Scn10a (sodium voltage-gated channel alpha subunit 10) - Rat Genome Database

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Gene: Scn10a (sodium voltage-gated channel alpha subunit 10) Heterocephalus glaber
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Symbol: Scn10a
Name: sodium voltage-gated channel alpha subunit 10
RGD ID: 18928399
Description: ENCODES a protein that exhibits transmembrane transporter binding (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ortholog); voltage-gated sodium channel activity (ortholog); INVOLVED IN AV node cell action potential (ortholog); behavioral response to pain (ortholog); bundle of His cell action potential (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH atrial fibrillation (ortholog); autistic disorder (ortholog); Brugada syndrome (ortholog); FOUND IN axon (ortholog); C-fiber (ortholog); clathrin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NaV1.8; sodium channel protein type 10 subunit alpha; sodium channel, voltage-gated, type X, alpha subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247312,254,445 - 2,355,738 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247312,254,445 - 2,356,174 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lidocaine pharmacokinetics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Scn10a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247312,254,445 - 2,355,738 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247312,254,445 - 2,356,174 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SCN10A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,696,807 - 38,816,217 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,696,802 - 38,816,286 (-)EnsemblGRCh38hg38GRCh38
GRCh37338,738,298 - 38,857,708 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,713,841 - 38,810,505 (-)NCBINCBI36Build 36hg18NCBI36
Build 34338,713,840 - 38,810,505NCBI
Celera338,677,898 - 38,774,543 (-)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,781,159 - 38,877,645 (-)NCBIHuRef
CHM1_1338,690,433 - 38,787,099 (-)NCBICHM1_1
T2T-CHM13v2.0338,709,028 - 38,828,431 (-)NCBIT2T-CHM13v2.0
Scn10a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,437,522 - 119,548,388 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,437,522 - 119,548,388 (-)EnsemblGRCm39 Ensembl
GRCm389119,608,456 - 119,719,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,608,456 - 119,719,322 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,517,584 - 119,603,478 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,457,165 - 119,543,058 (-)NCBIMGSCv36mm8
Celera9120,082,167 - 120,168,344 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
Scn10a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,228,424 - 128,340,749 (-)NCBIGRCr8
mRatBN7.28119,350,723 - 119,462,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,350,724 - 119,462,614 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,932,439 - 125,044,084 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,131,466 - 123,243,120 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,965,215 - 121,076,407 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,298,593 - 128,416,896 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,298,594 - 128,416,650 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,503,061 - 127,620,197 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,578,222 - 124,690,458 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,597,959 - 124,710,195 (-)NCBI
Celera8118,500,856 - 118,611,564 (-)NCBICelera
Cytogenetic Map8q32NCBI
Scn10a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,157,179 - 25,243,473 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542725,157,179 - 25,244,020 (+)NCBIChiLan1.0ChiLan1.0
SCN10A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,649,419 - 38,747,494 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,654,181 - 38,752,256 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,593,765 - 38,691,172 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,876,068 - 38,972,247 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,876,068 - 38,972,247 (-)Ensemblpanpan1.1panPan2
SCN10A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,420,468 - 8,527,414 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,420,472 - 8,527,383 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,460,551 - 8,567,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,708,298 - 8,817,466 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,709,728 - 8,817,466 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,523,267 - 8,630,160 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,664,475 - 8,771,500 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,658,580 - 8,765,552 (-)NCBIUU_Cfam_GSD_1.0
Scn10a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,871,017 - 194,982,033 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647328,010,123 - 28,102,124 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647328,010,123 - 28,102,124 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN10A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,481,255 - 23,570,379 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,481,537 - 23,570,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,726,454 - 25,805,806 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SCN10A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115624,962 - 724,018 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15625,742 - 721,963 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660639,354,464 - 9,451,595 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000017039   ⟹   ENSHGLP00000016868
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247312,254,445 - 2,355,738 (+)Ensembl
RefSeq Acc Id: XM_021259819   ⟹   XP_021115478
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247312,254,445 - 2,356,174 (+)NCBI
RefSeq Acc Id: XM_021259827   ⟹   XP_021115486
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247312,254,445 - 2,356,174 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021115478 (Get FASTA)   NCBI Sequence Viewer  
  XP_021115486 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AEV53349 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016868
RefSeq Acc Id: XP_021115486   ⟸   XM_021259827
- Peptide Label: isoform X2
- UniProtKB: G9DCX4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021115478   ⟸   XM_021259819
- Peptide Label: isoform X1
- UniProtKB: G9DCX4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000016868   ⟸   ENSHGLT00000017039


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012062 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000017039 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  iswi atpase UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  Na_channel_asu UniProtKB/TrEMBL
  Na_chnl_inactivation_gate UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  VGCC_Ca_Na UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene Scn10a ENTREZGENE
PANTHER PTHR10037 UniProtKB/TrEMBL
  PTHR10037:SF208 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
PRINTS NACHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0AAX6T0B2_HETGA UniProtKB/TrEMBL
  A0AAX6T4S8_HETGA UniProtKB/TrEMBL
  G9DCX4 ENTREZGENE, UniProtKB/TrEMBL