Tnfsf12 (TNF superfamily member 12) - Rat Genome Database

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Gene: Tnfsf12 (TNF superfamily member 12) Heterocephalus glaber
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Symbol: Tnfsf12
Name: TNF superfamily member 12
RGD ID: 18935744
Description: ENCODES a protein that exhibits cytokine activity (inferred); receptor ligand activity (inferred); tumor necrosis factor receptor binding (inferred); INVOLVED IN extrinsic apoptotic signaling pathway (ortholog); positive regulation of extrinsic apoptotic signaling pathway (ortholog); positive regulation of protein catabolic process (ortholog); ASSOCIATED WITH atrial fibrillation (ortholog); Brain Injuries (ortholog); common variable immunodeficiency (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand superfamily member 12; tumor necrosis factor superfamily member 12
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,166,168 - 10,175,433 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,165,694 - 10,176,042 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tnfsf12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,166,168 - 10,175,433 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,165,694 - 10,176,042 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TNFSF12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,549,058 - 7,557,881 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,548,508 - 7,557,890 (+)EnsemblGRCh38hg38GRCh38
GRCh37177,452,375 - 7,461,198 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,393,099 - 7,401,931 (+)NCBINCBI36Build 36hg18NCBI36
Build 34177,393,098 - 7,401,930NCBI
Celera177,478,712 - 7,487,530 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,333,866 - 7,355,392 (+)NCBIHuRef
CHM1_1177,461,331 - 7,470,169 (+)NCBICHM1_1
T2T-CHM13v2.0177,453,339 - 7,462,142 (+)NCBIT2T-CHM13v2.0
Tnfsf12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,577,066 - 69,586,924 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,577,076 - 69,586,675 (-)EnsemblGRCm39 Ensembl
GRCm381169,686,240 - 69,696,098 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,686,250 - 69,695,849 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,499,850 - 69,509,499 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,502,543 - 69,511,949 (-)NCBIMGSCv36mm8
MGSCv361170,270,455 - 70,279,861 (-)NCBIMGSCv36mm8
Cytogenetic Map11B3NCBI
cM Map1142.86NCBI
Tnfsf12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,902,616 - 54,912,628 (-)NCBIGRCr8
mRatBN7.21054,403,870 - 54,413,213 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,403,870 - 54,413,213 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,066,503 - 59,075,779 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,555,055 - 58,564,331 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,062,637 - 54,071,959 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,290,780 - 56,300,137 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,290,780 - 56,300,077 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,036,418 - 56,045,765 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,503,756 - 56,513,053 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,517,378 - 56,526,676 (-)NCBI
Celera1053,558,386 - 53,567,669 (-)NCBICelera
Cytogenetic Map10q24NCBI
TNFSF12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,142,978 - 15,152,912 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,110,025 - 17,118,977 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,581,163 - 7,589,809 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,567,875 - 7,579,827 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,567,766 - 7,575,575 (+)Ensemblpanpan1.1panPan2
TNFSF12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,473,543 - 32,481,596 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,473,083 - 32,481,121 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,613,463 - 32,620,979 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,579,095 - 32,586,611 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,578,582 - 32,586,769 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,546,765 - 32,554,285 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,503,222 - 32,510,742 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,682,308 - 32,689,823 (+)NCBIUU_Cfam_GSD_1.0
LOC101977665
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,356,954 - 47,365,595 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595830,466 - 839,748 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595831,252 - 839,783 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFSF12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,843,026 - 52,853,325 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,843,026 - 52,853,328 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TNFSF12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,926,302 - 6,935,070 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605914,473,330 - 14,482,339 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000014311   ⟹   ENSHGLP00000014168
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478610,166,168 - 10,175,433 (+)Ensembl
RefSeq Acc Id: XM_013076789   ⟹   XP_012932243
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478610,165,694 - 10,175,433 (+)NCBI
RefSeq Acc Id: XM_013076790   ⟹   XP_012932244
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478610,165,694 - 10,175,433 (+)NCBI
RefSeq Acc Id: XM_021238148   ⟹   XP_021093807
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478610,166,082 - 10,176,042 (+)NCBI
Protein Sequences
Protein RefSeqs XP_012932243 (Get FASTA)   NCBI Sequence Viewer  
  XP_012932244 (Get FASTA)   NCBI Sequence Viewer  
  XP_021093807 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014168
RefSeq Acc Id: XP_012932243   ⟸   XM_013076789
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QZV7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012932244   ⟸   XM_013076790
- Peptide Label: isoform X3
- UniProtKB: A0AAX6R4N2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093807   ⟸   XM_021238148
- Peptide Label: isoform X1
- UniProtKB: A0AAX6R8A5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000014168   ⟸   ENSHGLT00000014311


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010122 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000014311 ENTREZGENE
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro TNF_dom UniProtKB/TrEMBL
  TNF_Ligand_Superfamily UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/TrEMBL
NCBI Gene Tnfsf12 ENTREZGENE
PANTHER PROTEIN EIGER UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 12 UniProtKB/TrEMBL
Pfam TNF UniProtKB/TrEMBL
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  TNF_2 UniProtKB/TrEMBL
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP TNF-like UniProtKB/TrEMBL
UniProt A0AAX6QZV7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R4N2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6R8A5 ENTREZGENE, UniProtKB/TrEMBL