variant	not specified [RCV004234737]	Chr7:28956386 [GRCh38] Chr7:28996002 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2153C>T (p.Ala718Val)	single nucleotide variant	not specified [RCV004172563]	Chr7:28955894 [GRCh38] Chr7:28995510 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1997G>A (p.Gly666Glu)	single nucleotide variant	not specified [RCV004193483]	Chr7:28956050 [GRCh38] Chr7:28995666 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1429G>C (p.Gly477Arg)	single nucleotide variant	not specified [RCV004197904]	Chr7:28956618 [GRCh38] Chr7:28996234 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.23G>A (p.Arg8His)	single nucleotide variant	not specified [RCV004152503]	Chr7:28958024 [GRCh38] Chr7:28997640 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.285C>G (p.Ile95Met)	single nucleotide variant	not specified [RCV004169845]	Chr7:28957762 [GRCh38] Chr7:28997378 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1964C>T (p.Thr655Ile)	single nucleotide variant	not specified [RCV004144579]	Chr7:28956083 [GRCh38] Chr7:28995699 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.38T>C (p.Val13Ala)	single nucleotide variant	not specified [RCV004080385]	Chr7:28958009 [GRCh38] Chr7:28997625 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2088G>C (p.Gln696His)	single nucleotide variant	not specified [RCV004076848]	Chr7:28955959 [GRCh38] Chr7:28995575 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2179C>T (p.Arg727Trp)	single nucleotide variant	not specified [RCV004273678]	Chr7:28955868 [GRCh38] Chr7:28995484 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.224C>A (p.Thr75Lys)	single nucleotide variant	not specified [RCV004249623]	Chr7:28957823 [GRCh38] Chr7:28997439 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1691C>T (p.Ala564Val)	single nucleotide variant	not specified [RCV004280110]	Chr7:28956356 [GRCh38] Chr7:28995972 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.367G>A (p.Ala123Thr)	single nucleotide variant	not specified [RCV004294348]	Chr7:28957680 [GRCh38] Chr7:28997296 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2362A>G (p.Met788Val)	single nucleotide variant	not specified [RCV004324148]	Chr7:28955685 [GRCh38] Chr7:28995301 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2320C>G (p.Leu774Val)	single nucleotide variant	not specified [RCV004251660]	Chr7:28955727 [GRCh38] Chr7:28995343 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1616C>A (p.Ala539Glu)	single nucleotide variant	not specified [RCV004331022]	Chr7:28956431 [GRCh38] Chr7:28996047 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2207T>C (p.Val736Ala)	single nucleotide variant	not specified [RCV004349659]	Chr7:28955840 [GRCh38] Chr7:28995456 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1846G>C (p.Gly616Arg)	single nucleotide variant	not specified [RCV004339207]	Chr7:28956201 [GRCh38] Chr7:28995817 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1597A>G (p.Thr533Ala)	single nucleotide variant	not specified [RCV004363829]	Chr7:28956450 [GRCh38] Chr7:28996066 [GRCh37] Chr7:7p14.3	uncertain significance
GRCh37/hg19 7p14.3(chr7:28871712-29219094)x4	copy number gain	not provided [RCV003485350]	Chr7:28871712..29219094 [GRCh37] Chr7:7p14.3	uncertain significance
GRCh37/hg19 7p14.3(chr7:28940557-31806164)x3	copy number gain	not specified [RCV003986729]	Chr7:28940557..31806164 [GRCh37] Chr7:7p14.3	uncertain significance
GRCh37/hg19 7p21.1-14.3(chr7:17736012-30663423)x1	copy number loss	not specified [RCV003986712]	Chr7:17736012..30663423 [GRCh37] Chr7:7p21.1-14.3	pathogenic
NM_014817.4(TRIL):c.1664T>G (p.Leu555Arg)	single nucleotide variant	not specified [RCV004473606]	Chr7:28956383 [GRCh38] Chr7:28995999 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.37G>A (p.Val13Met)	single nucleotide variant	not specified [RCV004473617]	Chr7:28958010 [GRCh38] Chr7:28997626 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1055A>T (p.Tyr352Phe)	single nucleotide variant	not specified [RCV004473601]	Chr7:28956992 [GRCh38] Chr7:28996608 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1376A>G (p.Gln459Arg)	single nucleotide variant	not specified [RCV004473602]	Chr7:28956671 [GRCh38] Chr7:28996287 [GRCh37] Chr7:7p14.3	likely benign
NM_014817.4(TRIL):c.1492G>A (p.Val498Ile)	single nucleotide variant	not specified [RCV004473603]	Chr7:28956555 [GRCh38] Chr7:28996171 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.26T>C (p.Leu9Pro)	single nucleotide variant	not specified [RCV004473616]	Chr7:28958021 [GRCh38] Chr7:28997637 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.686G>C (p.Arg229Pro)	single nucleotide variant	not specified [RCV004473618]	Chr7:28957361 [GRCh38] Chr7:28996977 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2116A>G (p.Asn706Asp)	single nucleotide variant	not specified [RCV004473610]	Chr7:28955931 [GRCh38] Chr7:28995547 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.14G>T (p.Arg5Leu)	single nucleotide variant	not specified [RCV004473604]	Chr7:28958033 [GRCh38] Chr7:28997649 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1522T>C (p.Ser508Pro)	single nucleotide variant	not specified [RCV004473605]	Chr7:28956525 [GRCh38] Chr7:28996141 [GRCh37] Chr7:7p14.3	likely benign
NM_014817.4(TRIL):c.1762T>C (p.Cys588Arg)	single nucleotide variant	not specified [RCV004473607]	Chr7:28956285 [GRCh38] Chr7:28995901 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2084A>G (p.Tyr695Cys)	single nucleotide variant	not specified [RCV004473609]	Chr7:28955963 [GRCh38] Chr7:28995579 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2159G>C (p.Arg720Pro)	single nucleotide variant	not specified [RCV004473611]	Chr7:28955888 [GRCh38] Chr7:28995504 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2188C>T (p.Arg730Trp)	single nucleotide variant	not specified [RCV004473612]	Chr7:28955859 [GRCh38] Chr7:28995475 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2189G>A (p.Arg730Gln)	single nucleotide variant	not specified [RCV004473613]	Chr7:28955858 [GRCh38] Chr7:28995474 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.373G>A (p.Gly125Ser)	single nucleotide variant	not specified [RCV004687639]	Chr7:28957674 [GRCh38] Chr7:28997290 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1555C>G (p.Arg519Gly)	single nucleotide variant	not specified [RCV004677594]	Chr7:28956492 [GRCh38] Chr7:28996108 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.176A>C (p.His59Pro)	single nucleotide variant	not specified [RCV004677595]	Chr7:28957871 [GRCh38] Chr7:28997487 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.2402G>A (p.Arg801Gln)	single nucleotide variant	not specified [RCV004677590]	Chr7:28955645 [GRCh38] Chr7:28995261 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.371C>G (p.Pro124Arg)	single nucleotide variant	not specified [RCV004677591]	Chr7:28957676 [GRCh38] Chr7:28997292 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.1262C>T (p.Ala421Val)	single nucleotide variant	not specified [RCV004677592]	Chr7:28956785 [GRCh38] Chr7:28996401 [GRCh37] Chr7:7p14.3	likely benign
NM_014817.4(TRIL):c.1366C>T (p.Leu456Phe)	single nucleotide variant	not specified [RCV004677596]	Chr7:28956681 [GRCh38] Chr7:28996297 [GRCh37] Chr7:7p14.3	uncertain significance
NM_014817.4(TRIL):c.617G>A (p.Arg206His)	single nucleotide variant	not specified [RCV004677597]	Chr7:28957430 [GRCh38] Chr7:28997046 [GRCh37] Chr7:7p14.3	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	129
Count of miRNA genes:	63
Interacting mature miRNAs:	65
Transcripts:	ENST00000322982, ENST00000539664
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
597428916	GWAS1524990_H	protein measurement QTL GWAS1524990 (human)		3e-31	protein measurement		7	28956184	28956185	Human
2289453	BW297_H	Body weight QTL 297 (human)	3.83		Body weight	body mass index	7	23349464	49349464	Human

