Mylk3 (myosin light chain kinase 3) - Rat Genome Database

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Gene: Mylk3 (myosin light chain kinase 3) Heterocephalus glaber
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Symbol: Mylk3
Name: myosin light chain kinase 3
RGD ID: 18924857
Description: ENCODES a protein that exhibits calcium/calmodulin-dependent protein kinase activity (ortholog); myosin light chain kinase activity (ortholog); INVOLVED IN cardiac myofibril assembly (ortholog); cellular response to interleukin-1 (ortholog); positive regulation of membrane permeability (ortholog); ASSOCIATED WITH glycogen storage disease IXB (ortholog); Parkinson's disease 17 (ortholog); FOUND IN actin cytoskeleton (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Putative myosin light chain kinase 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624914198,803 - 239,427 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624914200,914 - 251,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (ISO)
cytoplasm  (ISO)
cytosol  (ISO)
nucleus  (IEA)

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Mylk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624914198,803 - 239,427 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624914200,914 - 251,699 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MYLK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381646,702,282 - 46,763,246 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1646,702,282 - 46,790,407 (-)EnsemblGRCh38hg38GRCh38
GRCh371646,736,194 - 46,797,158 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361645,293,695 - 45,339,722 (-)NCBINCBI36Build 36hg18NCBI36
Celera1631,244,379 - 31,290,436 (-)NCBICelera
Cytogenetic Map16q11.2NCBI
HuRef1632,625,650 - 32,671,687 (-)NCBIHuRef
CHM1_11648,143,152 - 48,189,182 (-)NCBICHM1_1
T2T-CHM13v2.01652,499,182 - 52,560,128 (-)NCBIT2T-CHM13v2.0
Mylk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39886,050,933 - 86,112,969 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl886,050,932 - 86,112,974 (-)EnsemblGRCm39 Ensembl
GRCm38885,324,928 - 85,386,340 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,324,303 - 85,386,345 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,848,828 - 87,889,223 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36885,030,905 - 85,070,828 (-)NCBIMGSCv36mm8
MGSCv36888,215,034 - 88,255,429 (-)NCBIMGSCv36mm8
Celera889,618,765 - 89,675,102 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.61NCBI
Mylk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81937,858,298 - 37,916,805 (+)NCBIGRCr8
mRatBN7.21921,685,085 - 21,743,587 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1921,691,929 - 21,742,954 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1923,398,906 - 23,432,675 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01928,593,424 - 28,627,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01931,556,254 - 31,590,023 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01927,388,163 - 27,442,451 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1927,404,712 - 27,441,536 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01938,356,781 - 38,408,247 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41923,068,059 - 23,101,629 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11923,072,884 - 23,120,712 (+)NCBI
Celera1921,568,596 - 21,602,349 (+)NCBICelera
Cytogenetic Map19q11NCBI
Mylk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955448255,119 - 287,712 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955448254,280 - 287,451 (-)NCBIChiLan1.0ChiLan1.0
MYLK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21856,160,641 - 56,224,653 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11662,065,765 - 62,129,712 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01626,966,653 - 27,029,413 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11645,858,723 - 45,919,859 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1645,863,863 - 45,905,082 (-)Ensemblpanpan1.1panPan2
MYLK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,382,436 - 8,416,740 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,381,854 - 8,416,368 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha158,535,870 - 8,570,561 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0158,498,390 - 8,533,075 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl158,498,832 - 8,531,004 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1158,327,588 - 8,362,127 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0158,408,586 - 8,443,037 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0158,424,303 - 8,458,844 (+)NCBIUU_Cfam_GSD_1.0
Mylk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934959,441,555 - 59,499,618 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647589,570 - 126,025 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647589,717 - 137,866 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYLK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl637,850,754 - 37,920,754 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1637,850,117 - 37,920,862 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MYLK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1532,553,897 - 32,593,968 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl532,553,602 - 32,593,638 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604743,993,073 - 44,049,954 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000002718   ⟹   ENSHGLP00000002664
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624914198,803 - 239,427 (-)Ensembl
RefSeq Acc Id: XM_004873886   ⟹   XP_004873943
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624914200,914 - 239,386 (-)NCBI
RefSeq Acc Id: XM_004873887   ⟹   XP_004873944
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624914200,914 - 248,015 (-)NCBI
RefSeq Acc Id: XM_004873888   ⟹   XP_004873945
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624914200,914 - 251,699 (-)NCBI
RefSeq Acc Id: XM_021251477   ⟹   XP_021107136
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624914200,914 - 229,318 (-)NCBI
RefSeq Acc Id: XM_021251478   ⟹   XP_021107137
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624914200,914 - 229,240 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004873943 (Get FASTA)   NCBI Sequence Viewer  
  XP_004873944 (Get FASTA)   NCBI Sequence Viewer  
  XP_004873945 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107136 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107137 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB16146 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000002664
RefSeq Acc Id: XP_004873945   ⟸   XM_004873888
- Peptide Label: isoform X3
- UniProtKB: G5C3N4 (UniProtKB/TrEMBL),   A0AAX6QDY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004873944   ⟸   XM_004873887
- Peptide Label: isoform X2
- UniProtKB: G5C3N4 (UniProtKB/TrEMBL),   A0AAX6QE75 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004873943   ⟸   XM_004873886
- Peptide Label: isoform X1
- UniProtKB: G5C3N4 (UniProtKB/TrEMBL),   A0AAX6QIF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021107136   ⟸   XM_021251477
- Peptide Label: isoform X4
- UniProtKB: A0AAX6SF00 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021107137   ⟸   XM_021251478
- Peptide Label: isoform X5
- UniProtKB: A0AAX6SGJ8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000002664   ⟸   ENSHGLT00000002718


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000002008 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000002718 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Mylk3 ENTREZGENE
PANTHER MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE 17 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL
UniProt A0AAX6QDY3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QE75 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QIF4 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SF00 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SGJ8 ENTREZGENE, UniProtKB/TrEMBL
  G5C3N4 ENTREZGENE, UniProtKB/TrEMBL