Mcub (mitochondrial calcium uniporter dominant negative subunit beta) - Rat Genome Database

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Gene: Mcub (mitochondrial calcium uniporter dominant negative subunit beta) Heterocephalus glaber
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Symbol: Mcub
Name: mitochondrial calcium uniporter dominant negative subunit beta (Ensembl:mitochondrial calcium uniporter dominant negative beta subunit)
RGD ID: 18916904
Description: ENCODES a protein that exhibits calcium channel inhibitor activity (ortholog); monoatomic ion channel activity (ortholog); INVOLVED IN mitochondrial calcium ion homeostasis (ortholog); mitochondrial calcium ion transmembrane transport (ortholog); negative regulation of calcium import into the mitochondrion (ortholog); FOUND IN calcium channel complex (ortholog); intracellular membrane-bounded organelle (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: calcium uniporter regulatory subunit MCUb, mitochondrial; mitochondrial calcium uniporter dominant negative beta subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624830189,553 - 260,149 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624830187,458 - 260,130 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Mcub
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624830189,553 - 260,149 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624830187,458 - 260,130 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MCUB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384109,560,246 - 109,688,719 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4109,560,209 - 109,688,719 (+)EnsemblGRCh38hg38GRCh38
GRCh374110,481,402 - 110,609,875 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364110,700,866 - 110,828,321 (+)NCBINCBI36Build 36hg18NCBI36
Celera4107,775,242 - 107,902,535 (+)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4106,214,109 - 106,341,864 (+)NCBIHuRef
CHM1_14110,457,999 - 110,585,481 (+)NCBICHM1_1
T2T-CHM13v2.04112,862,358 - 112,990,653 (+)NCBIT2T-CHM13v2.0
Mcub
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,708,609 - 129,763,850 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,708,609 - 129,763,855 (-)EnsemblGRCm39 Ensembl
GRCm383129,914,960 - 129,970,211 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,914,960 - 129,970,206 (-)EnsemblGRCm38mm10GRCm38
MGSCv373129,617,878 - 129,673,124 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,907,001 - 129,962,228 (-)NCBIMGSCv36mm8
Celera3136,429,291 - 136,484,776 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map359.56NCBI
Mcub
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82221,153,525 - 221,223,814 (-)NCBIGRCr8
mRatBN7.22218,479,301 - 218,549,594 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2218,479,301 - 218,549,593 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2226,157,632 - 226,228,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02224,057,331 - 224,128,127 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,914,976 - 218,985,772 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02235,353,506 - 235,356,936 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.02230,198,346 - 230,274,033 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2230,199,343 - 230,273,709 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02249,552,830 - 249,624,586 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42227,374,643 - 227,378,517 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12227,361,322 - 227,369,993 (-)NCBI
Celera2210,760,554 - 210,829,049 (-)NCBICelera
Cytogenetic Map2q43NCBI
Mcub
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955496585,528 - 658,762 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955496584,912 - 658,794 (-)NCBIChiLan1.0ChiLan1.0
MCUB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23107,652,060 - 107,781,329 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14107,950,617 - 108,073,904 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,062,220 - 102,186,200 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14112,631,323 - 112,753,943 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4112,631,323 - 112,753,943 (+)Ensemblpanpan1.1panPan2
MCUB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13229,793,439 - 29,890,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3229,793,556 - 29,890,033 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3212,139,957 - 12,235,980 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,013,611 - 30,113,415 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,013,606 - 30,113,401 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,007,796 - 30,107,905 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03229,752,940 - 29,852,400 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,997,080 - 10,097,330 (-)NCBIUU_Cfam_GSD_1.0
Mcub
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530111,039,245 - 11,163,891 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936563787,100 - 911,612 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936563787,104 - 912,424 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCUB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8112,539,189 - 112,651,261 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18112,539,188 - 112,651,417 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28120,683,277 - 120,733,636 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCUB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1757,481,617 - 57,591,742 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl757,481,568 - 57,591,609 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603736,131,501 - 36,243,773 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000001295   ⟹   ENSHGLP00000001253
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624830189,553 - 260,149 (-)Ensembl
RefSeq Acc Id: XM_021245481   ⟹   XP_021101140
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624830187,458 - 260,130 (-)NCBI
RefSeq Acc Id: XM_021245482   ⟹   XP_021101141
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624830187,458 - 249,955 (-)NCBI
RefSeq Acc Id: XM_021245483   ⟹   XP_021101142
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624830187,458 - 259,859 (-)NCBI
Protein Sequences
Protein RefSeqs XP_021101140 (Get FASTA)   NCBI Sequence Viewer  
  XP_021101141 (Get FASTA)   NCBI Sequence Viewer  
  XP_021101142 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000001253
Reference Protein Sequences
RefSeq Acc Id: XP_021101140   ⟸   XM_021245481
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021101142   ⟸   XM_021245483
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021101141   ⟸   XM_021245482
- Peptide Label: isoform X2
RefSeq Acc Id: ENSHGLP00000001253   ⟸   ENSHGLT00000001295


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000975 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000001295 ENTREZGENE
NCBI Gene Mcub ENTREZGENE