Rad17 (RAD17 checkpoint clamp loader component) - Rat Genome Database

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Gene: Rad17 (RAD17 checkpoint clamp loader component) Heterocephalus glaber
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Symbol: Rad17
Name: RAD17 checkpoint clamp loader component
RGD ID: 18929528
Description: ENCODES a protein that exhibits chromatin-protein adaptor activity (ortholog); INVOLVED IN DNA damage response (ortholog); mitotic intra-S DNA damage checkpoint signaling (ortholog); negative regulation of DNA replication (ortholog); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog); FOUND IN chromosome, telomeric region (ortholog); nucleolus (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cell cycle checkpoint protein RAD17; RAD17 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905249,511 - 276,922 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624905244,811 - 277,362 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rad17
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905249,511 - 276,922 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624905244,811 - 277,362 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
RAD17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38569,369,293 - 69,414,801 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl569,369,293 - 69,414,801 (+)EnsemblGRCh38hg38GRCh38
GRCh37568,665,120 - 68,710,628 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,700,880 - 68,746,384 (+)NCBINCBI36Build 36hg18NCBI36
Build 34568,701,394 - 68,746,382NCBI
Celera565,667,788 - 65,713,573 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef565,621,167 - 65,666,871 (+)NCBIHuRef
CHM1_1568,664,968 - 68,710,363 (+)NCBICHM1_1
T2T-CHM13v2.0570,195,078 - 70,240,793 (+)NCBIT2T-CHM13v2.0
Rad17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,753,672 - 100,787,569 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,753,672 - 100,787,559 (-)EnsemblGRCm39 Ensembl
GRCm3813100,617,164 - 100,651,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,617,164 - 100,651,051 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,387,119 - 101,421,014 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613101,717,422 - 101,751,091 (-)NCBIMGSCv36mm8
Celera13104,227,151 - 104,261,234 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Rad17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,498,335 - 33,528,614 (-)NCBIGRCr8
mRatBN7.2231,764,260 - 31,794,542 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,764,261 - 31,794,072 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,898,690 - 38,928,598 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,939,110 - 36,969,086 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,796,969 - 31,827,030 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,634,353 - 30,664,618 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,634,354 - 30,664,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,793,990 - 49,824,254 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,424,504 - 31,454,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,344,873 - 31,374,682 (-)NCBI
Celera227,776,957 - 27,806,762 (-)NCBICelera
Cytogenetic Map2q12NCBI
Rad17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495557578,335 - 115,129 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495557578,686 - 115,072 (+)NCBIChiLan1.0ChiLan1.0
RAD17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2444,504,519 - 44,550,381 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1542,658,144 - 42,704,006 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0544,586,083 - 44,630,719 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1546,156,294 - 46,202,197 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,156,294 - 46,202,197 (-)Ensemblpanpan1.1panPan2
RAD17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,407,184 - 54,437,676 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,407,228 - 54,437,632 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,373,442 - 51,404,005 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0254,918,224 - 54,949,486 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl254,918,240 - 54,949,601 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1251,976,717 - 52,013,771 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,750,007 - 52,780,574 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,640,400 - 53,670,962 (+)NCBIUU_Cfam_GSD_1.0
Rad17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,279,855 - 191,315,720 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936480216,208 - 252,070 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936480216,216 - 252,178 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAD17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,499,669 - 47,529,702 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,499,669 - 47,529,703 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,424,228 - 51,448,330 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAD17
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,456,174 - 65,501,665 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl465,457,763 - 65,501,157 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604914,192,461 - 14,238,156 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000000438   ⟹   ENSHGLP00000000400
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624905249,511 - 276,922 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000000439   ⟹   ENSHGLP00000000401
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624905250,299 - 276,922 (+)Ensembl
RefSeq Acc Id: XM_021250690   ⟹   XP_021106349
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624905244,811 - 277,362 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021106349 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000400
GenBank Protein JAN96934 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021106349   ⟸   XM_021250690
- UniProtKB: A0AAX6SCZ2 (UniProtKB/TrEMBL),   A0A0P6IXY2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000000401   ⟸   ENSHGLT00000000439
Ensembl Acc Id: ENSHGLP00000000400   ⟸   ENSHGLT00000000438


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000374 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000000438 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro Checkpoint_prot_Rad17_Rad24 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Rad17/Rad24_fun/met UniProtKB/TrEMBL
NCBI Gene Rad17 ENTREZGENE
PANTHER CELL CYCLE CHECKPOINT PROTEIN RAD17 UniProtKB/TrEMBL
  PTHR12172 UniProtKB/TrEMBL
Pfam Rad17 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0P6IXY2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SCZ2 ENTREZGENE, UniProtKB/TrEMBL