Markers in Region

RH91399

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	7	28,994,210 - 28,994,350	UniSTS	GRCh37
Build 36	7	28,960,735 - 28,960,875	RGD	NCBI36
Celera	7	28,983,790 - 28,983,930	RGD
Cytogenetic Map	7	p14.3	UniSTS
HuRef	7	28,876,076 - 28,876,216	UniSTS
CRA_TCAGchr7v2	7	29,044,442 - 29,044,582	UniSTS
GeneMap99-GB4 RH Map	7	132.17	UniSTS

A004Y37

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	11	129,760,871 - 129,761,056	UniSTS	GRCh37
GRCh37	7	28,993,004 - 28,993,186	UniSTS	GRCh37
Build 36	7	28,959,529 - 28,959,711	RGD	NCBI36
Celera	7	28,982,584 - 28,982,766	RGD
Celera	11	126,929,032 - 126,929,217	UniSTS
Cytogenetic Map	7	p14.3	UniSTS
Cytogenetic Map	11	q24-q25	UniSTS
HuRef	7	28,874,870 - 28,875,052	UniSTS
HuRef	11	125,713,164 - 125,713,349	UniSTS
CRA_TCAGchr7v2	7	29,043,236 - 29,043,418	UniSTS
GeneMap99-GB4 RH Map	7	132.55	UniSTS
Whitehead-RH Map	7	91.2	UniSTS

RH45431

Human Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	7	p14.3	UniSTS
GeneMap99-GB4 RH Map	7	131.21	UniSTS

D3S1315

Human Assembly	Chr	Position (strand)	Source
Cytogenetic Map	7	p14.3	UniSTS
TNG Radiation Hybrid Map	7	13817.0	UniSTS
Stanford-G3 RH Map	7	1020.0	UniSTS
GeneMap99-G3 RH Map	7	1020.0	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2314	2787	2222	4870	1508	1983	5	432	985	273	2209	5864	5466	38	3693	652	1609	1455	170	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_014817	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB014544	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC005013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK293803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AMYH02015433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC036337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CD580022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH236948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000539664 ⟹ ENSP00000479256

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	7	28,953,358 - 28,958,330 (-)	Ensembl

RefSeq Acc Id:

NM_014817 ⟹ NP_055632

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	7	28,953,358 - 28,958,330 (-)	NCBI
GRCh37	7	28,992,974 - 28,998,029 (-)	RGD
Build 36	7	28,959,499 - 28,964,554 (-)	NCBI Archive
Celera	7	28,982,554 - 28,987,608 (-)	RGD
HuRef	7	28,874,840 - 28,879,894 (-)	RGD
CHM1_1	7	28,993,172 - 28,998,227 (-)	NCBI
T2T-CHM13v2.0	7	29,090,882 - 29,095,853 (-)	NCBI
CRA_TCAGchr7v2	7	29,043,206 - 29,048,260 (-)	RGD

Sequence:

show sequence

CCCGCCCGCCGACGCGCACCCGGAGAAACAGTTTTATACAGAAATGCAACAAGTAGTACCCGGG
GTCTGCAGAGCGCCCCGCGCCGCCTGACTTGGCCGGGCGAAGCCCGCCTGCAGAGACCCGGGCC
GGCCTCCGGACAAAGGACGGAGGAGGGGCTGGACGGCGCTGCGAAGTCCGAAAGAGGCCATTTA
GCGACTCTGGCCAGGCTAAGGGGAATGCAGAGGAGACACAGAGCCGGCGGGCCAAGAGGACGAT
CCGGCCGCTGCACGCAGGGCGGGAGGCGATGGAGGCTGCCCGCGCCTTGCGCCTCCTGCTCGTG
GTGTGCGGCTGCCTCGCGCTCCCGCCGCTGGCCGAGCCCGTGTGCCCGGAGCGCTGCGACTGCC
AGCATCCCCAGCATCTCCTGTGCACCAACAGGGGGCTCCGCGTAGTGCCCAAGACCAGCTCGCT
GCCGAGCCCCCACGACGTGCTCACCTACAGCCTCGGCGGCAACTTCATAACCAACATCACGGCC
TTCGACTTCCACCGTCTGGGGCAGCTCAGACGGCTGGACCTGCAGTACAACCAGATCCGCTCTC
TGCACCCCAAGACCTTCGAGAAGCTCTCGCGGCTGGAAGAGCTGTACCTGGGGAACAACCTCTT
GCAGGCGCTCGCCCCGGGCACGCTGGCCCCGCTGCGCAAGCTGCGCATCCTCTACGCCAACGGG
AACGAGATCAGCCGCCTAAGCCGCGGCTCCTTCGAGGGCCTGGAGAGTCTAGTCAAGCTGCGGC
TGGACGGGAACGCCCTGGGGGCGCTGCCGGACGCGGTCTTCGCTCCCTTGGGCAACCTGCTCTA
CCTACATCTGGAGTCCAACCGGATCCGCTTTCTGGGCAAGAACGCCTTCGCCCAGCTAGGCAAG
CTGCGCTTCCTCAACCTCTCTGCCAACGAGCTACAGCCCTCCCTGCGCCACGCGGCCACCTTCG
CACCGCTGCGCTCCCTCTCCTCCCTCATCCTCTCGGCCAACAACCTGCAGCACCTCGGGCCGCG
CATCTTCCAGCACCTGCCACGTCTCGGCCTGCTCTCGCTCAGGGGCAACCAGCTCACGCACCTC
GCGCCTGAGGCCTTTTGGGGCTTGGAGGCCCTGCGCGAGCTGCGCCTGGAGGGTAATCGGCTGA
GCCAGCTGCCAACTGCGCTGCTGGAGCCTCTGCACAGCCTGGAGGCGCTGGACCTGAGCGGCAA
TGAGCTGTCCGCCCTGCACCCGGCCACCTTCGGCCACCTGGGCCGGCTGCGCGAGCTCAGCCTG
CGCAACAACGCGCTCAGCGCCCTATCCGGGGACATCTTCGCCGCCAGCCCAGCCCTTTATCGGC
TGGATCTAGACGGCAACGGCTGGACCTGCGACTGCCGGCTGCGAGGCCTGAAGCGCTGGATGGG
CGACTGGCACTCGCAGGGCCGGCTCCTCACTGTCTTCGTGCAGTGTCGCCACCCCCCGGCCCTG
CGAGGCAAATACCTGGATTACCTGGATGACCAGCAGCTGCAAAATGGATCCTGCGCGGATCCCT
CGCCCTCAGCTTCCCTGACCGCTGACCGCAGGCGGCAGCCCCTACCCACGGCCGCAGGGGAGGA
GATGACGCCACCTGCAGGTCTCGCGGAGGAGCTGCCGCCGCAGCCGCAGCTCCAGCAGCAGGGG
CGATTTCTAGCTGGGGTGGCCTGGGATGGGGCCGCCAGGGAGCTGGTAGGCAACCGCAGCGCCC
TAAGGCTGAGTCGGCGGGGCCCGGGCCTCCAGCAGCCCAGCCCCTCCGTCGCTGCCGCCGCGGG
CCCGGCTCCACAGTCCCTAGACCTGCACAAGAAGCCCCAGCGGGGCCGTCCGACTCGGGCAGAT
CCCGCCCTCGCGGAGCCCACCCCAACGGCCTCTCCTGGCTCTGCGCCATCGCCCGCCGGCGACC
CCTGGCAGCGCGCGACGAAGCATCGTCTGGGCACGGAGCACCAGGAGCGTGCCGCCCAGTCCGA
CGGTGGGGCCGGGCTGCCGCCGCTGGTGTCCGACCCATGCGACTTCAACAAGTTCATTCTGTGC
AACCTGACGGTGGAGGCGGTGGGCGCAGACAGCGCCTCGGTGCGCTGGGCCGTGCGCGAGCACC
