Msh4 (mutS homolog 4) - Rat Genome Database

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Gene: Msh4 (mutS homolog 4) Heterocephalus glaber
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Symbol: Msh4
Name: mutS homolog 4
RGD ID: 18916850
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP-dependent DNA damage sensor activity (inferred); DNA binding (inferred); INVOLVED IN female gamete generation (ortholog); homologous chromosome pairing at meiosis (ortholog); meiotic cell cycle (ortholog); ASSOCIATED WITH genetic disease (ortholog); hereditary breast ovarian cancer syndrome (ortholog); medium chain acyl-CoA dehydrogenase deficiency (ortholog); FOUND IN chromosome (ortholog); condensed chromosome (ortholog); condensed nuclear chromosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mutS protein homolog 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474221,098,101 - 21,167,398 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474221,098,102 - 21,167,472 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Msh4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474221,098,101 - 21,167,398 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474221,098,102 - 21,167,472 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
MSH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38175,796,882 - 75,913,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl175,796,882 - 75,913,242 (+)EnsemblGRCh38hg38GRCh38
GRCh37176,262,567 - 76,378,927 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,035,218 - 76,151,511 (+)NCBINCBI36Build 36hg18NCBI36
Build 34175,974,650 - 76,090,944NCBI
Celera174,502,536 - 74,619,128 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef174,392,386 - 74,509,072 (+)NCBIHuRef
CHM1_1176,377,843 - 76,494,293 (+)NCBICHM1_1
T2T-CHM13v2.0175,633,544 - 75,751,219 (+)NCBIT2T-CHM13v2.0
Msh4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393153,562,783 - 153,611,495 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3153,562,786 - 153,611,775 (-)EnsemblGRCm39 Ensembl
GRCm383153,857,141 - 153,906,138 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3153,857,149 - 153,906,138 (-)EnsemblGRCm38mm10GRCm38
MGSCv373153,520,111 - 153,569,102 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363153,794,533 - 153,843,524 (-)NCBIMGSCv36mm8
Celera3160,320,812 - 160,369,813 (-)NCBICelera
Cytogenetic Map3H3NCBI
cM Map378.7NCBI
Msh4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82245,445,118 - 245,504,493 (-)NCBIGRCr8
mRatBN7.22242,785,392 - 242,844,609 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2242,792,661 - 242,843,487 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2250,616,144 - 250,666,160 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02248,509,973 - 248,559,983 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02243,408,533 - 243,458,548 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02260,057,708 - 260,108,897 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2260,057,855 - 260,108,897 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02278,716,760 - 278,773,060 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42251,801,090 - 251,851,133 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12251,815,109 - 251,866,523 (-)NCBI
Celera2234,728,057 - 234,775,779 (-)NCBICelera
Cytogenetic Map2q45NCBI
Msh4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542317,093,573 - 17,154,910 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542317,093,573 - 17,154,910 (-)NCBIChiLan1.0ChiLan1.0
MSH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21150,974,838 - 151,096,427 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11150,135,382 - 150,256,962 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0175,011,947 - 75,130,036 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1176,983,852 - 77,099,896 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl176,983,852 - 77,099,896 (+)Ensemblpanpan1.1panPan2
MSH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1670,745,777 - 70,822,507 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl670,746,634 - 70,823,004 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha673,406,292 - 73,487,796 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0671,334,444 - 71,416,137 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1670,834,791 - 70,912,065 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0670,780,166 - 70,856,995 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0671,269,093 - 71,350,596 (-)NCBIUU_Cfam_GSD_1.0
Msh4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505887,311,249 - 87,388,210 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365712,822,058 - 2,898,562 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365712,827,283 - 2,898,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12057,283,723 - 57,397,871 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2057,284,575 - 57,396,797 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603360,112,696 - 60,228,261 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000007372   ⟹   ENSHGLP00000007287
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474221,098,101 - 21,167,398 (-)Ensembl
RefSeq Acc Id: XM_004841428   ⟹   XP_004841485
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474221,098,102 - 21,167,472 (-)NCBI
RefSeq Acc Id: XM_021255516   ⟹   XP_021111175
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474221,098,102 - 21,167,472 (-)NCBI
RefSeq Acc Id: XM_021255517   ⟹   XP_021111176
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474221,099,948 - 21,167,472 (-)NCBI
RefSeq Acc Id: XM_021255519   ⟹   XP_021111178
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474221,110,700 - 21,167,472 (-)NCBI
RefSeq Acc Id: XM_021255520   ⟹   XP_021111179
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474221,098,102 - 21,167,059 (-)NCBI
RefSeq Acc Id: XM_021255521   ⟹   XP_021111180
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474221,105,519 - 21,167,472 (-)NCBI
RefSeq Acc Id: XM_021255522   ⟹   XP_021111181
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474221,110,893 - 21,167,472 (-)NCBI
RefSeq Acc Id: XM_021255523   ⟹   XP_021111182
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474221,098,102 - 21,167,472 (-)NCBI
RefSeq Acc Id: XP_021111182   ⟸   XM_021255523
- Peptide Label: isoform X8
- UniProtKB: A0A0P6J6H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111175   ⟸   XM_021255516
- Peptide Label: isoform X2
- UniProtKB: A0A0P6J6H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004841485   ⟸   XM_004841428
- Peptide Label: isoform X1
- UniProtKB: A0A0P6J6H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111179   ⟸   XM_021255520
- Peptide Label: isoform X5
- UniProtKB: A0A0P6J6H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111176   ⟸   XM_021255517
- Peptide Label: isoform X3
- UniProtKB: A0A0P6J6H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111180   ⟸   XM_021255521
- Peptide Label: isoform X6
- UniProtKB: A0A0P6J6H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111178   ⟸   XM_021255519
- Peptide Label: isoform X4
- UniProtKB: A0A0P6J6H3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111181   ⟸   XM_021255522
- Peptide Label: isoform X7
- UniProtKB: A0A0P6J6H3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000007287   ⟸   ENSHGLT00000007372


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000005307 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000007372 ENTREZGENE
Gene3D-CATH 1.10.1420.10 UniProtKB/TrEMBL
  3.30.420.110 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro DNA_mismatch_repair_MutS_C UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_clamp UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_core UniProtKB/TrEMBL
  DNA_mismatch_repair_MutS_sf UniProtKB/TrEMBL
  DNA_mmatch_repair_MutS_con_dom UniProtKB/TrEMBL
  MutS_con_dom_sf UniProtKB/TrEMBL
  MutS_family UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Msh4 ENTREZGENE
PANTHER MUTS PROTEIN HOMOLOG 4 UniProtKB/TrEMBL
  PTHR11361 UniProtKB/TrEMBL
Pfam MutS_II UniProtKB/TrEMBL
  MutS_III UniProtKB/TrEMBL
  MutS_IV UniProtKB/TrEMBL
  MutS_V UniProtKB/TrEMBL
PROSITE DNA_MISMATCH_REPAIR_2 UniProtKB/TrEMBL
SMART MUTSac UniProtKB/TrEMBL
  MUTSd UniProtKB/TrEMBL
Superfamily-SCOP SSF48334 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF53150 UniProtKB/TrEMBL
UniProt A0A0P6J6H3 ENTREZGENE, UniProtKB/TrEMBL