Ctsql1 (cathepsin Q like 1) - Rat Genome Database

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Gene: Ctsql1 (cathepsin Q like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ctsql1 (Ensembl: LOC100364523)
Name: cathepsin Q like 1 (Ensembl:Ctsq protein-like)
RGD ID: 2320837
Description: Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cathepsin Q; cathepsin Q-like; cathepsin Q2; Ctsq; Ctsq protein-like; CtsQ2; LOC100364523
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,687,315 - 3,692,714 (-)NCBIGRCr8
mRatBN7.2173,681,700 - 3,687,099 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,681,717 - 3,687,099 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx173,701,210 - 3,706,606 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0175,242,874 - 5,248,268 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,697,674 - 3,703,070 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0174,045,024 - 4,050,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,045,041 - 4,050,423 (-)EnsemblRnor6.0rn6Rnor6.0
Celera173,810,915 - 3,816,345 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Ctsql1
19 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat


Expression

RNA-SEQ Expression

ectoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
10 1 1 1 10 13

Sequence


Ensembl Acc Id: ENSRNOT00000084780   ⟹   ENSRNOP00000072469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl173,681,717 - 3,687,099 (-)Ensembl
Rnor_6.0 Ensembl174,045,041 - 4,050,423 (-)Ensembl
RefSeq Acc Id: NM_001329884   ⟹   NP_001316813
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,687,315 - 3,692,714 (-)NCBI
mRatBN7.2173,681,700 - 3,687,099 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001316813 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI07914 (Get FASTA)   NCBI Sequence Viewer  
  AAO27844 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072469.1
Ensembl Acc Id: ENSRNOP00000072469   ⟸   ENSRNOT00000084780
RefSeq Acc Id: NP_001316813   ⟸   NM_001329884
- Peptide Label: precursor
- UniProtKB: Q32PZ8 (UniProtKB/TrEMBL),   A6KAE2 (UniProtKB/TrEMBL),   Q812B7 (UniProtKB/TrEMBL),   A0A0G2K319 (UniProtKB/TrEMBL)
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32PZ8-F1-model_v2 AlphaFold Q32PZ8 1-343 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2320837 AgrOrtholog
BioCyc Gene G2FUF-10478 BioCyc
Ensembl Genes ENSRNOG00000056519 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084780.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2250 UniProtKB/TrEMBL
  Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/TrEMBL
KEGG Report rno:100364523 UniProtKB/TrEMBL
NCBI Gene 100364523 ENTREZGENE
PANTHER CATHEPSIN Q UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/TrEMBL
PhenoGen Ctsql1 PhenoGen
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056519 RatGTEx
SMART Inhibitor_I29 UniProtKB/TrEMBL
  Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A0G2K319 ENTREZGENE, UniProtKB/TrEMBL
  A6KAE2 ENTREZGENE, UniProtKB/TrEMBL
  Q32PZ8 ENTREZGENE
  Q812B7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q32PZ8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-13 Ctsql1  cathepsin Q like 1  Ctsq  cathepsin Q  Name and Symbol changed 629549 APPROVED
2023-09-19 Ctsq  cathepsin Q  LOC100364523  Ctsq protein-like  Symbol and Name Changed 1299863 APPROVED
2010-05-05 LOC100364523  Ctsq protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL