Fkbp2 (FK506 binding protein 2) - Rat Genome Database

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Gene: Fkbp2 (FK506 binding protein 2) Mus musculus
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Symbol: Fkbp2
Name: FK506 binding protein 2
RGD ID: 30309870
MGI Page MGI
Description: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and regulation of transcription by RNA polymerase II. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in central nervous system and retina. Orthologous to human FKBP2 (FKBP prolyl isomerase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 13 kDa FK506-binding protein; 13 kDa FKBP; 13kD; immunophilin FKBP13; mFKBP; mFKBP1; mFKBP13; mFKBP2; peptidyl-prolyl cis-trans isomerase FKBP2; PPIase FKBP2; rotamase
RGD Orthologs
Human
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,955,105 - 6,957,832 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,955,109 - 6,957,869 (-)EnsemblGRCm39 Ensembl
GRCm38196,977,737 - 6,980,464 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,977,741 - 6,980,501 (-)EnsemblGRCm38mm10GRCm38
MGSCv37197,052,229 - 7,054,951 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera196,754,656 - 6,757,379 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:7505249   PMID:8941644   PMID:9531554   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:15582152   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:17015433   PMID:18799693   PMID:21267068   PMID:21873635   PMID:30335684   PMID:30550785   PMID:30713523   PMID:32325033   PMID:36417873  


Genomics

Comparative Map Data
Fkbp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39196,955,105 - 6,957,832 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl196,955,109 - 6,957,869 (-)EnsemblGRCm39 Ensembl
GRCm38196,977,737 - 6,980,464 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl196,977,741 - 6,980,501 (-)EnsemblGRCm38mm10GRCm38
MGSCv37197,052,229 - 7,054,951 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera196,754,656 - 6,757,379 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.12NCBI
FKBP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381164,241,095 - 64,244,135 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1164,241,003 - 64,244,132 (+)EnsemblGRCh38hg38GRCh38
GRCh371164,008,567 - 64,011,607 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map11q13.1NCBI
HuRef1160,336,305 - 60,339,499 (+)NCBIHuRef
CHM1_11163,891,413 - 63,894,607 (+)NCBICHM1_1
T2T-CHM13v2.01164,231,119 - 64,234,159 (+)NCBIT2T-CHM13v2.0
FKBP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl19,992,149 - 9,994,012 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038107,330,612 - 107,333,759 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fkbp2
43 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
25394536Skmw86_mskeletal muscle weight 86, TA (mouse)1950648178957825Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000070878   ⟹   ENSMUSP00000066839
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,955,109 - 6,957,808 (-)Ensembl
Ensembl Acc Id: ENSMUST00000177752   ⟹   ENSMUSP00000136438
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,955,112 - 6,957,869 (-)Ensembl
Ensembl Acc Id: ENSMUST00000237119   ⟹   ENSMUSP00000157679
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,955,758 - 6,957,233 (-)Ensembl
Ensembl Acc Id: ENSMUST00000238181   ⟹   ENSMUSP00000158226
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl196,955,115 - 6,957,618 (-)Ensembl
RefSeq Acc Id: NM_001166368   ⟹   NP_001159840
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,955,105 - 6,957,832 (-)NCBI
GRCm38196,977,737 - 6,980,464 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001360286   ⟹   NP_001347215
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,955,105 - 6,957,454 (-)NCBI
GRCm38196,977,737 - 6,980,086 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001360288   ⟹   NP_001347217
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,955,105 - 6,956,760 (-)NCBI
GRCm38196,977,737 - 6,979,392 (-)NCBI
Sequence:
RefSeq Acc Id: NM_008020   ⟹   NP_032046
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39196,955,105 - 6,957,832 (-)NCBI
GRCm38196,977,737 - 6,980,464 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001159840   ⟸   NM_001166368
- Peptide Label: precursor
- UniProtKB: P45878 (UniProtKB/Swiss-Prot),   Q3TND1 (UniProtKB/TrEMBL),   Q3UND3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_032046   ⟸   NM_008020
- Peptide Label: precursor
- UniProtKB: P45878 (UniProtKB/Swiss-Prot),   Q3TND1 (UniProtKB/TrEMBL),   Q3UND3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001347215   ⟸   NM_001360286
- Peptide Label: precursor
- UniProtKB: P45878 (UniProtKB/Swiss-Prot),   Q3TND1 (UniProtKB/TrEMBL),   Q3UND3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001347217   ⟸   NM_001360288
- Peptide Label: precursor
- UniProtKB: P45878 (UniProtKB/Swiss-Prot),   Q3TND1 (UniProtKB/TrEMBL),   Q3UND3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000158226   ⟸   ENSMUST00000238181
Ensembl Acc Id: ENSMUSP00000157679   ⟸   ENSMUST00000237119
Ensembl Acc Id: ENSMUSP00000066839   ⟸   ENSMUST00000070878
Ensembl Acc Id: ENSMUSP00000136438   ⟸   ENSMUST00000177752
Protein Domains
PPIase FKBP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P45878-F1-model_v2 AlphaFold P45878 1-140 view protein structure

Promoters
RGD ID:13678716
Promoter ID:EPDNEW_M23507
Type:initiation region
Name:Fkbp2_1
Description:Mus musculus FK506 binding protein 2 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38196,980,440 - 6,980,500EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSMUSG00000056629 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000070878 ENTREZGENE
  ENSMUST00000070878.9 UniProtKB/Swiss-Prot
  ENSMUST00000177752 ENTREZGENE
  ENSMUST00000177752.9 UniProtKB/Swiss-Prot
  ENSMUST00000237119.2 UniProtKB/TrEMBL
  ENSMUST00000238181.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FKBP2/11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPIase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PPIase_FKBP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14227 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95542 ENTREZGENE
NCBI Gene Fkbp2 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45779 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FKBP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fkbp2 PhenoGen
PROSITE FKBP_PPIASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP FKBP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B9J3_MOUSE UniProtKB/TrEMBL
  A0A494BAX7_MOUSE UniProtKB/TrEMBL
  FKBP2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TND1 ENTREZGENE, UniProtKB/TrEMBL
  Q3UND3 ENTREZGENE, UniProtKB/TrEMBL