GCAGTCCCCGGCCGCTGGGCGGCGCGCGCTTCCGCCTGCTCTTTGACCGCTTTGGCCAGCAGCC
CAAGTTCCACCGCTTCGTCTACCTGCCTGAGAGCAGCGACTCGGCCACGCTGCGCGAGCTGCGC
GGGGACACCCCCTACCTGGTGTGCGTGGAGGGCGTGCTTGGGGGCCGTGTCTGCCCTGTGGCTC
CCCGGGACCACTGCGCGGGGCTGGTCACCCTACCGGAGGCCGGGAGCCGGGGCGGCGTCGACTA
CCAGCTGCTGACCTTGGCCCTGCTGACGGTCAACGCGCTGCTGGTGCTCCTGGCCTTGGCGGCC
TGGGCGTCTCGCTGGCTGCGTAGGAAACTGCGGGCTAGGCGGAAGGGCGGGGCCCCGGTCCACG
TTCGGCACATGTACTCCACCCGACGGCCCCTGCGCTCCATGGGCACCGGCGTGTCCGCCGACTT
CTCGGGATTCCAGTCGCACCGGCCACGCACCACCGTGTGCGCGCTCAGTGAGGCGGACCTCATC
GAATTCCCCTGCGACCGCTTCATGGACAGTGCGGGCGGCGGCGCGGGCGGCAGCCTGAGACGGG
AGGACCGTCTCCTGCAGCGATTTGCCGACTAGGTCCAGGGCATATAGAGACCATCTCATTGGCC
CTAAGGAGCCGCCTCTCCGTGAGGCCCACCAGCCCACCTCAGGGGAAGTGCCGTTTTGTGCACT
TGCCAGAGAGGCCGGTGGGGACAGAGGGCCAATTCGGGCACCATCCCCCAATTCCCAATACTCG
AGAAGTAAATGGATGGTACTTGGTGGTCAGAGCCAGAGTAGGGGACAAATGGATGGTGGGATGC
TGAGGTCGGAGGCTTCGCTTGGAGGCTTTGACACAGCTATGCGAATGGCTTTTGTAGCACTGCA
ATGCAGAAGCCAGGCTTTGGGGGTAGAAAGGGGGTGCTTGTGCCCCCAACATGGCCAGAAATAT
TTGGGTGCATGCTTTTTGTTTGCTCAGTGTCAAACAGAGAAGTTTTGTTTCTATTTAAGGAAGG
AACTTATTACCATTACAAAGGAGGCTTGGCCAGGGACTCCACTGGTTTGGTGATCTCTGCCAAG
AAGGGGGATGTAAACAGGTGGTAAAGTTTAACATACCCGCCAAGGAACTCGTTTATGTTGGCTG
ATAGAGCATTCAGGATACCTTAAAGTTTAATAAGAGACGCATTTTTTTTTTTCAAAAATGTGAA
AAGCTCTGACATTTAACGAACTGACCAATAGACTCAAGGACTGTTTTAGTTGGACTGGGCCATT
TTATTATGTTCCTTTTAATATTAACAGTACAAGAGCGCTTGCTGACTTCGAGGATAACTAAGAT
TACATACTTTCTCAGGAGAAGGCTGCATGCAAGACTTCTCTGTCAGGGTTGCTCCTGTGGCTTT
TTTAATTTTATTTTTTTAAACCTATATATGGAAAAGGAAATTTCAATGCCAGATTTGATAAAAG
AATGTGATGTATATGTAGCTGATGACCCACTGGGGAACACCAGTGTTCCAGTTCACTTACCACA
TCTGTGACAGTGTGTTTAGATTGGAATAAATGTGATGCATTACTTCTTATGTTTTTATCAGTGA
CATGGTTGACTGTGCCCTAATTCTCTTGAGTTGCAGTTAAGCAATGAAGGTTATTTCCTAATAG
GGAAGCAAAAGGTGATTGTCAATTGATAGTTTAATGTTTGACCACATTAGTGTCTTTATATGAA
ATAGTAGAGGGGAAGAAATTATAGAAAACAAATGTGAAAAAAATACACCAGTGGGTATCTGTTC
TACTAAAACCAGAAGATTGTTATGAGTACTTAAACCTCACTGTGAAATAATGATATATTTTGCA
ATTAATCCCTCCCCAACTGAGTGTCTTACTGTGTTATTAAATCTTATCTTTTAGTTAATAGTTG
CAGTATTTCTTTTAAATGTTTTTGTTTTAAACTTAGGGGTAGGATCCTTTATTTGTTCAGTTGT
TTCCAACTATTTGGGATACTTTCATTCCCTGCTATTTATGAAGTACATGTTTATCACTAAGTGT
AGTGGTTTGGTTTACATTAATAATTTTATGTGTGGTCTAAAAATGCAGTCACTAAGAGAATGTA
CACTGTGGTTATGGTCACAGTGGTTATGGATTTATTGGCAGTGGAGTACCATGGAGGTCACTGC
AATGGTGCTAAGGCTGACAGTGGAATCTTCTGTTTAGGGCCTTAAGCCCCTGAGGGTCCTGGTG
ACTCAGGGAATCCATCACAGCCCCGGGTCTTTCACCCCAGTTCACTCCTTTTATGTTTGGCCTA
GATTGACCCATGCCTGCCCTCTTCTCAACAGCTGAGTAGGGAACCAGCCATCTGAATGAGCTGA
TCGTTGTTTATGTTCAAATGAGTAAATGTCCAGACCACTTAAAACTACAGCTGCTTTTCTGGCA
GTCTCGTCTGCGGGGCCAAAACTTAATAAACCACAGGAAATAGACTGTCATTCTTAGTTTGCTG
CCAGGGCTTATTTTAGATTGAGAGCATACTGGTACATGAGAGCAGTAGTGTTGTTTGCTCTTAT
TTTCAACCAGGGAGCTATCTGGCACCTTTTGTGCTCCTGGCTTTTTTCAATCATAGCACTATTG
CATCTCCTAGCTATTTCTTTTGCCCAGCAGGGTAATATTGAGTCCCATTGCAAGTATGGACAAG
GCCTCTGGTTCTCCTCACCACCCACCTTTTCAGCCATAGAACATCACTGAAAATGCCTAATGCC
TGGATCTGTGTTCTACTTTAGTTTCACTGGGAAGTCTTTCAGTGGGAGATGAATAAATGTTATA
CATTGTTATGTCCAGTTATGTCAATAAACCCACTAATAGAGATAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_055632	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH36337	(Get FASTA)	NCBI Sequence Viewer
	BAA31619	(Get FASTA)	NCBI Sequence Viewer
	BAG57211	(Get FASTA)	NCBI Sequence Viewer
	EAL24208	(Get FASTA)	NCBI Sequence Viewer
	EAL24209	(Get FASTA)	NCBI Sequence Viewer
	EAW93913	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000479256
	ENSP00000479256.1
GenBank Protein	Q7L0X0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_055632 ⟸ NM_014817
- Peptide Label:	precursor
- UniProtKB:	Q7L0X0 (UniProtKB/Swiss-Prot), A4D1A6 (UniProtKB/Swiss-Prot), O75139 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MEAARALRLLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTY SLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLA PLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIR FLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLG LLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPAT FGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLL TVFVQCRHPPALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQPLPTAAGEEMTPPAGLAE ELPPQPQLQQQGRFLAGVAWDGAARELVGNRSALRLSRRGPGLQQPSPSVAAAAGPAPQSLDLH KKPQRGRPTRADPALAEPTPTASPGSAPSPAGDPWQRATKHRLGTEHQERAAQSDGGAGLPPLV SDPCDFNKFILCNLTVEAVGADSASVRWAVREHRSPRPLGGARFRLLFDRFGQQPKFHRFVYLP ESSDSATLRELRGDTPYLVCVEGVLGGRVCPVAPRDHCAGLVTLPEAGSRGGVDYQLLTLALLT VNALLVLLALAAWASRWLRRKLRARRKGGAPVHVRHMYSTRRPLRSMGTGVSADFSGFQSHRPR TTVCALSEADLIEFPCDRFMDSAGGGAGGSLRREDRLLQRFAD hide sequence

