Ctsql1 (cathepsin Q like 1) - Rat Genome Database

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Gene: Ctsql1 (cathepsin Q like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ctsql1
Name: cathepsin Q like 1
RGD ID: 2320837
Description: Predicted to enable cysteine-type peptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cathepsin Q; cathepsin Q-like; cathepsin Q2; Ctsq; Ctsq protein-like; CtsQ2; LOC100364523
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,687,315 - 3,692,714 (-)NCBIGRCr8
mRatBN7.2173,681,700 - 3,687,099 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,681,717 - 3,687,099 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx173,701,210 - 3,706,606 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0175,242,874 - 5,248,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,697,674 - 3,703,070 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0174,045,024 - 4,050,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,045,041 - 4,050,423 (-)EnsemblRnor6.0rn6Rnor6.0
Celera173,810,915 - 3,816,345 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ctsql1Ratproteolysis involved_inIEAInterPro:IPR0006681600115GO_REF:0000002InterProGO_REF:0000002

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ctsql1Ratcysteine-type peptidase activity enablesIEAInterPro:IPR000668 and InterPro:IPR0131281600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932  



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Variants in Ctsql1
19 total Variants

1 to 10 of 10 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat

1 to 10 of 10 rows



ectoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
10 1 1 1 10 13



Ensembl Acc Id: ENSRNOT00000084780   ⟹   ENSRNOP00000072469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl173,681,717 - 3,687,099 (-)Ensembl
Rnor_6.0 Ensembl174,045,041 - 4,050,423 (-)Ensembl
RefSeq Acc Id: NM_001329884   ⟹   NP_001316813
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,687,315 - 3,692,714 (-)NCBI
mRatBN7.2173,681,700 - 3,687,099 (-)NCBI
Protein RefSeqs NP_001316813 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI07914 (Get FASTA)   NCBI Sequence Viewer  
  AAO27844 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072469
  ENSRNOP00000072469.1
Ensembl Acc Id: ENSRNOP00000072469   ⟸   ENSRNOT00000084780
RefSeq Acc Id: NP_001316813   ⟸   NM_001329884
- Peptide Label: precursor
- UniProtKB: Q32PZ8 (UniProtKB/TrEMBL),   A6KAE2 (UniProtKB/TrEMBL),   Q812B7 (UniProtKB/TrEMBL),   A0A0G2K319 (UniProtKB/TrEMBL)
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q32PZ8-F1-model_v2 AlphaFold Q32PZ8 1-343 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-10478 BioCyc
Ensembl Genes ENSRNOG00000056519 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084780 ENTREZGENE
  ENSRNOT00000084780.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2250 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/TrEMBL
KEGG Report rno:100364523 UniProtKB/TrEMBL
NCBI Gene 100364523 ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/TrEMBL
PhenoGen Ctsql1 PhenoGen
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056519 RatGTEx
SMART Inhibitor_I29 UniProtKB/TrEMBL
  Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A0G2K319 ENTREZGENE, UniProtKB/TrEMBL
  A6KAE2 ENTREZGENE, UniProtKB/TrEMBL
  Q32PZ8 ENTREZGENE
  Q812B7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q32PZ8 UniProtKB/TrEMBL
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-13 Ctsql1  cathepsin Q like 1  Ctsq  cathepsin Q  Name and Symbol changed 629549 APPROVED
2023-09-19 Ctsq  cathepsin Q  LOC100364523  Ctsq protein-like  Symbol and Name Changed 1299863 APPROVED
2010-05-05 LOC100364523  Ctsq protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL