Diras1 (DIRAS family GTPase 1) - Rat Genome Database

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Gene: Diras1 (DIRAS family GTPase 1) Heterocephalus glaber
Analyze
Symbol: Diras1
Name: DIRAS family GTPase 1
RGD ID: 18915942
Description: ENCODES a protein that exhibits mitogen-activated protein kinase binding (ortholog); INVOLVED IN positive regulation of MAP kinase activity (ortholog); ASSOCIATED WITH early myoclonic encephalopathy (ortholog); Neurodevelopmental Disorders (ortholog); progressive myoclonus epilepsy 9 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GTP-binding protein Di-Ras1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,809,660 - 5,816,819 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,808,355 - 5,816,865 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Diras1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,809,660 - 5,816,819 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,808,355 - 5,816,865 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DIRAS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,714,567 - 2,721,372 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,714,567 - 2,721,372 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,714,565 - 2,721,370 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,665,565 - 2,672,369 (-)NCBINCBI36Build 36hg18NCBI36
Build 34192,665,564 - 2,672,369NCBI
Celera192,650,904 - 2,657,729 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,484,453 - 2,491,186 (-)NCBIHuRef
CHM1_1192,714,145 - 2,720,965 (-)NCBICHM1_1
T2T-CHM13v2.0192,689,849 - 2,696,659 (-)NCBIT2T-CHM13v2.0
Diras1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,855,423 - 80,862,038 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,855,423 - 80,861,496 (-)EnsemblGRCm39 Ensembl
GRCm381081,019,589 - 81,025,835 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,019,589 - 81,025,662 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,482,335 - 80,488,122 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,422,719 - 80,428,506 (-)NCBIMGSCv36mm8
Celera1082,039,688 - 82,045,475 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Diras1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,338,660 - 9,343,524 (+)NCBIGRCr8
mRatBN7.278,687,964 - 8,692,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,687,942 - 8,693,831 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,572,446 - 11,577,301 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,447,941 - 13,452,796 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,314,453 - 11,319,308 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,556,192 - 11,561,056 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,556,192 - 11,561,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,723,556 - 11,728,420 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,171,727 - 10,176,591 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,174,785 - 10,175,421 (+)NCBI
Celera76,875,230 - 6,880,094 (+)NCBICelera
Cytogenetic Map7q11NCBI
Diras1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,004,548 - 5,005,144 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,002,803 - 5,005,203 (-)NCBIChiLan1.0ChiLan1.0
DIRAS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2207,108,885 - 7,115,747 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,340,786 - 6,347,646 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,738,941 - 1,745,786 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,697,756 - 2,702,656 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,700,396 - 2,700,992 (-)Ensemblpanpan1.1panPan2
DIRAS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,469,283 - 56,477,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,474,105 - 56,474,701 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,265,522 - 56,273,545 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,202,556 - 57,210,586 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,207,381 - 57,207,977 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,255,599 - 56,263,614 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,740,475 - 56,748,499 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,940,863 - 56,948,888 (+)NCBIUU_Cfam_GSD_1.0
Diras1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,251,871 - 216,261,808 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,572,400 - 1,590,779 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,572,975 - 1,575,971 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIRAS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,908,509 - 75,929,151 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,921,145 - 75,927,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,433,513 - 76,439,218 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233654
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,491,978 - 2,494,791 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,493,475 - 2,494,071 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660816,107,528 - 6,112,512 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Sequence


Ensembl Acc Id: ENSHGLT00000018871   ⟹   ENSHGLP00000018685
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248285,809,660 - 5,816,819 (-)Ensembl
RefSeq Acc Id: XM_004865783   ⟹   XP_004865840
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248285,808,355 - 5,816,865 (-)NCBI
RefSeq Acc Id: XM_004865784   ⟹   XP_004865841
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248285,808,355 - 5,816,864 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004865840 (Get FASTA)   NCBI Sequence Viewer  
  XP_004865841 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB14635 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000018685
  ENSHGLP00100058016
RefSeq Acc Id: XP_004865840   ⟸   XM_004865783
- UniProtKB: G5BZC4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004865841   ⟸   XM_004865784
- UniProtKB: G5BZC4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000018685   ⟸   ENSHGLT00000018871


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000013381 Ensembl, ENTREZGENE
  ENSHGLG00100036351 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000018871 ENTREZGENE
  ENSHGLT00100076005 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/TrEMBL
KEGG Report hgl:101711644 UniProtKB/TrEMBL
NCBI Gene Diras1 ENTREZGENE
PANTHER GTP-BINDING PROTEIN DI-RAS1 UniProtKB/TrEMBL
  PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt G5BZC4 ENTREZGENE, UniProtKB/TrEMBL