Det1 (DET1 partner of COP1 E3 ubiquitin ligase) - Rat Genome Database

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Gene: Det1 (DET1 partner of COP1 E3 ubiquitin ligase) Heterocephalus glaber
Analyze
Symbol: Det1
Name: DET1 partner of COP1 E3 ubiquitin ligase
RGD ID: 18924946
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN protein-containing complex assembly (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (ortholog); Cul4A-RING E3 ubiquitin ligase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: de-etiolated homolog 1; DET1 homolog; DET1, COP1 ubiquitin ligase partner
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476815,870,035 - 15,884,201 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476815,869,949 - 15,919,368 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Det1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476815,870,035 - 15,884,201 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476815,869,949 - 15,919,368 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DET1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381588,501,919 - 88,546,703 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1588,494,440 - 88,546,681 (-)EnsemblGRCh38hg38GRCh38
GRCh371589,045,150 - 89,089,934 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361586,856,718 - 86,890,888 (-)NCBINCBI36Build 36hg18NCBI36
Build 341586,856,717 - 86,890,888NCBI
Celera1565,456,264 - 65,490,480 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1565,167,746 - 65,201,951 (-)NCBIHuRef
CHM1_11588,897,510 - 88,931,698 (-)NCBICHM1_1
T2T-CHM13v2.01586,256,518 - 86,301,304 (-)NCBIT2T-CHM13v2.0
Det1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39778,471,293 - 78,497,272 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl778,471,295 - 78,497,011 (-)EnsemblGRCm39 Ensembl
GRCm38778,821,545 - 78,847,524 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl778,821,547 - 78,847,263 (-)EnsemblGRCm38mm10GRCm38
MGSCv37785,972,360 - 85,992,097 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36778,700,987 - 78,720,724 (-)NCBIMGSCv36mm8
Celera776,239,485 - 76,252,619 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.81NCBI
Det1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,159,120 - 142,175,366 (-)NCBIGRCr8
mRatBN7.21132,749,736 - 132,765,963 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1132,749,756 - 132,765,923 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1140,663,635 - 140,679,998 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01147,833,053 - 147,849,417 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01140,750,742 - 140,767,105 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01140,519,755 - 140,535,969 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1140,519,702 - 140,535,934 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,494,829 - 141,511,032 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,552,235 - 134,566,070 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11134,627,799 - 134,653,445 (-)NCBI
Celera1124,823,167 - 124,836,180 (-)NCBICelera
Cytogenetic Map1q31NCBI
Det1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,393,156 - 16,408,613 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541616,393,199 - 16,408,144 (+)NCBIChiLan1.0ChiLan1.0
DET1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21678,060,249 - 78,093,815 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11581,761,168 - 81,798,350 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01567,203,101 - 67,238,185 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11586,411,937 - 86,444,812 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1586,411,937 - 86,444,789 (-)Ensemblpanpan1.1panPan2
DET1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1351,725,931 - 51,765,487 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl351,725,926 - 51,775,185 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,381,456 - 54,401,993 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0352,164,909 - 52,185,430 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl352,163,086 - 52,185,416 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1351,687,160 - 51,707,677 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0351,897,298 - 51,917,838 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0352,236,406 - 52,256,959 (-)NCBIUU_Cfam_GSD_1.0
Det1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,778,229 - 131,798,719 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648314,535,800 - 14,556,248 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648314,535,771 - 14,556,236 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DET1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1191,263,448 - 191,284,967 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11191,263,449 - 191,284,973 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,696,333 - 212,717,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DET1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1297,078,777 - 7,103,174 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl297,078,578 - 7,096,486 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605939,745,934 - 39,770,360 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000011838   ⟹   ENSHGLP00000011710
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476815,870,035 - 15,884,201 (-)Ensembl
RefSeq Acc Id: XM_004852741   ⟹   XP_004852798
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476815,869,949 - 15,884,218 (-)NCBI
RefSeq Acc Id: XM_021264798   ⟹   XP_021120457
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476815,869,949 - 15,919,368 (-)NCBI
RefSeq Acc Id: XM_021264799   ⟹   XP_021120458
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476815,869,949 - 15,919,367 (-)NCBI
RefSeq Acc Id: XM_021264800   ⟹   XP_021120459
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476815,869,949 - 15,919,364 (-)NCBI
RefSeq Acc Id: XM_021264802   ⟹   XP_021120461
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476815,869,949 - 15,882,526 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004852798 (Get FASTA)   NCBI Sequence Viewer  
  XP_021120457 (Get FASTA)   NCBI Sequence Viewer  
  XP_021120458 (Get FASTA)   NCBI Sequence Viewer  
  XP_021120459 (Get FASTA)   NCBI Sequence Viewer  
  XP_021120461 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000011710
RefSeq Acc Id: XP_021120457   ⟸   XM_021264798
- Peptide Label: isoform X1
- UniProtKB: G5CA81 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120458   ⟸   XM_021264799
- Peptide Label: isoform X2
- UniProtKB: G5CA81 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120459   ⟸   XM_021264800
- Peptide Label: isoform X3
- UniProtKB: G5CA81 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004852798   ⟸   XM_004852741
- Peptide Label: isoform X4
- UniProtKB: G5CA81 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021120461   ⟸   XM_021264802
- Peptide Label: isoform X4
- UniProtKB: G5CA81 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000011710   ⟸   ENSHGLT00000011838


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008396 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000011838 ENTREZGENE
InterPro De-etiolated_protein_1_Det1 UniProtKB/TrEMBL
NCBI Gene Det1 ENTREZGENE
PANTHER DET1 HOMOLOG UniProtKB/TrEMBL
  DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG UniProtKB/TrEMBL
Pfam Det1 UniProtKB/TrEMBL
UniProt A0AAX6TFY0_HETGA UniProtKB/TrEMBL
  A0AAX6TH79_HETGA UniProtKB/TrEMBL
  A0AAX6TIL7_HETGA UniProtKB/TrEMBL
  A0AAX6TK68_HETGA UniProtKB/TrEMBL
  G5CA81 ENTREZGENE, UniProtKB/TrEMBL