LOC111365144 (Nos2 promoter region) - Rat Genome Database

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Gene: LOC111365144 (Nos2 promoter region) Mus musculus
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Symbol: LOC111365144
Name: Nos2 promoter region
RGD ID: 39131203
Description: This region represents the promoter of the nitric oxide synthase 2 gene (Nos2), also known as iNOS, and includes multiple DNase I hypersensitive sites. This promoter is activated by interferon gamma and lipopolysaccharide through binding of interferon regulatory factor 1, nuclear factor kappa B, signal transducer and activator of transcription 1, high mobility group AT-hook 1, and POU family transcription factors to recognition sites in this region. This promoter is also regulated by other effectors of cell growth, including hypoxia, peroxisome proliferator activated receptor, tumor necrosis factor, and retinoic acid. This region may be epigenetically repressed by DNA methylation, which may interfere with binding of nuclear factor kappa B to this sequence. Unlike most promoters, histone acetylation was found suppress activity of this region. [provided by RefSeq, Nov 2017]
Type: biological-region
RefSeq Status: REVIEWED
Previously known as: Rr366816
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,810,061 - 78,811,815 (+)NCBIGRCm39GRCm39mm39
GRCm381178,919,235 - 78,920,989 (+)NCBIGRCm38GRCm38mm10GRCm38
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LOC111365144Mousemalaria  ISOLOC111365141 (Homo sapiens)8554872ClinVar Annotator: match by term: Malaria and resistance toClinVarPMID:12433515

1 to 10 of 13 rows
PMID:1372907   PMID:7474651   PMID:7493996   PMID:7500013   PMID:7508926   PMID:7510419   PMID:7514592   PMID:7518621   PMID:7520478   PMID:7528267   PMID:7537042   PMID:7538909  
PMID:7541763   PMID:7684434   PMID:7692452   PMID:8604025   PMID:8613707   PMID:8631766   PMID:8637893   PMID:8642266   PMID:8645207   PMID:8649986   PMID:8726465   PMID:8805668  
PMID:8939960   PMID:8995425   PMID:9115299   PMID:9130592   PMID:9164945   PMID:9245708   PMID:9305901   PMID:9435553   PMID:9480829   PMID:9523565   PMID:9619447   PMID:9679644  
PMID:9704020   PMID:9754583   PMID:9794431   PMID:9878805   PMID:9880529   PMID:9886415   PMID:9988718   PMID:10051498   PMID:10085127   PMID:10085153   PMID:10102579   PMID:10198420  
PMID:10200320   PMID:10202009   PMID:10203355   PMID:10229861   PMID:10229863   PMID:10334391   PMID:10334927   PMID:10352298   PMID:10356322   PMID:10679484   PMID:10711324   PMID:10772914  
PMID:10844594   PMID:10847627   PMID:10848596   PMID:10852612   PMID:10860828   PMID:10898490   PMID:10973958   PMID:11036073   PMID:11056164   PMID:11071874   PMID:11131279   PMID:11134960  
PMID:11171562   PMID:11213468   PMID:11399519   PMID:11451748   PMID:11724787   PMID:11755929   PMID:11961057   PMID:12007705   PMID:12057007   PMID:12138131   PMID:12225970   PMID:12429737  
PMID:12466152   PMID:12574380   PMID:12595462   PMID:12794164   PMID:12808130   PMID:12896968   PMID:14599292   PMID:14662860   PMID:14669979   PMID:14978160   PMID:15240720   PMID:15308624  
PMID:15464038   PMID:15582593   PMID:15863904   PMID:15907790   PMID:15950726   PMID:16003322   PMID:16025135   PMID:16148131   PMID:16155409   PMID:16174862   PMID:16177323   PMID:16274887  
PMID:16284791   PMID:16377003   PMID:16417967   PMID:16464859   PMID:16527246   PMID:16609073   PMID:16828070   PMID:17035338   PMID:17041221   PMID:17418925   PMID:17588951   PMID:17615555  
1 to 10 of 13 rows



LOC111365144
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391178,810,061 - 78,811,815 (+)NCBIGRCm39GRCm39mm39
GRCm381178,919,235 - 78,920,989 (+)NCBIGRCm38GRCm38mm10GRCm38
LOC111365141
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381727,800,158 - 27,817,264 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371726,127,184 - 26,144,290 (+)NCBIGRCh37GRCh37hg19GRCh37
T2T-CHM13v2.01728,741,555 - 28,758,667 (+)NCBIT2T-CHM13v2.0

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Variants in LOC111365144
76 total Variants

1 to 10 of 53 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4141365Ltxs3_mlethal factor toxin susceptibility 3 (mouse)Not determined117757387380746358Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse

1 to 10 of 53 rows








Database
Acc Id
Source(s)
NCBI Gene LOC111365144 ENTREZGENE
PhenoGen LOC111365144 PhenoGen