Ensembl Acc Id:

ENSP00000479256 ⟸ ENST00000539664

Protein Domains

LRRCT LRRNT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q7L0X0-F1-model_v2	AlphaFold	Q7L0X0	1-811	view protein structure

Promoters

RGD ID:

6806325

Promoter ID:

HG_KWN:56740

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell

Transcripts:

ENST00000322982, NM_014817, UC003SZT.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	7	28,963,501 - 28,964,001 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:22200	AgrOrtholog
COSMIC	TRIL	COSMIC
Ensembl Genes	ENSG00000255690	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000539664	ENTREZGENE
	ENST00000539664.3	UniProtKB/Swiss-Prot
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000255690	GTEx
HGNC ID	HGNC:22200	ENTREZGENE
Human Proteome Map	TRIL	Human Proteome Map
InterPro	Cys-rich_flank_reg_C	UniProtKB/Swiss-Prot
	Dev_Immune_Receptor	UniProtKB/Swiss-Prot
	FN3_dom	UniProtKB/Swiss-Prot
	Leu-rich_rpt	UniProtKB/Swiss-Prot
	Leu-rich_rpt_typical-subtyp	UniProtKB/Swiss-Prot
	LRR_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	hsa:9865	UniProtKB/Swiss-Prot
NCBI Gene	9865	ENTREZGENE
OMIM	613356	OMIM
PANTHER	SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN	UniProtKB/Swiss-Prot
	TLR4 INTERACTOR WITH LEUCINE RICH REPEATS	UniProtKB/Swiss-Prot
Pfam	LRR_8	UniProtKB/Swiss-Prot
PharmGKB	PA166048954	PharmGKB
PROSITE	LRR	UniProtKB/Swiss-Prot
SMART	LRR_TYP	UniProtKB/Swiss-Prot
	LRRCT	UniProtKB/Swiss-Prot
Superfamily-SCOP	L domain-like	UniProtKB/Swiss-Prot
UniProt	A4D1A6	ENTREZGENE
	O75139	ENTREZGENE
	Q7L0X0	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	A4D1A6	UniProtKB/Swiss-Prot
	O75139	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-14	TRIL	TLR4 interactor with leucine rich repeats	TRIL	TLR4 interactor with leucine-rich repeats	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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